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Fusion gene ID: 38209 |
FusionGeneSummary for TLR6_PPP4R1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TLR6_PPP4R1 | Fusion gene ID: 38209 | Hgene | Tgene | Gene symbol | TLR6 | PPP4R1 | Gene ID | 10333 | 9989 |
| Gene name | toll like receptor 6 | protein phosphatase 4 regulatory subunit 1 | |
| Synonyms | CD286 | MEG1|PP4(Rmeg)|PP4R1 | |
| Cytomap | 4p14 | 18p11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | toll-like receptor 6 | serine/threonine-protein phosphatase 4 regulatory subunit 1serine/threonine phosphatase 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y2C9 | Q8TF05 | |
| Ensembl transtripts involved in fusion gene | ENST00000436693, ENST00000381950, | ENST00000400556, ENST00000400555, ENST00000580583, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 7 X 5=280 |
| # samples | 1 | 8 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TLR6 [Title/Abstract] AND PPP4R1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TLR6 | GO:0001775 | cell activation | 15294986 |
| Hgene | TLR6 | GO:0042496 | detection of diacyl bacterial lipopeptide | 19931471 |
| Hgene | TLR6 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 10231569 |
| Hgene | TLR6 | GO:0043507 | positive regulation of JUN kinase activity | 10231569 |
| Hgene | TLR6 | GO:0071726 | cellular response to diacyl bacterial lipopeptide | 16880211|19931471 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA670438 | TLR6 | chr4 | 38858382 | - | PPP4R1 | chr18 | 9570491 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000436693 | ENST00000400556 | TLR6 | chr4 | 38858382 | - | PPP4R1 | chr18 | 9570491 | - |
| 5UTR-3CDS | ENST00000436693 | ENST00000400555 | TLR6 | chr4 | 38858382 | - | PPP4R1 | chr18 | 9570491 | - |
| 5UTR-intron | ENST00000436693 | ENST00000580583 | TLR6 | chr4 | 38858382 | - | PPP4R1 | chr18 | 9570491 | - |
| intron-3CDS | ENST00000381950 | ENST00000400556 | TLR6 | chr4 | 38858382 | - | PPP4R1 | chr18 | 9570491 | - |
| intron-3CDS | ENST00000381950 | ENST00000400555 | TLR6 | chr4 | 38858382 | - | PPP4R1 | chr18 | 9570491 | - |
| intron-intron | ENST00000381950 | ENST00000580583 | TLR6 | chr4 | 38858382 | - | PPP4R1 | chr18 | 9570491 | - |
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FusionProtFeatures for TLR6_PPP4R1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TLR6 | PPP4R1 |
| Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylatedand, to a lesser extent, triacylated lipopeptides(PubMed:20037584). In response to diacylated lipopeptides, formsthe activation cluster TLR2:TLR6:CD14:CD36, this cluster triggerssignaling from the cell surface and subsequently is targeted tothe Golgi in a lipid-raft dependent pathway (PubMed:16880211).Acts via MYD88 and TRAF6, leading to NF-kappa-B activation,cytokine secretion and the inflammatory response. Recognizesmycoplasmal macrophage-activating lipopeptide-2kD (MALP-2),soluble tuberculosis factor (STF), phenol-soluble modulin (PSM)and B.burgdorferi outer surface protein A lipoprotein (OspA-L)cooperatively with TLR2 (PubMed:11441107). In complex with TLR4,promotes sterile inflammation in monocytes/macrophages in responseto oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. Inthis context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of aheterodimer of TLR4 and TLR6, which is rapidly internalized andtriggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88signaling pathway, and CCL5 cytokine, via TICAM1 signalingpathway, as well as IL1B secretion (PubMed:11441107,PubMed:20037584). {ECO:0000269|PubMed:11441107,ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:20037584}. | Regulatory subunit of serine/threonine-proteinphosphatase 4. May play a role in regulation of cell division inrenal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role indephosphorylation and regulation of HDAC3.{ECO:0000269|PubMed:15805470}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TLR6_PPP4R1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TLR6_PPP4R1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TLR6_PPP4R1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TLR6_PPP4R1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TLR6 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
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