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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38308

FusionGeneSummary for TMCO3_MCF2L

check button Fusion gene summary
Fusion gene informationFusion gene name: TMCO3_MCF2L
Fusion gene ID: 38308
HgeneTgene
Gene symbol

TMCO3

MCF2L

Gene ID

55002

23263

Gene nametransmembrane and coiled-coil domains 3MCF.2 cell line derived transforming sequence like
SynonymsC13orf11ARHGEF14|DBS|OST
Cytomap

13q34

13q34

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane and coiled-coil domain-containing protein 3putative LAG1-interacting proteinguanine nucleotide exchange factor DBSDBL's big sisterMCF2 transforming sequence-like protein
Modification date2018051920180519
UniProtAcc

Q6UWJ1

O15068

Ensembl transtripts involved in fusion geneENST00000434316, ENST00000375391, 
ENST00000474393, 		ENST00000375608, 
ENST00000442652, ENST00000375604, 
ENST00000397030, ENST00000535094, 
ENST00000421756, ENST00000375601, 
ENST00000397036, ENST00000434480, 
ENST00000423482, ENST00000375597, 
ENST00000397024, ENST00000480321, 
ENST00000397021, 
Fusion gene scores* DoF score8 X 6 X 5=2404 X 7 X 4=112
# samples 86
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/112*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMCO3 [Title/Abstract] AND MCF2L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-69-7979-01ATMCO3chr13

114152820

+MCF2Lchr13

113564224

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000434316ENST00000375608TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000434316ENST00000442652TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000434316ENST00000375604TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000434316ENST00000397030TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000434316ENST00000535094TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000434316ENST00000421756TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000434316ENST00000375601TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-3UTRENST00000434316ENST00000397036TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000434316ENST00000434480TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000434316ENST00000423482TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000434316ENST00000375597TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000434316ENST00000397024TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000434316ENST00000480321TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000434316ENST00000397021TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000375391ENST00000375608TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000375391ENST00000442652TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000375391ENST00000375604TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000375391ENST00000397030TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000375391ENST00000535094TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000375391ENST00000421756TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000375391ENST00000375601TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-3UTRENST00000375391ENST00000397036TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000375391ENST00000434480TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000375391ENST00000423482TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000375391ENST00000375597TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000375391ENST00000397024TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000375391ENST00000480321TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
5CDS-intronENST00000375391ENST00000397021TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
3UTR-intronENST00000474393ENST00000375608TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
3UTR-intronENST00000474393ENST00000442652TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
3UTR-intronENST00000474393ENST00000375604TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
3UTR-intronENST00000474393ENST00000397030TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
3UTR-intronENST00000474393ENST00000535094TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
3UTR-intronENST00000474393ENST00000421756TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
3UTR-intronENST00000474393ENST00000375601TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
3UTR-3UTRENST00000474393ENST00000397036TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
3UTR-intronENST00000474393ENST00000434480TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
3UTR-intronENST00000474393ENST00000423482TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
3UTR-intronENST00000474393ENST00000375597TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
3UTR-intronENST00000474393ENST00000397024TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
3UTR-intronENST00000474393ENST00000480321TMCO3chr13

114152820

+MCF2Lchr13

113564224

+
3UTR-intronENST00000474393ENST00000397021TMCO3chr13

114152820

+MCF2Lchr13

113564224

+

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FusionProtFeatures for TMCO3_MCF2L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMCO3

Q6UWJ1

MCF2L

O15068

Probable Na(+)/H(+) antiporter. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMCO3_MCF2L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMCO3_MCF2L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMCO3EGFR, ELAVL1, HSPB1, GLP1R, TAP2, FNDC5, COG4, IFT57, HEMK1, SLC25A17, TYK2, PSME2, ATG9A, PXMP2, PIGQ, SQLE, GUF1, POTEF, CUL4B, ATP13A2, SREBF2, TUBB8, FADS1, TUBB3, DPH6, TUBA4A, ATP13A3, CUL4A, ADCK2, STX17, SLC26A6, DCAF8, SLC25A6, GGCX, AGPAT5, TMBIM6, DNAAF5, TMEM259, METTL13, TRIM25MCF2LRAC1, CDC42, RHOA, YAE1D1, RABAC1, AIMP2, GNB1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMCO3_MCF2L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMCO3_MCF2L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource