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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38085

FusionGeneSummary for TIAM2_RAD1

check button Fusion gene summary
Fusion gene informationFusion gene name: TIAM2_RAD1
Fusion gene ID: 38085
HgeneTgene
Gene symbol

TIAM2

RAD1

Gene ID

26230

5810

Gene nameT cell lymphoma invasion and metastasis 2RAD1 checkpoint DNA exonuclease
SynonymsSTEF|TIAM-2HRAD1|REC1
Cytomap

6q25.2-q25.3

5p13.2

Type of geneprotein-codingprotein-coding
DescriptionT-lymphoma invasion and metastasis-inducing protein 2SIF and TIAM1-like exchange factorcell cycle checkpoint protein RAD1DNA repair exonuclease REC1DNA repair exonuclease rad1 homologRAD1 checkpoint clamp componentRAD1 homologcell cycle checkpoint protein Hrad1checkpoint control protein HRAD1exonuclease homolog RAD1rad1-like DNA dam
Modification date2018051920180523
UniProtAcc

Q8IVF5

O60671

Ensembl transtripts involved in fusion geneENST00000461783, ENST00000449545, 
ENST00000367174, ENST00000456144, 
ENST00000318981, ENST00000360366, 
ENST00000529824, ENST00000456877, 
ENST00000528391, ENST00000275246, 
ENST00000382038, ENST00000341754, 
Fusion gene scores* DoF score8 X 8 X 3=1922 X 2 X 1=4
# samples 102
** MAII scorelog2(10/192*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: TIAM2 [Title/Abstract] AND RAD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRAD1

GO:0071479

cellular response to ionizing radiation

21659603


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU629140TIAM2chr6

155284994

-RAD1chr5

34908559

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000461783ENST00000382038TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000461783ENST00000341754TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000449545ENST00000382038TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000449545ENST00000341754TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000367174ENST00000382038TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000367174ENST00000341754TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000456144ENST00000382038TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000456144ENST00000341754TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000318981ENST00000382038TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000318981ENST00000341754TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000360366ENST00000382038TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000360366ENST00000341754TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000529824ENST00000382038TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000529824ENST00000341754TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000456877ENST00000382038TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000456877ENST00000341754TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000528391ENST00000382038TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000528391ENST00000341754TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000275246ENST00000382038TIAM2chr6

155284994

-RAD1chr5

34908559

+
intron-3UTRENST00000275246ENST00000341754TIAM2chr6

155284994

-RAD1chr5

34908559

+

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FusionProtFeatures for TIAM2_RAD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TIAM2

Q8IVF5

RAD1

O60671

Modulates the activity of RHO-like proteins and connectsextracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTPexchange activity of RHO-like GTPases and activates them. Mediatesextracellular laminin signals to activate Rac1, contributing toneurite growth. Involved in lamellipodial formation andadvancement of the growth cone of embryonic hippocampal neurons.Promotes migration of neurons in the cerebral cortex. Whenoverexpressed, induces membrane ruffling accompanied by theaccumulation of actin filaments along the altered plasma membrane(By similarity). Activates specifically RAC1, but not CDC42 andRHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}. Component of the 9-1-1 cell-cycle checkpoint responsecomplex that plays a major role in DNA repair (PubMed:10846170,PubMed:10884395). The 9-1-1 complex is recruited to DNA lesionupon damage by the RAD17-replication factor C (RFC) clamp loadercomplex (PubMed:12578958). Acts then as a sliding clamp platformon DNA for several proteins involved in long-patch base excisionrepair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulatesDNA polymerase beta (POLB) activity by increasing its affinity forthe 3'-OH end of the primer-template and stabilizes POLB to thosesites where LP-BER proceeds; endonuclease FEN1 cleavage activityon substrates with double, nick, or gap flaps of distinctsequences and lengths; and DNA ligase I (LIG1) on long-patch baseexcision repair substrates (PubMed:15314187, PubMed:15556996,PubMed:15871698). The 9-1-1 complex is necessary for therecruitment of RHNO1 to sites of double-stranded breaks (DSB)occurring during the S phase (PubMed:21659603). Isoform 1possesses 3'->5' double stranded DNA exonuclease activity(PubMed:9660799). {ECO:0000269|PubMed:10846170,ECO:0000269|PubMed:10884395, ECO:0000269|PubMed:12578958,ECO:0000269|PubMed:15314187, ECO:0000269|PubMed:15556996,ECO:0000269|PubMed:15871698, ECO:0000269|PubMed:21659603,ECO:0000269|PubMed:9660799}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TIAM2_RAD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TIAM2_RAD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TIAM2_RAD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TIAM2_RAD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTIAM2C0236969Substance-Related Disorders1CTD_human