![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 38063 |
FusionGeneSummary for TIA1_HSPA13 |
![]() |
Fusion gene information | Fusion gene name: TIA1_HSPA13 | Fusion gene ID: 38063 | Hgene | Tgene | Gene symbol | TIA1 | HSPA13 | Gene ID | 7072 | 6782 |
Gene name | TIA1 cytotoxic granule associated RNA binding protein | heat shock protein family A (Hsp70) member 13 | |
Synonyms | TIA-1|WDM | STCH | |
Cytomap | 2p13.3 | 21q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | nucleolysin TIA-1 isoform p40nucleolysin TIA-1T-cell-restricted intracellular antigen-1p40-TIA-1 (containing p15-TIA-1) | heat shock 70 kDa protein 13heat shock protein 70kDa family, member 13microsomal stress 70 protein ATPase corestress 70 protein chaperone, microsome-associated, 60kDstress 70 protein chaperone, microsome-associated, 60kDastress-70 protein chaperone m | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P31483 | P48723 | |
Ensembl transtripts involved in fusion gene | ENST00000433529, ENST00000415783, ENST00000282574, ENST00000445587, ENST00000482876, ENST00000416149, | ENST00000285667, ENST00000544452, ENST00000478035, | |
Fusion gene scores | * DoF score | 8 X 5 X 7=280 | 3 X 3 X 2=18 |
# samples | 8 | 3 | |
** MAII score | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TIA1 [Title/Abstract] AND HSPA13 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TIA1 | GO:0048024 | regulation of mRNA splicing, via spliceosome | 11106748 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | T06637 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000433529 | ENST00000285667 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-3CDS | ENST00000433529 | ENST00000544452 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-intron | ENST00000433529 | ENST00000478035 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-3CDS | ENST00000415783 | ENST00000285667 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-3CDS | ENST00000415783 | ENST00000544452 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-intron | ENST00000415783 | ENST00000478035 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-3CDS | ENST00000282574 | ENST00000285667 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-3CDS | ENST00000282574 | ENST00000544452 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-intron | ENST00000282574 | ENST00000478035 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-3CDS | ENST00000445587 | ENST00000285667 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-3CDS | ENST00000445587 | ENST00000544452 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-intron | ENST00000445587 | ENST00000478035 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-3CDS | ENST00000482876 | ENST00000285667 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-3CDS | ENST00000482876 | ENST00000544452 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-intron | ENST00000482876 | ENST00000478035 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-3CDS | ENST00000416149 | ENST00000285667 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-3CDS | ENST00000416149 | ENST00000544452 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
intron-intron | ENST00000416149 | ENST00000478035 | TIA1 | chr2 | 70444115 | + | HSPA13 | chr21 | 15746130 | + |
Top |
FusionProtFeatures for TIA1_HSPA13 |
![]() |
Hgene | Tgene |
TIA1 | HSPA13 |
Involved in alternative pre-RNA splicing and regulationof mRNA translation by binding to AU-rich elements (AREs) locatedin mRNA 3' untranslated regions (3' UTRs). Possesses nucleolyticactivity against cytotoxic lymphocyte target cells. May beinvolved in apoptosis. | Has peptide-independent ATPase activity. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TIA1_HSPA13 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TIA1_HSPA13 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TIA1_HSPA13 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TIA1_HSPA13 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TIA1 | C0221054 | Welander Distal Myopathy | 1 | UNIPROT |