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Fusion gene ID: 38291 |
FusionGeneSummary for TMCC1_ACTR10 |
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Fusion gene information | Fusion gene name: TMCC1_ACTR10 | Fusion gene ID: 38291 | Hgene | Tgene | Gene symbol | TMCC1 | ACTR10 | Gene ID | 23023 | 55860 |
Gene name | transmembrane and coiled-coil domain family 1 | actin related protein 10 homolog | |
Synonyms | - | ACTR11|Arp10|Arp11|HARP11 | |
Cytomap | 3q22.1 | 14q23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane and coiled-coil domains protein 1 | actin-related protein 10actin-related protein 11 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O94876 | Q9NZ32 | |
Ensembl transtripts involved in fusion gene | ENST00000432054, ENST00000393238, ENST00000426664, ENST00000329333, ENST00000515024, | ENST00000254286, | |
Fusion gene scores | * DoF score | 8 X 8 X 3=192 | 2 X 3 X 4=24 |
# samples | 10 | 4 | |
** MAII score | log2(10/192*10)=-0.941106310946431 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TMCC1 [Title/Abstract] AND ACTR10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-AR-A0TU-01A | TMCC1 | chr3 | 129513167 | - | ACTR10 | chr14 | 58669573 | + |
TCGA | LD | BRCA | TCGA-AR-A0TU-01A | TMCC1 | chr3 | 129546646 | - | ACTR10 | chr14 | 58669573 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000432054 | ENST00000254286 | TMCC1 | chr3 | 129513167 | - | ACTR10 | chr14 | 58669573 | + |
intron-3CDS | ENST00000393238 | ENST00000254286 | TMCC1 | chr3 | 129513167 | - | ACTR10 | chr14 | 58669573 | + |
intron-3CDS | ENST00000426664 | ENST00000254286 | TMCC1 | chr3 | 129513167 | - | ACTR10 | chr14 | 58669573 | + |
Frame-shift | ENST00000329333 | ENST00000254286 | TMCC1 | chr3 | 129513167 | - | ACTR10 | chr14 | 58669573 | + |
intron-3CDS | ENST00000515024 | ENST00000254286 | TMCC1 | chr3 | 129513167 | - | ACTR10 | chr14 | 58669573 | + |
intron-3CDS | ENST00000432054 | ENST00000254286 | TMCC1 | chr3 | 129546646 | - | ACTR10 | chr14 | 58669573 | + |
Frame-shift | ENST00000393238 | ENST00000254286 | TMCC1 | chr3 | 129546646 | - | ACTR10 | chr14 | 58669573 | + |
Frame-shift | ENST00000426664 | ENST00000254286 | TMCC1 | chr3 | 129546646 | - | ACTR10 | chr14 | 58669573 | + |
intron-3CDS | ENST00000329333 | ENST00000254286 | TMCC1 | chr3 | 129546646 | - | ACTR10 | chr14 | 58669573 | + |
intron-3CDS | ENST00000515024 | ENST00000254286 | TMCC1 | chr3 | 129546646 | - | ACTR10 | chr14 | 58669573 | + |
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FusionProtFeatures for TMCC1_ACTR10 |
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Hgene | Tgene |
TMCC1 | ACTR10 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMCC1_ACTR10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMCC1_ACTR10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMCC1 | ZDHHC17, APP, TEX28 | ACTR10 | DCTN4, ACTR1A, ACTR1B, DCTN2, DCTN3, LMNB1, RABEP1, NAGK, CSPP1, ORC6, C9orf24, CAPZA2, GPS2, CA10, LOC554223, DCTN1, KIF11, MYO19, DUSP13, DCTN6, KLHL2, DEFB127, UQCRH, RIC8A, PDGFD, MIS18A, C16orf45, RPS19BP1, C1orf106, RHOC, MAPK8IP3, NEXN, CCDC120, NGEF, BCL7C, ACTBL2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMCC1_ACTR10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMCC1_ACTR10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |