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Fusion gene ID: 38209 |
FusionGeneSummary for TLR6_PPP4R1 |
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Fusion gene information | Fusion gene name: TLR6_PPP4R1 | Fusion gene ID: 38209 | Hgene | Tgene | Gene symbol | TLR6 | PPP4R1 | Gene ID | 10333 | 9989 |
Gene name | toll like receptor 6 | protein phosphatase 4 regulatory subunit 1 | |
Synonyms | CD286 | MEG1|PP4(Rmeg)|PP4R1 | |
Cytomap | 4p14 | 18p11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | toll-like receptor 6 | serine/threonine-protein phosphatase 4 regulatory subunit 1serine/threonine phosphatase 4 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9Y2C9 | Q8TF05 | |
Ensembl transtripts involved in fusion gene | ENST00000436693, ENST00000381950, | ENST00000400556, ENST00000400555, ENST00000580583, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 7 X 5=280 |
# samples | 1 | 8 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TLR6 [Title/Abstract] AND PPP4R1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TLR6 | GO:0001775 | cell activation | 15294986 |
Hgene | TLR6 | GO:0042496 | detection of diacyl bacterial lipopeptide | 19931471 |
Hgene | TLR6 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 10231569 |
Hgene | TLR6 | GO:0043507 | positive regulation of JUN kinase activity | 10231569 |
Hgene | TLR6 | GO:0071726 | cellular response to diacyl bacterial lipopeptide | 16880211|19931471 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA670438 | TLR6 | chr4 | 38858382 | - | PPP4R1 | chr18 | 9570491 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000436693 | ENST00000400556 | TLR6 | chr4 | 38858382 | - | PPP4R1 | chr18 | 9570491 | - |
5UTR-3CDS | ENST00000436693 | ENST00000400555 | TLR6 | chr4 | 38858382 | - | PPP4R1 | chr18 | 9570491 | - |
5UTR-intron | ENST00000436693 | ENST00000580583 | TLR6 | chr4 | 38858382 | - | PPP4R1 | chr18 | 9570491 | - |
intron-3CDS | ENST00000381950 | ENST00000400556 | TLR6 | chr4 | 38858382 | - | PPP4R1 | chr18 | 9570491 | - |
intron-3CDS | ENST00000381950 | ENST00000400555 | TLR6 | chr4 | 38858382 | - | PPP4R1 | chr18 | 9570491 | - |
intron-intron | ENST00000381950 | ENST00000580583 | TLR6 | chr4 | 38858382 | - | PPP4R1 | chr18 | 9570491 | - |
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FusionProtFeatures for TLR6_PPP4R1 |
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Hgene | Tgene |
TLR6 | PPP4R1 |
Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylatedand, to a lesser extent, triacylated lipopeptides(PubMed:20037584). In response to diacylated lipopeptides, formsthe activation cluster TLR2:TLR6:CD14:CD36, this cluster triggerssignaling from the cell surface and subsequently is targeted tothe Golgi in a lipid-raft dependent pathway (PubMed:16880211).Acts via MYD88 and TRAF6, leading to NF-kappa-B activation,cytokine secretion and the inflammatory response. Recognizesmycoplasmal macrophage-activating lipopeptide-2kD (MALP-2),soluble tuberculosis factor (STF), phenol-soluble modulin (PSM)and B.burgdorferi outer surface protein A lipoprotein (OspA-L)cooperatively with TLR2 (PubMed:11441107). In complex with TLR4,promotes sterile inflammation in monocytes/macrophages in responseto oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. Inthis context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of aheterodimer of TLR4 and TLR6, which is rapidly internalized andtriggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88signaling pathway, and CCL5 cytokine, via TICAM1 signalingpathway, as well as IL1B secretion (PubMed:11441107,PubMed:20037584). {ECO:0000269|PubMed:11441107,ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:20037584}. | Regulatory subunit of serine/threonine-proteinphosphatase 4. May play a role in regulation of cell division inrenal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role indephosphorylation and regulation of HDAC3.{ECO:0000269|PubMed:15805470}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TLR6_PPP4R1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TLR6_PPP4R1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TLR6_PPP4R1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TLR6_PPP4R1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TLR6 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |