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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38280

FusionGeneSummary for TMC5_GPRC5B

check button Fusion gene summary
Fusion gene informationFusion gene name: TMC5_GPRC5B
Fusion gene ID: 38280
HgeneTgene
Gene symbol

TMC5

GPRC5B

Gene ID

79838

51704

Gene nametransmembrane channel like 5G protein-coupled receptor class C group 5 member B
Synonyms-RAIG-2|RAIG2
Cytomap

16p12.3

16p12.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane channel-like protein 5G-protein coupled receptor family C group 5 member BG protein-coupled receptor, family C, group 1, member Bretinoic acid responsive gene proteinretinoic acid-induced gene 2 protein
Modification date2018052320180519
UniProtAcc

Q6UXY8

Q9NZH0

Ensembl transtripts involved in fusion geneENST00000563675, ENST00000541464, 
ENST00000381414, ENST00000396229, 
ENST00000542583, ENST00000219821, 
ENST00000561503, ENST00000564959, 
ENST00000300571, ENST00000569102, 
ENST00000535671, ENST00000569479, 
ENST00000537135, ENST00000569847, 
Fusion gene scores* DoF score5 X 4 X 4=804 X 4 X 2=32
# samples 64
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMC5 [Title/Abstract] AND GPRC5B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-L5-A8NU-01ATMC5chr16

19508485

+GPRC5Bchr16

19883272

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000563675ENST00000300571TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
intron-intronENST00000563675ENST00000569102TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
intron-intronENST00000563675ENST00000535671TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
intron-intronENST00000563675ENST00000569479TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
intron-intronENST00000563675ENST00000537135TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
intron-intronENST00000563675ENST00000569847TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
Frame-shiftENST00000541464ENST00000300571TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000541464ENST00000569102TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000541464ENST00000535671TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000541464ENST00000569479TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000541464ENST00000537135TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000541464ENST00000569847TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
Frame-shiftENST00000381414ENST00000300571TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000381414ENST00000569102TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000381414ENST00000535671TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000381414ENST00000569479TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000381414ENST00000537135TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000381414ENST00000569847TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
Frame-shiftENST00000396229ENST00000300571TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000396229ENST00000569102TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000396229ENST00000535671TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000396229ENST00000569479TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000396229ENST00000537135TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000396229ENST00000569847TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
Frame-shiftENST00000542583ENST00000300571TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000542583ENST00000569102TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000542583ENST00000535671TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000542583ENST00000569479TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000542583ENST00000537135TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000542583ENST00000569847TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
Frame-shiftENST00000219821ENST00000300571TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000219821ENST00000569102TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000219821ENST00000535671TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000219821ENST00000569479TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000219821ENST00000537135TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000219821ENST00000569847TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
Frame-shiftENST00000561503ENST00000300571TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000561503ENST00000569102TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000561503ENST00000535671TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000561503ENST00000569479TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000561503ENST00000537135TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000561503ENST00000569847TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
Frame-shiftENST00000564959ENST00000300571TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000564959ENST00000569102TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000564959ENST00000535671TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000564959ENST00000569479TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000564959ENST00000537135TMC5chr16

19508485

+GPRC5Bchr16

19883272

-
5CDS-intronENST00000564959ENST00000569847TMC5chr16

19508485

+GPRC5Bchr16

19883272

-

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FusionProtFeatures for TMC5_GPRC5B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMC5

Q6UXY8

GPRC5B

Q9NZH0

Probable ion channel. {ECO:0000250}. Unknown. This retinoic acid-inducible G-protein coupledreceptor provide evidence for a possible interaction betweenretinoid and G-protein signaling pathways.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMC5_GPRC5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMC5_GPRC5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMC5NUMBL, TRIM25GPRC5BC11orf71, ADRB2, TMEM171, CSGALNACT1, LPAR1, TNFRSF1A, CD70, MPP7, IPPK, CHRND, CD97, STXBP1, STX4, SDCBP, SEC63, STXBP3, ATP5B, DLG1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMC5_GPRC5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMC5_GPRC5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource