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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38138

FusionGeneSummary for TJP1_RNASE1

check button Fusion gene summary
Fusion gene informationFusion gene name: TJP1_RNASE1
Fusion gene ID: 38138
HgeneTgene
Gene symbol

TJP1

RNASE1

Gene ID

7082

6035

Gene nametight junction protein 1ribonuclease A family member 1, pancreatic
SynonymsZO-1RAC1|RIB1|RNS1
Cytomap

15q13.1

14q11.2

Type of geneprotein-codingprotein-coding
Descriptiontight junction protein ZO-1zona occludens 1zonula occludens 1 proteinribonuclease pancreaticHP-RNaseRIB-1RNase 1RNase ARNase upI-1ribonuclease 1ribonuclease A C1ribonuclease, RNase A family, 1 (pancreatic)
Modification date2018052220180523
UniProtAcc

Q07157

P07998

Ensembl transtripts involved in fusion geneENST00000346128, ENST00000400011, 
ENST00000356107, ENST00000545208, 
ENST00000495972, 
ENST00000397967, 
ENST00000340900, ENST00000412779, 
ENST00000555698, ENST00000397970, 
Fusion gene scores* DoF score5 X 6 X 3=904 X 4 X 2=32
# samples 64
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TJP1 [Title/Abstract] AND RNASE1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRNASE1

GO:0051607

defense response to virus

9826755

TgeneRNASE1

GO:0090501

RNA phosphodiester bond hydrolysis

9826755


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF847087TJP1chr15

30018605

+RNASE1chr14

21270057

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000346128ENST00000397967TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000346128ENST00000340900TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000346128ENST00000412779TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000346128ENST00000555698TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000346128ENST00000397970TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000400011ENST00000397967TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000400011ENST00000340900TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000400011ENST00000412779TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000400011ENST00000555698TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000400011ENST00000397970TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000356107ENST00000397967TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000356107ENST00000340900TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000356107ENST00000412779TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000356107ENST00000555698TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000356107ENST00000397970TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000545208ENST00000397967TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000545208ENST00000340900TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000545208ENST00000412779TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000545208ENST00000555698TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000545208ENST00000397970TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000495972ENST00000397967TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000495972ENST00000340900TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000495972ENST00000412779TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000495972ENST00000555698TJP1chr15

30018605

+RNASE1chr14

21270057

+
intron-3CDSENST00000495972ENST00000397970TJP1chr15

30018605

+RNASE1chr14

21270057

+

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FusionProtFeatures for TJP1_RNASE1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TJP1

Q07157

RNASE1

P07998

TJP1, TJP2, and TJP3 are closely related scaffoldingproteins that link tight junction (TJ) transmembrane proteins suchas claudins, junctional adhesion molecules, and occludin to theactin cytoskeleton (PubMed:7798316, PubMed:9792688). The tightjunction acts to limit movement of substances through theparacellular space and as a boundary between the compositionallydistinct apical and basolateral plasma membrane domains ofepithelial and endothelial cells. Necessary for lumenogenesis, andparticularly efficient epithelial polarization and barrierformation (By similarity). Plays a role in the regulation of cellmigration by targeting CDC42BPB to the leading edge of migratingcells (PubMed:21240187). Plays an important role in podosomeformation and associated function, thus regulating cell adhesionand matrix remodeling (PubMed:20930113). With TJP2 and TJP3,participates to the junctional retention and stability of thetranscription factor DBPA, but is not involved in its shuttling tothe nucleus (By similarity). {ECO:0000250|UniProtKB:O97758,ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TJP1_RNASE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TJP1_RNASE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TJP1_RNASE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRNASE1P07998DB02325Isopropyl AlcoholRibonuclease pancreaticsmall moleculeapproved|investigational
TgeneRNASE1P07998DB04272Citric AcidRibonuclease pancreaticsmall moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for TJP1_RNASE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource