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Fusion gene ID: 38280 |
FusionGeneSummary for TMC5_GPRC5B |
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Fusion gene information | Fusion gene name: TMC5_GPRC5B | Fusion gene ID: 38280 | Hgene | Tgene | Gene symbol | TMC5 | GPRC5B | Gene ID | 79838 | 51704 |
Gene name | transmembrane channel like 5 | G protein-coupled receptor class C group 5 member B | |
Synonyms | - | RAIG-2|RAIG2 | |
Cytomap | 16p12.3 | 16p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane channel-like protein 5 | G-protein coupled receptor family C group 5 member BG protein-coupled receptor, family C, group 1, member Bretinoic acid responsive gene proteinretinoic acid-induced gene 2 protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q6UXY8 | Q9NZH0 | |
Ensembl transtripts involved in fusion gene | ENST00000563675, ENST00000541464, ENST00000381414, ENST00000396229, ENST00000542583, ENST00000219821, ENST00000561503, ENST00000564959, | ENST00000300571, ENST00000569102, ENST00000535671, ENST00000569479, ENST00000537135, ENST00000569847, | |
Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 4 X 4 X 2=32 |
# samples | 6 | 4 | |
** MAII score | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TMC5 [Title/Abstract] AND GPRC5B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-L5-A8NU-01A | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000563675 | ENST00000300571 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
intron-intron | ENST00000563675 | ENST00000569102 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
intron-intron | ENST00000563675 | ENST00000535671 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
intron-intron | ENST00000563675 | ENST00000569479 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
intron-intron | ENST00000563675 | ENST00000537135 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
intron-intron | ENST00000563675 | ENST00000569847 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
Frame-shift | ENST00000541464 | ENST00000300571 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000541464 | ENST00000569102 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000541464 | ENST00000535671 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000541464 | ENST00000569479 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000541464 | ENST00000537135 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000541464 | ENST00000569847 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
Frame-shift | ENST00000381414 | ENST00000300571 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000381414 | ENST00000569102 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000381414 | ENST00000535671 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000381414 | ENST00000569479 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000381414 | ENST00000537135 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000381414 | ENST00000569847 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
Frame-shift | ENST00000396229 | ENST00000300571 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000396229 | ENST00000569102 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000396229 | ENST00000535671 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000396229 | ENST00000569479 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000396229 | ENST00000537135 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000396229 | ENST00000569847 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
Frame-shift | ENST00000542583 | ENST00000300571 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000542583 | ENST00000569102 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000542583 | ENST00000535671 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000542583 | ENST00000569479 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000542583 | ENST00000537135 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000542583 | ENST00000569847 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
Frame-shift | ENST00000219821 | ENST00000300571 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000219821 | ENST00000569102 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000219821 | ENST00000535671 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000219821 | ENST00000569479 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000219821 | ENST00000537135 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000219821 | ENST00000569847 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
Frame-shift | ENST00000561503 | ENST00000300571 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000561503 | ENST00000569102 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000561503 | ENST00000535671 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000561503 | ENST00000569479 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000561503 | ENST00000537135 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000561503 | ENST00000569847 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
Frame-shift | ENST00000564959 | ENST00000300571 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000564959 | ENST00000569102 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000564959 | ENST00000535671 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000564959 | ENST00000569479 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000564959 | ENST00000537135 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
5CDS-intron | ENST00000564959 | ENST00000569847 | TMC5 | chr16 | 19508485 | + | GPRC5B | chr16 | 19883272 | - |
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FusionProtFeatures for TMC5_GPRC5B |
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Hgene | Tgene |
TMC5 | GPRC5B |
Probable ion channel. {ECO:0000250}. | Unknown. This retinoic acid-inducible G-protein coupledreceptor provide evidence for a possible interaction betweenretinoid and G-protein signaling pathways. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMC5_GPRC5B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMC5_GPRC5B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMC5 | NUMBL, TRIM25 | GPRC5B | C11orf71, ADRB2, TMEM171, CSGALNACT1, LPAR1, TNFRSF1A, CD70, MPP7, IPPK, CHRND, CD97, STXBP1, STX4, SDCBP, SEC63, STXBP3, ATP5B, DLG1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMC5_GPRC5B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMC5_GPRC5B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |