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Fusion gene ID: 38086 |
FusionGeneSummary for TIAM2_TFB1M |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TIAM2_TFB1M | Fusion gene ID: 38086 | Hgene | Tgene | Gene symbol | TIAM2 | TFB1M | Gene ID | 26230 | 51106 |
| Gene name | T cell lymphoma invasion and metastasis 2 | transcription factor B1, mitochondrial | |
| Synonyms | STEF|TIAM-2 | CGI-75|CGI75|mtTFB|mtTFB1 | |
| Cytomap | 6q25.2-q25.3 | 6q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | T-lymphoma invasion and metastasis-inducing protein 2SIF and TIAM1-like exchange factor | dimethyladenosine transferase 1, mitochondrialS-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1h-mtTFB1hTFB1Mhomolog of yeast mitochondrial transcription factor Bmitochondrial 12S rRNA dimethylase 1mitochondrial dimethyladenosine tr | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IVF5 | Q8WVM0 | |
| Ensembl transtripts involved in fusion gene | ENST00000461783, ENST00000449545, ENST00000367174, ENST00000456144, ENST00000318981, ENST00000360366, ENST00000529824, ENST00000456877, ENST00000528391, ENST00000275246, | ENST00000367166, ENST00000480390, | |
| Fusion gene scores | * DoF score | 8 X 8 X 3=192 | 2 X 2 X 2=8 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/192*10)=-0.941106310946431 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/8*10)=1.90689059560852 | |
| Context | PubMed: TIAM2 [Title/Abstract] AND TFB1M [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM993771 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - | ||
| ChiTaRS3.1 | CN479315 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000461783 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000461783 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| intron-3CDS | ENST00000449545 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| intron-intron | ENST00000449545 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| Frame-shift | ENST00000367174 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000367174 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| Frame-shift | ENST00000456144 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000456144 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| Frame-shift | ENST00000318981 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000318981 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| Frame-shift | ENST00000360366 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000360366 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| In-frame | ENST00000529824 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000529824 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| Frame-shift | ENST00000456877 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000456877 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| In-frame | ENST00000528391 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000528391 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| In-frame | ENST00000275246 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000275246 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
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FusionProtFeatures for TIAM2_TFB1M |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TIAM2 | TFB1M |
| Modulates the activity of RHO-like proteins and connectsextracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTPexchange activity of RHO-like GTPases and activates them. Mediatesextracellular laminin signals to activate Rac1, contributing toneurite growth. Involved in lamellipodial formation andadvancement of the growth cone of embryonic hippocampal neurons.Promotes migration of neurons in the cerebral cortex. Whenoverexpressed, induces membrane ruffling accompanied by theaccumulation of actin filaments along the altered plasma membrane(By similarity). Activates specifically RAC1, but not CDC42 andRHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}. | S-adenosyl-L-methionine-dependent methyltransferasewhich specifically dimethylates mitochondrial 12S rRNA at theconserved stem loop. Also required for basal transcription ofmitochondrial DNA, probably via its interaction with POLRMT andTFAM. Stimulates transcription independently of themethyltransferase activity. {ECO:0000269|PubMed:11809803,ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12897151}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TIAM2_TFB1M |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TIAM2_TFB1M |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TIAM2_TFB1M |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TIAM2_TFB1M |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TIAM2 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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