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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38099

FusionGeneSummary for TIMM13_BAIAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: TIMM13_BAIAP2
Fusion gene ID: 38099
HgeneTgene
Gene symbol

TIMM13

BAIAP2

Gene ID

26517

10458

Gene nametranslocase of inner mitochondrial membrane 13BAI1 associated protein 2
SynonymsTIM13|TIM13B|TIMM13A|TIMM13B|ppv1BAP2|FLAF3|IRSP53
Cytomap

19p13.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial import inner membrane translocase subunit Tim13mitochondrial import inner membrane translocase subunit Tim13Btranslocase of inner mitochondrial membrane 13 homologbrain-specific angiogenesis inhibitor 1-associated protein 2IRS-58IRSp53/58fas ligand-associated factor 3insulin receptor substrate of 53 kDainsulin receptor substrate p53/p58insulin receptor substrate protein of 53 kDa
Modification date2018052320180523
UniProtAcc

Q9Y5L4

Q9UQB8

Ensembl transtripts involved in fusion geneENST00000215570, ENST00000591871, 
ENST00000392411, ENST00000321280, 
ENST00000428708, ENST00000575712, 
ENST00000575245, ENST00000435091, 
ENST00000321300, ENST00000573894, 
ENST00000416299, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 7 X 6=420
# samples 110
** MAII scorelog2(1/1*10)=3.32192809488736log2(10/420*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TIMM13 [Title/Abstract] AND BAIAP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN308207TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000215570ENST00000392411TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000215570ENST00000321280TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000215570ENST00000428708TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000215570ENST00000575712TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000215570ENST00000575245TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000215570ENST00000435091TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000215570ENST00000321300TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000215570ENST00000573894TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000215570ENST00000416299TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000591871ENST00000392411TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000591871ENST00000321280TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000591871ENST00000428708TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000591871ENST00000575712TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000591871ENST00000575245TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000591871ENST00000435091TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000591871ENST00000321300TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000591871ENST00000573894TIMM13chr19

2426921

-BAIAP2chr17

79064989

+
intron-intronENST00000591871ENST00000416299TIMM13chr19

2426921

-BAIAP2chr17

79064989

+

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FusionProtFeatures for TIMM13_BAIAP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TIMM13

Q9Y5L4

BAIAP2

Q9UQB8

Mitochondrial intermembrane chaperone that participatesin the import and insertion of some multi-pass transmembraneproteins into the mitochondrial inner membrane. Also required forthe transfer of beta-barrel precursors from the TOM complex to thesorting and assembly machinery (SAM complex) of the outermembrane. Acts as a chaperone-like protein that protects thehydrophobic precursors from aggregation and guide them through themitochondrial intermembrane space. The TIMM8-TIMM13 complexmediates the import of proteins such as TIMM23, SLC25A12/ARALAR1and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDacomplex mediates the import of much more proteins.{ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}. Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of theactin cytoskeleton by WASF family members and the Arp2/3 complex.Plays a role in neurite growth. Acts syngeristically with ENAH topromote filipodia formation. Plays a role in the reorganization ofthe actin cytoskeleton in response to bacterial infection.Participates in actin bundling when associated with EPS8,promoting filopodial protrusions. {ECO:0000269|PubMed:11130076,ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106,ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TIMM13_BAIAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TIMM13_BAIAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TIMM13_BAIAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TIMM13_BAIAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource