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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38218

FusionGeneSummary for TM4SF18_WWTR1

check button Fusion gene summary
Fusion gene informationFusion gene name: TM4SF18_WWTR1
Fusion gene ID: 38218
HgeneTgene
Gene symbol

TM4SF18

WWTR1

Gene ID

116441

25937

Gene nametransmembrane 4 L six family member 18WW domain containing transcription regulator 1
SynonymsL6DTAZ
Cytomap

3q25.1

3q25.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane 4 L6 family member 18WW domain-containing transcription regulator protein 1transcriptional co-activator with PDZ-binding motif
Modification date2018052320180522
UniProtAcc

Q96CE8

Q9GZV5

Ensembl transtripts involved in fusion geneENST00000296059, ENST00000470080, 
ENST00000465804, ENST00000360632, 
ENST00000467467, ENST00000474080, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 4 X 6=144
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TM4SF18 [Title/Abstract] AND WWTR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWWTR1

GO:0008284

positive regulation of cell proliferation

18227151

TgeneWWTR1

GO:0010718

positive regulation of epithelial to mesenchymal transition

18227151

TgeneWWTR1

GO:0017145

stem cell division

18568018

TgeneWWTR1

GO:0035329

hippo signaling

18227151|20412773

TgeneWWTR1

GO:0060390

regulation of SMAD protein signal transduction

18568018


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0AT-01ATM4SF18chr3

149042667

-WWTR1chr3

149260324

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000296059ENST00000465804TM4SF18chr3

149042667

-WWTR1chr3

149260324

-
Frame-shitENST00000296059ENST00000360632TM4SF18chr3

149042667

-WWTR1chr3

149260324

-
Frame-shitENST00000296059ENST00000467467TM4SF18chr3

149042667

-WWTR1chr3

149260324

-
5CDS-intronENST00000296059ENST00000474080TM4SF18chr3

149042667

-WWTR1chr3

149260324

-
Frame-shitENST00000470080ENST00000465804TM4SF18chr3

149042667

-WWTR1chr3

149260324

-
Frame-shitENST00000470080ENST00000360632TM4SF18chr3

149042667

-WWTR1chr3

149260324

-
Frame-shitENST00000470080ENST00000467467TM4SF18chr3

149042667

-WWTR1chr3

149260324

-
5CDS-intronENST00000470080ENST00000474080TM4SF18chr3

149042667

-WWTR1chr3

149260324

-

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FusionProtFeatures for TM4SF18_WWTR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TM4SF18

Q96CE8

WWTR1

Q9GZV5

Transcriptional coactivator which acts as a downstreamregulatory target in the Hippo signaling pathway that plays apivotal role in organ size control and tumor suppression byrestricting proliferation and promoting apoptosis. The core ofthis pathway is composed of a kinase cascade wherein STK3/MST2 andSTK4/MST1, in complex with its regulatory protein SAV1,phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8and NKX2-1/TTF1-dependent gene activation. Regulates the nuclearaccumulation of SMADS and has a key role in coupling them to thetranscriptional machinery such as the mediator complex. Regulatesembryonic stem-cell self-renewal, promotes cell proliferation andepithelial-mesenchymal transition. {ECO:0000269|PubMed:11118213,ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018,ECO:0000269|PubMed:19010321}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TM4SF18_WWTR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TM4SF18_WWTR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TM4SF18TMEM65, CD320, STXBP1, TMEM179B, CD47, REEP5WWTR1TEAD4, TEAD3, SLC9A3R2, YWHAE, YWHAZ, YWHAG, KLF5, PPP1CA, TP53BP2, BTRC, YWHAQ, LATS1, NOTCH1, MED28, DVL1, DVL2, DVL3, HIF1A, AMOTL1, AMOT, TEAD1, FBXW11, TEAD2, LATS2, WBP2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TM4SF18_WWTR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TM4SF18_WWTR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWWTR1C0026846Muscular Atrophy1CTD_human