FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 38078

FusionGeneSummary for TIAM1_PCBP3

check button Fusion gene summary
Fusion gene informationFusion gene name: TIAM1_PCBP3
Fusion gene ID: 38078
HgeneTgene
Gene symbol

TIAM1

PCBP3

Gene ID

7074

54039

Gene nameT cell lymphoma invasion and metastasis 1poly(rC) binding protein 3
SynonymsTIAM-1ALPHA-CP3|PCBP3-OT1|PCBP3OT
Cytomap

21q22.11

21q22.3

Type of geneprotein-codingprotein-coding
DescriptionT-lymphoma invasion and metastasis-inducing protein 1human T-lymphoma invasion and metastasis inducing TIAM1 proteinpoly(rC)-binding protein 3PCBP3 overlapping transcript 1PCBP3-overlapping transcriptpoly(rC) binding protein 3 overlapping transcript
Modification date2018052220180519
UniProtAcc

Q13009

P57721

Ensembl transtripts involved in fusion geneENST00000286827, ENST00000541036, 
ENST00000469412, 
ENST00000400314, 
ENST00000400310, ENST00000449640, 
ENST00000400309, ENST00000400308, 
ENST00000400304, ENST00000423045, 
Fusion gene scores* DoF score8 X 5 X 5=2004 X 4 X 4=64
# samples 94
** MAII scorelog2(9/200*10)=-1.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TIAM1 [Title/Abstract] AND PCBP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTIAM1

GO:0008284

positive regulation of cell proliferation

25032858

HgeneTIAM1

GO:0010717

regulation of epithelial to mesenchymal transition

20826792

HgeneTIAM1

GO:0030335

positive regulation of cell migration

25032858

HgeneTIAM1

GO:0032092

positive regulation of protein binding

23109420

HgeneTIAM1

GO:0090630

activation of GTPase activity

23109420


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CR-7367-01ATIAM1chr21

32711558

-PCBP3chr21

47316122

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000286827ENST00000400314TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000286827ENST00000400310TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000286827ENST00000449640TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000286827ENST00000400309TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000286827ENST00000400308TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-intronENST00000286827ENST00000400304TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-intronENST00000286827ENST00000423045TIAM1chr21

32711558

-PCBP3chr21

47316122

+
intron-3CDSENST00000541036ENST00000400314TIAM1chr21

32711558

-PCBP3chr21

47316122

+
intron-3CDSENST00000541036ENST00000400310TIAM1chr21

32711558

-PCBP3chr21

47316122

+
intron-3CDSENST00000541036ENST00000449640TIAM1chr21

32711558

-PCBP3chr21

47316122

+
intron-3CDSENST00000541036ENST00000400309TIAM1chr21

32711558

-PCBP3chr21

47316122

+
intron-3CDSENST00000541036ENST00000400308TIAM1chr21

32711558

-PCBP3chr21

47316122

+
intron-intronENST00000541036ENST00000400304TIAM1chr21

32711558

-PCBP3chr21

47316122

+
intron-intronENST00000541036ENST00000423045TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000469412ENST00000400314TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000469412ENST00000400310TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000469412ENST00000449640TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000469412ENST00000400309TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000469412ENST00000400308TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-intronENST00000469412ENST00000400304TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-intronENST00000469412ENST00000423045TIAM1chr21

32711558

-PCBP3chr21

47316122

+

Top

FusionProtFeatures for TIAM1_PCBP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TIAM1

Q13009

PCBP3

P57721

Modulates the activity of RHO-like proteins and connectsextracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTPexchange activity of RHO-like GTPases and activates them.Activates RAC1, CDC42, and to a lesser extent RHOA. Required fornormal cell adhesion and cell migration.{ECO:0000269|PubMed:20361982}. Single-stranded nucleic acid binding protein that bindspreferentially to oligo dC. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TIAM1_PCBP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TIAM1_PCBP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TIAM1PPP1R9B, MAPK8IP2, MAPK8IP1, RAC1, HRAS, MYC, CD44, PRKCA, PRKCB, PRKCG, PRKCE, PRKCD, PRKCZ, ANK1, ANK3, NME1, YWHAG, WHSC1, UBC, ALB, YWHAE, CFTR, BTRC, CSNK1A1, CSNK1E, FBXW11, DARS, KBTBD6, KBTBD7, CTDSPL, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, CGN, RTKN, MAST3, LIMA1, MAGI1, PPM1H, TESK2, DCLK1, ZNF638, DENND4C, SRSF12, SYDE1, AGAP1, CDC25B, CDK16, HDAC4, MAPKAP1, NF1, FAM110B, USP21, CBY1, ANKRD34A, FAM53C, NADK, CDC25C, FAM110A, CAMSAP2, KIAA1804, RASAL2, GIGYF2, PHLDB2, PLEKHA7, KIF1C, INPP5EPCBP3RUVBL1, RUVBL2, RBM39, PTBP1, PTBP2, SPEN, PFKL, FAM96B, FTH1, PCBP1, RHOD, KCTD17, AKR1B10, TSTA3, PDCD2L, DLD, PPP1R18, DCP2, BBOX1, PCM1, CEP128, CDC73, HDAC10, WNT16, TYW3, COLGALT2, CCDC6, GBP2, METTL25, DVL3, OCRL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TIAM1_PCBP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TIAM1_PCBP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTIAM1C1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human