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Fusion gene ID: 38135 |
FusionGeneSummary for TJAP1_ABCC10 |
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Fusion gene information | Fusion gene name: TJAP1_ABCC10 | Fusion gene ID: 38135 | Hgene | Tgene | Gene symbol | TJAP1 | ABCC10 | Gene ID | 93643 | 89845 |
Gene name | tight junction associated protein 1 | ATP binding cassette subfamily C member 10 | |
Synonyms | PILT|TJP4 | EST182763|MRP7|SIMRP7 | |
Cytomap | 6p21.1 | 6p21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | tight junction-associated protein 1protein incorporated later into tight junctionstight junction associated protein 1 (peripheral)tight junction protein 4 (peripheral) | multidrug resistance-associated protein 7ATP-binding cassette sub-family C member 10ATP-binding cassette, sub-family C (CFTR/MRP), member 10 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q5JTD0 | Q5T3U5 | |
Ensembl transtripts involved in fusion gene | ENST00000372445, ENST00000436109, ENST00000372444, ENST00000372449, ENST00000259751, ENST00000372452, ENST00000438588, ENST00000483640, | ENST00000372530, ENST00000443426, ENST00000244533, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
# samples | 4 | 1 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: TJAP1 [Title/Abstract] AND ABCC10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-85-8353-01A | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000372445 | ENST00000372530 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-intron | ENST00000372445 | ENST00000443426 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-intron | ENST00000372445 | ENST00000244533 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-3CDS | ENST00000436109 | ENST00000372530 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-intron | ENST00000436109 | ENST00000443426 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-intron | ENST00000436109 | ENST00000244533 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
5UTR-3CDS | ENST00000372444 | ENST00000372530 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
5UTR-intron | ENST00000372444 | ENST00000443426 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
5UTR-intron | ENST00000372444 | ENST00000244533 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-3CDS | ENST00000372449 | ENST00000372530 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-intron | ENST00000372449 | ENST00000443426 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-intron | ENST00000372449 | ENST00000244533 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-3CDS | ENST00000259751 | ENST00000372530 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-intron | ENST00000259751 | ENST00000443426 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-intron | ENST00000259751 | ENST00000244533 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-3CDS | ENST00000372452 | ENST00000372530 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-intron | ENST00000372452 | ENST00000443426 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-intron | ENST00000372452 | ENST00000244533 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-3CDS | ENST00000438588 | ENST00000372530 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-intron | ENST00000438588 | ENST00000443426 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-intron | ENST00000438588 | ENST00000244533 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-3CDS | ENST00000483640 | ENST00000372530 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-intron | ENST00000483640 | ENST00000443426 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
intron-intron | ENST00000483640 | ENST00000244533 | TJAP1 | chr6 | 43446456 | + | ABCC10 | chr6 | 43409600 | + |
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FusionProtFeatures for TJAP1_ABCC10 |
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Hgene | Tgene |
TJAP1 | ABCC10 |
ATP-dependent transporter probably involved in cellulardetoxification through lipophilic anion extrusion.{ECO:0000269|PubMed:12527806, ECO:0000269|PubMed:15256465}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TJAP1_ABCC10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TJAP1_ABCC10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TJAP1 | DLG1, ELAVL1, SF3B3, PPME1, FHL3, CORO1A, XPO1, ACSL4, CTR9, ZWINT, CHST15, VPS18, MIS12, SYNC, APBA2, APBA3, TRIM25 | ABCC10 | HNRNPD, TEX264, ECSIT, SLC17A2, ATP2B2, CHRND, PCDHAC2, CHRM4, SV2C |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TJAP1_ABCC10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TJAP1_ABCC10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |