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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 38282

FusionGeneSummary for TMC5_SYT17

check button Fusion gene summary
Fusion gene informationFusion gene name: TMC5_SYT17
Fusion gene ID: 38282
HgeneTgene
Gene symbol

TMC5

SYT17

Gene ID

79838

51760

Gene nametransmembrane channel like 5synaptotagmin 17
Synonyms-sytXVII
Cytomap

16p12.3

16p12.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane channel-like protein 5synaptotagmin-17B/K proteinsynaptotagmin XVII
Modification date2018052320180523
UniProtAcc

Q6UXY8

Q9BSW7

Ensembl transtripts involved in fusion geneENST00000563675, ENST00000541464, 
ENST00000381414, ENST00000396229, 
ENST00000542583, ENST00000219821, 
ENST00000561503, ENST00000564959, 
ENST00000355377, ENST00000562034, 
ENST00000562711, ENST00000568433, 
ENST00000568115, 
Fusion gene scores* DoF score5 X 4 X 4=803 X 3 X 2=18
# samples 63
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMC5 [Title/Abstract] AND SYT17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSYT17

GO:1903861

positive regulation of dendrite extension

23999003


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-49-4501-01ATMC5chr16

19441962

+SYT17chr16

19234367

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000563675ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
In-frameENST00000563675ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
In-frameENST00000563675ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
In-frameENST00000563675ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
In-frameENST00000563675ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000541464ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000541464ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000541464ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000541464ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000541464ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000381414ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000381414ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000381414ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000381414ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000381414ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000396229ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000396229ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000396229ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000396229ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000396229ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000542583ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000542583ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000542583ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000542583ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000542583ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000219821ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000219821ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000219821ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000219821ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000219821ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000561503ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000561503ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000561503ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000561503ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000561503ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000564959ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000564959ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000564959ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000564959ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000564959ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+

Top

FusionProtFeatures for TMC5_SYT17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMC5

Q6UXY8

SYT17

Q9BSW7

Probable ion channel. {ECO:0000250}. Plays a role in dendrite formation by melanocytes(PubMed:23999003). {ECO:0000269|PubMed:23999003}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSYT17chr16:19441962chr16:19234367ENST00000355377+48323_426317475DomainC2 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118140_143-86761Compositional biasNote=Poly-Ser
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221140_143-27949Compositional biasNote=Poly-Ser
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222140_143-271007Compositional biasNote=Poly-Ser
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222140_143-271007Compositional biasNote=Poly-Ser
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118140_143-97648Compositional biasNote=Poly-Ser
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+1181_458-86761Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118480_485-86761Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118509_525-86761Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118547_619-86761Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118641_654-86761Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118676_698-86761Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118720_732-86761Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118754_786-86761Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118808_835-86761Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118857_900-86761Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118922_1006-86761Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+2211_458-27949Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221480_485-27949Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221509_525-27949Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221547_619-27949Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221641_654-27949Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221676_698-27949Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221720_732-27949Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221754_786-27949Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221808_835-27949Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221857_900-27949Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221922_1006-27949Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+2221_458-271007Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222480_485-271007Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222509_525-271007Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222547_619-271007Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222641_654-271007Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222676_698-271007Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222720_732-271007Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222754_786-271007Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222808_835-271007Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222857_900-271007Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222922_1006-271007Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+2221_458-271007Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222480_485-271007Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222509_525-271007Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222547_619-271007Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222641_654-271007Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222676_698-271007Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222720_732-271007Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222754_786-271007Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222808_835-271007Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222857_900-271007Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222922_1006-271007Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+1181_458-97648Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118480_485-97648Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118509_525-97648Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118547_619-97648Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118641_654-97648Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118676_698-97648Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118720_732-97648Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118754_786-97648Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118808_835-97648Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118857_900-97648Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118922_1006-97648Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118459_479-86761TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118486_508-86761TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118526_546-86761TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118620_640-86761TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118655_675-86761TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118699_719-86761TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118733_753-86761TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118787_807-86761TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118836_856-86761TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118901_921-86761TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221459_479-27949TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221486_508-27949TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221526_546-27949TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221620_640-27949TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221655_675-27949TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221699_719-27949TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221733_753-27949TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221787_807-27949TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221836_856-27949TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221901_921-27949TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222459_479-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222486_508-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222526_546-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222620_640-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222655_675-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222699_719-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222733_753-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222787_807-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222836_856-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222901_921-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222459_479-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222486_508-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222526_546-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222620_640-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222655_675-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222699_719-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222733_753-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222787_807-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222836_856-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222901_921-271007TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118459_479-97648TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118486_508-97648TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118526_546-97648TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118620_640-97648TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118655_675-97648TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118699_719-97648TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118733_753-97648TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118787_807-97648TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118836_856-97648TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118901_921-97648TransmembraneHelical
TgeneSYT17chr16:19441962chr16:19234367ENST00000355377+4823_40317475Compositional biasNote=Cys-rich
TgeneSYT17chr16:19441962chr16:19234367ENST00000355377+48186_294317475DomainC2 1


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FusionGeneSequence for TMC5_SYT17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000355377_chr16_19234367_+_249aa
ERRPTQACAASGGHQDMRLCLQSATWNIQTSDQHHRLXPSVNHLHPSSHQKPAXRTHGHVTPVFSTTSXDQVGLHNICIYLGQSKNNKGK
KNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESFSFKVPQEELENASL

>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000562034_chr16_19234367_+_249aa
ERRPTQACAASGGHQDMRLCLQSATWNIQTSDQHHRLXPSVNHLHPSSHQKPAXRTHGHVTPVFSTTSXDQVGLHNICIYLGQSKNNKGK
KNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESFSFKVPQEELENASL

>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000562711_chr16_19234367_+_249aa
ERRPTQACAASGGHQDMRLCLQSATWNIQTSDQHHRLXPSVNHLHPSSHQKPAXRTHGHVTPVFSTTSXDQVGLHNICIYLGQSKNNKGK
KNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESFSFKVPQEELENASL

>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000568433_chr16_19234367_+_249aa
ERRPTQACAASGGHQDMRLCLQSATWNIQTSDQHHRLXPSVNHLHPSSHQKPAXRTHGHVTPVFSTTSXDQVGLHNICIYLGQSKNNKGK
KNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESFSFKVPQEELENASL

>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000568115_chr16_19234367_+_228aa
ERRPTQACAASGGHQDMRLCLQSATWNIQTSDQHHRLXPSVNHLHPSSHQKPAXRTHGHVTPVFSTTSXDQVGLHNICIYLGQSKNNKGK
KNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESFSFKVPQEELENASL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000355377_chr16_19234367_+_747nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGTTTTCGGCCACAACATGAAGAGCAGCAATGACTTCATCGGGAGGATCGTCATTGGCCAGTACTCTTCAGGCCCCTCTGAG
ACCAACCACTGGAGGCGCATGCTCAACACGCACCGCACAGCCGTGGAGCAGTGGCATAGCCTGAGGTCCCGAGCTGAGTGTGACCGCGTG

>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000562034_chr16_19234367_+_747nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGTTTTCGGCCACAACATGAAGAGCAGCAATGACTTCATCGGGAGGATCGTCATTGGCCAGTACTCTTCAGGCCCCTCTGAG
ACCAACCACTGGAGGCGCATGCTCAACACGCACCGCACAGCCGTGGAGCAGTGGCATAGCCTGAGGTCCCGAGCTGAGTGTGACCGCGTG

>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000562711_chr16_19234367_+_747nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGTTTTCGGCCACAACATGAAGAGCAGCAATGACTTCATCGGGAGGATCGTCATTGGCCAGTACTCTTCAGGCCCCTCTGAG
ACCAACCACTGGAGGCGCATGCTCAACACGCACCGCACAGCCGTGGAGCAGTGGCATAGCCTGAGGTCCCGAGCTGAGTGTGACCGCGTG

>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000568433_chr16_19234367_+_747nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGTTTTCGGCCACAACATGAAGAGCAGCAATGACTTCATCGGGAGGATCGTCATTGGCCAGTACTCTTCAGGCCCCTCTGAG
ACCAACCACTGGAGGCGCATGCTCAACACGCACCGCACAGCCGTGGAGCAGTGGCATAGCCTGAGGTCCCGAGCTGAGTGTGACCGCGTG

>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000568115_chr16_19234367_+_684nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGGATCCAACAGCCCCATACCAGCCTGCGAACTGAGTAGTCACCCAGCTCATGGTATCAGTCCTTGGATACCCTCACCTGGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000355377_chr16_19234367_+_2001nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGTTTTCGGCCACAACATGAAGAGCAGCAATGACTTCATCGGGAGGATCGTCATTGGCCAGTACTCTTCAGGCCCCTCTGAG
ACCAACCACTGGAGGCGCATGCTCAACACGCACCGCACAGCCGTGGAGCAGTGGCATAGCCTGAGGTCCCGAGCTGAGTGTGACCGCGTG
TCTCCTGCCTCCCTGGAGGTGACCTGAGGGCTGCAGGGAAGGCAGCTTTCATTTGTTTAAAAAAAAAAAAAAAAGACGGAAAAAAATGTG
TCACATACTATTACATCCACACCTGCATACACACTCGCAACATGTCTACACACGTCCACACACACAGACACACAGATACCCCAAATCCTC
TCAGAACTGAGAGGAAGCTGACTATTGATCACAAAATGGCCGCCCTCAGTTGAGTGAGGCCTAGGAACTTTCCGGAAGCCCCATCCATAG
ATCACAAGCTCAGTGGGCTCTGCCGTGGGACTTATTGGCAGTGCCTGCTCTTGTCAATACTCCTGCCCCAAAATGCACTTTCAACCCTCA
GGCCAGAGAAAGGACCTCCCAAAGGGTGCCAAGCTCCATCAAGACTAAATTTACCAAGAGTTTGGCCAGTGTGTGGGAGACTTGAACACC
CCCCACTTCCGAAACACACACCTACTGGGTAACTTCTGAACAGGCTGCTGTTCCCTGGGGTTCTTCAAACCTGATACCTTTCTCCAAAGG
TGTAAGTATCTTTGTCTTCTCCGTAGTAAATGTGATAACTAGATTATGGGCCATTTGGAGAAACCAAATGGCAACCAAAACTATTCCAGT
GTCAGAAGCCTTTCCTGGCTTAACAGAATTGTTCTTGTGTTAGCTCATCCCAGGGAACGCCCTGTGGGTATGTATGTGTATGTCCTCGTG
CATGTGCCCTCACAGGCGAACACGTGTGTGCCTATGTGTCCTCTTGGAGAGCATGGCGATGGGCCAGGACCTCAGCCCTGAGCACTGCCT
TCTCTCTGCCTCTCCTGTCCAGTGAGAGTCCAACCAGTGTCCTCCTGTCTGTCAGAGATCCCACTTTGGATAAAAGTAGTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTGTAAAGTAAATAGGATATGATAGAGCAAAAGTAACATTTTTTGACCGAATCATGGTGATTGTGACCCA
CGAAAGACATACAAAGACTTGATATATGGATTAAAATGGCTATCACACCCCATCCATGATGATCTTCTTCCTTAATCATACTCTGAGGAT
CTTTCTGTGTTTTTCTGTGAACGAATGTCACGTCTCTCGTGCTAAGGAATTAGTGTAGTTAGAATAGATCTCTCTCTCTCTCTCTTTCTC
TCTCTCTCTTTCCTCTCTCTCTGTTGGATGCTTCTGTATCTTTTTCCACAGCATAATGTCTGGTGTGATGGGGAGCTATTTATTGAAATT

>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000562034_chr16_19234367_+_799nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGTTTTCGGCCACAACATGAAGAGCAGCAATGACTTCATCGGGAGGATCGTCATTGGCCAGTACTCTTCAGGCCCCTCTGAG
ACCAACCACTGGAGGCGCATGCTCAACACGCACCGCACAGCCGTGGAGCAGTGGCATAGCCTGAGGTCCCGAGCTGAGTGTGACCGCGTG

>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000562711_chr16_19234367_+_778nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGTTTTCGGCCACAACATGAAGAGCAGCAATGACTTCATCGGGAGGATCGTCATTGGCCAGTACTCTTCAGGCCCCTCTGAG
ACCAACCACTGGAGGCGCATGCTCAACACGCACCGCACAGCCGTGGAGCAGTGGCATAGCCTGAGGTCCCGAGCTGAGTGTGACCGCGTG

>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000568433_chr16_19234367_+_789nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGTTTTCGGCCACAACATGAAGAGCAGCAATGACTTCATCGGGAGGATCGTCATTGGCCAGTACTCTTCAGGCCCCTCTGAG
ACCAACCACTGGAGGCGCATGCTCAACACGCACCGCACAGCCGTGGAGCAGTGGCATAGCCTGAGGTCCCGAGCTGAGTGTGACCGCGTG

>In-frame_TMC5_ENST00000563675_chr16_19441962_+_SYT17_ENST00000568115_chr16_19234367_+_688nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGGATCCAACAGCCCCATACCAGCCTGCGAACTGAGTAGTCACCCAGCTCATGGTATCAGTCCTTGGATACCCTCACCTGGA


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FusionGenePPI for TMC5_SYT17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMC5NUMBL, TRIM25SYT17CCDC85B, CHMP4A, NINL, TSC22D4, APTX, APP, MEOX1, MEOX2, TRAF2, IKZF1, RUNDC3A, MID2, NIF3L1, GMCL1, CEP63, CEP70, SSX2IP, FAM9B, TF, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMC5_SYT17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMC5_SYT17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource