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Fusion gene ID: 38423 |
FusionGeneSummary for TMEM135_GPD1L |
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Fusion gene information | Fusion gene name: TMEM135_GPD1L | Fusion gene ID: 38423 | Hgene | Tgene | Gene symbol | TMEM135 | GPD1L | Gene ID | 65084 | 23171 |
Gene name | transmembrane protein 135 | glycerol-3-phosphate dehydrogenase 1 like | |
Synonyms | PMP52 | GPD1-L | |
Cytomap | 11q14.2 | 3p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protein 135peroxisomal membrane protein 52 | glycerol-3-phosphate dehydrogenase 1-like protein | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q86UB9 | Q8N335 | |
Ensembl transtripts involved in fusion gene | ENST00000340353, ENST00000532959, ENST00000305494, ENST00000535167, ENST00000355734, | ENST00000282541, | |
Fusion gene scores | * DoF score | 12 X 6 X 7=504 | 6 X 3 X 6=108 |
# samples | 14 | 7 | |
** MAII score | log2(14/504*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMEM135 [Title/Abstract] AND GPD1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-FG-5963-02A | TMEM135 | chr11 | 86749228 | + | GPD1L | chr3 | 32169568 | + |
TCGA | RV | LGG | TCGA-FG-5963-01A | TMEM135 | chr11 | 86749228 | + | GPD1L | chr3 | 32169568 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000340353 | ENST00000282541 | TMEM135 | chr11 | 86749228 | + | GPD1L | chr3 | 32169568 | + |
intron-3CDS | ENST00000532959 | ENST00000282541 | TMEM135 | chr11 | 86749228 | + | GPD1L | chr3 | 32169568 | + |
Frame-shift | ENST00000305494 | ENST00000282541 | TMEM135 | chr11 | 86749228 | + | GPD1L | chr3 | 32169568 | + |
5UTR-3CDS | ENST00000535167 | ENST00000282541 | TMEM135 | chr11 | 86749228 | + | GPD1L | chr3 | 32169568 | + |
Frame-shift | ENST00000355734 | ENST00000282541 | TMEM135 | chr11 | 86749228 | + | GPD1L | chr3 | 32169568 | + |
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FusionProtFeatures for TMEM135_GPD1L |
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Hgene | Tgene |
TMEM135 | GPD1L |
Involved in mitochondrial metabolism by regulating thebalance between mitochondrial fusion and fission. May act as aregulator of mitochondrial fission that promotes DNM1L-dependentfission through activation of DNM1L. May be involved in peroxisomeorganization. {ECO:0000250|UniProtKB:Q5U4F4,ECO:0000250|UniProtKB:Q9CYV5}. | Plays a role in regulating cardiac sodium current;decreased enzymatic activity with resulting increased levels ofglycerol 3-phosphate activating the DPD1L-dependent SCN5Aphosphorylation pathway, may ultimately lead to decreased sodiumcurrent; cardiac sodium current may also be reduced due toalterations of NAD(H) balance induced by DPD1L.{ECO:0000269|PubMed:19666841, ECO:0000269|PubMed:19745168}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM135_GPD1L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM135_GPD1L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMEM135 | SMPD3 | GPD1L | ELAVL1, BSG, FAS, PALM2, ART3, ISLR, TGOLN2, ALDOA, ALDOC, CYCS, GNPNAT1, ACO2, CKMT1A, CKMT1B, FH, GAPDH, GPT2, MYH7B, PHGDH, PYCRL, PGM1, TPI1, UPP1, GPD1, LAMP2, FAM174A, C1orf85, CCL5, DKKL1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM135_GPD1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM135_GPD1L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TMEM135 | C3714756 | Intellectual Disability | 1 | CTD_human |
Tgene | GPD1L | C2673193 | Brugada Syndrome 2 | 3 | CTD_human;UNIPROT |
Tgene | GPD1L | C0038644 | Sudden infant death syndrome | 2 | UNIPROT |
Tgene | GPD1L | C0015695 | Fatty Liver | 1 | CTD_human |