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Fusion gene ID: 3813 |
FusionGeneSummary for BAIAP2L1_MET |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BAIAP2L1_MET | Fusion gene ID: 3813 | Hgene | Tgene | Gene symbol | BAIAP2L1 | MET | Gene ID | 55971 | 8731 |
| Gene name | BAI1 associated protein 2 like 1 | RNA guanine-7 methyltransferase | |
| Synonyms | IRTKS | CMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMet | |
| Cytomap | 7q21.3-q22.1 | 18p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1BAI1-associated protein 2-like protein 1insulin receptor tyrosine kinase substrate | mRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UHR4 | P08581 | |
| Ensembl transtripts involved in fusion gene | ENST00000005260, ENST00000462558, | ENST00000397752, ENST00000318493, ENST00000436117, ENST00000495962, ENST00000539704, | |
| Fusion gene scores | * DoF score | 7 X 4 X 6=168 | 11 X 10 X 9=990 |
| # samples | 7 | 20 | |
| ** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/990*10)=-2.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BAIAP2L1 [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BAIAP2L1 | GO:0009617 | response to bacterium | 19366662 |
| Hgene | BAIAP2L1 | GO:0030838 | positive regulation of actin filament polymerization | 21098279 |
| Tgene | MET | GO:0006370 | 7-methylguanosine mRNA capping | 27422871 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRP | TCGA-BQ-7049-01A | BAIAP2L1 | chr7 | 97939757 | - | MET | chr7 | 116414935 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000005260 | ENST00000397752 | BAIAP2L1 | chr7 | 97939757 | - | MET | chr7 | 116414935 | + |
| In-frame | ENST00000005260 | ENST00000318493 | BAIAP2L1 | chr7 | 97939757 | - | MET | chr7 | 116414935 | + |
| 5CDS-intron | ENST00000005260 | ENST00000436117 | BAIAP2L1 | chr7 | 97939757 | - | MET | chr7 | 116414935 | + |
| 5CDS-intron | ENST00000005260 | ENST00000495962 | BAIAP2L1 | chr7 | 97939757 | - | MET | chr7 | 116414935 | + |
| 5CDS-intron | ENST00000005260 | ENST00000539704 | BAIAP2L1 | chr7 | 97939757 | - | MET | chr7 | 116414935 | + |
| 5UTR-3CDS | ENST00000462558 | ENST00000397752 | BAIAP2L1 | chr7 | 97939757 | - | MET | chr7 | 116414935 | + |
| 5UTR-3CDS | ENST00000462558 | ENST00000318493 | BAIAP2L1 | chr7 | 97939757 | - | MET | chr7 | 116414935 | + |
| 5UTR-intron | ENST00000462558 | ENST00000436117 | BAIAP2L1 | chr7 | 97939757 | - | MET | chr7 | 116414935 | + |
| 5UTR-intron | ENST00000462558 | ENST00000495962 | BAIAP2L1 | chr7 | 97939757 | - | MET | chr7 | 116414935 | + |
| 5UTR-intron | ENST00000462558 | ENST00000539704 | BAIAP2L1 | chr7 | 97939757 | - | MET | chr7 | 116414935 | + |
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FusionProtFeatures for BAIAP2L1_MET |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BAIAP2L1 | MET |
| May function as adapter protein. Involved in theformation of clusters of actin bundles. Plays a role in thereorganization of the actin cytoskeleton in response to bacterialinfection. {ECO:0000269|PubMed:17430976,ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. | Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding tohepatocyte growth factor/HGF ligand. Regulates many physiologicalprocesses including proliferation, scattering, morphogenesis andsurvival. Ligand binding at the cell surface inducesautophosphorylation of MET on its intracellular domain thatprovides docking sites for downstream signaling molecules.Following activation by ligand, interacts with the PI3-kinasesubunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.Recruitment of these downstream effectors by MET leads to theactivation of several signaling cascades including the RAS-ERK,PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation isassociated with the morphogenetic effects while PI3K/AKTcoordinates prosurvival effects. During embryonic development, METsignaling plays a role in gastrulation, development and migrationof muscles and neuronal precursors, angiogenesis and kidneyformation. In adults, participates in wound healing as well asorgan regeneration and tissue remodeling. Promotes alsodifferentiation and proliferation of hematopoietic cells. Mayregulate cortical bone osteogenesis (By similarity).{ECO:0000250|UniProtKB:P16056}. Acts as a receptor for Listeria internalin inlB,mediating entry of the pathogen into cells. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BAIAP2L1 | chr7:97939757 | chr7:116414935 | ENST00000005260 | - | 9 | 14 | 115_154 | 318 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BAIAP2L1 | chr7:97939757 | chr7:116414935 | ENST00000005260 | - | 9 | 14 | 1_249 | 318 | 512 | Domain | IMD |
| Tgene | >MET | chr7:97939757 | chr7:116414935 | ENST00000318493 | + | 13 | 21 | 1078_1345 | 1027 | 1409 | Domain | Protein kinase |
| Tgene | >MET | chr7:97939757 | chr7:116414935 | ENST00000397752 | + | 13 | 21 | 1078_1345 | 1009 | 1391 | Domain | Protein kinase |
| Tgene | >MET | chr7:97939757 | chr7:116414935 | ENST00000436117 | + | 0 | 9 | 1078_1345 | 0 | 765 | Domain | Protein kinase |
| Tgene | >MET | chr7:97939757 | chr7:116414935 | ENST00000436117 | + | 0 | 9 | 27_515 | 0 | 765 | Domain | Sema |
| Tgene | >MET | chr7:97939757 | chr7:116414935 | ENST00000436117 | + | 0 | 9 | 563_655 | 0 | 765 | Domain | Note=IPT/TIG 1 |
| Tgene | >MET | chr7:97939757 | chr7:116414935 | ENST00000436117 | + | 0 | 9 | 657_739 | 0 | 765 | Domain | Note=IPT/TIG 2 |
| Tgene | >MET | chr7:97939757 | chr7:116414935 | ENST00000436117 | + | 0 | 9 | 742_836 | 0 | 765 | Domain | Note=IPT/TIG 3 |
| Tgene | >MET | chr7:97939757 | chr7:116414935 | ENST00000318493 | + | 13 | 21 | 1084_1092 | 1027 | 1409 | Nucleotide binding | ATP |
| Tgene | >MET | chr7:97939757 | chr7:116414935 | ENST00000397752 | + | 13 | 21 | 1084_1092 | 1009 | 1391 | Nucleotide binding | ATP |
| Tgene | >MET | chr7:97939757 | chr7:116414935 | ENST00000436117 | + | 0 | 9 | 1084_1092 | 0 | 765 | Nucleotide binding | ATP |
| Tgene | >MET | chr7:97939757 | chr7:116414935 | ENST00000436117 | + | 0 | 9 | 25_932 | 0 | 765 | Topological domain | Extracellular |
| Tgene | >MET | chr7:97939757 | chr7:116414935 | ENST00000436117 | + | 0 | 9 | 956_1390 | 0 | 765 | Topological domain | Cytoplasmic |
| Tgene | >MET | chr7:97939757 | chr7:116414935 | ENST00000436117 | + | 0 | 9 | 933_955 | 0 | 765 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >BAIAP2L1 | chr7:97939757 | chr7:116414935 | ENST00000005260 | - | 9 | 14 | 339_402 | 318 | 512 | Domain | SH3 |
| Hgene | >BAIAP2L1 | chr7:97939757 | chr7:116414935 | ENST00000005260 | - | 9 | 14 | 483_511 | 318 | 512 | Region | Note=Binds F-actin |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000318493 | + | 13 | 21 | 27_515 | 1027 | 1409 | Domain | Sema |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000318493 | + | 13 | 21 | 563_655 | 1027 | 1409 | Domain | Note=IPT/TIG 1 |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000318493 | + | 13 | 21 | 657_739 | 1027 | 1409 | Domain | Note=IPT/TIG 2 |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000318493 | + | 13 | 21 | 742_836 | 1027 | 1409 | Domain | Note=IPT/TIG 3 |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000397752 | + | 13 | 21 | 27_515 | 1009 | 1391 | Domain | Sema |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000397752 | + | 13 | 21 | 563_655 | 1009 | 1391 | Domain | Note=IPT/TIG 1 |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000397752 | + | 13 | 21 | 657_739 | 1009 | 1391 | Domain | Note=IPT/TIG 2 |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000397752 | + | 13 | 21 | 742_836 | 1009 | 1391 | Domain | Note=IPT/TIG 3 |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000318493 | + | 13 | 21 | 25_932 | 1027 | 1409 | Topological domain | Extracellular |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000318493 | + | 13 | 21 | 956_1390 | 1027 | 1409 | Topological domain | Cytoplasmic |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000397752 | + | 13 | 21 | 25_932 | 1009 | 1391 | Topological domain | Extracellular |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000397752 | + | 13 | 21 | 956_1390 | 1009 | 1391 | Topological domain | Cytoplasmic |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000318493 | + | 13 | 21 | 933_955 | 1027 | 1409 | Transmembrane | Helical |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000397752 | + | 13 | 21 | 933_955 | 1009 | 1391 | Transmembrane | Helical |
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FusionGeneSequence for BAIAP2L1_MET |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_BAIAP2L1_ENST00000005260_chr7_97939757_-_MET_ENST00000397752_chr7_116414935_+_700aa MSRGPEEVNRLTESTYRNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNESLD ENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIAD GCKEALLEEKRRFCFLVDKHCGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQASPMIERSNVV RKDYDTLSKCSPKMPPAPSGRAYTSPLIDMFNNPATAAPNSQRVNNSTDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTV HIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLS LLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYD KEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWH >In-frame_BAIAP2L1_ENST00000005260_chr7_97939757_-_MET_ENST00000318493_chr7_116414935_+_700aa MSRGPEEVNRLTESTYRNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNESLD ENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIAD GCKEALLEEKRRFCFLVDKHCGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQASPMIERSNVV RKDYDTLSKCSPKMPPAPSGRAYTSPLIDMFNNPATAAPNSQRVNNSTDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTV HIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLS LLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYD KEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_BAIAP2L1_ENST00000005260_chr7_97939757_-_MET_ENST00000397752_chr7_116414935_+_2100nt ATGTCCCGGGGGCCCGAGGAGGTGAACCGGCTCACGGAGAGCACCTACCGGAATGTTATGGAACAGTTCAATCCTGGGCTGCGAAATTTA ATAAACCTGGGGAAAAATTATGAGAAAGCTGTAAACGCTATGATCCTGGCAGGAAAAGCCTACTACGATGGAGTGGCCAAGATCGGTGAG ATTGCCACTGGGTCCCCCGTGTCAACTGAACTGGGACATGTCCTCATAGAGATTTCAAGTACCCACAAGAAACTCAACGAGAGTCTTGAT GAAAATTTTAAAAAATTCCACAAAGAGATTATCCATGAGCTGGAGAAGAAGATAGAACTTGACGTGAAATATATGAACGCAACTCTAAAA AGATACCAAACAGAACACAAGAATAAATTAGAGTCTTTGGAGAAATCCCAAGCTGAGTTGAAGAAGATCAGAAGGAAAAGCCAAGGAAGC CGAAACGCACTCAAATATGAACACAAAGAAATTGAGTATGTGGAGACCGTTACTTCTCGTCAGAGTGAAATCCAGAAATTCATTGCAGAT GGTTGCAAAGAGGCTCTGCTTGAAGAGAAGAGGCGCTTCTGCTTTCTGGTTGATAAGCACTGTGGCTTTGCAAACCACATACATTATTAT CACTTACAGTCTGCAGAACTACTGAATTCCAAGCTGCCTCGGTGGCAGGAGACCTGTGTTGATGCCATCAAAGTGCCAGAGAAAATCATG AATATGATCGAAGAAATAAAGACCCCAGCCTCTACCCCCGTGTCTGGAACTCCTCAGGCTTCACCCATGATCGAGAGAAGCAATGTGGTT AGGAAAGATTACGACACCCTTTCTAAATGCTCACCAAAGATGCCCCCCGCTCCTTCAGGCAGAGCATATACCAGTCCCTTGATCGATATG TTTAATAACCCAGCCACGGCTGCCCCGAATTCACAAAGGGTAAATAATTCAACAGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGC CGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTC CACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAAT GAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCC TTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCG CTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAAT GAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTC CACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGAT AAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACC ACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGAT ATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCAC CCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCAT GTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGTGGACACA >In-frame_BAIAP2L1_ENST00000005260_chr7_97939757_-_MET_ENST00000318493_chr7_116414935_+_2100nt ATGTCCCGGGGGCCCGAGGAGGTGAACCGGCTCACGGAGAGCACCTACCGGAATGTTATGGAACAGTTCAATCCTGGGCTGCGAAATTTA ATAAACCTGGGGAAAAATTATGAGAAAGCTGTAAACGCTATGATCCTGGCAGGAAAAGCCTACTACGATGGAGTGGCCAAGATCGGTGAG ATTGCCACTGGGTCCCCCGTGTCAACTGAACTGGGACATGTCCTCATAGAGATTTCAAGTACCCACAAGAAACTCAACGAGAGTCTTGAT GAAAATTTTAAAAAATTCCACAAAGAGATTATCCATGAGCTGGAGAAGAAGATAGAACTTGACGTGAAATATATGAACGCAACTCTAAAA AGATACCAAACAGAACACAAGAATAAATTAGAGTCTTTGGAGAAATCCCAAGCTGAGTTGAAGAAGATCAGAAGGAAAAGCCAAGGAAGC CGAAACGCACTCAAATATGAACACAAAGAAATTGAGTATGTGGAGACCGTTACTTCTCGTCAGAGTGAAATCCAGAAATTCATTGCAGAT GGTTGCAAAGAGGCTCTGCTTGAAGAGAAGAGGCGCTTCTGCTTTCTGGTTGATAAGCACTGTGGCTTTGCAAACCACATACATTATTAT CACTTACAGTCTGCAGAACTACTGAATTCCAAGCTGCCTCGGTGGCAGGAGACCTGTGTTGATGCCATCAAAGTGCCAGAGAAAATCATG AATATGATCGAAGAAATAAAGACCCCAGCCTCTACCCCCGTGTCTGGAACTCCTCAGGCTTCACCCATGATCGAGAGAAGCAATGTGGTT AGGAAAGATTACGACACCCTTTCTAAATGCTCACCAAAGATGCCCCCCGCTCCTTCAGGCAGAGCATATACCAGTCCCTTGATCGATATG TTTAATAACCCAGCCACGGCTGCCCCGAATTCACAAAGGGTAAATAATTCAACAGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGC CGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTC CACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAAT GAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCC TTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCG CTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAAT GAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTC CACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGAT AAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACC ACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGAT ATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCAC CCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCAT GTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGTGGACACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_BAIAP2L1_ENST00000005260_chr7_97939757_-_MET_ENST00000397752_chr7_116414935_+_4578nt CTCCTCTGCTCCTCGAAGAAGGCCAGGGCGGCGCTGCCGCAAGTTTTGACATTTTCGCAGCGGAGACGCGCGCGGGCACTCTCGGGCCGA CGGCTGCGGCGGCGGCCGACCCTCCAGAGCCCCTTAGTCGCGCCCCGGCCCTCCCGCTGCCCGGAGTCCGGCGGCCACGAGGCCCAGCCG CGTCCTCCCGCGCTTGCTCGCCCGGCGGCCGCAGCCATGTCCCGGGGGCCCGAGGAGGTGAACCGGCTCACGGAGAGCACCTACCGGAAT GTTATGGAACAGTTCAATCCTGGGCTGCGAAATTTAATAAACCTGGGGAAAAATTATGAGAAAGCTGTAAACGCTATGATCCTGGCAGGA AAAGCCTACTACGATGGAGTGGCCAAGATCGGTGAGATTGCCACTGGGTCCCCCGTGTCAACTGAACTGGGACATGTCCTCATAGAGATT TCAAGTACCCACAAGAAACTCAACGAGAGTCTTGATGAAAATTTTAAAAAATTCCACAAAGAGATTATCCATGAGCTGGAGAAGAAGATA GAACTTGACGTGAAATATATGAACGCAACTCTAAAAAGATACCAAACAGAACACAAGAATAAATTAGAGTCTTTGGAGAAATCCCAAGCT GAGTTGAAGAAGATCAGAAGGAAAAGCCAAGGAAGCCGAAACGCACTCAAATATGAACACAAAGAAATTGAGTATGTGGAGACCGTTACT TCTCGTCAGAGTGAAATCCAGAAATTCATTGCAGATGGTTGCAAAGAGGCTCTGCTTGAAGAGAAGAGGCGCTTCTGCTTTCTGGTTGAT AAGCACTGTGGCTTTGCAAACCACATACATTATTATCACTTACAGTCTGCAGAACTACTGAATTCCAAGCTGCCTCGGTGGCAGGAGACC TGTGTTGATGCCATCAAAGTGCCAGAGAAAATCATGAATATGATCGAAGAAATAAAGACCCCAGCCTCTACCCCCGTGTCTGGAACTCCT CAGGCTTCACCCATGATCGAGAGAAGCAATGTGGTTAGGAAAGATTACGACACCCTTTCTAAATGCTCACCAAAGATGCCCCCCGCTCCT TCAGGCAGAGCATATACCAGTCCCTTGATCGATATGTTTAATAACCCAGCCACGGCTGCCCCGAATTCACAAAGGGTAAATAATTCAACA GATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGAC TCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTA GTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGAC AATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATC ATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATAC ATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCC AAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAG GTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGG ATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGA GGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCA GACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCG ATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTG TCATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACA GTCCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGG ACTTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCACGGA CCAATGGCCTGCAGCCGTGACAACACTCCTGTCATATTGGAGTCCAAAACTTGAATTCTGGGTTGAATTTTTTAAAAATCAGGTACCACT TGATTTCATATGGGAAATTGAAGCAGGAAATATTGAGGGCTTCTTGATCACAGAAAACTCAGAAGAGATAGTAATGCTCAGGACAGGAGC GGCAGCCCCAGAACAGGCCACTCATTTAGAATTCTAGTGTTTCAAAACACTTTTGTGTGTTGTATGGTCAATAACATTTTTCATTACTGA TGGTGTCATTCACCCATTAGGTAAACATTCCCTTTTAAATGTTTGTTTGTTTTTTGAGACAGGATCTCACTCTGTTGCCAGGGCTGTAGT GCAGTGGTGTGATCATAGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCCTCCCGAATAGCTGGGACTACAGGCGCACACCACCATCCC CGGCTAATTTTTGTATTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCAAGGCTGGTTTCAAACTCCTGGACTCAAGAAATCCACCCACC TCAGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACTGCGCCCAGCCCTTATAAATTTTTGTATAGACATTCCTTTGGTTGGAAGAA TATTTATAGGCAATACAGTCAAAGTTTCAAAATAGCATCACACAAAACATGTTTATAAATGAACAGGATGTAATGTACATAGATGACATT AAGAAAATTTGTATGAAATAATTTAGTCATCATGAAATATTTAGTTGTCATATAAAAACCCACTGTTTGAGAATGATGCTACTCTGATCT AATGAATGTGAACATGTAGATGTTTTGTGTGTATTTTTTTAAATGAAAACTCAAAATAAGACAAGTAATTTGTTGATAAATATTTTTAAA GATAACTCAGCATGTTTGTAAAGCAGGATACATTTTACTAAAAGGTTCATTGGTTCCAATCACAGCTCATAGGTAGAGCAAAGAAAGGGT GGATGGATTGAAAAGATTAGCCTCTGTCTCGGTGGCAGGTTCCCACCTCGCAAGCAATTGGAAACAAAACTTTTGGGGAGTTTTATTTTG CATTAGGGTGTGTTTTATGTTAAGCAAAACATACTTTAGAAACAAATGAAAAAGGCAATTGAAAATCCCAGCTATTTCACCTAGATGGAA TAGCCACCCTGAGCAGAACTTTGTGATGCTTCATTCTGTGGAATTTTGTGCTTGCTACTGTATAGTGCATGTGGTGTAGGTTACTCTAAC TGGTTTTGTCGACGTAAACATTTAAAGTGTTATATTTTTTATAAAAATGTTTATTTTTAATGATATGAGAAAAATTTTGTTAGGCCACAA AAACACTGCACTGTGAACATTTTAGAAAAGGTATGTCAGACTGGGATTAATGACAGCATGATTTTCAATGACTGTAAATTGCGATAAGGA AATGTACTGATTGCCAATACACCCCACCCTCATTACATCATCAGGACTTGAAGCCAAGGGTTAACCCAGCAAGCTACAAAGAGGGTGTGT CACACTGAAACTCAATAGTTGAGTTTGGCTGTTGTTGCAGGAAAATGATTATAACTAAAAGCTCTCTGATAGTGCAGAGACTTACCAGAA GACACAAGGAATTGTACTGAAGAGCTATTACAATCCAAATATTGCCGTTTCATAAATGTAATAAGTAATACTAATTCACAGAGTATTGTA AATGGTGGATGACAAAAGAAAATCTGCTCTGTGGAAAGAAAGAACTGTCTCTACCAGGGTCAAGAGCATGAACGCATCAATAGAAAGAAC TCGGGGAAACATCCCATCAACAGGACTACACACTTGTATATACATTCTTGAGAACACTGCAATGTGAAAATCACGTTTGCTATTTATAAA CTTGTCCTTAGATTAATGTGTCTGGACAGATTGTGGGAGTAAGTGATTCTTCTAAGAATTAGATACTTGTCACTGCCTATACCTGCAGCT >In-frame_BAIAP2L1_ENST00000005260_chr7_97939757_-_MET_ENST00000318493_chr7_116414935_+_2534nt CTCCTCTGCTCCTCGAAGAAGGCCAGGGCGGCGCTGCCGCAAGTTTTGACATTTTCGCAGCGGAGACGCGCGCGGGCACTCTCGGGCCGA CGGCTGCGGCGGCGGCCGACCCTCCAGAGCCCCTTAGTCGCGCCCCGGCCCTCCCGCTGCCCGGAGTCCGGCGGCCACGAGGCCCAGCCG CGTCCTCCCGCGCTTGCTCGCCCGGCGGCCGCAGCCATGTCCCGGGGGCCCGAGGAGGTGAACCGGCTCACGGAGAGCACCTACCGGAAT GTTATGGAACAGTTCAATCCTGGGCTGCGAAATTTAATAAACCTGGGGAAAAATTATGAGAAAGCTGTAAACGCTATGATCCTGGCAGGA AAAGCCTACTACGATGGAGTGGCCAAGATCGGTGAGATTGCCACTGGGTCCCCCGTGTCAACTGAACTGGGACATGTCCTCATAGAGATT TCAAGTACCCACAAGAAACTCAACGAGAGTCTTGATGAAAATTTTAAAAAATTCCACAAAGAGATTATCCATGAGCTGGAGAAGAAGATA GAACTTGACGTGAAATATATGAACGCAACTCTAAAAAGATACCAAACAGAACACAAGAATAAATTAGAGTCTTTGGAGAAATCCCAAGCT GAGTTGAAGAAGATCAGAAGGAAAAGCCAAGGAAGCCGAAACGCACTCAAATATGAACACAAAGAAATTGAGTATGTGGAGACCGTTACT TCTCGTCAGAGTGAAATCCAGAAATTCATTGCAGATGGTTGCAAAGAGGCTCTGCTTGAAGAGAAGAGGCGCTTCTGCTTTCTGGTTGAT AAGCACTGTGGCTTTGCAAACCACATACATTATTATCACTTACAGTCTGCAGAACTACTGAATTCCAAGCTGCCTCGGTGGCAGGAGACC TGTGTTGATGCCATCAAAGTGCCAGAGAAAATCATGAATATGATCGAAGAAATAAAGACCCCAGCCTCTACCCCCGTGTCTGGAACTCCT CAGGCTTCACCCATGATCGAGAGAAGCAATGTGGTTAGGAAAGATTACGACACCCTTTCTAAATGCTCACCAAAGATGCCCCCCGCTCCT TCAGGCAGAGCATATACCAGTCCCTTGATCGATATGTTTAATAACCCAGCCACGGCTGCCCCGAATTCACAAAGGGTAAATAATTCAACA GATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGAC TCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTA GTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGAC AATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATC ATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATAC ATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCC AAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAG GTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGG ATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGA GGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCA GACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCG ATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTG TCATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACA GTCCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGG ACTTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCACGGA |
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FusionGenePPI for BAIAP2L1_MET |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BAIAP2L1 | PRKAA2, PRKAB2, TERF1, TERF2, TP53, MDM2, BRD4, KHDRBS1, FASLG, VCP, EPS8, WAS, HECW2, BAIAP2, NPHP1, TMEM17, CENPJ, SORT1, TACC1, PSMD14, ZWINT, SGTB, IP6K3, BAG6, CDH1, GPRC5C, MUM1, TMEM184A, MARVELD2 | MET | GLMN, CDH1, CTNNB1, HGF, RANBP9, GRB2, CBL, SH3KBP1, RANBP10, SRC, SHC1, SOS1, STAT3, GAB1, GAB2, LRIG1, INPPL1, DCN, SPSB1, SPSB2, SPSB3, SPSB4, CBLC, STUB1, HSPA4, HSP90AA1, GGA3, GNG12, FBXO6, HGS, CRK, CEACAM21, LGALS9, PCBP1, CASP3, SOCS1, HSP90AB1, EGFR, ERBB3, MET, CHEK1, PTEN, SCGB1D1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000318493 | + | 13 | 21 | 1320_1359 | 1027 | 1409 | MUC20 |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000397752 | + | 13 | 21 | 1320_1359 | 1009 | 1391 | MUC20 |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000436117 | + | 0 | 9 | 1320_1359 | 0 | 765 | MUC20 |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000318493 | + | 13 | 21 | 1212_1390 | 1027 | 1409 | RANBP9 |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000397752 | + | 13 | 21 | 1212_1390 | 1009 | 1391 | RANBP9 |
| Tgene | MET | chr7:97939757 | chr7:116414935 | ENST00000436117 | + | 0 | 9 | 1212_1390 | 0 | 765 | RANBP9 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BAIAP2L1_MET |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | MET | P08581 | DB08865 | Crizotinib | Hepatocyte growth factor receptor | small molecule | approved |
| Tgene | MET | P08581 | DB08875 | Cabozantinib | Hepatocyte growth factor receptor | small molecule | approved|investigational |
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RelatedDiseases for BAIAP2L1_MET |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BAIAP2L1 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Tgene | MET | C1336839 | Type 1 Papillary Renal Cell Carcinoma | 5 | UNIPROT |
| Tgene | MET | C0007131 | Non-Small Cell Lung Carcinoma | 4 | CTD_human |
| Tgene | MET | C0001418 | Adenocarcinoma | 2 | CTD_human |
| Tgene | MET | C0004352 | Autistic Disorder | 2 | CTD_human |
| Tgene | MET | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
| Tgene | MET | C0038356 | Stomach Neoplasms | 2 | CTD_human |
| Tgene | MET | C0004114 | Astrocytoma | 1 | CTD_human |
| Tgene | MET | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Tgene | MET | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Tgene | MET | C0009241 | Cognition Disorders | 1 | CTD_human |
| Tgene | MET | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Tgene | MET | C0017636 | Glioblastoma | 1 | CTD_human |
| Tgene | MET | C0019189 | Hepatitis, Chronic | 1 | CTD_human |
| Tgene | MET | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Tgene | MET | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
| Tgene | MET | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Tgene | MET | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | MET | C0027819 | Neuroblastoma | 1 | CTD_human |
| Tgene | MET | C0029463 | Osteosarcoma | 1 | CTD_human |
| Tgene | MET | C0036341 | Schizophrenia | 1 | CTD_human |
| Tgene | MET | C0037199 | Sinusitis | 1 | CTD_human |
| Tgene | MET | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | MET | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Tgene | MET | C1876165 | Copper-Overload Cirrhosis | 1 | CTD_human |
| Tgene | MET | C2239176 | Liver carcinoma | 1 | CTD_human;HPO;UNIPROT |
| Tgene | MET | C4084709 | DEAFNESS, AUTOSOMAL RECESSIVE 97 | 1 | UNIPROT |
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