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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38330

FusionGeneSummary for TMED3_PCMTD2

check button Fusion gene summary
Fusion gene informationFusion gene name: TMED3_PCMTD2
Fusion gene ID: 38330
HgeneTgene
Gene symbol

TMED3

PCMTD2

Gene ID

23423

55251

Gene nametransmembrane p24 trafficking protein 3protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
SynonymsC15orf22|P24B|p24g4|p24gamma4|p26C20orf36
Cytomap

15q25.1

20q13.33

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane emp24 domain-containing protein 3integral type I proteinmembrane protein p24Bp24 family protein gamma-4testis tissue sperm-binding protein Li 48etransmembrane emp24 protein transport domain containing 3protein-L-isoaspartate O-methyltransferase domain-containing protein 2
Modification date2018052920180523
UniProtAcc

Q9Y3Q3

Q9NV79

Ensembl transtripts involved in fusion geneENST00000424155, ENST00000299705, 
ENST00000536821, ENST00000558562, 
ENST00000299468, ENST00000369758, 
ENST00000609372, ENST00000308824, 
ENST00000266078, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 1=4
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: TMED3 [Title/Abstract] AND PCMTD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A12P-01ATMED3chr15

79705899

+PCMTD2chr20

62899240

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000424155ENST00000299468TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000424155ENST00000369758TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000424155ENST00000609372TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000424155ENST00000308824TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000424155ENST00000266078TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-3CDSENST00000299705ENST00000299468TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000299705ENST00000369758TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000299705ENST00000609372TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000299705ENST00000308824TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000299705ENST00000266078TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-3CDSENST00000536821ENST00000299468TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000536821ENST00000369758TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000536821ENST00000609372TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000536821ENST00000308824TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000536821ENST00000266078TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-3CDSENST00000558562ENST00000299468TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000558562ENST00000369758TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000558562ENST00000609372TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000558562ENST00000308824TMED3chr15

79705899

+PCMTD2chr20

62899240

+
intron-intronENST00000558562ENST00000266078TMED3chr15

79705899

+PCMTD2chr20

62899240

+

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FusionProtFeatures for TMED3_PCMTD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMED3

Q9Y3Q3

PCMTD2

Q9NV79

Potential role in vesicular protein trafficking, mainlyin the early secretory pathway. Contributes to the coupledlocalization of TMED2 and TMED10 in the cis-Golgi network.{ECO:0000269|PubMed:10852829}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMED3_PCMTD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMED3_PCMTD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMED3GORASP2, GORASP1, MOV10, NXF1, TMED10, CCPG1, TMED4, OSBPL8, TMED2, HS1BP3, BLZF1, TMEM30A, KIAA1715PCMTD2TCEB2, TCEB1, CUL5, CUL2, ATP13A2, TRIP13, VAC14, AUP1, SEPT3, MRPS11, PCGF1, DPPA4, NANOG, POU5F1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMED3_PCMTD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMED3_PCMTD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource