FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 38283

FusionGeneSummary for TMC5_TMC5

check button Fusion gene summary
Fusion gene informationFusion gene name: TMC5_TMC5
Fusion gene ID: 38283
HgeneTgene
Gene symbol

TMC5

TMC5

Gene ID

79838

79838

Gene nametransmembrane channel like 5transmembrane channel like 5
Synonyms--
Cytomap

16p12.3

16p12.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane channel-like protein 5transmembrane channel-like protein 5
Modification date2018052320180523
UniProtAcc

Q6UXY8

Q6UXY8

Ensembl transtripts involved in fusion geneENST00000563675, ENST00000541464, 
ENST00000381414, ENST00000396229, 
ENST00000542583, ENST00000219821, 
ENST00000561503, ENST00000564959, 
ENST00000563675, ENST00000541464, 
ENST00000381414, ENST00000396229, 
ENST00000542583, ENST00000219821, 
ENST00000561503, ENST00000564959, 
Fusion gene scores* DoF score5 X 4 X 4=806 X 8 X 3=144
# samples 67
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMC5 [Title/Abstract] AND TMC5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW856759TMC5chr16

19475715

-TMC5chr16

19485826

-
ChiTaRS3.1AI344053TMC5chr16

19421962

-TMC5chr16

19498338

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000563675ENST00000563675TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000563675ENST00000541464TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000563675ENST00000381414TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000563675ENST00000396229TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000563675ENST00000542583TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000563675ENST00000219821TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000563675ENST00000561503TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000563675ENST00000564959TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000541464ENST00000563675TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000541464ENST00000541464TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000541464ENST00000381414TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000541464ENST00000396229TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000541464ENST00000542583TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000541464ENST00000219821TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000541464ENST00000561503TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000541464ENST00000564959TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000381414ENST00000563675TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000381414ENST00000541464TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000381414ENST00000381414TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000381414ENST00000396229TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000381414ENST00000542583TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000381414ENST00000219821TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000381414ENST00000561503TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000381414ENST00000564959TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000396229ENST00000563675TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000396229ENST00000541464TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000396229ENST00000381414TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000396229ENST00000396229TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000396229ENST00000542583TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000396229ENST00000219821TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000396229ENST00000561503TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000396229ENST00000564959TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000542583ENST00000563675TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000542583ENST00000541464TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000542583ENST00000381414TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000542583ENST00000396229TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000542583ENST00000542583TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000542583ENST00000219821TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000542583ENST00000561503TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000542583ENST00000564959TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000219821ENST00000563675TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000219821ENST00000541464TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000219821ENST00000381414TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000219821ENST00000396229TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000219821ENST00000542583TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000219821ENST00000219821TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000219821ENST00000561503TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000219821ENST00000564959TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000561503ENST00000563675TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000561503ENST00000541464TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000561503ENST00000381414TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000561503ENST00000396229TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000561503ENST00000542583TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000561503ENST00000219821TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000561503ENST00000561503TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000561503ENST00000564959TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000564959ENST00000563675TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000564959ENST00000541464TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000564959ENST00000381414TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000564959ENST00000396229TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000564959ENST00000542583TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000564959ENST00000219821TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000564959ENST00000561503TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000564959ENST00000564959TMC5chr16

19475715

-TMC5chr16

19485826

-
intron-intronENST00000563675ENST00000563675TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000563675ENST00000541464TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000563675ENST00000381414TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000563675ENST00000396229TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000563675ENST00000542583TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000563675ENST00000219821TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000563675ENST00000561503TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000563675ENST00000564959TMC5chr16

19421962

-TMC5chr16

19498338

-
5UTR-intronENST00000541464ENST00000563675TMC5chr16

19421962

-TMC5chr16

19498338

-
5UTR-intronENST00000541464ENST00000541464TMC5chr16

19421962

-TMC5chr16

19498338

-
5UTR-intronENST00000541464ENST00000381414TMC5chr16

19421962

-TMC5chr16

19498338

-
5UTR-intronENST00000541464ENST00000396229TMC5chr16

19421962

-TMC5chr16

19498338

-
5UTR-intronENST00000541464ENST00000542583TMC5chr16

19421962

-TMC5chr16

19498338

-
5UTR-intronENST00000541464ENST00000219821TMC5chr16

19421962

-TMC5chr16

19498338

-
5UTR-intronENST00000541464ENST00000561503TMC5chr16

19421962

-TMC5chr16

19498338

-
5UTR-intronENST00000541464ENST00000564959TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000381414ENST00000563675TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000381414ENST00000541464TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000381414ENST00000381414TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000381414ENST00000396229TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000381414ENST00000542583TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000381414ENST00000219821TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000381414ENST00000561503TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000381414ENST00000564959TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000396229ENST00000563675TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000396229ENST00000541464TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000396229ENST00000381414TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000396229ENST00000396229TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000396229ENST00000542583TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000396229ENST00000219821TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000396229ENST00000561503TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000396229ENST00000564959TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000542583ENST00000563675TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000542583ENST00000541464TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000542583ENST00000381414TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000542583ENST00000396229TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000542583ENST00000542583TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000542583ENST00000219821TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000542583ENST00000561503TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000542583ENST00000564959TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000219821ENST00000563675TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000219821ENST00000541464TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000219821ENST00000381414TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000219821ENST00000396229TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000219821ENST00000542583TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000219821ENST00000219821TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000219821ENST00000561503TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000219821ENST00000564959TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000561503ENST00000563675TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000561503ENST00000541464TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000561503ENST00000381414TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000561503ENST00000396229TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000561503ENST00000542583TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000561503ENST00000219821TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000561503ENST00000561503TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000561503ENST00000564959TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000564959ENST00000563675TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000564959ENST00000541464TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000564959ENST00000381414TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000564959ENST00000396229TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000564959ENST00000542583TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000564959ENST00000219821TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000564959ENST00000561503TMC5chr16

19421962

-TMC5chr16

19498338

-
intron-intronENST00000564959ENST00000564959TMC5chr16

19421962

-TMC5chr16

19498338

-

Top

FusionProtFeatures for TMC5_TMC5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMC5

Q6UXY8

TMC5

Q6UXY8

Probable ion channel. {ECO:0000250}. Probable ion channel. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TMC5_TMC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TMC5_TMC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TMC5_TMC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TMC5_TMC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource