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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38312

FusionGeneSummary for TMCO3_ST7

check button Fusion gene summary
Fusion gene informationFusion gene name: TMCO3_ST7
Fusion gene ID: 38312
HgeneTgene
Gene symbol

TMCO3

ST7

Gene ID

55002

29967

Gene nametransmembrane and coiled-coil domains 3LDL receptor related protein 12
SynonymsC13orf11ST7
Cytomap

13q34

8q22.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane and coiled-coil domain-containing protein 3putative LAG1-interacting proteinlow-density lipoprotein receptor-related protein 12suppressor of tumorigenicity 7 protein
Modification date2018051920180519
UniProtAcc

Q6UWJ1

Q9NRC1

Ensembl transtripts involved in fusion geneENST00000434316, ENST00000375391, 
ENST00000474393, 		ENST00000393446, 
ENST00000265437, ENST00000393451, 
ENST00000393449, ENST00000323984, 
ENST00000432298, ENST00000422922, 
ENST00000487459, ENST00000393443, 
ENST00000393447, ENST00000393444, 
ENST00000465133, 
Fusion gene scores* DoF score8 X 6 X 5=2408 X 6 X 5=240
# samples 88
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMCO3 [Title/Abstract] AND ST7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneST7

GO:0001764

neuron migration

26639854

TgeneST7

GO:0031175

neuron projection development

26639854


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-55-8620-01ATMCO3chr13

114145588

+ST7chr7

116739816

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000434316ENST00000393446TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3CDSENST00000434316ENST00000265437TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3CDSENST00000434316ENST00000393451TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3CDSENST00000434316ENST00000393449TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3CDSENST00000434316ENST00000323984TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3CDSENST00000434316ENST00000432298TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3CDSENST00000434316ENST00000422922TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3UTRENST00000434316ENST00000487459TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3UTRENST00000434316ENST00000393443TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3UTRENST00000434316ENST00000393447TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3UTRENST00000434316ENST00000393444TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3UTRENST00000434316ENST00000465133TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3CDSENST00000375391ENST00000393446TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3CDSENST00000375391ENST00000265437TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3CDSENST00000375391ENST00000393451TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3CDSENST00000375391ENST00000393449TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3CDSENST00000375391ENST00000323984TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3CDSENST00000375391ENST00000432298TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3CDSENST00000375391ENST00000422922TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3UTRENST00000375391ENST00000487459TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3UTRENST00000375391ENST00000393443TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3UTRENST00000375391ENST00000393447TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3UTRENST00000375391ENST00000393444TMCO3chr13

114145588

+ST7chr7

116739816

+
5UTR-3UTRENST00000375391ENST00000465133TMCO3chr13

114145588

+ST7chr7

116739816

+
3UTR-3CDSENST00000474393ENST00000393446TMCO3chr13

114145588

+ST7chr7

116739816

+
3UTR-3CDSENST00000474393ENST00000265437TMCO3chr13

114145588

+ST7chr7

116739816

+
3UTR-3CDSENST00000474393ENST00000393451TMCO3chr13

114145588

+ST7chr7

116739816

+
3UTR-3CDSENST00000474393ENST00000393449TMCO3chr13

114145588

+ST7chr7

116739816

+
3UTR-3CDSENST00000474393ENST00000323984TMCO3chr13

114145588

+ST7chr7

116739816

+
3UTR-3CDSENST00000474393ENST00000432298TMCO3chr13

114145588

+ST7chr7

116739816

+
3UTR-3CDSENST00000474393ENST00000422922TMCO3chr13

114145588

+ST7chr7

116739816

+
3UTR-3UTRENST00000474393ENST00000487459TMCO3chr13

114145588

+ST7chr7

116739816

+
3UTR-3UTRENST00000474393ENST00000393443TMCO3chr13

114145588

+ST7chr7

116739816

+
3UTR-3UTRENST00000474393ENST00000393447TMCO3chr13

114145588

+ST7chr7

116739816

+
3UTR-3UTRENST00000474393ENST00000393444TMCO3chr13

114145588

+ST7chr7

116739816

+
3UTR-3UTRENST00000474393ENST00000465133TMCO3chr13

114145588

+ST7chr7

116739816

+

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FusionProtFeatures for TMCO3_ST7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMCO3

Q6UWJ1

ST7

Q9NRC1

Probable Na(+)/H(+) antiporter. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMCO3_ST7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMCO3_ST7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMCO3EGFR, ELAVL1, HSPB1, GLP1R, TAP2, FNDC5, COG4, IFT57, HEMK1, SLC25A17, TYK2, PSME2, ATG9A, PXMP2, PIGQ, SQLE, GUF1, POTEF, CUL4B, ATP13A2, SREBF2, TUBB8, FADS1, TUBB3, DPH6, TUBA4A, ATP13A3, CUL4A, ADCK2, STX17, SLC26A6, DCAF8, SLC25A6, GGCX, AGPAT5, TMBIM6, DNAAF5, TMEM259, METTL13, TRIM25ST7NFKBIA, RIC3, KLRAP1, HLA-DQA1, MCOLN3, CD244, FAM189A2, PTGER3, CHRNA9, LRRTM2, EVC2, PTPRU, B4GAT1, CDH5, PCDHAC2, PCDHB11, PCDHB16, GPR21, CHRND, RNF19B, C3AR1, POLR2E, ZNRF4, HTR3A, FAM189B, LRRN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMCO3_ST7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMCO3_ST7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource