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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38340

FusionGeneSummary for TMEFF2_TMPRSS11B

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEFF2_TMPRSS11B
Fusion gene ID: 38340
HgeneTgene
Gene symbol

TMEFF2

TMPRSS11B

Gene ID

23671

132724

Gene nametransmembrane protein with EGF like and two follistatin like domains 2transmembrane serine protease 11B
SynonymsCT120.2|HPP1|TENB2|TPEF|TR|TR-2-
Cytomap

2q32.3

4q13.2

Type of geneprotein-codingprotein-coding
Descriptiontomoregulin-2cancer/testis antigen family 120, member 2hyperplastic polyposis protein 1transmembrane protein TENB2transmembrane protein with EGF-like and two follistatin-like domainstransmembrane protease serine 11Bairway trypsin-like protease 5transmembrane protease, serine 11B
Modification date2018051920180523
UniProtAcc

Q9UIK5

Q86T26

Ensembl transtripts involved in fusion geneENST00000392314, ENST00000272771, 
ENST00000487771, ENST00000409056, 
ENST00000332644, 
Fusion gene scores* DoF score7 X 4 X 2=561 X 1 X 1=1
# samples 81
** MAII scorelog2(8/56*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: TMEFF2 [Title/Abstract] AND TMPRSS11B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMEFF2

GO:0030336

negative regulation of cell migration

24632071

HgeneTMEFF2

GO:0044319

wound healing, spreading of cells

24632071

HgeneTMEFF2

GO:0051497

negative regulation of stress fiber assembly

24632071


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-ZG-A9LM-01ATMEFF2chr2

193044394

-TMPRSS11Bchr4

69098134

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000392314ENST00000332644TMEFF2chr2

193044394

-TMPRSS11Bchr4

69098134

-
In-frameENST00000272771ENST00000332644TMEFF2chr2

193044394

-TMPRSS11Bchr4

69098134

-
intron-3CDSENST00000487771ENST00000332644TMEFF2chr2

193044394

-TMPRSS11Bchr4

69098134

-
intron-3CDSENST00000409056ENST00000332644TMEFF2chr2

193044394

-TMPRSS11Bchr4

69098134

-

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FusionProtFeatures for TMEFF2_TMPRSS11B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEFF2

Q9UIK5

TMPRSS11B

Q86T26

Serine protease. {ECO:0000269|PubMed:24498351}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000272771-41085_137146375DomainKazal-like 1
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000392314-41085_137146347DomainKazal-like 1
TgeneTMPRSS11Bchr2:193044394chr4:69098134ENST00000332644-410185_415156417DomainPeptidase S1

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000272771-410176_229146375DomainKazal-like 2
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000272771-410261_301146375DomainEGF-like
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000392314-410176_229146347DomainKazal-like 2
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000392314-410261_301146347DomainEGF-like
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000409056-14176_2290176DomainKazal-like 2
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000409056-14261_3010176DomainEGF-like
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000409056-1485_1370176DomainKazal-like 1
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000272771-410303_320146375RegionNote=Required for shedding
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000392314-410303_320146347RegionNote=Required for shedding
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000409056-14303_3200176RegionNote=Required for shedding
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000272771-410342_374146375Topological domainCytoplasmic
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000272771-41041_320146375Topological domainExtracellular
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000392314-410342_374146347Topological domainCytoplasmic
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000392314-41041_320146347Topological domainExtracellular
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000409056-14342_3740176Topological domainCytoplasmic
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000409056-1441_3200176Topological domainExtracellular
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000272771-410321_341146375TransmembraneHelical
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000392314-410321_341146347TransmembraneHelical
HgeneTMEFF2chr2:193044394chr4:69098134ENST00000409056-14321_3410176TransmembraneHelical
TgeneTMPRSS11Bchr2:193044394chr4:69098134ENST00000332644-41043_160156417DomainSEA
TgeneTMPRSS11Bchr2:193044394chr4:69098134ENST00000332644-4101_17156417Topological domainCytoplasmic
TgeneTMPRSS11Bchr2:193044394chr4:69098134ENST00000332644-41039_416156417Topological domainExtracellular
TgeneTMPRSS11Bchr2:193044394chr4:69098134ENST00000332644-41018_38156417TransmembraneHelical%3B Signal-anchor for type II membrane protein


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FusionGeneSequence for TMEFF2_TMPRSS11B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TMEFF2_ENST00000392314_chr2_193044394_-_TMPRSS11B_ENST00000332644_chr4_69098134_-_407aa
MVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCV
CQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGEISKAASEMLTNNCCGRQVANSIITGNKIVNGKS
SLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKKNNSKDWTVNFGIVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEV
SFTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFMSGEADACQNDSGGPL

>In-frame_TMEFF2_ENST00000272771_chr2_193044394_-_TMPRSS11B_ENST00000332644_chr4_69098134_-_407aa
MVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCV
CQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGEISKAASEMLTNNCCGRQVANSIITGNKIVNGKS
SLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKKNNSKDWTVNFGIVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEV
SFTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFMSGEADACQNDSGGPL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TMEFF2_ENST00000392314_chr2_193044394_-_TMPRSS11B_ENST00000332644_chr4_69098134_-_1221nt
ATGGTGCTGTGGGAGTCCCCGCGGCAGTGCAGCAGCTGGACACTTTGCGAGGGCTTTTGCTGGCTGCTGCTGCTGCCCGTCATGCTACTC
ATCGTAGCCCGCCCGGTGAAGCTCGCTGCTTTCCCTACCTCCTTAAGTGACTGCCAAACGCCCACCGGCTGGAATTGCTCTGGTTATGAT
GACAGAGAAAATGATCTCTTCCTCTGTGACACCAACACCTGTAAATTTGATGGGGAATGTTTAAGAATTGGAGACACTGTGACTTGCGTC
TGTCAGTTCAAGTGCAACAATGACTATGTGCCTGTGTGTGGCTCCAATGGGGAGAGCTACCAGAATGAGTGTTACCTGCGACAGGCTGCA
TGCAAACAGCAGAGTGAGATACTTGTGGTGTCAGAAGGATCATGTGCCACAGATGCAGGATCAGGATCTGGAGATGGAGAAATCAGCAAG
GCTGCTTCTGAAATGCTTACCAACAACTGTTGTGGGAGACAAGTAGCCAACAGTATCATAACTGGCAACAAAATTGTGAATGGAAAAAGC
TCCCTGGAGGGGGCATGGCCATGGCAGGCCAGCATGCAATGGAAAGGCCGTCACTACTGTGGAGCCTCTCTGATCAGCAGCAGGTGGCTA
TTATCTGCAGCTCACTGCTTTGCTAAGAAAAATAATTCAAAAGATTGGACTGTCAACTTTGGAATTGTAGTAAATAAACCATATATGACA
CGGAAAGTCCAAAACATTATTTTTCATGAAAATTATAGCAGTCCTGGGCTTCATGATGATATTGCCCTTGTGCAGCTTGCTGAAGAAGTT
TCTTTTACAGAGTACATTCGTAAGATTTGTCTTCCTGAAGCCAAAATGAAGCTCTCAGAAAATGACAATGTTGTAGTTACAGGTTGGGGA
ACACTTTATATGAATGGTTCATTTCCAGTGATACTTCAAGAAGACTTTTTGAAGATTATTGACAACAAAATTTGCAATGCCTCATATGCA
TACTCTGGCTTTGTGACTGATACAATGTTATGTGCTGGATTTATGTCAGGAGAAGCTGATGCATGTCAGAATGATTCTGGTGGACCACTA
GCTTACCCTGATTCCAGAAATATCTGGCATCTTGTTGGAATAGTAAGCTGGGGTGATGGATGTGGTAAAAAGAATAAGCCAGGTGTCTAT

>In-frame_TMEFF2_ENST00000272771_chr2_193044394_-_TMPRSS11B_ENST00000332644_chr4_69098134_-_1221nt
ATGGTGCTGTGGGAGTCCCCGCGGCAGTGCAGCAGCTGGACACTTTGCGAGGGCTTTTGCTGGCTGCTGCTGCTGCCCGTCATGCTACTC
ATCGTAGCCCGCCCGGTGAAGCTCGCTGCTTTCCCTACCTCCTTAAGTGACTGCCAAACGCCCACCGGCTGGAATTGCTCTGGTTATGAT
GACAGAGAAAATGATCTCTTCCTCTGTGACACCAACACCTGTAAATTTGATGGGGAATGTTTAAGAATTGGAGACACTGTGACTTGCGTC
TGTCAGTTCAAGTGCAACAATGACTATGTGCCTGTGTGTGGCTCCAATGGGGAGAGCTACCAGAATGAGTGTTACCTGCGACAGGCTGCA
TGCAAACAGCAGAGTGAGATACTTGTGGTGTCAGAAGGATCATGTGCCACAGATGCAGGATCAGGATCTGGAGATGGAGAAATCAGCAAG
GCTGCTTCTGAAATGCTTACCAACAACTGTTGTGGGAGACAAGTAGCCAACAGTATCATAACTGGCAACAAAATTGTGAATGGAAAAAGC
TCCCTGGAGGGGGCATGGCCATGGCAGGCCAGCATGCAATGGAAAGGCCGTCACTACTGTGGAGCCTCTCTGATCAGCAGCAGGTGGCTA
TTATCTGCAGCTCACTGCTTTGCTAAGAAAAATAATTCAAAAGATTGGACTGTCAACTTTGGAATTGTAGTAAATAAACCATATATGACA
CGGAAAGTCCAAAACATTATTTTTCATGAAAATTATAGCAGTCCTGGGCTTCATGATGATATTGCCCTTGTGCAGCTTGCTGAAGAAGTT
TCTTTTACAGAGTACATTCGTAAGATTTGTCTTCCTGAAGCCAAAATGAAGCTCTCAGAAAATGACAATGTTGTAGTTACAGGTTGGGGA
ACACTTTATATGAATGGTTCATTTCCAGTGATACTTCAAGAAGACTTTTTGAAGATTATTGACAACAAAATTTGCAATGCCTCATATGCA
TACTCTGGCTTTGTGACTGATACAATGTTATGTGCTGGATTTATGTCAGGAGAAGCTGATGCATGTCAGAATGATTCTGGTGGACCACTA
GCTTACCCTGATTCCAGAAATATCTGGCATCTTGTTGGAATAGTAAGCTGGGGTGATGGATGTGGTAAAAAGAATAAGCCAGGTGTCTAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_TMEFF2_ENST00000392314_chr2_193044394_-_TMPRSS11B_ENST00000332644_chr4_69098134_-_2871nt
AGAGCTCGAGAGGCGGCTGCCGGGCTGCGGGGCGCCTTGACTCTCCCTCCACCCTGCCTCCTCGGGCTCCACTCGTCTGCCCCTGGACTC
CCGTCTCCTCCTGTCCTCCGGCTTCCCAGAGCTCCCTCCTTATGGCAGCAGCTTCCCGCGTCTCCGGCGCAGCTTCTCAGCGGACGACCC
TCTCGCTCCGGGGCTGAGCCCAGTCCCTGGATGTTGCTGAAACTCTCGAGATCATGCGCGGGTTTGGCTGCTGCTTCCCCGCCGGGTGCC
ACTGCCACCGCCGCCGCCTCTGCTGCCGCCGTCCGCGGGATGCTCAGTAGCCCGCTGCCCGGCCCCCGCGATCCTGTGTTCCTCGGAAGC
CGTTTGCTGCTGCAGAGTTGCACGAACTAGTCATGGTGCTGTGGGAGTCCCCGCGGCAGTGCAGCAGCTGGACACTTTGCGAGGGCTTTT
GCTGGCTGCTGCTGCTGCCCGTCATGCTACTCATCGTAGCCCGCCCGGTGAAGCTCGCTGCTTTCCCTACCTCCTTAAGTGACTGCCAAA
CGCCCACCGGCTGGAATTGCTCTGGTTATGATGACAGAGAAAATGATCTCTTCCTCTGTGACACCAACACCTGTAAATTTGATGGGGAAT
GTTTAAGAATTGGAGACACTGTGACTTGCGTCTGTCAGTTCAAGTGCAACAATGACTATGTGCCTGTGTGTGGCTCCAATGGGGAGAGCT
ACCAGAATGAGTGTTACCTGCGACAGGCTGCATGCAAACAGCAGAGTGAGATACTTGTGGTGTCAGAAGGATCATGTGCCACAGATGCAG
GATCAGGATCTGGAGATGGAGAAATCAGCAAGGCTGCTTCTGAAATGCTTACCAACAACTGTTGTGGGAGACAAGTAGCCAACAGTATCA
TAACTGGCAACAAAATTGTGAATGGAAAAAGCTCCCTGGAGGGGGCATGGCCATGGCAGGCCAGCATGCAATGGAAAGGCCGTCACTACT
GTGGAGCCTCTCTGATCAGCAGCAGGTGGCTATTATCTGCAGCTCACTGCTTTGCTAAGAAAAATAATTCAAAAGATTGGACTGTCAACT
TTGGAATTGTAGTAAATAAACCATATATGACACGGAAAGTCCAAAACATTATTTTTCATGAAAATTATAGCAGTCCTGGGCTTCATGATG
ATATTGCCCTTGTGCAGCTTGCTGAAGAAGTTTCTTTTACAGAGTACATTCGTAAGATTTGTCTTCCTGAAGCCAAAATGAAGCTCTCAG
AAAATGACAATGTTGTAGTTACAGGTTGGGGAACACTTTATATGAATGGTTCATTTCCAGTGATACTTCAAGAAGACTTTTTGAAGATTA
TTGACAACAAAATTTGCAATGCCTCATATGCATACTCTGGCTTTGTGACTGATACAATGTTATGTGCTGGATTTATGTCAGGAGAAGCTG
ATGCATGTCAGAATGATTCTGGTGGACCACTAGCTTACCCTGATTCCAGAAATATCTGGCATCTTGTTGGAATAGTAAGCTGGGGTGATG
GATGTGGTAAAAAGAATAAGCCAGGTGTCTATACTCGAGTGACTTCTTATCGCAATTGGATTACATCCAAGACTGGACTCTGAAAAAAAA
GGAATTATACAAAGGAACATAAAGACCACTGTAGGCTATCCTTATCTGTGGCTTTGGGATCTTTTTATTTTGATTGTTGGTAAACTAATC
ATTTTATTATATATAAAAATATAAATGTCTTTATTAATATTTTATTATATCTAAAACACTGTCCATGCATTTATTAATCTTTTAAATTAA
TGTAAGAGATAGGAAGAGGCCAGGTGTAGTGGCTCATGCCTGTAATCCTAGCACTTTGAGAGGCCGAGATAGGCGGATTGCTTGAGCCCA
GGAGTTTGAGGGCAGCCTGGGAAACATGGCTAAATCCGTGTTCAAAAAATACAAAAATTAGCTAGGCATGGTGGCGTGCACCTATAGTCC
CAGCTATTCAGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCAGCAGGTTGAGGCTGTGGTGATTTGTGATTGCGCCACCACTGCACTCCA
GCCTGGGCAACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAGGAGAGAAGAAAATAAAGAAGGCTAATATATAATTTTTCTTA
ATAGCTGAGTTGTGATTCATTTTACCATTATATTCAGAATTGACCTTAATTTGTTTTCCAGAATCAAAAGAAAATAAAATATAAATTTTG
AAACTATGAGAACATATATAGGGGATTTATCAAATGAGTTACTTTTTATTATATCAATTATAATTTCATTTTATTAACTGGAATAAGTGC
GAAAGTGTACATTACTTTTTAACTTATATGTGAAATGATTCATGTACCTCACAAAATCATGCAATCTTGCAGTGAAGAAGGAGTATCAGA
GCTCCAGCTACACTGAGTCTTTCAATTTACAGATCAAGAAACTGAAGACCAGAGAAGAGAAATGATTTGGTTAAAGTCACTCTCCATCAT
CTGTGATAAGTTGACAAATTTATCCTTACACAAATTTGTCCTCATTGAGTTGACATCCAAAATTTGTCAGGAATTAAAGAATGACTTTTG
AGTGGCAATTATTTATATAACATTTTCCATTGTCTTCATATTCACCTTTTGTCATTTGTTTGCTTTCTCTTGCAGCAAAAATAATATGAG
GTCATCAAGGGCAGAGAACTGTGTGGCATCTCCTTATAGTAAAAGTGCAATCATATGGATGGCTAACTTTGTAATCTCTACAAATAATTT

>In-frame_TMEFF2_ENST00000272771_chr2_193044394_-_TMPRSS11B_ENST00000332644_chr4_69098134_-_3664nt
AAACCTGCGAACGCTTGGGCTGGGTCGGAGCTGCGGGGGGCCTGGGAGGAGAGAGGGGAGAAGAGAGAAGGAAGGAGAGCGCCTGCCGGG
ATGGCTGAGCTGCCTCGGCGAGCAGCCTTGGGGTTGCACGCTCTTGTGGGAGATGCTGCTGTTGCTTCCAGGTCGGCAAGAGCGGTTCTA
ACACCATCGCCTCTCACCCTCTTTCCTGTAAATCCCTAGAGAAACGTCCCTGGCCTCTCCGCCGCGACATTCCCAGCCTGCATCCCCCTA
CAGCCTAGGCGGCGCGCTCCCGCACGCTGGAGCGCCGGTCGCCAGCAGGACGCCCTCTCCCGCGCCGACTCGCCCCTCTCTGCCCTGCTG
CTGCTGCTCCTCTGACACCTCCGCCCCCACCATCTCCAGCTCGGAGAGACGCCACCCAGCCGCGGCCCGCACTCGCGGCCCGGGGTCACG
CGCGGAAGAGGGGCGCTAGTCCGGACCCCGCCTTCGGTAGGGGGCGTCCTGGAGCGGAGAGTGAGGCGAATGGTATATGAGTGTGCGGGT
AGCCCACCCTGAAGCCCGAGCTTCTCATTTGAGCCATCCCCGCCTAGCCCCACTCGGGCCAGCGCCTGGCGAGCGAGCCCATCTGTGGCT
TCCGCGGCCGCCTCCTCCTTGCATCCTTGCACCTCCTCGTCGACCCCTCCCTCCCGGGACCTGCATCCTGCTCCACCAATCAGAGCCCGA
CTGCCTCTTCCCACGTGACCCCGGGCGGGCTGAGGACCTGCTGCTTCCCAAACGCCAGAGGGATGCGGGCGGCAGAGCTCGAGAGGCGGC
TGCCGGGCTGCGGGGCGCCTTGACTCTCCCTCCACCCTGCCTCCTCGGGCTCCACTCGTCTGCCCCTGGACTCCCGTCTCCTCCTGTCCT
CCGGCTTCCCAGAGCTCCCTCCTTATGGCAGCAGCTTCCCGCGTCTCCGGCGCAGCTTCTCAGCGGACGACCCTCTCGCTCCGGGGCTGA
GCCCAGTCCCTGGATGTTGCTGAAACTCTCGAGATCATGCGCGGGTTTGGCTGCTGCTTCCCCGCCGGGTGCCACTGCCACCGCCGCCGC
CTCTGCTGCCGCCGTCCGCGGGATGCTCAGTAGCCCGCTGCCCGGCCCCCGCGATCCTGTGTTCCTCGGAAGCCGTTTGCTGCTGCAGAG
TTGCACGAACTAGTCATGGTGCTGTGGGAGTCCCCGCGGCAGTGCAGCAGCTGGACACTTTGCGAGGGCTTTTGCTGGCTGCTGCTGCTG
CCCGTCATGCTACTCATCGTAGCCCGCCCGGTGAAGCTCGCTGCTTTCCCTACCTCCTTAAGTGACTGCCAAACGCCCACCGGCTGGAAT
TGCTCTGGTTATGATGACAGAGAAAATGATCTCTTCCTCTGTGACACCAACACCTGTAAATTTGATGGGGAATGTTTAAGAATTGGAGAC
ACTGTGACTTGCGTCTGTCAGTTCAAGTGCAACAATGACTATGTGCCTGTGTGTGGCTCCAATGGGGAGAGCTACCAGAATGAGTGTTAC
CTGCGACAGGCTGCATGCAAACAGCAGAGTGAGATACTTGTGGTGTCAGAAGGATCATGTGCCACAGATGCAGGATCAGGATCTGGAGAT
GGAGAAATCAGCAAGGCTGCTTCTGAAATGCTTACCAACAACTGTTGTGGGAGACAAGTAGCCAACAGTATCATAACTGGCAACAAAATT
GTGAATGGAAAAAGCTCCCTGGAGGGGGCATGGCCATGGCAGGCCAGCATGCAATGGAAAGGCCGTCACTACTGTGGAGCCTCTCTGATC
AGCAGCAGGTGGCTATTATCTGCAGCTCACTGCTTTGCTAAGAAAAATAATTCAAAAGATTGGACTGTCAACTTTGGAATTGTAGTAAAT
AAACCATATATGACACGGAAAGTCCAAAACATTATTTTTCATGAAAATTATAGCAGTCCTGGGCTTCATGATGATATTGCCCTTGTGCAG
CTTGCTGAAGAAGTTTCTTTTACAGAGTACATTCGTAAGATTTGTCTTCCTGAAGCCAAAATGAAGCTCTCAGAAAATGACAATGTTGTA
GTTACAGGTTGGGGAACACTTTATATGAATGGTTCATTTCCAGTGATACTTCAAGAAGACTTTTTGAAGATTATTGACAACAAAATTTGC
AATGCCTCATATGCATACTCTGGCTTTGTGACTGATACAATGTTATGTGCTGGATTTATGTCAGGAGAAGCTGATGCATGTCAGAATGAT
TCTGGTGGACCACTAGCTTACCCTGATTCCAGAAATATCTGGCATCTTGTTGGAATAGTAAGCTGGGGTGATGGATGTGGTAAAAAGAAT
AAGCCAGGTGTCTATACTCGAGTGACTTCTTATCGCAATTGGATTACATCCAAGACTGGACTCTGAAAAAAAAGGAATTATACAAAGGAA
CATAAAGACCACTGTAGGCTATCCTTATCTGTGGCTTTGGGATCTTTTTATTTTGATTGTTGGTAAACTAATCATTTTATTATATATAAA
AATATAAATGTCTTTATTAATATTTTATTATATCTAAAACACTGTCCATGCATTTATTAATCTTTTAAATTAATGTAAGAGATAGGAAGA
GGCCAGGTGTAGTGGCTCATGCCTGTAATCCTAGCACTTTGAGAGGCCGAGATAGGCGGATTGCTTGAGCCCAGGAGTTTGAGGGCAGCC
TGGGAAACATGGCTAAATCCGTGTTCAAAAAATACAAAAATTAGCTAGGCATGGTGGCGTGCACCTATAGTCCCAGCTATTCAGGAGGCT
GAGGTGGGAGGATTGCTTGAGCCCAGCAGGTTGAGGCTGTGGTGATTTGTGATTGCGCCACCACTGCACTCCAGCCTGGGCAACAGAGTG
AGACCCTGTCTCAAAAAAAAAAAAAAAAAAAGGAGAGAAGAAAATAAAGAAGGCTAATATATAATTTTTCTTAATAGCTGAGTTGTGATT
CATTTTACCATTATATTCAGAATTGACCTTAATTTGTTTTCCAGAATCAAAAGAAAATAAAATATAAATTTTGAAACTATGAGAACATAT
ATAGGGGATTTATCAAATGAGTTACTTTTTATTATATCAATTATAATTTCATTTTATTAACTGGAATAAGTGCGAAAGTGTACATTACTT
TTTAACTTATATGTGAAATGATTCATGTACCTCACAAAATCATGCAATCTTGCAGTGAAGAAGGAGTATCAGAGCTCCAGCTACACTGAG
TCTTTCAATTTACAGATCAAGAAACTGAAGACCAGAGAAGAGAAATGATTTGGTTAAAGTCACTCTCCATCATCTGTGATAAGTTGACAA
ATTTATCCTTACACAAATTTGTCCTCATTGAGTTGACATCCAAAATTTGTCAGGAATTAAAGAATGACTTTTGAGTGGCAATTATTTATA
TAACATTTTCCATTGTCTTCATATTCACCTTTTGTCATTTGTTTGCTTTCTCTTGCAGCAAAAATAATATGAGGTCATCAAGGGCAGAGA
ACTGTGTGGCATCTCCTTATAGTAAAAGTGCAATCATATGGATGGCTAACTTTGTAATCTCTACAAATAATTTACCTTATGTAATTTTCC


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FusionGenePPI for TMEFF2_TMPRSS11B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEFF2AGO2TMPRSS11BEPHA7, VKORC1, TMEM8A, SEMA4F, ADAMTS2, FZD2, GLRB, DCBLD2, DHFRL1, EDEM2, HLA-A, TMEM67, BACE2, SLC16A10, CTAGE5, MR1, B4GALT1, RNF167, SLC39A3, SLC7A2, CNTNAP3B, MSMO1, SLC38A7, TRAPPC2, NRP1, ABHD17B, CANX, HLA-B, LRFN3, ITGA7, ITGA6, GALNT11, C6orf120, SLC31A1, CD151, GAS6, TM9SF2, CD59, FBXO2, GALNT12, LPHN2, FAM69A, NPC2, POMGNT1, ZFPL1, PTPRK, ST3GAL2, SCARB1, ITPRIP, TXNDC15, MPZL1, C10orf35, LPHN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEFF2_TMPRSS11B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEFF2_TMPRSS11B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMEFF2C0032460Polycystic Ovary Syndrome1CTD_human
HgeneTMEFF2C0033578Prostatic Neoplasms1CTD_human