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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38096

FusionGeneSummary for TIMELESS_RPS15

check button Fusion gene summary
Fusion gene informationFusion gene name: TIMELESS_RPS15
Fusion gene ID: 38096
HgeneTgene
Gene symbol

TIMELESS

RPS15

Gene ID

8914

6209

Gene nametimeless circadian regulatorribosomal protein S15
SynonymsTIM|TIM1|hTIMRIG|S15
Cytomap

12q13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionprotein timeless homologTof1 homologtimeless circadian clock 1timeless homolog40S ribosomal protein S15homolog of rat insulinomainsulinoma proteinsmall ribosomal subunit protein uS19
Modification date2018052320180523
UniProtAcc

Q9UNS1

P62841

Ensembl transtripts involved in fusion geneENST00000229201, ENST00000553532, 
ENST00000554616, 		ENST00000233609, 
ENST00000586686, ENST00000591032, 
ENST00000589656, ENST00000593052, 
ENST00000591804, ENST00000586096, 
ENST00000585665, 
Fusion gene scores* DoF score3 X 3 X 3=271 X 1 X 1=1
# samples 31
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: TIMELESS [Title/Abstract] AND RPS15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTIMELESS

GO:0045892

negative regulation of transcription, DNA-templated

9856465


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1H38868TIMELESSchr12

56813379

-RPS15chr19

1440425

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000229201ENST00000233609TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000229201ENST00000586686TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000229201ENST00000591032TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000229201ENST00000589656TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000229201ENST00000593052TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000229201ENST00000591804TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3UTRENST00000229201ENST00000586096TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3UTRENST00000229201ENST00000585665TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000553532ENST00000233609TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000553532ENST00000586686TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000553532ENST00000591032TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000553532ENST00000589656TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000553532ENST00000593052TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000553532ENST00000591804TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3UTRENST00000553532ENST00000586096TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3UTRENST00000553532ENST00000585665TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000554616ENST00000233609TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000554616ENST00000586686TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000554616ENST00000591032TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000554616ENST00000589656TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000554616ENST00000593052TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3CDSENST00000554616ENST00000591804TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3UTRENST00000554616ENST00000586096TIMELESSchr12

56813379

-RPS15chr19

1440425

+
intron-3UTRENST00000554616ENST00000585665TIMELESSchr12

56813379

-RPS15chr19

1440425

+

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FusionProtFeatures for TIMELESS_RPS15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TIMELESS

Q9UNS1

RPS15

P62841

Plays an important role in the control of DNAreplication, maintenance of replication fork stability,maintenance of genome stability throughout normal DNA replicationand in the regulation of the circadian clock. Involved in thedetermination of period length and in the DNA damage-dependentphase advancing of the circadian clock. Negatively regulatesCLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation ofPER1 possibly via translocation of PER1 into the nucleus. Forms acomplex with TIPIN and this complex regulates DNA replicationprocesses under both normal and stress conditions, stabilizesreplication forks and influences both CHEK1 phosphorylation andthe intra-S phase checkpoint in response to genotoxic stress.Timeless promotes TIPIN nuclear localization. Involved in cellsurvival after DNA damage or replication stress. May bespecifically required for the ATR-CHEK1 pathway in the replicationcheckpoint induced by hydroxyurea or ultraviolet light. May alsoplay an important role in epithelial cell morphogenesis andformation of branching tubules. {ECO:0000269|PubMed:17141802,ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23418588,ECO:0000269|PubMed:9856465}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TIMELESS_RPS15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TIMELESS_RPS15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TIMELESS_RPS15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TIMELESS_RPS15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTIMELESSC0005586Bipolar Disorder5PSYGENET
HgeneTIMELESSC0011570Mental Depression2PSYGENET
HgeneTIMELESSC0011581Depressive disorder2PSYGENET
HgeneTIMELESSC0525045Mood Disorders2PSYGENET
TgeneRPS15C0038356Stomach Neoplasms1CTD_human