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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38324

FusionGeneSummary for TMED10_TTLL5

check button Fusion gene summary
Fusion gene informationFusion gene name: TMED10_TTLL5
Fusion gene ID: 38324
HgeneTgene
Gene symbol

TMED10

TTLL5

Gene ID

10972

254173

Gene nametransmembrane p24 trafficking protein 10tubulin tyrosine ligase like 10
SynonymsP24(DELTA)|S31I125|S31III125|TMP21|Tmp-21-I|p23|p24d1TTLL5
Cytomap

14q24.3

1p36.33

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane emp24 domain-containing protein 1021 kDa transmembrane trafficking proteinp24 family protein delta-1p24deltap24delta1testicular tissue protein Li 206transmembrane emp24-like trafficking protein 10transmembrane protein Tmp21inactive polyglycylase TTLL10tubulin tyrosine ligase-like family, member 10tubulin tyrosine ligase-like family, member 5tubulin--tyrosine ligase-like protein 10
Modification date2018052320180519
UniProtAcc

P49755

Q6EMB2

Ensembl transtripts involved in fusion geneENST00000303575, ENST00000557670, 
ENST00000557636, ENST00000286650, 
ENST00000298832, ENST00000556893, 
ENST00000554510, ENST00000556977, 
ENST00000555422, 
Fusion gene scores* DoF score6 X 5 X 4=1207 X 6 X 6=252
# samples 67
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMED10 [Title/Abstract] AND TTLL5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMED10

GO:0006886

intracellular protein transport

20427317

HgeneTMED10

GO:0035964

COPI-coated vesicle budding

10052452

TgeneTTLL5

GO:0018094

protein polyglycylation

19524510


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CV-6961-01ATMED10chr14

75643058

-TTLL5chr14

76286350

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000303575ENST00000557636TMED10chr14

75643058

-TTLL5chr14

76286350

+
5CDS-intronENST00000303575ENST00000286650TMED10chr14

75643058

-TTLL5chr14

76286350

+
5CDS-intronENST00000303575ENST00000298832TMED10chr14

75643058

-TTLL5chr14

76286350

+
5CDS-intronENST00000303575ENST00000556893TMED10chr14

75643058

-TTLL5chr14

76286350

+
5CDS-intronENST00000303575ENST00000554510TMED10chr14

75643058

-TTLL5chr14

76286350

+
5CDS-intronENST00000303575ENST00000556977TMED10chr14

75643058

-TTLL5chr14

76286350

+
5CDS-intronENST00000303575ENST00000555422TMED10chr14

75643058

-TTLL5chr14

76286350

+
intron-3CDSENST00000557670ENST00000557636TMED10chr14

75643058

-TTLL5chr14

76286350

+
intron-intronENST00000557670ENST00000286650TMED10chr14

75643058

-TTLL5chr14

76286350

+
intron-intronENST00000557670ENST00000298832TMED10chr14

75643058

-TTLL5chr14

76286350

+
intron-intronENST00000557670ENST00000556893TMED10chr14

75643058

-TTLL5chr14

76286350

+
intron-intronENST00000557670ENST00000554510TMED10chr14

75643058

-TTLL5chr14

76286350

+
intron-intronENST00000557670ENST00000556977TMED10chr14

75643058

-TTLL5chr14

76286350

+
intron-intronENST00000557670ENST00000555422TMED10chr14

75643058

-TTLL5chr14

76286350

+

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FusionProtFeatures for TMED10_TTLL5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMED10

P49755

TTLL5

Q6EMB2

Involved in vesicular protein trafficking. Mainlyfunctions in the early secretory pathway. Thought to act as cargoreceptor at the lumenal side for incorporation of secretory cargomolecules into transport vesicles and to be involved in vesiclecoat formation at the cytoplasmic side. In COPII vesicle-mediatedanterograde transport involved in the transport of GPI-anchoredproteins and proposed to act together with TMED2 as their cargoreceptor; the function specifically implies SEC24C and SEC24D ofthe COPII vesicle coat and lipid raft-like microdomains of the ER.Recognizes GPI anchors structural remodeled in the ER by PGAP1 andMPPE1 (By similarity). In COPI vesicle-mediated retrogradetransport involved in the biogenesis of COPI vesicles and vesiclecoat recruitment. On Golgi membranes, acts as primary receptor forARF1-GDP which is involved in COPI-vesicle formation. Increasescoatomer-dependent GTPase-activating activity of ARFGAP2. Involvedin trafficking of G protein-coupled receptors (GPCRs). RegulatesF2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to theplasma membrane thus contributing to receptor resensitization.Involved in trafficking of amyloid beta A4 protein and solubleAPP-beta release (independent of modulation of gamma-secretaseactivity). As part of the presenilin-dependent gamma-secretasecomplex regulates gamma-cleavages of the amyloid beta A4 proteinto yield amyloid-beta 40 (Abeta40). Involved in organization ofthe Golgi apparatus. {ECO:0000250, ECO:0000269|PubMed:10052452,ECO:0000269|PubMed:11726511, ECO:0000269|PubMed:16641999,ECO:0000269|PubMed:17288597, ECO:0000269|PubMed:19296914,ECO:0000269|PubMed:20427317, ECO:0000269|PubMed:21219331}. Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of thepolyglutamylation reaction rather than in the elongation step (Bysimilarity). Required for CCSAP localization to both spindle andcilia microtubules. Increases the effects of NCOA2 inglucocorticoid receptor-mediated repression and induction and inandrogen receptor-mediated induction (PubMed:17116691,PubMed:22493317). {ECO:0000250|UniProtKB:Q8CHB8,ECO:0000269|PubMed:17116691, ECO:0000269|PubMed:22493317}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTTLL5chr14:75643058chr14:76286350ENST00000286650+010552_557-69270Compositional biasNote=Poly-Arg
TgeneTTLL5chr14:75643058chr14:76286350ENST00000286650+010582_590-69270Compositional biasNote=Poly-Glu
TgeneTTLL5chr14:75643058chr14:76286350ENST00000286650+010776_780-69270Compositional biasNote=Poly-Glu
TgeneTTLL5chr14:75643058chr14:76286350ENST00000286650+010827_830-69270Compositional biasNote=Poly-Asn
TgeneTTLL5chr14:75643058chr14:76286350ENST00000556893+1217776_780608818Compositional biasNote=Poly-Glu
TgeneTTLL5chr14:75643058chr14:76286350ENST00000556893+1217827_830608818Compositional biasNote=Poly-Asn
TgeneTTLL5chr14:75643058chr14:76286350ENST00000286650+01062_407-69270DomainTTL
TgeneTTLL5chr14:75643058chr14:76286350ENST00000286650+010208_211-69270Nucleotide bindingATP binding
TgeneTTLL5chr14:75643058chr14:76286350ENST00000286650+010378_488-69270Regionc-MTBD region

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMED10chr14:75643058chr14:76286350ENST00000303575-1541_19375220DomainGOLD
HgeneTMED10chr14:75643058chr14:76286350ENST00000303575-15211_21975220MotifNote=COPI vesicle coat-binding
HgeneTMED10chr14:75643058chr14:76286350ENST00000303575-15147_17875220RegionNote=Required for TMED10 and TMED2 cis-Golgi network localization
HgeneTMED10chr14:75643058chr14:76286350ENST00000303575-1532_18575220Topological domainLumenal
HgeneTMED10chr14:75643058chr14:76286350ENST00000303575-15186_20675220TransmembraneHelical
TgeneTTLL5chr14:75643058chr14:76286350ENST00000298832+2632552_55710571282Compositional biasNote=Poly-Arg
TgeneTTLL5chr14:75643058chr14:76286350ENST00000298832+2632582_59010571282Compositional biasNote=Poly-Glu
TgeneTTLL5chr14:75643058chr14:76286350ENST00000298832+2632776_78010571282Compositional biasNote=Poly-Glu
TgeneTTLL5chr14:75643058chr14:76286350ENST00000298832+2632827_83010571282Compositional biasNote=Poly-Asn
TgeneTTLL5chr14:75643058chr14:76286350ENST00000556893+1217552_557608818Compositional biasNote=Poly-Arg
TgeneTTLL5chr14:75643058chr14:76286350ENST00000556893+1217582_590608818Compositional biasNote=Poly-Glu
TgeneTTLL5chr14:75643058chr14:76286350ENST00000298832+263262_40710571282DomainTTL
TgeneTTLL5chr14:75643058chr14:76286350ENST00000556893+121762_407608818DomainTTL
TgeneTTLL5chr14:75643058chr14:76286350ENST00000298832+2632208_21110571282Nucleotide bindingATP binding
TgeneTTLL5chr14:75643058chr14:76286350ENST00000556893+1217208_211608818Nucleotide bindingATP binding
TgeneTTLL5chr14:75643058chr14:76286350ENST00000298832+2632378_48810571282Regionc-MTBD region
TgeneTTLL5chr14:75643058chr14:76286350ENST00000556893+1217378_488608818Regionc-MTBD region


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FusionGeneSequence for TMED10_TTLL5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TMED10_ENST00000303575_chr14_75643058_-_TTLL5_ENST00000557636_chr14_76286350_+_285aa
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKVTNLNLATGIINRSS
ASAPPTLRPIISPSGPTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQS
RQLLDQSRARHQAIFGSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRRATSQKASNTRFRS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TMED10_ENST00000303575_chr14_75643058_-_TTLL5_ENST00000557636_chr14_76286350_+_855nt
ATGTCTGGTTTGTCTGGCCCACCAGCCCGGCGCGGCCCTTTTCCGTTAGCGTTGCTGCTTTTGTTCCTGCTCGGCCCCAGATTGGTCCTT
GCCATCTCCTTCCATCTGCCCATTAACTCTCGCAAGTGCCTCCGTGAGGAGATTCACAAGGACCTGCTAGTGACTGGCGCGTACGAGATC
TCCGACCAGTCTGGGGGCGCTGGCGGCCTGCGCAGCCACCTCAAGGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGT
GCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCAC
TCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGG
GTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCC
CGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAAT
GGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGC
GCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_TMED10_ENST00000303575_chr14_75643058_-_TTLL5_ENST00000557636_chr14_76286350_+_1014nt
CCCCGGTTCCGGCGCGGTTGAGGCCTTCGGTGGTGAACGAGTCTCCAGCACCATGTCTGGTTTGTCTGGCCCACCAGCCCGGCGCGGCCC
TTTTCCGTTAGCGTTGCTGCTTTTGTTCCTGCTCGGCCCCAGATTGGTCCTTGCCATCTCCTTCCATCTGCCCATTAACTCTCGCAAGTG
CCTCCGTGAGGAGATTCACAAGGACCTGCTAGTGACTGGCGCGTACGAGATCTCCGACCAGTCTGGGGGCGCTGGCGGCCTGCGCAGCCA
CCTCAAGGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCC
TAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGG
ATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAG
CTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGC
AATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGG
CCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACA
AGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGT
CAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGTAAATGAGCTTTTTTCAGAGCCAGAATCATACT


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FusionGenePPI for TMED10_TTLL5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMED10GORASP2, RYK, CDK2, COPA, COPB1, COPB2, COPG1, ARCN1, COPE, COPZ1, TMED9, SEC22B, VAMP2, PTRF, NIT2, S100A16, PRDX6, EIF3C, VCP, ATF2, SEC23B, UBL4A, DHODH, FBXO6, ASB8, RNF2, TMED1, GOLGB1, TMED4, TMED2, TMED7, TMED3, TMED5, EMC7, EPHX1, LMAN1, LMAN2, NAGLU, KRAS, COPG2, TCTN1, RAB5C, CDKN2AIP, RAB1A, TSSC1, LIPG, FGF3, PTPRO, COX15, HSD17B10, PDHA1, SDHA, TRIM25TTLL5TP53, TP73, CREB3, THBS3, MED4, PCM1, CEP128, OFD1, PTTG1, CEP135, FGFR1OP, GAR1, CCDC14, VWCE, TTC25, CACNG5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTMED10chr14:75643058chr14:76286350ENST00000303575-15207_21975220ARF1
HgeneTMED10chr14:75643058chr14:76286350ENST00000303575-15204_21975220COPG1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMED10_TTLL5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMED10_TTLL5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTTLL5C3495559Juvenile arthritis1CTD_human
TgeneTTLL5C4014501CONE-ROD DYSTROPHY 191UNIPROT