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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38135

FusionGeneSummary for TJAP1_ABCC10

check button Fusion gene summary
Fusion gene informationFusion gene name: TJAP1_ABCC10
Fusion gene ID: 38135
HgeneTgene
Gene symbol

TJAP1

ABCC10

Gene ID

93643

89845

Gene nametight junction associated protein 1ATP binding cassette subfamily C member 10
SynonymsPILT|TJP4EST182763|MRP7|SIMRP7
Cytomap

6p21.1

6p21.1

Type of geneprotein-codingprotein-coding
Descriptiontight junction-associated protein 1protein incorporated later into tight junctionstight junction associated protein 1 (peripheral)tight junction protein 4 (peripheral)multidrug resistance-associated protein 7ATP-binding cassette sub-family C member 10ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Modification date2018051920180523
UniProtAcc

Q5JTD0

Q5T3U5

Ensembl transtripts involved in fusion geneENST00000372445, ENST00000436109, 
ENST00000372444, ENST00000372449, 
ENST00000259751, ENST00000372452, 
ENST00000438588, ENST00000483640, 
ENST00000372530, ENST00000443426, 
ENST00000244533, 
Fusion gene scores* DoF score3 X 3 X 2=181 X 1 X 1=1
# samples 41
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: TJAP1 [Title/Abstract] AND ABCC10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-85-8353-01ATJAP1chr6

43446456

+ABCC10chr6

43409600

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000372445ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000372445ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000372445ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-3CDSENST00000436109ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000436109ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000436109ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
5UTR-3CDSENST00000372444ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
5UTR-intronENST00000372444ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
5UTR-intronENST00000372444ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-3CDSENST00000372449ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000372449ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000372449ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-3CDSENST00000259751ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000259751ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000259751ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-3CDSENST00000372452ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000372452ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000372452ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-3CDSENST00000438588ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000438588ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000438588ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-3CDSENST00000483640ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000483640ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000483640ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+

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FusionProtFeatures for TJAP1_ABCC10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TJAP1

Q5JTD0

ABCC10

Q5T3U5

ATP-dependent transporter probably involved in cellulardetoxification through lipophilic anion extrusion.{ECO:0000269|PubMed:12527806, ECO:0000269|PubMed:15256465}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TJAP1_ABCC10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TJAP1_ABCC10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TJAP1DLG1, ELAVL1, SF3B3, PPME1, FHL3, CORO1A, XPO1, ACSL4, CTR9, ZWINT, CHST15, VPS18, MIS12, SYNC, APBA2, APBA3, TRIM25ABCC10HNRNPD, TEX264, ECSIT, SLC17A2, ATP2B2, CHRND, PCDHAC2, CHRM4, SV2C


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TJAP1_ABCC10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TJAP1_ABCC10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource