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Fusion gene ID: 38076 |
FusionGeneSummary for TIAM1_NRIP1 |
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Fusion gene information | Fusion gene name: TIAM1_NRIP1 | Fusion gene ID: 38076 | Hgene | Tgene | Gene symbol | TIAM1 | NRIP1 | Gene ID | 7074 | 8204 |
Gene name | T cell lymphoma invasion and metastasis 1 | nuclear receptor interacting protein 1 | |
Synonyms | TIAM-1 | RIP140 | |
Cytomap | 21q22.11 | 21q11.2-q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | T-lymphoma invasion and metastasis-inducing protein 1human T-lymphoma invasion and metastasis inducing TIAM1 protein | nuclear receptor-interacting protein 1nuclear factor RIP140receptor-interacting protein 140 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q13009 | P48552 | |
Ensembl transtripts involved in fusion gene | ENST00000286827, ENST00000541036, ENST00000469412, | ENST00000318948, ENST00000400199, ENST00000400202, | |
Fusion gene scores | * DoF score | 8 X 5 X 5=200 | 2 X 1 X 2=4 |
# samples | 9 | 2 | |
** MAII score | log2(9/200*10)=-1.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: TIAM1 [Title/Abstract] AND NRIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TIAM1 | GO:0008284 | positive regulation of cell proliferation | 25032858 |
Hgene | TIAM1 | GO:0010717 | regulation of epithelial to mesenchymal transition | 20826792 |
Hgene | TIAM1 | GO:0030335 | positive regulation of cell migration | 25032858 |
Hgene | TIAM1 | GO:0032092 | positive regulation of protein binding | 23109420 |
Hgene | TIAM1 | GO:0090630 | activation of GTPase activity | 23109420 |
Tgene | NRIP1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10364267 |
Tgene | NRIP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7641693|10364267 |
Tgene | NRIP1 | GO:0071392 | cellular response to estradiol stimulus | 15831516 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-E9-A248-01A | TIAM1 | chr21 | 32638326 | - | NRIP1 | chr21 | 16340847 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000286827 | ENST00000318948 | TIAM1 | chr21 | 32638326 | - | NRIP1 | chr21 | 16340847 | - |
5CDS-5UTR | ENST00000286827 | ENST00000400199 | TIAM1 | chr21 | 32638326 | - | NRIP1 | chr21 | 16340847 | - |
5CDS-5UTR | ENST00000286827 | ENST00000400202 | TIAM1 | chr21 | 32638326 | - | NRIP1 | chr21 | 16340847 | - |
5CDS-5UTR | ENST00000541036 | ENST00000318948 | TIAM1 | chr21 | 32638326 | - | NRIP1 | chr21 | 16340847 | - |
5CDS-5UTR | ENST00000541036 | ENST00000400199 | TIAM1 | chr21 | 32638326 | - | NRIP1 | chr21 | 16340847 | - |
5CDS-5UTR | ENST00000541036 | ENST00000400202 | TIAM1 | chr21 | 32638326 | - | NRIP1 | chr21 | 16340847 | - |
intron-5UTR | ENST00000469412 | ENST00000318948 | TIAM1 | chr21 | 32638326 | - | NRIP1 | chr21 | 16340847 | - |
intron-5UTR | ENST00000469412 | ENST00000400199 | TIAM1 | chr21 | 32638326 | - | NRIP1 | chr21 | 16340847 | - |
intron-5UTR | ENST00000469412 | ENST00000400202 | TIAM1 | chr21 | 32638326 | - | NRIP1 | chr21 | 16340847 | - |
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FusionProtFeatures for TIAM1_NRIP1 |
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Hgene | Tgene |
TIAM1 | NRIP1 |
Modulates the activity of RHO-like proteins and connectsextracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTPexchange activity of RHO-like GTPases and activates them.Activates RAC1, CDC42, and to a lesser extent RHOA. Required fornormal cell adhesion and cell migration.{ECO:0000269|PubMed:20361982}. | Modulates transcriptional activation by steroidreceptors such as NR3C1, NR3C2 and ESR1. Also modulatestranscriptional repression by nuclear hormone receptors. Positiveregulator of the circadian clock gene expression: stimulatestranscription of ARNTL/BMAL1, CLOCK and CRY1 by acting as acoactivator for RORA and RORC. {ECO:0000269|PubMed:10364267,ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808,ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175,ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:7641693}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TIAM1_NRIP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TIAM1_NRIP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TIAM1 | PPP1R9B, MAPK8IP2, MAPK8IP1, RAC1, HRAS, MYC, CD44, PRKCA, PRKCB, PRKCG, PRKCE, PRKCD, PRKCZ, ANK1, ANK3, NME1, YWHAG, WHSC1, UBC, ALB, YWHAE, CFTR, BTRC, CSNK1A1, CSNK1E, FBXW11, DARS, KBTBD6, KBTBD7, CTDSPL, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, CGN, RTKN, MAST3, LIMA1, MAGI1, PPM1H, TESK2, DCLK1, ZNF638, DENND4C, SRSF12, SYDE1, AGAP1, CDC25B, CDK16, HDAC4, MAPKAP1, NF1, FAM110B, USP21, CBY1, ANKRD34A, FAM53C, NADK, CDC25C, FAM110A, CAMSAP2, KIAA1804, RASAL2, GIGYF2, PHLDB2, PLEKHA7, KIF1C, INPP5E | NRIP1 | NR5A1, NR0B1, LDOC1, TEX11, CEP70, CTBP2, TRAF2, CCDC85B, CTBP1, HDAC5, RARA, NR3C1, YWHAQ, RXRA, ESR1, AHR, PPARA, PPARG, THRA, RXRB, JUN, PRMT1, HDAC3, CARM1, XPO1, KPNB1, ESRRA, ESRRB, ESRRG, ESR2, E2F1, ACTN2, CIB1, NR1H2, THRB, RORB, NR1H3, VDR, HNF4A, NR5A2, ELAVL1, CDK8, NR3C2, APP, FHL1, DNMT1, DNMT3A, DNMT3B, PPARGC1A, ARPC3, BRCA1, MAGEA10, HDAC1, HDAC2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TIAM1_NRIP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TIAM1_NRIP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TIAM1 | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
Tgene | NRIP1 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Tgene | NRIP1 | C0018801 | Heart failure | 1 | CTD_human |
Tgene | NRIP1 | C0027051 | Myocardial Infarction | 1 | CTD_human |
Tgene | NRIP1 | C0036341 | Schizophrenia | 1 | CTD_human |
Tgene | NRIP1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |