FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 38072

FusionGeneSummary for TIAM1_BACH1

check button Fusion gene summary
Fusion gene informationFusion gene name: TIAM1_BACH1
Fusion gene ID: 38072
HgeneTgene
Gene symbol

TIAM1

BACH1

Gene ID

7074

83990

Gene nameT cell lymphoma invasion and metastasis 1BRCA1 interacting protein C-terminal helicase 1
SynonymsTIAM-1BACH1|FANCJ|OF
Cytomap

21q22.11

17q23.2

Type of geneprotein-codingprotein-coding
DescriptionT-lymphoma invasion and metastasis-inducing protein 1human T-lymphoma invasion and metastasis inducing TIAM1 proteinFanconi anemia group J proteinATP-dependent RNA helicase BRIP1BRCA1-associated C-terminal helicase 1BRCA1-binding helicase-like protein BACH1BRCA1/BRCA2-associated helicase 1
Modification date2018052220180523
UniProtAcc

Q13009

O14867

Ensembl transtripts involved in fusion geneENST00000286827, ENST00000541036, 
ENST00000469412, 
ENST00000286800, 
ENST00000399921, ENST00000462262, 
Fusion gene scores* DoF score8 X 5 X 5=2003 X 3 X 3=27
# samples 93
** MAII scorelog2(9/200*10)=-1.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TIAM1 [Title/Abstract] AND BACH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTIAM1

GO:0008284

positive regulation of cell proliferation

25032858

HgeneTIAM1

GO:0010717

regulation of epithelial to mesenchymal transition

20826792

HgeneTIAM1

GO:0030335

positive regulation of cell migration

25032858

HgeneTIAM1

GO:0032092

positive regulation of protein binding

23109420

HgeneTIAM1

GO:0090630

activation of GTPase activity

23109420

TgeneBACH1

GO:0006357

regulation of transcription by RNA polymerase II

14504288


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A3UA-01ATIAM1chr21

32711558

-BACH1chr21

30693542

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000286827ENST00000286800TIAM1chr21

32711558

-BACH1chr21

30693542

+
5UTR-5UTRENST00000286827ENST00000399921TIAM1chr21

32711558

-BACH1chr21

30693542

+
5UTR-intronENST00000286827ENST00000462262TIAM1chr21

32711558

-BACH1chr21

30693542

+
intron-5UTRENST00000541036ENST00000286800TIAM1chr21

32711558

-BACH1chr21

30693542

+
intron-5UTRENST00000541036ENST00000399921TIAM1chr21

32711558

-BACH1chr21

30693542

+
intron-intronENST00000541036ENST00000462262TIAM1chr21

32711558

-BACH1chr21

30693542

+
5UTR-5UTRENST00000469412ENST00000286800TIAM1chr21

32711558

-BACH1chr21

30693542

+
5UTR-5UTRENST00000469412ENST00000399921TIAM1chr21

32711558

-BACH1chr21

30693542

+
5UTR-intronENST00000469412ENST00000462262TIAM1chr21

32711558

-BACH1chr21

30693542

+

Top

FusionProtFeatures for TIAM1_BACH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TIAM1

Q13009

BACH1

O14867

Modulates the activity of RHO-like proteins and connectsextracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTPexchange activity of RHO-like GTPases and activates them.Activates RAC1, CDC42, and to a lesser extent RHOA. Required fornormal cell adhesion and cell migration.{ECO:0000269|PubMed:20361982}. Transcriptional regulator that acts as repressor oractivator. Binds, in vitro, to NF-E2 binding sites. Play importantroles in coordinating transcription activation and repression byMAFK.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TIAM1_BACH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TIAM1_BACH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TIAM1PPP1R9B, MAPK8IP2, MAPK8IP1, RAC1, HRAS, MYC, CD44, PRKCA, PRKCB, PRKCG, PRKCE, PRKCD, PRKCZ, ANK1, ANK3, NME1, YWHAG, WHSC1, UBC, ALB, YWHAE, CFTR, BTRC, CSNK1A1, CSNK1E, FBXW11, DARS, KBTBD6, KBTBD7, CTDSPL, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, CGN, RTKN, MAST3, LIMA1, MAGI1, PPM1H, TESK2, DCLK1, ZNF638, DENND4C, SRSF12, SYDE1, AGAP1, CDC25B, CDK16, HDAC4, MAPKAP1, NF1, FAM110B, USP21, CBY1, ANKRD34A, FAM53C, NADK, CDC25C, FAM110A, CAMSAP2, KIAA1804, RASAL2, GIGYF2, PHLDB2, PLEKHA7, KIF1C, INPP5EBACH1BACH1, BRCA1, PATZ1, RBCK1, PARK2, HMMR, MAFG, MAFK, TP53, HDAC1, NCOR1, XPO1, BRCA2, BARD1, BRCC3, NFE2L2, NBN, MRE11A, MLH1, TOPBP1, PALB2, MAFF, MAFB, ATF2, DDIT3, ANAPC5, FBXL17, NLK, CSNK1A1, SMAD3, SHMT2, MOV10, NXF1, RFPL2, CREB5, PLRG1, TAF4B, DDX39B, PABPN1, KIAA1429, TMEM208, PPHLN1, FAM83D, TBC1D10A, POTEKP, BATF3, XRCC6BP1, CREBZF, KIF2B, ZNF131, SLX1A, ATF7, FGFRL1, MLX, FBXO22, KIAA1468, ASAP3, NME8, TRIP11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TIAM1_BACH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TIAM1_BACH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTIAM1C1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human