FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 3824

FusionGeneSummary for BANK1_GSTCD

check button Fusion gene summary
Fusion gene informationFusion gene name: BANK1_GSTCD
Fusion gene ID: 3824
HgeneTgene
Gene symbol

BANK1

GSTCD

Gene ID

55024

79807

Gene nameB cell scaffold protein with ankyrin repeats 1glutathione S-transferase C-terminal domain containing
SynonymsBANK-
Cytomap

4q24

4q24

Type of geneprotein-codingprotein-coding
DescriptionB-cell scaffold protein with ankyrin repeatsglutathione S-transferase C-terminal domain-containing protein
Modification date2018051920180523
UniProtAcc

Q8NDB2

Q8NEC7

Ensembl transtripts involved in fusion geneENST00000504592, ENST00000322953, 
ENST00000428908, ENST00000508653, 
ENST00000444316, ENST00000510950, 
ENST00000515255, ENST00000394730, 
ENST00000515279, ENST00000360505, 
ENST00000394728, ENST00000507281, 
Fusion gene scores* DoF score3 X 2 X 1=64 X 2 X 3=24
# samples 34
** MAII scorelog2(3/6*10)=2.32192809488736log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BANK1 [Title/Abstract] AND GSTCD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBANK1

GO:0042113

B cell activation

11782428


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-YL-A8S8-01ABANK1chr4

102965064

+GSTCDchr4

106744111

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000504592ENST00000515255BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000504592ENST00000394730BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000504592ENST00000515279BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000504592ENST00000360505BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000504592ENST00000394728BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-intronENST00000504592ENST00000507281BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000322953ENST00000515255BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000322953ENST00000394730BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000322953ENST00000515279BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000322953ENST00000360505BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000322953ENST00000394728BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-intronENST00000322953ENST00000507281BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000428908ENST00000515255BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000428908ENST00000394730BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000428908ENST00000515279BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000428908ENST00000360505BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000428908ENST00000394728BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-intronENST00000428908ENST00000507281BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000508653ENST00000515255BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000508653ENST00000394730BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000508653ENST00000515279BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000508653ENST00000360505BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000508653ENST00000394728BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-intronENST00000508653ENST00000507281BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000444316ENST00000515255BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000444316ENST00000394730BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000444316ENST00000515279BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000444316ENST00000360505BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-3UTRENST00000444316ENST00000394728BANK1chr4

102965064

+GSTCDchr4

106744111

+
5CDS-intronENST00000444316ENST00000507281BANK1chr4

102965064

+GSTCDchr4

106744111

+
intron-3UTRENST00000510950ENST00000515255BANK1chr4

102965064

+GSTCDchr4

106744111

+
intron-3UTRENST00000510950ENST00000394730BANK1chr4

102965064

+GSTCDchr4

106744111

+
intron-3UTRENST00000510950ENST00000515279BANK1chr4

102965064

+GSTCDchr4

106744111

+
intron-3UTRENST00000510950ENST00000360505BANK1chr4

102965064

+GSTCDchr4

106744111

+
intron-3UTRENST00000510950ENST00000394728BANK1chr4

102965064

+GSTCDchr4

106744111

+
intron-intronENST00000510950ENST00000507281BANK1chr4

102965064

+GSTCDchr4

106744111

+

Top

FusionProtFeatures for BANK1_GSTCD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BANK1

Q8NDB2

GSTCD

Q8NEC7

Involved in B-cell receptor (BCR)-induced Ca(2+)mobilization from intracellular stores. Promotes Lyn-mediatedphosphorylation of IP3 receptors 1 and 2.{ECO:0000269|PubMed:11782428}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for BANK1_GSTCD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for BANK1_GSTCD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BANK1LYN, ITPR1, YWHAQGSTCDKDM1A, PRMT6, SUV39H2, BMP7, DAPP1, STAT3, TNS4, CLNK, XPO1, PLA2G10, C5AR2, FZD10, PHF19


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BANK1_GSTCD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for BANK1_GSTCD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBANK1C0024141Lupus Erythematosus, Systemic1CTD_human
TgeneGSTCDC0033578Prostatic Neoplasms1CTD_human