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Fusion gene ID: 38340 |
FusionGeneSummary for TMEFF2_TMPRSS11B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEFF2_TMPRSS11B | Fusion gene ID: 38340 | Hgene | Tgene | Gene symbol | TMEFF2 | TMPRSS11B | Gene ID | 23671 | 132724 |
| Gene name | transmembrane protein with EGF like and two follistatin like domains 2 | transmembrane serine protease 11B | |
| Synonyms | CT120.2|HPP1|TENB2|TPEF|TR|TR-2 | - | |
| Cytomap | 2q32.3 | 4q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tomoregulin-2cancer/testis antigen family 120, member 2hyperplastic polyposis protein 1transmembrane protein TENB2transmembrane protein with EGF-like and two follistatin-like domains | transmembrane protease serine 11Bairway trypsin-like protease 5transmembrane protease, serine 11B | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9UIK5 | Q86T26 | |
| Ensembl transtripts involved in fusion gene | ENST00000392314, ENST00000272771, ENST00000487771, ENST00000409056, | ENST00000332644, | |
| Fusion gene scores | * DoF score | 7 X 4 X 2=56 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/56*10)=0.514573172829758 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TMEFF2 [Title/Abstract] AND TMPRSS11B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TMEFF2 | GO:0030336 | negative regulation of cell migration | 24632071 |
| Hgene | TMEFF2 | GO:0044319 | wound healing, spreading of cells | 24632071 |
| Hgene | TMEFF2 | GO:0051497 | negative regulation of stress fiber assembly | 24632071 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-ZG-A9LM-01A | TMEFF2 | chr2 | 193044394 | - | TMPRSS11B | chr4 | 69098134 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000392314 | ENST00000332644 | TMEFF2 | chr2 | 193044394 | - | TMPRSS11B | chr4 | 69098134 | - |
| In-frame | ENST00000272771 | ENST00000332644 | TMEFF2 | chr2 | 193044394 | - | TMPRSS11B | chr4 | 69098134 | - |
| intron-3CDS | ENST00000487771 | ENST00000332644 | TMEFF2 | chr2 | 193044394 | - | TMPRSS11B | chr4 | 69098134 | - |
| intron-3CDS | ENST00000409056 | ENST00000332644 | TMEFF2 | chr2 | 193044394 | - | TMPRSS11B | chr4 | 69098134 | - |
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FusionProtFeatures for TMEFF2_TMPRSS11B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEFF2 | TMPRSS11B |
| Serine protease. {ECO:0000269|PubMed:24498351}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000272771 | - | 4 | 10 | 85_137 | 146 | 375 | Domain | Kazal-like 1 |
| Hgene | TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000392314 | - | 4 | 10 | 85_137 | 146 | 347 | Domain | Kazal-like 1 |
| Tgene | >TMPRSS11B | chr2:193044394 | chr4:69098134 | ENST00000332644 | - | 4 | 10 | 185_415 | 156 | 417 | Domain | Peptidase S1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000272771 | - | 4 | 10 | 176_229 | 146 | 375 | Domain | Kazal-like 2 |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000272771 | - | 4 | 10 | 261_301 | 146 | 375 | Domain | EGF-like |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000392314 | - | 4 | 10 | 176_229 | 146 | 347 | Domain | Kazal-like 2 |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000392314 | - | 4 | 10 | 261_301 | 146 | 347 | Domain | EGF-like |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000409056 | - | 1 | 4 | 176_229 | 0 | 176 | Domain | Kazal-like 2 |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000409056 | - | 1 | 4 | 261_301 | 0 | 176 | Domain | EGF-like |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000409056 | - | 1 | 4 | 85_137 | 0 | 176 | Domain | Kazal-like 1 |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000272771 | - | 4 | 10 | 303_320 | 146 | 375 | Region | Note=Required for shedding |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000392314 | - | 4 | 10 | 303_320 | 146 | 347 | Region | Note=Required for shedding |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000409056 | - | 1 | 4 | 303_320 | 0 | 176 | Region | Note=Required for shedding |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000272771 | - | 4 | 10 | 342_374 | 146 | 375 | Topological domain | Cytoplasmic |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000272771 | - | 4 | 10 | 41_320 | 146 | 375 | Topological domain | Extracellular |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000392314 | - | 4 | 10 | 342_374 | 146 | 347 | Topological domain | Cytoplasmic |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000392314 | - | 4 | 10 | 41_320 | 146 | 347 | Topological domain | Extracellular |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000409056 | - | 1 | 4 | 342_374 | 0 | 176 | Topological domain | Cytoplasmic |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000409056 | - | 1 | 4 | 41_320 | 0 | 176 | Topological domain | Extracellular |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000272771 | - | 4 | 10 | 321_341 | 146 | 375 | Transmembrane | Helical |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000392314 | - | 4 | 10 | 321_341 | 146 | 347 | Transmembrane | Helical |
| Hgene | >TMEFF2 | chr2:193044394 | chr4:69098134 | ENST00000409056 | - | 1 | 4 | 321_341 | 0 | 176 | Transmembrane | Helical |
| Tgene | TMPRSS11B | chr2:193044394 | chr4:69098134 | ENST00000332644 | - | 4 | 10 | 43_160 | 156 | 417 | Domain | SEA |
| Tgene | TMPRSS11B | chr2:193044394 | chr4:69098134 | ENST00000332644 | - | 4 | 10 | 1_17 | 156 | 417 | Topological domain | Cytoplasmic |
| Tgene | TMPRSS11B | chr2:193044394 | chr4:69098134 | ENST00000332644 | - | 4 | 10 | 39_416 | 156 | 417 | Topological domain | Extracellular |
| Tgene | TMPRSS11B | chr2:193044394 | chr4:69098134 | ENST00000332644 | - | 4 | 10 | 18_38 | 156 | 417 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for TMEFF2_TMPRSS11B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TMEFF2_ENST00000392314_chr2_193044394_-_TMPRSS11B_ENST00000332644_chr4_69098134_-_407aa MVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCV CQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGEISKAASEMLTNNCCGRQVANSIITGNKIVNGKS SLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKKNNSKDWTVNFGIVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEV SFTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFMSGEADACQNDSGGPL >In-frame_TMEFF2_ENST00000272771_chr2_193044394_-_TMPRSS11B_ENST00000332644_chr4_69098134_-_407aa MVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCV CQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGEISKAASEMLTNNCCGRQVANSIITGNKIVNGKS SLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKKNNSKDWTVNFGIVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEV SFTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFMSGEADACQNDSGGPL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TMEFF2_ENST00000392314_chr2_193044394_-_TMPRSS11B_ENST00000332644_chr4_69098134_-_1221nt ATGGTGCTGTGGGAGTCCCCGCGGCAGTGCAGCAGCTGGACACTTTGCGAGGGCTTTTGCTGGCTGCTGCTGCTGCCCGTCATGCTACTC ATCGTAGCCCGCCCGGTGAAGCTCGCTGCTTTCCCTACCTCCTTAAGTGACTGCCAAACGCCCACCGGCTGGAATTGCTCTGGTTATGAT GACAGAGAAAATGATCTCTTCCTCTGTGACACCAACACCTGTAAATTTGATGGGGAATGTTTAAGAATTGGAGACACTGTGACTTGCGTC TGTCAGTTCAAGTGCAACAATGACTATGTGCCTGTGTGTGGCTCCAATGGGGAGAGCTACCAGAATGAGTGTTACCTGCGACAGGCTGCA TGCAAACAGCAGAGTGAGATACTTGTGGTGTCAGAAGGATCATGTGCCACAGATGCAGGATCAGGATCTGGAGATGGAGAAATCAGCAAG GCTGCTTCTGAAATGCTTACCAACAACTGTTGTGGGAGACAAGTAGCCAACAGTATCATAACTGGCAACAAAATTGTGAATGGAAAAAGC TCCCTGGAGGGGGCATGGCCATGGCAGGCCAGCATGCAATGGAAAGGCCGTCACTACTGTGGAGCCTCTCTGATCAGCAGCAGGTGGCTA TTATCTGCAGCTCACTGCTTTGCTAAGAAAAATAATTCAAAAGATTGGACTGTCAACTTTGGAATTGTAGTAAATAAACCATATATGACA CGGAAAGTCCAAAACATTATTTTTCATGAAAATTATAGCAGTCCTGGGCTTCATGATGATATTGCCCTTGTGCAGCTTGCTGAAGAAGTT TCTTTTACAGAGTACATTCGTAAGATTTGTCTTCCTGAAGCCAAAATGAAGCTCTCAGAAAATGACAATGTTGTAGTTACAGGTTGGGGA ACACTTTATATGAATGGTTCATTTCCAGTGATACTTCAAGAAGACTTTTTGAAGATTATTGACAACAAAATTTGCAATGCCTCATATGCA TACTCTGGCTTTGTGACTGATACAATGTTATGTGCTGGATTTATGTCAGGAGAAGCTGATGCATGTCAGAATGATTCTGGTGGACCACTA GCTTACCCTGATTCCAGAAATATCTGGCATCTTGTTGGAATAGTAAGCTGGGGTGATGGATGTGGTAAAAAGAATAAGCCAGGTGTCTAT >In-frame_TMEFF2_ENST00000272771_chr2_193044394_-_TMPRSS11B_ENST00000332644_chr4_69098134_-_1221nt ATGGTGCTGTGGGAGTCCCCGCGGCAGTGCAGCAGCTGGACACTTTGCGAGGGCTTTTGCTGGCTGCTGCTGCTGCCCGTCATGCTACTC ATCGTAGCCCGCCCGGTGAAGCTCGCTGCTTTCCCTACCTCCTTAAGTGACTGCCAAACGCCCACCGGCTGGAATTGCTCTGGTTATGAT GACAGAGAAAATGATCTCTTCCTCTGTGACACCAACACCTGTAAATTTGATGGGGAATGTTTAAGAATTGGAGACACTGTGACTTGCGTC TGTCAGTTCAAGTGCAACAATGACTATGTGCCTGTGTGTGGCTCCAATGGGGAGAGCTACCAGAATGAGTGTTACCTGCGACAGGCTGCA TGCAAACAGCAGAGTGAGATACTTGTGGTGTCAGAAGGATCATGTGCCACAGATGCAGGATCAGGATCTGGAGATGGAGAAATCAGCAAG GCTGCTTCTGAAATGCTTACCAACAACTGTTGTGGGAGACAAGTAGCCAACAGTATCATAACTGGCAACAAAATTGTGAATGGAAAAAGC TCCCTGGAGGGGGCATGGCCATGGCAGGCCAGCATGCAATGGAAAGGCCGTCACTACTGTGGAGCCTCTCTGATCAGCAGCAGGTGGCTA TTATCTGCAGCTCACTGCTTTGCTAAGAAAAATAATTCAAAAGATTGGACTGTCAACTTTGGAATTGTAGTAAATAAACCATATATGACA CGGAAAGTCCAAAACATTATTTTTCATGAAAATTATAGCAGTCCTGGGCTTCATGATGATATTGCCCTTGTGCAGCTTGCTGAAGAAGTT TCTTTTACAGAGTACATTCGTAAGATTTGTCTTCCTGAAGCCAAAATGAAGCTCTCAGAAAATGACAATGTTGTAGTTACAGGTTGGGGA ACACTTTATATGAATGGTTCATTTCCAGTGATACTTCAAGAAGACTTTTTGAAGATTATTGACAACAAAATTTGCAATGCCTCATATGCA TACTCTGGCTTTGTGACTGATACAATGTTATGTGCTGGATTTATGTCAGGAGAAGCTGATGCATGTCAGAATGATTCTGGTGGACCACTA GCTTACCCTGATTCCAGAAATATCTGGCATCTTGTTGGAATAGTAAGCTGGGGTGATGGATGTGGTAAAAAGAATAAGCCAGGTGTCTAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TMEFF2_ENST00000392314_chr2_193044394_-_TMPRSS11B_ENST00000332644_chr4_69098134_-_2871nt AGAGCTCGAGAGGCGGCTGCCGGGCTGCGGGGCGCCTTGACTCTCCCTCCACCCTGCCTCCTCGGGCTCCACTCGTCTGCCCCTGGACTC CCGTCTCCTCCTGTCCTCCGGCTTCCCAGAGCTCCCTCCTTATGGCAGCAGCTTCCCGCGTCTCCGGCGCAGCTTCTCAGCGGACGACCC TCTCGCTCCGGGGCTGAGCCCAGTCCCTGGATGTTGCTGAAACTCTCGAGATCATGCGCGGGTTTGGCTGCTGCTTCCCCGCCGGGTGCC ACTGCCACCGCCGCCGCCTCTGCTGCCGCCGTCCGCGGGATGCTCAGTAGCCCGCTGCCCGGCCCCCGCGATCCTGTGTTCCTCGGAAGC CGTTTGCTGCTGCAGAGTTGCACGAACTAGTCATGGTGCTGTGGGAGTCCCCGCGGCAGTGCAGCAGCTGGACACTTTGCGAGGGCTTTT GCTGGCTGCTGCTGCTGCCCGTCATGCTACTCATCGTAGCCCGCCCGGTGAAGCTCGCTGCTTTCCCTACCTCCTTAAGTGACTGCCAAA CGCCCACCGGCTGGAATTGCTCTGGTTATGATGACAGAGAAAATGATCTCTTCCTCTGTGACACCAACACCTGTAAATTTGATGGGGAAT GTTTAAGAATTGGAGACACTGTGACTTGCGTCTGTCAGTTCAAGTGCAACAATGACTATGTGCCTGTGTGTGGCTCCAATGGGGAGAGCT ACCAGAATGAGTGTTACCTGCGACAGGCTGCATGCAAACAGCAGAGTGAGATACTTGTGGTGTCAGAAGGATCATGTGCCACAGATGCAG GATCAGGATCTGGAGATGGAGAAATCAGCAAGGCTGCTTCTGAAATGCTTACCAACAACTGTTGTGGGAGACAAGTAGCCAACAGTATCA TAACTGGCAACAAAATTGTGAATGGAAAAAGCTCCCTGGAGGGGGCATGGCCATGGCAGGCCAGCATGCAATGGAAAGGCCGTCACTACT GTGGAGCCTCTCTGATCAGCAGCAGGTGGCTATTATCTGCAGCTCACTGCTTTGCTAAGAAAAATAATTCAAAAGATTGGACTGTCAACT TTGGAATTGTAGTAAATAAACCATATATGACACGGAAAGTCCAAAACATTATTTTTCATGAAAATTATAGCAGTCCTGGGCTTCATGATG ATATTGCCCTTGTGCAGCTTGCTGAAGAAGTTTCTTTTACAGAGTACATTCGTAAGATTTGTCTTCCTGAAGCCAAAATGAAGCTCTCAG AAAATGACAATGTTGTAGTTACAGGTTGGGGAACACTTTATATGAATGGTTCATTTCCAGTGATACTTCAAGAAGACTTTTTGAAGATTA TTGACAACAAAATTTGCAATGCCTCATATGCATACTCTGGCTTTGTGACTGATACAATGTTATGTGCTGGATTTATGTCAGGAGAAGCTG ATGCATGTCAGAATGATTCTGGTGGACCACTAGCTTACCCTGATTCCAGAAATATCTGGCATCTTGTTGGAATAGTAAGCTGGGGTGATG GATGTGGTAAAAAGAATAAGCCAGGTGTCTATACTCGAGTGACTTCTTATCGCAATTGGATTACATCCAAGACTGGACTCTGAAAAAAAA GGAATTATACAAAGGAACATAAAGACCACTGTAGGCTATCCTTATCTGTGGCTTTGGGATCTTTTTATTTTGATTGTTGGTAAACTAATC ATTTTATTATATATAAAAATATAAATGTCTTTATTAATATTTTATTATATCTAAAACACTGTCCATGCATTTATTAATCTTTTAAATTAA TGTAAGAGATAGGAAGAGGCCAGGTGTAGTGGCTCATGCCTGTAATCCTAGCACTTTGAGAGGCCGAGATAGGCGGATTGCTTGAGCCCA GGAGTTTGAGGGCAGCCTGGGAAACATGGCTAAATCCGTGTTCAAAAAATACAAAAATTAGCTAGGCATGGTGGCGTGCACCTATAGTCC CAGCTATTCAGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCAGCAGGTTGAGGCTGTGGTGATTTGTGATTGCGCCACCACTGCACTCCA GCCTGGGCAACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAGGAGAGAAGAAAATAAAGAAGGCTAATATATAATTTTTCTTA ATAGCTGAGTTGTGATTCATTTTACCATTATATTCAGAATTGACCTTAATTTGTTTTCCAGAATCAAAAGAAAATAAAATATAAATTTTG AAACTATGAGAACATATATAGGGGATTTATCAAATGAGTTACTTTTTATTATATCAATTATAATTTCATTTTATTAACTGGAATAAGTGC GAAAGTGTACATTACTTTTTAACTTATATGTGAAATGATTCATGTACCTCACAAAATCATGCAATCTTGCAGTGAAGAAGGAGTATCAGA GCTCCAGCTACACTGAGTCTTTCAATTTACAGATCAAGAAACTGAAGACCAGAGAAGAGAAATGATTTGGTTAAAGTCACTCTCCATCAT CTGTGATAAGTTGACAAATTTATCCTTACACAAATTTGTCCTCATTGAGTTGACATCCAAAATTTGTCAGGAATTAAAGAATGACTTTTG AGTGGCAATTATTTATATAACATTTTCCATTGTCTTCATATTCACCTTTTGTCATTTGTTTGCTTTCTCTTGCAGCAAAAATAATATGAG GTCATCAAGGGCAGAGAACTGTGTGGCATCTCCTTATAGTAAAAGTGCAATCATATGGATGGCTAACTTTGTAATCTCTACAAATAATTT >In-frame_TMEFF2_ENST00000272771_chr2_193044394_-_TMPRSS11B_ENST00000332644_chr4_69098134_-_3664nt AAACCTGCGAACGCTTGGGCTGGGTCGGAGCTGCGGGGGGCCTGGGAGGAGAGAGGGGAGAAGAGAGAAGGAAGGAGAGCGCCTGCCGGG ATGGCTGAGCTGCCTCGGCGAGCAGCCTTGGGGTTGCACGCTCTTGTGGGAGATGCTGCTGTTGCTTCCAGGTCGGCAAGAGCGGTTCTA ACACCATCGCCTCTCACCCTCTTTCCTGTAAATCCCTAGAGAAACGTCCCTGGCCTCTCCGCCGCGACATTCCCAGCCTGCATCCCCCTA CAGCCTAGGCGGCGCGCTCCCGCACGCTGGAGCGCCGGTCGCCAGCAGGACGCCCTCTCCCGCGCCGACTCGCCCCTCTCTGCCCTGCTG CTGCTGCTCCTCTGACACCTCCGCCCCCACCATCTCCAGCTCGGAGAGACGCCACCCAGCCGCGGCCCGCACTCGCGGCCCGGGGTCACG CGCGGAAGAGGGGCGCTAGTCCGGACCCCGCCTTCGGTAGGGGGCGTCCTGGAGCGGAGAGTGAGGCGAATGGTATATGAGTGTGCGGGT AGCCCACCCTGAAGCCCGAGCTTCTCATTTGAGCCATCCCCGCCTAGCCCCACTCGGGCCAGCGCCTGGCGAGCGAGCCCATCTGTGGCT TCCGCGGCCGCCTCCTCCTTGCATCCTTGCACCTCCTCGTCGACCCCTCCCTCCCGGGACCTGCATCCTGCTCCACCAATCAGAGCCCGA CTGCCTCTTCCCACGTGACCCCGGGCGGGCTGAGGACCTGCTGCTTCCCAAACGCCAGAGGGATGCGGGCGGCAGAGCTCGAGAGGCGGC TGCCGGGCTGCGGGGCGCCTTGACTCTCCCTCCACCCTGCCTCCTCGGGCTCCACTCGTCTGCCCCTGGACTCCCGTCTCCTCCTGTCCT CCGGCTTCCCAGAGCTCCCTCCTTATGGCAGCAGCTTCCCGCGTCTCCGGCGCAGCTTCTCAGCGGACGACCCTCTCGCTCCGGGGCTGA GCCCAGTCCCTGGATGTTGCTGAAACTCTCGAGATCATGCGCGGGTTTGGCTGCTGCTTCCCCGCCGGGTGCCACTGCCACCGCCGCCGC CTCTGCTGCCGCCGTCCGCGGGATGCTCAGTAGCCCGCTGCCCGGCCCCCGCGATCCTGTGTTCCTCGGAAGCCGTTTGCTGCTGCAGAG TTGCACGAACTAGTCATGGTGCTGTGGGAGTCCCCGCGGCAGTGCAGCAGCTGGACACTTTGCGAGGGCTTTTGCTGGCTGCTGCTGCTG CCCGTCATGCTACTCATCGTAGCCCGCCCGGTGAAGCTCGCTGCTTTCCCTACCTCCTTAAGTGACTGCCAAACGCCCACCGGCTGGAAT TGCTCTGGTTATGATGACAGAGAAAATGATCTCTTCCTCTGTGACACCAACACCTGTAAATTTGATGGGGAATGTTTAAGAATTGGAGAC ACTGTGACTTGCGTCTGTCAGTTCAAGTGCAACAATGACTATGTGCCTGTGTGTGGCTCCAATGGGGAGAGCTACCAGAATGAGTGTTAC CTGCGACAGGCTGCATGCAAACAGCAGAGTGAGATACTTGTGGTGTCAGAAGGATCATGTGCCACAGATGCAGGATCAGGATCTGGAGAT GGAGAAATCAGCAAGGCTGCTTCTGAAATGCTTACCAACAACTGTTGTGGGAGACAAGTAGCCAACAGTATCATAACTGGCAACAAAATT GTGAATGGAAAAAGCTCCCTGGAGGGGGCATGGCCATGGCAGGCCAGCATGCAATGGAAAGGCCGTCACTACTGTGGAGCCTCTCTGATC AGCAGCAGGTGGCTATTATCTGCAGCTCACTGCTTTGCTAAGAAAAATAATTCAAAAGATTGGACTGTCAACTTTGGAATTGTAGTAAAT AAACCATATATGACACGGAAAGTCCAAAACATTATTTTTCATGAAAATTATAGCAGTCCTGGGCTTCATGATGATATTGCCCTTGTGCAG CTTGCTGAAGAAGTTTCTTTTACAGAGTACATTCGTAAGATTTGTCTTCCTGAAGCCAAAATGAAGCTCTCAGAAAATGACAATGTTGTA GTTACAGGTTGGGGAACACTTTATATGAATGGTTCATTTCCAGTGATACTTCAAGAAGACTTTTTGAAGATTATTGACAACAAAATTTGC AATGCCTCATATGCATACTCTGGCTTTGTGACTGATACAATGTTATGTGCTGGATTTATGTCAGGAGAAGCTGATGCATGTCAGAATGAT TCTGGTGGACCACTAGCTTACCCTGATTCCAGAAATATCTGGCATCTTGTTGGAATAGTAAGCTGGGGTGATGGATGTGGTAAAAAGAAT AAGCCAGGTGTCTATACTCGAGTGACTTCTTATCGCAATTGGATTACATCCAAGACTGGACTCTGAAAAAAAAGGAATTATACAAAGGAA CATAAAGACCACTGTAGGCTATCCTTATCTGTGGCTTTGGGATCTTTTTATTTTGATTGTTGGTAAACTAATCATTTTATTATATATAAA AATATAAATGTCTTTATTAATATTTTATTATATCTAAAACACTGTCCATGCATTTATTAATCTTTTAAATTAATGTAAGAGATAGGAAGA GGCCAGGTGTAGTGGCTCATGCCTGTAATCCTAGCACTTTGAGAGGCCGAGATAGGCGGATTGCTTGAGCCCAGGAGTTTGAGGGCAGCC TGGGAAACATGGCTAAATCCGTGTTCAAAAAATACAAAAATTAGCTAGGCATGGTGGCGTGCACCTATAGTCCCAGCTATTCAGGAGGCT GAGGTGGGAGGATTGCTTGAGCCCAGCAGGTTGAGGCTGTGGTGATTTGTGATTGCGCCACCACTGCACTCCAGCCTGGGCAACAGAGTG AGACCCTGTCTCAAAAAAAAAAAAAAAAAAAGGAGAGAAGAAAATAAAGAAGGCTAATATATAATTTTTCTTAATAGCTGAGTTGTGATT CATTTTACCATTATATTCAGAATTGACCTTAATTTGTTTTCCAGAATCAAAAGAAAATAAAATATAAATTTTGAAACTATGAGAACATAT ATAGGGGATTTATCAAATGAGTTACTTTTTATTATATCAATTATAATTTCATTTTATTAACTGGAATAAGTGCGAAAGTGTACATTACTT TTTAACTTATATGTGAAATGATTCATGTACCTCACAAAATCATGCAATCTTGCAGTGAAGAAGGAGTATCAGAGCTCCAGCTACACTGAG TCTTTCAATTTACAGATCAAGAAACTGAAGACCAGAGAAGAGAAATGATTTGGTTAAAGTCACTCTCCATCATCTGTGATAAGTTGACAA ATTTATCCTTACACAAATTTGTCCTCATTGAGTTGACATCCAAAATTTGTCAGGAATTAAAGAATGACTTTTGAGTGGCAATTATTTATA TAACATTTTCCATTGTCTTCATATTCACCTTTTGTCATTTGTTTGCTTTCTCTTGCAGCAAAAATAATATGAGGTCATCAAGGGCAGAGA ACTGTGTGGCATCTCCTTATAGTAAAAGTGCAATCATATGGATGGCTAACTTTGTAATCTCTACAAATAATTTACCTTATGTAATTTTCC |
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FusionGenePPI for TMEFF2_TMPRSS11B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TMEFF2 | AGO2 | TMPRSS11B | EPHA7, VKORC1, TMEM8A, SEMA4F, ADAMTS2, FZD2, GLRB, DCBLD2, DHFRL1, EDEM2, HLA-A, TMEM67, BACE2, SLC16A10, CTAGE5, MR1, B4GALT1, RNF167, SLC39A3, SLC7A2, CNTNAP3B, MSMO1, SLC38A7, TRAPPC2, NRP1, ABHD17B, CANX, HLA-B, LRFN3, ITGA7, ITGA6, GALNT11, C6orf120, SLC31A1, CD151, GAS6, TM9SF2, CD59, FBXO2, GALNT12, LPHN2, FAM69A, NPC2, POMGNT1, ZFPL1, PTPRK, ST3GAL2, SCARB1, ITPRIP, TXNDC15, MPZL1, C10orf35, LPHN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEFF2_TMPRSS11B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEFF2_TMPRSS11B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TMEFF2 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| Hgene | TMEFF2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
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