FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 38081

FusionGeneSummary for TIAM2_MKLN1

check button Fusion gene summary
Fusion gene informationFusion gene name: TIAM2_MKLN1
Fusion gene ID: 38081
HgeneTgene
Gene symbol

TIAM2

MKLN1

Gene ID

26230

4289

Gene nameT cell lymphoma invasion and metastasis 2muskelin 1
SynonymsSTEF|TIAM-2TWA2
Cytomap

6q25.2-q25.3

7q32.3

Type of geneprotein-codingprotein-coding
DescriptionT-lymphoma invasion and metastasis-inducing protein 2SIF and TIAM1-like exchange factormuskelinmuskelin 1, intracellular mediator containing kelch motifs
Modification date2018051920180522
UniProtAcc

Q8IVF5

Q9UL63

Ensembl transtripts involved in fusion geneENST00000461783, ENST00000449545, 
ENST00000367174, ENST00000456144, 
ENST00000318981, ENST00000360366, 
ENST00000529824, ENST00000456877, 
ENST00000528391, ENST00000275246, 
ENST00000421797, ENST00000429546, 
ENST00000352689, ENST00000498778, 
Fusion gene scores* DoF score8 X 8 X 3=19210 X 9 X 6=540
# samples 1011
** MAII scorelog2(10/192*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/540*10)=-2.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TIAM2 [Title/Abstract] AND MKLN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ371784TIAM2chr6

155161303

+MKLN1chr7

131124903

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000461783ENST00000421797TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000461783ENST00000429546TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000461783ENST00000352689TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000461783ENST00000498778TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000449545ENST00000421797TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000449545ENST00000429546TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000449545ENST00000352689TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000449545ENST00000498778TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000367174ENST00000421797TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000367174ENST00000429546TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000367174ENST00000352689TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000367174ENST00000498778TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000456144ENST00000421797TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000456144ENST00000429546TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000456144ENST00000352689TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000456144ENST00000498778TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000318981ENST00000421797TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000318981ENST00000429546TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000318981ENST00000352689TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000318981ENST00000498778TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000360366ENST00000421797TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000360366ENST00000429546TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000360366ENST00000352689TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000360366ENST00000498778TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000529824ENST00000421797TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000529824ENST00000429546TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000529824ENST00000352689TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000529824ENST00000498778TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000456877ENST00000421797TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000456877ENST00000429546TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000456877ENST00000352689TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000456877ENST00000498778TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000528391ENST00000421797TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000528391ENST00000429546TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000528391ENST00000352689TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000528391ENST00000498778TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000275246ENST00000421797TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000275246ENST00000429546TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000275246ENST00000352689TIAM2chr6

155161303

+MKLN1chr7

131124903

+
intron-intronENST00000275246ENST00000498778TIAM2chr6

155161303

+MKLN1chr7

131124903

+

Top

FusionProtFeatures for TIAM2_MKLN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TIAM2

Q8IVF5

MKLN1

Q9UL63

Modulates the activity of RHO-like proteins and connectsextracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTPexchange activity of RHO-like GTPases and activates them. Mediatesextracellular laminin signals to activate Rac1, contributing toneurite growth. Involved in lamellipodial formation andadvancement of the growth cone of embryonic hippocampal neurons.Promotes migration of neurons in the cerebral cortex. Whenoverexpressed, induces membrane ruffling accompanied by theaccumulation of actin filaments along the altered plasma membrane(By similarity). Activates specifically RAC1, but not CDC42 andRHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}. Acts as a mediator of cell spreading and cytoskeletalresponses to the extracellular matrix component THBS1.{ECO:0000250|UniProtKB:O89050}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TIAM2_MKLN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TIAM2_MKLN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TIAM2_MKLN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TIAM2_MKLN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTIAM2C0236969Substance-Related Disorders1CTD_human