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Fusion gene ID: 38142 |
FusionGeneSummary for TJP1_YPEL5 |
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Fusion gene information | Fusion gene name: TJP1_YPEL5 | Fusion gene ID: 38142 | Hgene | Tgene | Gene symbol | TJP1 | YPEL5 | Gene ID | 7082 | 51646 |
Gene name | tight junction protein 1 | yippee like 5 | |
Synonyms | ZO-1 | CGI-127 | |
Cytomap | 15q13.1 | 2p23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | tight junction protein ZO-1zona occludens 1zonula occludens 1 protein | protein yippee-like 5 | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | Q07157 | P62699 | |
Ensembl transtripts involved in fusion gene | ENST00000346128, ENST00000400011, ENST00000356107, ENST00000545208, ENST00000495972, | ENST00000379520, ENST00000379519, ENST00000261353, ENST00000402003, ENST00000402708, ENST00000495673, | |
Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 2 X 2 X 2=8 |
# samples | 6 | 2 | |
** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: TJP1 [Title/Abstract] AND YPEL5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU620057 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000346128 | ENST00000379520 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000346128 | ENST00000379519 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000346128 | ENST00000261353 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000346128 | ENST00000402003 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-intron | ENST00000346128 | ENST00000402708 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-intron | ENST00000346128 | ENST00000495673 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000400011 | ENST00000379520 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000400011 | ENST00000379519 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000400011 | ENST00000261353 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000400011 | ENST00000402003 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-intron | ENST00000400011 | ENST00000402708 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-intron | ENST00000400011 | ENST00000495673 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000356107 | ENST00000379520 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000356107 | ENST00000379519 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000356107 | ENST00000261353 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000356107 | ENST00000402003 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-intron | ENST00000356107 | ENST00000402708 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-intron | ENST00000356107 | ENST00000495673 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000545208 | ENST00000379520 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000545208 | ENST00000379519 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000545208 | ENST00000261353 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000545208 | ENST00000402003 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-intron | ENST00000545208 | ENST00000402708 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-intron | ENST00000545208 | ENST00000495673 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000495972 | ENST00000379520 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000495972 | ENST00000379519 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000495972 | ENST00000261353 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-3UTR | ENST00000495972 | ENST00000402003 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-intron | ENST00000495972 | ENST00000402708 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
intron-intron | ENST00000495972 | ENST00000495673 | TJP1 | chr15 | 30027791 | - | YPEL5 | chr2 | 30382417 | - |
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FusionProtFeatures for TJP1_YPEL5 |
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Hgene | Tgene |
TJP1 | YPEL5 |
TJP1, TJP2, and TJP3 are closely related scaffoldingproteins that link tight junction (TJ) transmembrane proteins suchas claudins, junctional adhesion molecules, and occludin to theactin cytoskeleton (PubMed:7798316, PubMed:9792688). The tightjunction acts to limit movement of substances through theparacellular space and as a boundary between the compositionallydistinct apical and basolateral plasma membrane domains ofepithelial and endothelial cells. Necessary for lumenogenesis, andparticularly efficient epithelial polarization and barrierformation (By similarity). Plays a role in the regulation of cellmigration by targeting CDC42BPB to the leading edge of migratingcells (PubMed:21240187). Plays an important role in podosomeformation and associated function, thus regulating cell adhesionand matrix remodeling (PubMed:20930113). With TJP2 and TJP3,participates to the junctional retention and stability of thetranscription factor DBPA, but is not involved in its shuttling tothe nucleus (By similarity). {ECO:0000250|UniProtKB:O97758,ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TJP1_YPEL5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TJP1_YPEL5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TJP1_YPEL5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TJP1_YPEL5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |