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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38075

FusionGeneSummary for TIAM1_NCAM2

check button Fusion gene summary
Fusion gene informationFusion gene name: TIAM1_NCAM2
Fusion gene ID: 38075
HgeneTgene
Gene symbol

TIAM1

NCAM2

Gene ID

7074

4685

Gene nameT cell lymphoma invasion and metastasis 1neural cell adhesion molecule 2
SynonymsTIAM-1NCAM21
Cytomap

21q22.11

21q21.1

Type of geneprotein-codingprotein-coding
DescriptionT-lymphoma invasion and metastasis-inducing protein 1human T-lymphoma invasion and metastasis inducing TIAM1 proteinneural cell adhesion molecule 2N-CAM-2NCAM-2
Modification date2018052220180523
UniProtAcc

Q13009

O15394

Ensembl transtripts involved in fusion geneENST00000286827, ENST00000541036, 
ENST00000469412, 		ENST00000400546, 
ENST00000284894, ENST00000535285, 
ENST00000486367, 
Fusion gene scores* DoF score8 X 5 X 5=2008 X 7 X 3=168
# samples 98
** MAII scorelog2(9/200*10)=-1.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TIAM1 [Title/Abstract] AND NCAM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTIAM1

GO:0008284

positive regulation of cell proliferation

25032858

HgeneTIAM1

GO:0010717

regulation of epithelial to mesenchymal transition

20826792

HgeneTIAM1

GO:0030335

positive regulation of cell migration

25032858

HgeneTIAM1

GO:0032092

positive regulation of protein binding

23109420

HgeneTIAM1

GO:0090630

activation of GTPase activity

23109420


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-QC-AA9N-01ATIAM1chr21

32931240

-NCAM2chr21

22696703

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000286827ENST00000400546TIAM1chr21

32931240

-NCAM2chr21

22696703

+
5UTR-3CDSENST00000286827ENST00000284894TIAM1chr21

32931240

-NCAM2chr21

22696703

+
5UTR-3CDSENST00000286827ENST00000535285TIAM1chr21

32931240

-NCAM2chr21

22696703

+
5UTR-intronENST00000286827ENST00000486367TIAM1chr21

32931240

-NCAM2chr21

22696703

+
intron-3CDSENST00000541036ENST00000400546TIAM1chr21

32931240

-NCAM2chr21

22696703

+
intron-3CDSENST00000541036ENST00000284894TIAM1chr21

32931240

-NCAM2chr21

22696703

+
intron-3CDSENST00000541036ENST00000535285TIAM1chr21

32931240

-NCAM2chr21

22696703

+
intron-intronENST00000541036ENST00000486367TIAM1chr21

32931240

-NCAM2chr21

22696703

+
intron-3CDSENST00000469412ENST00000400546TIAM1chr21

32931240

-NCAM2chr21

22696703

+
intron-3CDSENST00000469412ENST00000284894TIAM1chr21

32931240

-NCAM2chr21

22696703

+
intron-3CDSENST00000469412ENST00000535285TIAM1chr21

32931240

-NCAM2chr21

22696703

+
intron-intronENST00000469412ENST00000486367TIAM1chr21

32931240

-NCAM2chr21

22696703

+

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FusionProtFeatures for TIAM1_NCAM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TIAM1

Q13009

NCAM2

O15394

Modulates the activity of RHO-like proteins and connectsextracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTPexchange activity of RHO-like GTPases and activates them.Activates RAC1, CDC42, and to a lesser extent RHOA. Required fornormal cell adhesion and cell migration.{ECO:0000269|PubMed:20361982}. May play important roles in selective fasciculation andzone-to-zone projection of the primary olfactory axons.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TIAM1_NCAM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TIAM1_NCAM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TIAM1PPP1R9B, MAPK8IP2, MAPK8IP1, RAC1, HRAS, MYC, CD44, PRKCA, PRKCB, PRKCG, PRKCE, PRKCD, PRKCZ, ANK1, ANK3, NME1, YWHAG, WHSC1, UBC, ALB, YWHAE, CFTR, BTRC, CSNK1A1, CSNK1E, FBXW11, DARS, KBTBD6, KBTBD7, CTDSPL, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, CGN, RTKN, MAST3, LIMA1, MAGI1, PPM1H, TESK2, DCLK1, ZNF638, DENND4C, SRSF12, SYDE1, AGAP1, CDC25B, CDK16, HDAC4, MAPKAP1, NF1, FAM110B, USP21, CBY1, ANKRD34A, FAM53C, NADK, CDC25C, FAM110A, CAMSAP2, KIAA1804, RASAL2, GIGYF2, PHLDB2, PLEKHA7, KIF1C, INPP5ENCAM2QDPR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TIAM1_NCAM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TIAM1_NCAM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTIAM1C1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human