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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38155

FusionGeneSummary for TKT_CENPF

check button Fusion gene summary
Fusion gene informationFusion gene name: TKT_CENPF
Fusion gene ID: 38155
HgeneTgene
Gene symbol

TKT

CENPF

Gene ID

7086

1063

Gene nametransketolasecentromere protein F
SynonymsHEL-S-48|HEL107|SDDHD|TK|TKT1CENF|CILD31|PRO1779|STROMS|hcp-1
Cytomap

3p21.1

1q41

Type of geneprotein-codingprotein-coding
Descriptiontransketolaseepididymis luminal protein 107epididymis secretory protein Li 48centromere protein FAH antigenCENP-F kinetochore proteincell-cycle-dependent 350K nuclear proteincentromere protein F, 350/400kDakinetochore protein CENPFmitosin
Modification date2018051920180522
UniProtAcc

P29401

P49454

Ensembl transtripts involved in fusion geneENST00000462138, ENST00000423525, 
ENST00000461139, ENST00000423516, 
ENST00000296289, 
ENST00000366955, 
ENST00000467765, 
Fusion gene scores* DoF score5 X 8 X 3=1206 X 6 X 2=72
# samples 106
** MAII scorelog2(10/120*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TKT [Title/Abstract] AND CENPF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTKT

GO:0046166

glyceraldehyde-3-phosphate biosynthetic process

9611778

TgeneCENPF

GO:0015031

protein transport

12974617

TgeneCENPF

GO:0045892

negative regulation of transcription, DNA-templated

15677469

TgeneCENPF

GO:0051310

metaphase plate congression

15870278


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-R6-A8W8-01BTKTchr3

53274267

-CENPFchr1

214832214

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000462138ENST00000366955TKTchr3

53274267

-CENPFchr1

214832214

+
5CDS-intronENST00000462138ENST00000467765TKTchr3

53274267

-CENPFchr1

214832214

+
Frame-shitENST00000423525ENST00000366955TKTchr3

53274267

-CENPFchr1

214832214

+
5CDS-intronENST00000423525ENST00000467765TKTchr3

53274267

-CENPFchr1

214832214

+
intron-3CDSENST00000461139ENST00000366955TKTchr3

53274267

-CENPFchr1

214832214

+
intron-intronENST00000461139ENST00000467765TKTchr3

53274267

-CENPFchr1

214832214

+
Frame-shitENST00000423516ENST00000366955TKTchr3

53274267

-CENPFchr1

214832214

+
5CDS-intronENST00000423516ENST00000467765TKTchr3

53274267

-CENPFchr1

214832214

+
Frame-shitENST00000296289ENST00000366955TKTchr3

53274267

-CENPFchr1

214832214

+
5CDS-intronENST00000296289ENST00000467765TKTchr3

53274267

-CENPFchr1

214832214

+

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FusionProtFeatures for TKT_CENPF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TKT

P29401

CENPF

P49454

Catalyzes the transfer of a two-carbon ketol group froma ketose donor to an aldose acceptor, via a covalent intermediatewith the cofactor thiamine pyrophosphate.{ECO:0000269|PubMed:27259054}. Required for kinetochore function and chromosomesegregation in mitosis. Required for kinetochore localization ofdynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasmamembrane by acting as a link between recycling vesicles and themicrotubule network though its association with STX4 and SNAP25.Acts as a potential inhibitor of pocket protein-mediated cellularprocesses during development by regulating the activity of RBproteins during cell division and proliferation. May play aregulatory or permissive role in the normal embryoniccardiomyocyte cell cycle and in promoting continued mitosis intransformed, abnormally dividing neonatal cardiomyocytes.Interaction with RB directs embryonic stem cells toward a cardiaclineage. Involved in the regulation of DNA synthesis and hencecell cycle progression, via its C-terminus. Has a potential roleregulating skeletal myogenesis and in cell differentiation inembryogenesis. Involved in dendritic cell regulation of T-cellimmunity against chlamydia. {ECO:0000269|PubMed:12974617,ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:7542657,ECO:0000269|PubMed:7651420}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TKT_CENPF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TKT_CENPF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TKTTKT, ATG5, PIK3C2A, H2AFX, HDAC5, ISG15, TERF1, CUL3, CDK2, MYOC, TPI1, TALDO1, AHCYL1, IGBP1, UBE2I, UFC1, PKM, VDAC3, UGDH, UFM1, SSSCA1, PRDX1, UBE2D1, DYNC1LI1, MYC, FN1, SQSTM1, FBXO6, FUS, MAPK8, ACAA2, ACP1, AKR1A1, AKR1B1, AKR1B15, LOC101930400, AKR1C2, ALDH4A1, ALDOA, CALR, COX17, DUT, ENO1, ENO2, ENO3, ESD, FABP5, FABP7, FH, GAPDH, GLRX, GPI, GPX4, HINT1, HSPA4L, HSPE1, IDH1, ITPA, LDHA, LDHAL6B, LDHB, LYPLA2, MIF, NANS, NEDD8, NME1-NME2, NME2, P4HB, PCBP1, PCMT1, PDCD6, PDCD6IP, PGK1, PGM2, PITPNB, PLS3, PMP2, RAB10, RPE, SCYL2, SF1, SOD2, STAT4, STIP1, ABHD14B, AK2, ANXA7, ASS1, C11orf54, CALU, CAPG, CFL1, COTL1, DAZAP1, EZR, FKBP7, FSCN1, GLO1, GLOD4, HSD17B10, HSPA9, HSPB1, LAP3, MSN, PAICS, PIR, PTGES3, RDX, RPIA, RSU1, SLC2A9, SOD1, SPR, SRI, TAGLN2, TAGLN3, C12orf5, VAPA, WDR1, YKT6, VCP, XRCC6, NTRK1, IFI16, PPME1, EXOSC9, PRKCD, MCM2, BCOR, U2AF2, SERPINB5, KHNYN, GREB1, SMG8, DMWD, ATG2B, FIGNL1, POLA2, WDR54, C5orf34, WDR19, MOCOS, POTEF, WDR41, STIL, GOLGA4, MED20, EIF2AK4, TBL1X, CAMK2B, TRIM32, KDM5C, SPC25, MED17, LCMT2, TUBA4A, PLEC, DPP9, EML4, HTT, TRAPPC8, AASDH, TBC1D4, COQ2, DNM1L, SDHA, SOAT1, VDAC1, BRCA1, TESCENPFTOP3B, CENPF, ALK, NPM1, TERF1, TERF2, NDEL1, SVIL, ARRB2, SIRT7, COPS6, NUP107, NUP133, NQO2, HECW2, CUL7, OBSL1, CCDC68, FNTB, RNF166, MYC, NFKBIA, POLH, G3BP1, CDCA5, MZT1, CENPU, NANOG, CCDC33, IKBKG, TCP10L, GOPC, FAM167A, FBXL5, COG6, TMA16, ESAM, WASF3, MAP7D2, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TKT_CENPF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TKT_CENPF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTKTC0001973Alcoholic Intoxication, Chronic2PSYGENET
HgeneTKTC0024667Animal Mammary Neoplasms1CTD_human
HgeneTKTC0024668Mammary Neoplasms, Experimental1CTD_human
HgeneTKTC0027626Neoplasm Invasiveness1CTD_human
HgeneTKTC0043121Wernicke Encephalopathy1CTD_human
HgeneTKTC0242184Hypoxia1CTD_human
TgeneCENPFC1458155Mammary Neoplasms1CTD_human