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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38291

FusionGeneSummary for TMCC1_ACTR10

check button Fusion gene summary
Fusion gene informationFusion gene name: TMCC1_ACTR10
Fusion gene ID: 38291
HgeneTgene
Gene symbol

TMCC1

ACTR10

Gene ID

23023

55860

Gene nametransmembrane and coiled-coil domain family 1actin related protein 10 homolog
Synonyms-ACTR11|Arp10|Arp11|HARP11
Cytomap

3q22.1

14q23.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane and coiled-coil domains protein 1actin-related protein 10actin-related protein 11
Modification date2018052320180522
UniProtAcc

O94876

Q9NZ32

Ensembl transtripts involved in fusion geneENST00000432054, ENST00000393238, 
ENST00000426664, ENST00000329333, 
ENST00000515024, 
ENST00000254286, 
Fusion gene scores* DoF score8 X 8 X 3=1922 X 3 X 4=24
# samples 104
** MAII scorelog2(10/192*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMCC1 [Title/Abstract] AND ACTR10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A0TU-01ATMCC1chr3

129513167

-ACTR10chr14

58669573

+
TCGALDBRCATCGA-AR-A0TU-01ATMCC1chr3

129546646

-ACTR10chr14

58669573

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000432054ENST00000254286TMCC1chr3

129513167

-ACTR10chr14

58669573

+
intron-3CDSENST00000393238ENST00000254286TMCC1chr3

129513167

-ACTR10chr14

58669573

+
intron-3CDSENST00000426664ENST00000254286TMCC1chr3

129513167

-ACTR10chr14

58669573

+
Frame-shitENST00000329333ENST00000254286TMCC1chr3

129513167

-ACTR10chr14

58669573

+
intron-3CDSENST00000515024ENST00000254286TMCC1chr3

129513167

-ACTR10chr14

58669573

+
intron-3CDSENST00000432054ENST00000254286TMCC1chr3

129546646

-ACTR10chr14

58669573

+
Frame-shitENST00000393238ENST00000254286TMCC1chr3

129546646

-ACTR10chr14

58669573

+
Frame-shitENST00000426664ENST00000254286TMCC1chr3

129546646

-ACTR10chr14

58669573

+
intron-3CDSENST00000329333ENST00000254286TMCC1chr3

129546646

-ACTR10chr14

58669573

+
intron-3CDSENST00000515024ENST00000254286TMCC1chr3

129546646

-ACTR10chr14

58669573

+

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FusionProtFeatures for TMCC1_ACTR10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMCC1

O94876

ACTR10

Q9NZ32


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMCC1_ACTR10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMCC1_ACTR10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMCC1ZDHHC17, APP, TEX28ACTR10DCTN4, ACTR1A, ACTR1B, DCTN2, DCTN3, LMNB1, RABEP1, NAGK, CSPP1, ORC6, C9orf24, CAPZA2, GPS2, CA10, LOC554223, DCTN1, KIF11, MYO19, DUSP13, DCTN6, KLHL2, DEFB127, UQCRH, RIC8A, PDGFD, MIS18A, C16orf45, RPS19BP1, C1orf106, RHOC, MAPK8IP3, NEXN, CCDC120, NGEF, BCL7C, ACTBL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMCC1_ACTR10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMCC1_ACTR10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource