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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38305

FusionGeneSummary for TMCO3_ATP11A

check button Fusion gene summary
Fusion gene informationFusion gene name: TMCO3_ATP11A
Fusion gene ID: 38305
HgeneTgene
Gene symbol

TMCO3

ATP11A

Gene ID

55002

23250

Gene nametransmembrane and coiled-coil domains 3ATPase phospholipid transporting 11A
SynonymsC13orf11ATPIH|ATPIS
Cytomap

13q34

13q34

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane and coiled-coil domain-containing protein 3putative LAG1-interacting proteinprobable phospholipid-transporting ATPase IHATPase, class VI, type 11AP4-ATPase flippase complex alpha subunit ATP11Aphospholipid-translocating ATPasepotential phospholipid-transporting ATPase IH
Modification date2018051920180523
UniProtAcc

Q6UWJ1

P98196

Ensembl transtripts involved in fusion geneENST00000434316, ENST00000375391, 
ENST00000474393, 		ENST00000283558, 
ENST00000375630, ENST00000487903, 
ENST00000375645, ENST00000419448, 
Fusion gene scores* DoF score8 X 6 X 5=24011 X 10 X 4=440
# samples 813
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/440*10)=-1.7589919004962
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMCO3 [Title/Abstract] AND ATP11A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-KF-A41W-01ATMCO3chr13

114193822

+ATP11Achr13

113439449

+
TCGALDSARCTCGA-KF-A41W-01ATMCO3chr13

114193822

+ATP11Achr13

113371636

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000434316ENST00000283558TMCO3chr13

114193822

+ATP11Achr13

113439449

+
Frame-shiftENST00000434316ENST00000375630TMCO3chr13

114193822

+ATP11Achr13

113439449

+
Frame-shiftENST00000434316ENST00000487903TMCO3chr13

114193822

+ATP11Achr13

113439449

+
Frame-shiftENST00000434316ENST00000375645TMCO3chr13

114193822

+ATP11Achr13

113439449

+
5CDS-intronENST00000434316ENST00000419448TMCO3chr13

114193822

+ATP11Achr13

113439449

+
intron-3CDSENST00000375391ENST00000283558TMCO3chr13

114193822

+ATP11Achr13

113439449

+
intron-3CDSENST00000375391ENST00000375630TMCO3chr13

114193822

+ATP11Achr13

113439449

+
intron-3CDSENST00000375391ENST00000487903TMCO3chr13

114193822

+ATP11Achr13

113439449

+
intron-3CDSENST00000375391ENST00000375645TMCO3chr13

114193822

+ATP11Achr13

113439449

+
intron-intronENST00000375391ENST00000419448TMCO3chr13

114193822

+ATP11Achr13

113439449

+
intron-3CDSENST00000474393ENST00000283558TMCO3chr13

114193822

+ATP11Achr13

113439449

+
intron-3CDSENST00000474393ENST00000375630TMCO3chr13

114193822

+ATP11Achr13

113439449

+
intron-3CDSENST00000474393ENST00000487903TMCO3chr13

114193822

+ATP11Achr13

113439449

+
intron-3CDSENST00000474393ENST00000375645TMCO3chr13

114193822

+ATP11Achr13

113439449

+
intron-intronENST00000474393ENST00000419448TMCO3chr13

114193822

+ATP11Achr13

113439449

+
5CDS-intronENST00000434316ENST00000283558TMCO3chr13

114193822

+ATP11Achr13

113371636

+
5CDS-intronENST00000434316ENST00000375630TMCO3chr13

114193822

+ATP11Achr13

113371636

+
5CDS-intronENST00000434316ENST00000487903TMCO3chr13

114193822

+ATP11Achr13

113371636

+
5CDS-intronENST00000434316ENST00000375645TMCO3chr13

114193822

+ATP11Achr13

113371636

+
5CDS-3UTRENST00000434316ENST00000419448TMCO3chr13

114193822

+ATP11Achr13

113371636

+
intron-intronENST00000375391ENST00000283558TMCO3chr13

114193822

+ATP11Achr13

113371636

+
intron-intronENST00000375391ENST00000375630TMCO3chr13

114193822

+ATP11Achr13

113371636

+
intron-intronENST00000375391ENST00000487903TMCO3chr13

114193822

+ATP11Achr13

113371636

+
intron-intronENST00000375391ENST00000375645TMCO3chr13

114193822

+ATP11Achr13

113371636

+
intron-3UTRENST00000375391ENST00000419448TMCO3chr13

114193822

+ATP11Achr13

113371636

+
intron-intronENST00000474393ENST00000283558TMCO3chr13

114193822

+ATP11Achr13

113371636

+
intron-intronENST00000474393ENST00000375630TMCO3chr13

114193822

+ATP11Achr13

113371636

+
intron-intronENST00000474393ENST00000487903TMCO3chr13

114193822

+ATP11Achr13

113371636

+
intron-intronENST00000474393ENST00000375645TMCO3chr13

114193822

+ATP11Achr13

113371636

+
intron-3UTRENST00000474393ENST00000419448TMCO3chr13

114193822

+ATP11Achr13

113371636

+

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FusionProtFeatures for TMCO3_ATP11A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMCO3

Q6UWJ1

ATP11A

P98196

Probable Na(+)/H(+) antiporter. {ECO:0000250}. Catalytic component of a P4-ATPase flippase complexwhich catalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules (Probable). May be involved in the uptake offarnesyltransferase inhibitor drugs, such as lonafarnib.{ECO:0000269|PubMed:15860663, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMCO3_ATP11A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMCO3_ATP11A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMCO3EGFR, ELAVL1, HSPB1, GLP1R, TAP2, FNDC5, COG4, IFT57, HEMK1, SLC25A17, TYK2, PSME2, ATG9A, PXMP2, PIGQ, SQLE, GUF1, POTEF, CUL4B, ATP13A2, SREBF2, TUBB8, FADS1, TUBB3, DPH6, TUBA4A, ATP13A3, CUL4A, ADCK2, STX17, SLC26A6, DCAF8, SLC25A6, GGCX, AGPAT5, TMBIM6, DNAAF5, TMEM259, METTL13, TRIM25ATP11ATMEM30A, NPDC1, PICK1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMCO3_ATP11A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMCO3_ATP11A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneATP11AC1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET