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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 38162

FusionGeneSummary for TLCD2_LRP5

check button Fusion gene summary
Fusion gene informationFusion gene name: TLCD2_LRP5
Fusion gene ID: 38162
HgeneTgene
Gene symbol

TLCD2

LRP5

Gene ID

727910

4041

Gene nameTLC domain containing 2LDL receptor related protein 5
Synonyms-BMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2
Cytomap

17p13.3

11q13.2

Type of geneprotein-codingprotein-coding
DescriptionTLC domain-containing protein 2low-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7
Modification date2018051920180523
UniProtAcc

A6NGC4

O75197

Ensembl transtripts involved in fusion geneENST00000330676, ENST00000294304, 
ENST00000529481, 
Fusion gene scores* DoF score2 X 2 X 2=810 X 9 X 7=630
# samples 212
** MAII scorelog2(2/8*10)=1.32192809488736log2(12/630*10)=-2.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TLCD2 [Title/Abstract] AND LRP5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLRP5

GO:0008284

positive regulation of cell proliferation

9790987

TgeneLRP5

GO:0016055

Wnt signaling pathway

17955262

TgeneLRP5

GO:0044332

Wnt signaling pathway involved in dorsal/ventral axis specification

11029007

TgeneLRP5

GO:0045840

positive regulation of mitotic nuclear division

9790987

TgeneLRP5

GO:0045893

positive regulation of transcription, DNA-templated

15035989|17955262

TgeneLRP5

GO:0045944

positive regulation of transcription by RNA polymerase II

12857724

TgeneLRP5

GO:0060070

canonical Wnt signaling pathway

12121999|12857724|15035989


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDACCTCGA-OR-A5K2-01ATLCD2chr17

1612793

-LRP5chr11

68177382

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000330676ENST00000294304TLCD2chr17

1612793

-LRP5chr11

68177382

+
5CDS-intronENST00000330676ENST00000529481TLCD2chr17

1612793

-LRP5chr11

68177382

+

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FusionProtFeatures for TLCD2_LRP5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TLCD2

A6NGC4

LRP5

O75197

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggersbeta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surfacecoreceptor of Wnt/beta-catenin signaling, which plays a pivotalrole in bone formation. Plays a role in norrin (NDP) signaltransduction (PubMed:27228167). The Wnt-induced Fzd/LRP6coreceptor complex recruits DVL1 polymers to the plasma membranewhich, in turn, recruits the AXIN1/GSK3B-complex to the cellsurface promoting the formation of signalsomes and inhibitingAXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascularregression in the eye (By similarity). Required for posteriorpatterning of the epiblast during gastrulation (By similarity).{ECO:0000250|UniProtKB:Q91VN0, ECO:0000269|PubMed:11336703,ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154,ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503,ECO:0000269|PubMed:27228167}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTLCD2chr17:1612793chr11:68177382ENST00000330676-343_23114265TransmembraneHelical
HgeneTLCD2chr17:1612793chr11:68177382ENST00000330676-3442_62114265TransmembraneHelical
HgeneTLCD2chr17:1612793chr11:68177382ENST00000330676-3477_97114265TransmembraneHelical
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231495_16106971616Compositional biasNote=Pro-rich
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231213_12546971616DomainNote=EGF-like 4
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231258_12966971616DomainLDL-receptor class A 1
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231297_13336971616DomainLDL-receptor class A 2
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231335_13716971616DomainLDL-receptor class A 3
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823902_9426971616DomainNote=EGF-like 3
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231500_15066971616MotifNote=PPPSP motif A
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231538_15456971616MotifNote=PPPSP motif B
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231574_15816971616MotifNote=PPPSP motif C
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231591_15966971616MotifNote=PPPSP motif D
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231605_16126971616MotifNote=PPPSP motif E
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823945_12126971616RegionNote=Beta-propeller 4
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231036_10786971616RepeatNote=LDL-receptor class B 17
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231079_11236971616RepeatNote=LDL-receptor class B 18
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231124_11646971616RepeatNote=LDL-receptor class B 19
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231165_12076971616RepeatNote=LDL-receptor class B 20
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823730_7726971616RepeatNote=LDL-receptor class B 12
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823773_8156971616RepeatNote=LDL-receptor class B 13
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823816_8556971616RepeatNote=LDL-receptor class B 14
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823819_8226971616RepeatNote=YWTD 10
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823856_8986971616RepeatNote=LDL-receptor class B 15
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823859_8626971616RepeatNote=YWTD 11
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823989_10356971616RepeatNote=LDL-receptor class B 16
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231408_16156971616Topological domainCytoplasmic
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+8231385_14076971616TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTLCD2chr17:1612793chr11:68177382ENST00000330676-3434_227114265DomainTLC
HgeneTLCD2chr17:1612793chr11:68177382ENST00000330676-34114_134114265TransmembraneHelical
HgeneTLCD2chr17:1612793chr11:68177382ENST00000330676-34169_189114265TransmembraneHelical
HgeneTLCD2chr17:1612793chr11:68177382ENST00000330676-34199_219114265TransmembraneHelical
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823295_3376971616DomainNote=EGF-like 1
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823601_6416971616DomainNote=EGF-like 2
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+82332_2886971616RegionNote=Beta-propeller 1
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823341_6026971616RegionNote=Beta-propeller 2
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823644_9036971616RegionNote=Beta-propeller 3
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823120_1626971616RepeatNote=LDL-receptor class B 2
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823123_1266971616RepeatNote=YWTD 2
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823163_2066971616RepeatNote=LDL-receptor class B 3
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823166_1696971616RepeatNote=YWTD 3
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823207_2476971616RepeatNote=LDL-receptor class B 4
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823248_2906971616RepeatNote=LDL-receptor class B 5
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823251_2546971616RepeatNote=YWTD 4
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823385_4276971616RepeatNote=LDL-receptor class B 6
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823388_3916971616RepeatNote=YWTD 5
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823428_4706971616RepeatNote=LDL-receptor class B 7
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823431_4346971616RepeatNote=YWTD 6
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823471_5146971616RepeatNote=LDL-receptor class B 8
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823474_4776971616RepeatNote=YWTD 7
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823515_5576971616RepeatNote=LDL-receptor class B 9
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823558_6006971616RepeatNote=LDL-receptor class B 10
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823559_5626971616RepeatNote=YWTD 8
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823687_7296971616RepeatNote=LDL-receptor class B 11
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+823690_6936971616RepeatNote=YWTD 9
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+82375_1196971616RepeatNote=LDL-receptor class B 1
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+82378_816971616RepeatNote=YWTD 1
TgeneLRP5chr17:1612793chr11:68177382ENST00000294304+82332_13846971616Topological domainExtracellular


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FusionGeneSequence for TLCD2_LRP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TLCD2_ENST00000330676_chr17_1612793_-_LRP5_ENST00000294304_chr11_68177382_+_1033aa
MAPTGLLVAGASFLAFRGLHWGLRRLPTPESAARDRWQWWNLCVSLAHSLLSGTGALLGLSLYPQMAADPIHGHPRWALVLVAVSVGYFL
ADGADLLWNQTLGKTWDLLCHHLVTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNP
RSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQ
YSDTIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSP
PTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDTDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDI
YSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTL
GKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFS
AHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQF
PCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGI
ILSLFVMGGVTFVCQRVVCQRTAGANGPFPHETVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASS
SSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDSDPT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TLCD2_ENST00000330676_chr17_1612793_-_LRP5_ENST00000294304_chr11_68177382_+_3099nt
ATGGCGCCCACGGGGCTCCTGGTGGCCGGCGCCTCCTTCCTCGCGTTCCGGGGGCTGCACTGGGGGTTGCGGCGGCTGCCCACGCCGGAA
TCGGCCGCTCGGGACCGCTGGCAGTGGTGGAACCTCTGCGTCTCCCTGGCGCACAGCCTGCTCTCGGGGACCGGGGCGCTGCTCGGCCTG
TCACTGTACCCTCAGATGGCCGCCGACCCCATCCATGGCCACCCGCGCTGGGCTCTGGTGCTGGTGGCTGTGTCTGTGGGTTACTTCCTG
GCAGACGGAGCTGACCTGCTGTGGAACCAGACCTTGGGCAAGACCTGGGATCTTCTCTGTCATCATTTGGTGACCATCAGCCGCGCCTTC
ATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTAC
TGGGCCGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCG
AGGTCGCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGG
ACCAACTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTG
GACACCAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAG
TACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAG
GGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGT
GGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCCG
CCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATCCTGCCCCTG
CATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATCAAGCGAGCC
AAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGCATCGACATC
TACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTGGTGCTGCGT
GGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCAGCCAAGATC
GAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGACAACACACTG
GGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAGGACGCCAAC
ATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTGGAGAAGACC
ACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAGGAGTTCTCA
GCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGCCCAGTCCAC
CTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAGATCGACTGT
ATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCCGCCCAGTTC
CCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCGGACTGTGAC
GCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGACTGTATCGAC
GGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTCATTGGCATC
ATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGGCCCTTCCCG
CACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGCATCGCATGC
GGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGGGCCTCGTCC
AGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCCTGTACAACATG
GACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGACGACGCCCTGC
AGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACTCAGACCCCTAT
CCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCTACTTCCATCTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_TLCD2_ENST00000330676_chr17_1612793_-_LRP5_ENST00000294304_chr11_68177382_+_3500nt
CGGCTGCTCCAATCACCGCCCAGGCGAGGGACTGGGCGTGGACGAACGGGGAAAAGTTCCTGCTGATCCCAAAGGCGCGGCGGGGAGGGG
AGCCGGGGCCCCAGCCCTGCCGGGAAACGGGTTCCCAGTCCCGGCCGAGAGCGCGGGCGCCGAGGGGACCGACCCGGACTCCCCGCAACC
CCCCAACCGCCAGGCCATGGCGCCCACGGGGCTCCTGGTGGCCGGCGCCTCCTTCCTCGCGTTCCGGGGGCTGCACTGGGGGTTGCGGCG
GCTGCCCACGCCGGAATCGGCCGCTCGGGACCGCTGGCAGTGGTGGAACCTCTGCGTCTCCCTGGCGCACAGCCTGCTCTCGGGGACCGG
GGCGCTGCTCGGCCTGTCACTGTACCCTCAGATGGCCGCCGACCCCATCCATGGCCACCCGCGCTGGGCTCTGGTGCTGGTGGCTGTGTC
TGTGGGTTACTTCCTGGCAGACGGAGCTGACCTGCTGTGGAACCAGACCTTGGGCAAGACCTGGGATCTTCTCTGTCATCATTTGGTGAC
CATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGAT
GGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAG
GGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCG
GGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCT
CTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCC
GTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAA
CCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCA
CAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAG
CCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGA
TCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCA
GAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGA
CCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCAT
GGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGA
CCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGT
GGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGAC
CCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGA
GCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAG
CCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTG
CTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCAC
AGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTG
CTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGA
CGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTT
CCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGG
GCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGC
CAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTT
CACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGT
CACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCC
CTCCCTGTACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCC
CCCGACGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTC
GGACTCAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAG
GAGCTACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATCCTGACCTCGGCCGGGCCACTCTGGCTTCTCTGTGCCCCT
GTAAATAGTTTTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAAAAATAAATATAATTGGGATTTTAAAAACATGAGAAATGT


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FusionGenePPI for TLCD2_LRP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TLCD2TMEM30A, TCTN2, TCTN3LRP5AXIN1, SMAD9, CAPRIN2, SOST, DKK1, FZD8, TAZ, RASD2, SUSD4, PARP16, POMK, B3GALT2, ETV6, CHST9, LIPH, PRSS37, CSNK1A1, TGIF2LY, DKKL1, SERPINA12, ST8SIA4, SCGB1D1, DKK4, MGAT4C, F9, FAM3B, C4orf26, FCGRT, PODN, ADAM33, BRINP3, LRRC4C, CLPSL1, NXPH2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TLCD2_LRP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TLCD2_LRP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLRP5C0432252Osteoporosis with pseudoglioma8CTD_human;ORPHANET;UNIPROT
TgeneLRP5C1866176EXUDATIVE VITREORETINOPATHY 4 (disorder)8CTD_human;UNIPROT
TgeneLRP5C1866079BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 15UNIPROT
TgeneLRP5C0242852Proliferative vitreoretinopathy1CTD_human
TgeneLRP5C0432273Worth disease1CTD_human;ORPHANET;UNIPROT
TgeneLRP5C1843330OSTEOPETROSIS, AUTOSOMAL DOMINANT 11CTD_human;ORPHANET;UNIPROT
TgeneLRP5C1851402Exudative vitreoretinopathy 11ORPHANET;UNIPROT