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Fusion gene ID: 38373 |
FusionGeneSummary for TMEM117_PRIM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM117_PRIM1 | Fusion gene ID: 38373 | Hgene | Tgene | Gene symbol | TMEM117 | PRIM1 | Gene ID | 84216 | 5557 |
| Gene name | transmembrane protein 117 | DNA primase subunit 1 | |
| Synonyms | - | p49 | |
| Cytomap | 12q12 | 12q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 117 | DNA primase small subunitDNA primase 1DNA primase 49 kDa subunitDNA primase subunit 48primase (DNA) subunit 1primase p49 subunitprimase polypeptide 1, 49kDaprimase, DNA, polypeptide 1 (49kDa) | |
| Modification date | 20180329 | 20180523 | |
| UniProtAcc | Q9H0C3 | P49642 | |
| Ensembl transtripts involved in fusion gene | ENST00000551577, ENST00000266534, ENST00000536799, ENST00000546978, | ENST00000338193, ENST00000552408, | |
| Fusion gene scores | * DoF score | 11 X 6 X 7=462 | 7 X 6 X 7=294 |
| # samples | 11 | 8 | |
| ** MAII score | log2(11/462*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/294*10)=-1.877744249949 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM117 [Title/Abstract] AND PRIM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A1L4-01A | TMEM117 | chr12 | 44238731 | + | PRIM1 | chr12 | 57144979 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000551577 | ENST00000338193 | TMEM117 | chr12 | 44238731 | + | PRIM1 | chr12 | 57144979 | - |
| 5CDS-5UTR | ENST00000551577 | ENST00000552408 | TMEM117 | chr12 | 44238731 | + | PRIM1 | chr12 | 57144979 | - |
| In-frame | ENST00000266534 | ENST00000338193 | TMEM117 | chr12 | 44238731 | + | PRIM1 | chr12 | 57144979 | - |
| 5CDS-5UTR | ENST00000266534 | ENST00000552408 | TMEM117 | chr12 | 44238731 | + | PRIM1 | chr12 | 57144979 | - |
| Frame-shift | ENST00000536799 | ENST00000338193 | TMEM117 | chr12 | 44238731 | + | PRIM1 | chr12 | 57144979 | - |
| 5CDS-5UTR | ENST00000536799 | ENST00000552408 | TMEM117 | chr12 | 44238731 | + | PRIM1 | chr12 | 57144979 | - |
| intron-3CDS | ENST00000546978 | ENST00000338193 | TMEM117 | chr12 | 44238731 | + | PRIM1 | chr12 | 57144979 | - |
| intron-5UTR | ENST00000546978 | ENST00000552408 | TMEM117 | chr12 | 44238731 | + | PRIM1 | chr12 | 57144979 | - |
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FusionProtFeatures for TMEM117_PRIM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM117 | PRIM1 |
| Involved in endoplasmic reticulum (ER) stress-inducedcell death pathway. {ECO:0000269|PubMed:28285135}. | DNA primase is the polymerase that synthesizes small RNAprimers for the Okazaki fragments made during discontinuous DNAreplication. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 1_15 | 92 | 515 | Topological domain | Cytoplasmic |
| Hgene | TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 37_65 | 92 | 515 | Topological domain | Extracellular |
| Hgene | TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 16_36 | 92 | 515 | Transmembrane | Helical |
| Hgene | TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 66_86 | 92 | 515 | Transmembrane | Helical |
| Tgene | >PRIM1 | chr12:44238731 | chr12:57144979 | ENST00000338193 | - | 0 | 13 | 121_131 | 34 | 421 | Motif | Note=Zinc knuckle motif |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 132_154 | 92 | 515 | Topological domain | Extracellular |
| Hgene | >TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 176_198 | 92 | 515 | Topological domain | Cytoplasmic |
| Hgene | >TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 220_239 | 92 | 515 | Topological domain | Extracellular |
| Hgene | >TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 261_295 | 92 | 515 | Topological domain | Cytoplasmic |
| Hgene | >TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 317_394 | 92 | 515 | Topological domain | Extracellular |
| Hgene | >TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 416_514 | 92 | 515 | Topological domain | Cytoplasmic |
| Hgene | >TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 87_110 | 92 | 515 | Topological domain | Cytoplasmic |
| Hgene | >TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 111_131 | 92 | 515 | Transmembrane | Helical |
| Hgene | >TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 155_175 | 92 | 515 | Transmembrane | Helical |
| Hgene | >TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 199_219 | 92 | 515 | Transmembrane | Helical |
| Hgene | >TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 240_260 | 92 | 515 | Transmembrane | Helical |
| Hgene | >TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 296_316 | 92 | 515 | Transmembrane | Helical |
| Hgene | >TMEM117 | chr12:44238731 | chr12:57144979 | ENST00000266534 | + | 2 | 8 | 395_415 | 92 | 515 | Transmembrane | Helical |
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FusionGeneSequence for TMEM117_PRIM1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TMEM117_ENST00000551577_chr12_44238731_+_PRIM1_ENST00000338193_chr12_57144979_-_479aa MGKDFRYYFQHPWSRMIVAYLVIFFNFLIFAEDPVSHSQTEANVIVVGNCFSFVTNKYPRGVGWRILKVLLWLLAILTGLIAGKFLFHQR LFVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCC SSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFI RKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNIKNDKYGPWLEWEIMLQYCF PRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAISTNEEEKEENEAESDVKHRTRDYKKTSLAPYV >In-frame_TMEM117_ENST00000266534_chr12_44238731_+_PRIM1_ENST00000338193_chr12_57144979_-_479aa MGKDFRYYFQHPWSRMIVAYLVIFFNFLIFAEDPVSHSQTEANVIVVGNCFSFVTNKYPRGVGWRILKVLLWLLAILTGLIAGKFLFHQR LFVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCC SSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFI RKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNIKNDKYGPWLEWEIMLQYCF PRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAISTNEEEKEENEAESDVKHRTRDYKKTSLAPYV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TMEM117_ENST00000551577_chr12_44238731_+_PRIM1_ENST00000338193_chr12_57144979_-_1437nt ATGGGTAAAGACTTTCGTTACTATTTCCAGCATCCCTGGTCTCGCATGATTGTGGCTTACTTGGTGATCTTCTTTAACTTCTTAATATTT GCGGAGGACCCAGTTTCTCATAGCCAAACAGAAGCCAATGTTATTGTTGTTGGAAACTGTTTTTCATTTGTTACAAATAAATACCCTAGA GGAGTTGGCTGGAGGATTTTGAAGGTGCTTCTATGGCTACTTGCCATTCTCACAGGACTAATAGCTGGCAAATTTCTGTTCCATCAGCGT TTGTTTGTGATAAAGAATTACTTTCAACACCGTGAATTTTCATTCACATTGAAAGATGATATTTACATTCGCTACCAATCCTTCAACAAC CAGAGTGATCTGGAAAAGGAGATGCAGAAAATGAATCCATACAAGATTGATATAGGCGCAGTATATTCTCACAGACCCAATCAACACAAT ACAGTGAAGCTGGGAGCTTTCCAGGCTCAGGAAAAAGAACTGGTATTTGACATTGACATGACAGACTATGACGATGTGAGGAGATGTTGT AGTTCTGCAGACATATGTCCTAAGTGCTGGACCCTCATGACAATGGCCATACGCATCATTGACAGAGCATTGAAGGAGGACTTTGGATTT AAGCATCGTCTCTGGGTATATTCTGGAAGGAGAGGTGTTCATTGTTGGGTCTGTGATGAATCAGTTAGAAAACTGTCTTCTGCAGTACGT TCTGGGATAGTTGAGTATTTGAGCCTTGTAAAGGGTGGTCAAGACGTTAAAAAGAAAGTTCACCTAAGTGAAAAAATTCACCCTTTTATC AGAAAATCTATAAACATAATAAAAAAATACTTTGAAGAATATGCCTTGGTTAATCAAGATATTCTCGAAAATAAAGAAAGCTGGGATAAG ATTTTAGCCCTTGTTCCTGAAACAATTCATGATGAACTTCAACAAAGCTTCCAAAAGTCTCACAATTCACTTCAGCGTTGGGAGCACTTG AAGAAAGTAGCCAGCAGATATCAGAATAACATCAAAAATGACAAATATGGACCCTGGCTGGAGTGGGAGATTATGCTCCAGTACTGTTTT CCACGGCTGGATATCAATGTCAGCAAAGGAATCAATCATCTACTGAAGAGCCCTTTTAGTGTTCATCCTAAAACAGGTCGCATATCTGTG CCTATTGATTTGCAGAAAGTGGACCAGTTTGATCCATTTACTGTTCCGACCATAAGCTTCATCTGCCGTGAATTGGATGCCATTTCCACT AATGAAGAGGAAAAAGAGGAGAATGAAGCTGAATCTGATGTCAAACATAGAACCAGAGATTATAAGAAGACCAGTCTAGCACCTTATGTG >In-frame_TMEM117_ENST00000266534_chr12_44238731_+_PRIM1_ENST00000338193_chr12_57144979_-_1437nt ATGGGTAAAGACTTTCGTTACTATTTCCAGCATCCCTGGTCTCGCATGATTGTGGCTTACTTGGTGATCTTCTTTAACTTCTTAATATTT GCGGAGGACCCAGTTTCTCATAGCCAAACAGAAGCCAATGTTATTGTTGTTGGAAACTGTTTTTCATTTGTTACAAATAAATACCCTAGA GGAGTTGGCTGGAGGATTTTGAAGGTGCTTCTATGGCTACTTGCCATTCTCACAGGACTAATAGCTGGCAAATTTCTGTTCCATCAGCGT TTGTTTGTGATAAAGAATTACTTTCAACACCGTGAATTTTCATTCACATTGAAAGATGATATTTACATTCGCTACCAATCCTTCAACAAC CAGAGTGATCTGGAAAAGGAGATGCAGAAAATGAATCCATACAAGATTGATATAGGCGCAGTATATTCTCACAGACCCAATCAACACAAT ACAGTGAAGCTGGGAGCTTTCCAGGCTCAGGAAAAAGAACTGGTATTTGACATTGACATGACAGACTATGACGATGTGAGGAGATGTTGT AGTTCTGCAGACATATGTCCTAAGTGCTGGACCCTCATGACAATGGCCATACGCATCATTGACAGAGCATTGAAGGAGGACTTTGGATTT AAGCATCGTCTCTGGGTATATTCTGGAAGGAGAGGTGTTCATTGTTGGGTCTGTGATGAATCAGTTAGAAAACTGTCTTCTGCAGTACGT TCTGGGATAGTTGAGTATTTGAGCCTTGTAAAGGGTGGTCAAGACGTTAAAAAGAAAGTTCACCTAAGTGAAAAAATTCACCCTTTTATC AGAAAATCTATAAACATAATAAAAAAATACTTTGAAGAATATGCCTTGGTTAATCAAGATATTCTCGAAAATAAAGAAAGCTGGGATAAG ATTTTAGCCCTTGTTCCTGAAACAATTCATGATGAACTTCAACAAAGCTTCCAAAAGTCTCACAATTCACTTCAGCGTTGGGAGCACTTG AAGAAAGTAGCCAGCAGATATCAGAATAACATCAAAAATGACAAATATGGACCCTGGCTGGAGTGGGAGATTATGCTCCAGTACTGTTTT CCACGGCTGGATATCAATGTCAGCAAAGGAATCAATCATCTACTGAAGAGCCCTTTTAGTGTTCATCCTAAAACAGGTCGCATATCTGTG CCTATTGATTTGCAGAAAGTGGACCAGTTTGATCCATTTACTGTTCCGACCATAAGCTTCATCTGCCGTGAATTGGATGCCATTTCCACT AATGAAGAGGAAAAAGAGGAGAATGAAGCTGAATCTGATGTCAAACATAGAACCAGAGATTATAAGAAGACCAGTCTAGCACCTTATGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TMEM117_ENST00000551577_chr12_44238731_+_PRIM1_ENST00000338193_chr12_57144979_-_1672nt CGACGCCGCCGGCCCGTCTCGCCGCGCTTCCCAGCGAGGCCGCCGGCGCGCCGAGGGCTGTGCTCGACCGCGAATCCCGTGTGCAGTCGC CCCGCGCCCCGCGCGACCCTTCGGGTAAACTACGAACTGGGAGTTCTGAAGAATGGGTAAAGACTTTCGTTACTATTTCCAGCATCCCTG GTCTCGCATGATTGTGGCTTACTTGGTGATCTTCTTTAACTTCTTAATATTTGCGGAGGACCCAGTTTCTCATAGCCAAACAGAAGCCAA TGTTATTGTTGTTGGAAACTGTTTTTCATTTGTTACAAATAAATACCCTAGAGGAGTTGGCTGGAGGATTTTGAAGGTGCTTCTATGGCT ACTTGCCATTCTCACAGGACTAATAGCTGGCAAATTTCTGTTCCATCAGCGTTTGTTTGTGATAAAGAATTACTTTCAACACCGTGAATT TTCATTCACATTGAAAGATGATATTTACATTCGCTACCAATCCTTCAACAACCAGAGTGATCTGGAAAAGGAGATGCAGAAAATGAATCC ATACAAGATTGATATAGGCGCAGTATATTCTCACAGACCCAATCAACACAATACAGTGAAGCTGGGAGCTTTCCAGGCTCAGGAAAAAGA ACTGGTATTTGACATTGACATGACAGACTATGACGATGTGAGGAGATGTTGTAGTTCTGCAGACATATGTCCTAAGTGCTGGACCCTCAT GACAATGGCCATACGCATCATTGACAGAGCATTGAAGGAGGACTTTGGATTTAAGCATCGTCTCTGGGTATATTCTGGAAGGAGAGGTGT TCATTGTTGGGTCTGTGATGAATCAGTTAGAAAACTGTCTTCTGCAGTACGTTCTGGGATAGTTGAGTATTTGAGCCTTGTAAAGGGTGG TCAAGACGTTAAAAAGAAAGTTCACCTAAGTGAAAAAATTCACCCTTTTATCAGAAAATCTATAAACATAATAAAAAAATACTTTGAAGA ATATGCCTTGGTTAATCAAGATATTCTCGAAAATAAAGAAAGCTGGGATAAGATTTTAGCCCTTGTTCCTGAAACAATTCATGATGAACT TCAACAAAGCTTCCAAAAGTCTCACAATTCACTTCAGCGTTGGGAGCACTTGAAGAAAGTAGCCAGCAGATATCAGAATAACATCAAAAA TGACAAATATGGACCCTGGCTGGAGTGGGAGATTATGCTCCAGTACTGTTTTCCACGGCTGGATATCAATGTCAGCAAAGGAATCAATCA TCTACTGAAGAGCCCTTTTAGTGTTCATCCTAAAACAGGTCGCATATCTGTGCCTATTGATTTGCAGAAAGTGGACCAGTTTGATCCATT TACTGTTCCGACCATAAGCTTCATCTGCCGTGAATTGGATGCCATTTCCACTAATGAAGAGGAAAAAGAGGAGAATGAAGCTGAATCTGA TGTCAAACATAGAACCAGAGATTATAAGAAGACCAGTCTAGCACCTTATGTGAAAGTTTTTGAACATTTTCTTGAAAATCTGGATAAATC CCGAAAAGGAGAACTTCTTAAGAAGAGTGATTTACAAAAAGATTTCTGAAGACAGAGCTCCTCAAACCATTGTGGATATCTTCTGCCTTC >In-frame_TMEM117_ENST00000266534_chr12_44238731_+_PRIM1_ENST00000338193_chr12_57144979_-_1657nt GTCTCGCCGCGCTTCCCAGCGAGGCCGCCGGCGCGCCGAGGGCTGTGCTCGACCGCGAATCCCGTGTGCAGTCGCCCCGCGCCCCGCGCG ACCCTTCGGGTAAACTACGAACTGGGAGTTCTGAAGAATGGGTAAAGACTTTCGTTACTATTTCCAGCATCCCTGGTCTCGCATGATTGT GGCTTACTTGGTGATCTTCTTTAACTTCTTAATATTTGCGGAGGACCCAGTTTCTCATAGCCAAACAGAAGCCAATGTTATTGTTGTTGG AAACTGTTTTTCATTTGTTACAAATAAATACCCTAGAGGAGTTGGCTGGAGGATTTTGAAGGTGCTTCTATGGCTACTTGCCATTCTCAC AGGACTAATAGCTGGCAAATTTCTGTTCCATCAGCGTTTGTTTGTGATAAAGAATTACTTTCAACACCGTGAATTTTCATTCACATTGAA AGATGATATTTACATTCGCTACCAATCCTTCAACAACCAGAGTGATCTGGAAAAGGAGATGCAGAAAATGAATCCATACAAGATTGATAT AGGCGCAGTATATTCTCACAGACCCAATCAACACAATACAGTGAAGCTGGGAGCTTTCCAGGCTCAGGAAAAAGAACTGGTATTTGACAT TGACATGACAGACTATGACGATGTGAGGAGATGTTGTAGTTCTGCAGACATATGTCCTAAGTGCTGGACCCTCATGACAATGGCCATACG CATCATTGACAGAGCATTGAAGGAGGACTTTGGATTTAAGCATCGTCTCTGGGTATATTCTGGAAGGAGAGGTGTTCATTGTTGGGTCTG TGATGAATCAGTTAGAAAACTGTCTTCTGCAGTACGTTCTGGGATAGTTGAGTATTTGAGCCTTGTAAAGGGTGGTCAAGACGTTAAAAA GAAAGTTCACCTAAGTGAAAAAATTCACCCTTTTATCAGAAAATCTATAAACATAATAAAAAAATACTTTGAAGAATATGCCTTGGTTAA TCAAGATATTCTCGAAAATAAAGAAAGCTGGGATAAGATTTTAGCCCTTGTTCCTGAAACAATTCATGATGAACTTCAACAAAGCTTCCA AAAGTCTCACAATTCACTTCAGCGTTGGGAGCACTTGAAGAAAGTAGCCAGCAGATATCAGAATAACATCAAAAATGACAAATATGGACC CTGGCTGGAGTGGGAGATTATGCTCCAGTACTGTTTTCCACGGCTGGATATCAATGTCAGCAAAGGAATCAATCATCTACTGAAGAGCCC TTTTAGTGTTCATCCTAAAACAGGTCGCATATCTGTGCCTATTGATTTGCAGAAAGTGGACCAGTTTGATCCATTTACTGTTCCGACCAT AAGCTTCATCTGCCGTGAATTGGATGCCATTTCCACTAATGAAGAGGAAAAAGAGGAGAATGAAGCTGAATCTGATGTCAAACATAGAAC CAGAGATTATAAGAAGACCAGTCTAGCACCTTATGTGAAAGTTTTTGAACATTTTCTTGAAAATCTGGATAAATCCCGAAAAGGAGAACT TCTTAAGAAGAGTGATTTACAAAAAGATTTCTGAAGACAGAGCTCCTCAAACCATTGTGGATATCTTCTGCCTTCAACCACAGATCAAAT |
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FusionGenePPI for TMEM117_PRIM1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TMEM117 | PRIM1 | XRCC5, RAE1, RPA1, RPA2, RPA3, COPS6, POLA1, PRIM2, POLA2, POLE, MDC1, MMS19, FAM96B, CIAO1, MOV10, NXF1, EGFR, KLHL20, OBFC1, LIPH, CCAR1, DUSP9, NLGN4Y, RNF31, DCAF10, NCAPH2, C6orf141, AK9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM117_PRIM1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM117_PRIM1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TMEM117 | C0008370 | Cholestasis | 1 | CTD_human |
| Hgene | TMEM117 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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