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Fusion gene ID: 38378 |
FusionGeneSummary for TMEM11_BOD1L1 |
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Fusion gene information | Fusion gene name: TMEM11_BOD1L1 | Fusion gene ID: 38378 | Hgene | Tgene | Gene symbol | TMEM11 | BOD1L1 | Gene ID | 8834 | 259282 |
Gene name | transmembrane protein 11 | biorientation of chromosomes in cell division 1 like 1 | |
Synonyms | C17orf35|PM1|PMI | BOD1L|FAM44A | |
Cytomap | 17p11.2 | 4p15.33 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protein 11, mitochondrialputative receptor protein | biorientation of chromosomes in cell division protein 1-like 1biorientation of chromosomes in cell division 1-likefamily with sequence similarity 44, member A | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P17152 | Q8NFC6 | |
Ensembl transtripts involved in fusion gene | ENST00000317635, ENST00000584432, | ENST00000040738, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 1=4 |
# samples | 3 | 2 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: TMEM11 [Title/Abstract] AND BOD1L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BOD1L1 | GO:0006974 | cellular response to DNA damage stimulus | 26166705 |
Tgene | BOD1L1 | GO:0031297 | replication fork processing | 26166705 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA672851 | TMEM11 | chr17 | 21117764 | + | BOD1L1 | chr4 | 13584361 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000317635 | ENST00000040738 | TMEM11 | chr17 | 21117764 | + | BOD1L1 | chr4 | 13584361 | - |
intron-3CDS | ENST00000584432 | ENST00000040738 | TMEM11 | chr17 | 21117764 | + | BOD1L1 | chr4 | 13584361 | - |
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FusionProtFeatures for TMEM11_BOD1L1 |
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Hgene | Tgene |
TMEM11 | BOD1L1 |
Plays a role in mitochondrial morphogenesis.{ECO:0000269|PubMed:21274005}. | Component of the fork protection machinery required toprotect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalledreplication forks and protecting RAD51 nucleofilaments from theantirecombinogenic activities of FBH1 and BLM (PubMed:26166705).Does not regulate spindle orientation (PubMed:26166705).{ECO:0000269|PubMed:26166705}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM11_BOD1L1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM11_BOD1L1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM11_BOD1L1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM11_BOD1L1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |