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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38421

FusionGeneSummary for TMEM135_ELOVL1

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM135_ELOVL1
Fusion gene ID: 38421
HgeneTgene
Gene symbol

TMEM135

ELOVL1

Gene ID

65084

64834

Gene nametransmembrane protein 135ELOVL fatty acid elongase 1
SynonymsPMP52CGI-88|Ssc1
Cytomap

11q14.2

1p34.2

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 135peroxisomal membrane protein 52elongation of very long chain fatty acids protein 13-keto acyl-CoA synthase ELOVL1ELOVL FA elongase 1elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1very long chain 3-ketoacyl-CoA synthase 1very long chain 3-oxoacyl-CoA
Modification date2018051920180523
UniProtAcc

Q86UB9

Q9BW60

Ensembl transtripts involved in fusion geneENST00000340353, ENST00000532959, 
ENST00000305494, ENST00000535167, 
ENST00000355734, 		ENST00000372458, 
ENST00000413844, ENST00000470769, 
Fusion gene scores* DoF score12 X 6 X 7=5043 X 3 X 3=27
# samples 143
** MAII scorelog2(14/504*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMEM135 [Title/Abstract] AND ELOVL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneELOVL1

GO:0019367

fatty acid elongation, saturated fatty acid

20166112|20937905

TgeneELOVL1

GO:0034625

fatty acid elongation, monounsaturated fatty acid

20166112

TgeneELOVL1

GO:0042761

very long-chain fatty acid biosynthetic process

20166112|20937905


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-20-1682-01ATMEM135chr11

86947726

+ELOVL1chr1

43831294

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000340353ENST00000372458TMEM135chr11

86947726

+ELOVL1chr1

43831294

-
5CDS-5UTRENST00000340353ENST00000413844TMEM135chr11

86947726

+ELOVL1chr1

43831294

-
5CDS-5UTRENST00000340353ENST00000470769TMEM135chr11

86947726

+ELOVL1chr1

43831294

-
5CDS-5UTRENST00000532959ENST00000372458TMEM135chr11

86947726

+ELOVL1chr1

43831294

-
5CDS-5UTRENST00000532959ENST00000413844TMEM135chr11

86947726

+ELOVL1chr1

43831294

-
5CDS-5UTRENST00000532959ENST00000470769TMEM135chr11

86947726

+ELOVL1chr1

43831294

-
5CDS-5UTRENST00000305494ENST00000372458TMEM135chr11

86947726

+ELOVL1chr1

43831294

-
5CDS-5UTRENST00000305494ENST00000413844TMEM135chr11

86947726

+ELOVL1chr1

43831294

-
5CDS-5UTRENST00000305494ENST00000470769TMEM135chr11

86947726

+ELOVL1chr1

43831294

-
5CDS-5UTRENST00000535167ENST00000372458TMEM135chr11

86947726

+ELOVL1chr1

43831294

-
5CDS-5UTRENST00000535167ENST00000413844TMEM135chr11

86947726

+ELOVL1chr1

43831294

-
5CDS-5UTRENST00000535167ENST00000470769TMEM135chr11

86947726

+ELOVL1chr1

43831294

-
intron-5UTRENST00000355734ENST00000372458TMEM135chr11

86947726

+ELOVL1chr1

43831294

-
intron-5UTRENST00000355734ENST00000413844TMEM135chr11

86947726

+ELOVL1chr1

43831294

-
intron-5UTRENST00000355734ENST00000470769TMEM135chr11

86947726

+ELOVL1chr1

43831294

-

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FusionProtFeatures for TMEM135_ELOVL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM135

Q86UB9

ELOVL1

Q9BW60

Involved in mitochondrial metabolism by regulating thebalance between mitochondrial fusion and fission. May act as aregulator of mitochondrial fission that promotes DNM1L-dependentfission through activation of DNM1L. May be involved in peroxisomeorganization. {ECO:0000250|UniProtKB:Q5U4F4,ECO:0000250|UniProtKB:Q9CYV5}. Catalyzes the first and rate-limiting reaction of thefour that constitute the long-chain fatty acids elongation cycle.This endoplasmic reticulum-bound enzymatic process, allows theaddition of 2 carbons to the chain of long- and very long-chainfatty acids/VLCFAs per cycle. Condensing enzyme that exhibitsactivity toward saturated C18 to C26 acyl-CoA substrates, with thehighest activity towards C22:0 acyl-CoA. May participate in theproduction of both saturated and monounsaturated VLCFAs ofdifferent chain lengths that are involved in multiple biologicalprocesses as precursors of membrane lipids and lipid mediators.Important for saturated C24:0 and monounsaturated C24:1sphingolipid synthesis. Indirectly inhibits RPE65 via productionof VLCFAs. {ECO:0000255|HAMAP-Rule:MF_03201,ECO:0000269|PubMed:20166112, ECO:0000269|PubMed:20937905}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM135_ELOVL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM135_ELOVL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM135SMPD3ELOVL1PSMD10, TWF2, GLP1R, CERS2, HSD17B12, TECR, MOV10, NXF1, TCTN3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM135_ELOVL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM135_ELOVL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMEM135C3714756Intellectual Disability1CTD_human