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Fusion gene ID: 3826 |
FusionGeneSummary for BANP_NID2 |
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Fusion gene information | Fusion gene name: BANP_NID2 | Fusion gene ID: 3826 | Hgene | Tgene | Gene symbol | BANP | NID2 | Gene ID | 54971 | 22795 |
Gene name | BTG3 associated nuclear protein | nidogen 2 | |
Synonyms | BEND1|SMAR1|SMARBP1 | NID-2 | |
Cytomap | 16q24.2 | 14q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein BANPBEN domain-containing protein 1scaffold/matrix-associated region-1-binding protein | nidogen-2osteonidogen | |
Modification date | 20180520 | 20180522 | |
UniProtAcc | Q8N9N5 | Q14112 | |
Ensembl transtripts involved in fusion gene | ENST00000286122, ENST00000355163, ENST00000479780, ENST00000393208, ENST00000355022, ENST00000538234, ENST00000393207, ENST00000481948, | ENST00000541773, ENST00000216286, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 4 X 4 X 2=32 |
# samples | 4 | 4 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: BANP [Title/Abstract] AND NID2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DB118469 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000286122 | ENST00000541773 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
intron-3CDS | ENST00000286122 | ENST00000216286 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
intron-3CDS | ENST00000355163 | ENST00000541773 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
intron-3CDS | ENST00000355163 | ENST00000216286 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
intron-3CDS | ENST00000479780 | ENST00000541773 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
intron-3CDS | ENST00000479780 | ENST00000216286 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
intron-3CDS | ENST00000393208 | ENST00000541773 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
intron-3CDS | ENST00000393208 | ENST00000216286 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
intron-3CDS | ENST00000355022 | ENST00000541773 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
intron-3CDS | ENST00000355022 | ENST00000216286 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
intron-3CDS | ENST00000538234 | ENST00000541773 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
intron-3CDS | ENST00000538234 | ENST00000216286 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
intron-3CDS | ENST00000393207 | ENST00000541773 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
intron-3CDS | ENST00000393207 | ENST00000216286 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
3UTR-3CDS | ENST00000481948 | ENST00000541773 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
3UTR-3CDS | ENST00000481948 | ENST00000216286 | BANP | chr16 | 88105027 | + | NID2 | chr14 | 52481996 | - |
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FusionProtFeatures for BANP_NID2 |
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Hgene | Tgene |
BANP | NID2 |
Controls V(D)J recombination during T-cell developmentby repressing T-cell receptor (TCR) beta enhancer function. Bindsto scaffold/matrix attachment region beta (S/MARbeta), an ATC-richDNA sequence located upstream of the TCR beta enhancer. Repressescyclin D1 transcription by recruiting HDAC1 to its promoter,thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. PromotesTP53 'Ser-15' phosphorylation and nuclear accumulation, whichcauses cell cycle arrest (By similarity). {ECO:0000250,ECO:0000269|PubMed:16166625}. | Cell adhesion glycoprotein which is widely distributedin basement membranes. Binds to collagens I and IV, to perlecanand to laminin 1. Does not bind fibulins. It probably has a rolein cell-extracellular matrix interactions. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BANP_NID2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BANP_NID2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BANP_NID2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BANP_NID2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | NID2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |