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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38063

FusionGeneSummary for TIA1_HSPA13

check button Fusion gene summary
Fusion gene informationFusion gene name: TIA1_HSPA13
Fusion gene ID: 38063
HgeneTgene
Gene symbol

TIA1

HSPA13

Gene ID

7072

6782

Gene nameTIA1 cytotoxic granule associated RNA binding proteinheat shock protein family A (Hsp70) member 13
SynonymsTIA-1|WDMSTCH
Cytomap

2p13.3

21q11.2

Type of geneprotein-codingprotein-coding
Descriptionnucleolysin TIA-1 isoform p40nucleolysin TIA-1T-cell-restricted intracellular antigen-1p40-TIA-1 (containing p15-TIA-1)heat shock 70 kDa protein 13heat shock protein 70kDa family, member 13microsomal stress 70 protein ATPase corestress 70 protein chaperone, microsome-associated, 60kDstress 70 protein chaperone, microsome-associated, 60kDastress-70 protein chaperone m
Modification date2018051920180523
UniProtAcc

P31483

P48723

Ensembl transtripts involved in fusion geneENST00000433529, ENST00000415783, 
ENST00000282574, ENST00000445587, 
ENST00000482876, ENST00000416149, 
ENST00000285667, ENST00000544452, 
ENST00000478035, 
Fusion gene scores* DoF score8 X 5 X 7=2803 X 3 X 2=18
# samples 83
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TIA1 [Title/Abstract] AND HSPA13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTIA1

GO:0048024

regulation of mRNA splicing, via spliceosome

11106748


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T06637TIA1chr2

70444115

+HSPA13chr21

15746130

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000433529ENST00000285667TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-3CDSENST00000433529ENST00000544452TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-intronENST00000433529ENST00000478035TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-3CDSENST00000415783ENST00000285667TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-3CDSENST00000415783ENST00000544452TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-intronENST00000415783ENST00000478035TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-3CDSENST00000282574ENST00000285667TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-3CDSENST00000282574ENST00000544452TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-intronENST00000282574ENST00000478035TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-3CDSENST00000445587ENST00000285667TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-3CDSENST00000445587ENST00000544452TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-intronENST00000445587ENST00000478035TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-3CDSENST00000482876ENST00000285667TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-3CDSENST00000482876ENST00000544452TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-intronENST00000482876ENST00000478035TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-3CDSENST00000416149ENST00000285667TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-3CDSENST00000416149ENST00000544452TIA1chr2

70444115

+HSPA13chr21

15746130

+
intron-intronENST00000416149ENST00000478035TIA1chr2

70444115

+HSPA13chr21

15746130

+

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FusionProtFeatures for TIA1_HSPA13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TIA1

P31483

HSPA13

P48723

Involved in alternative pre-RNA splicing and regulationof mRNA translation by binding to AU-rich elements (AREs) locatedin mRNA 3' untranslated regions (3' UTRs). Possesses nucleolyticactivity against cytotoxic lymphocyte target cells. May beinvolved in apoptosis. Has peptide-independent ATPase activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TIA1_HSPA13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TIA1_HSPA13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TIA1_HSPA13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TIA1_HSPA13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTIA1C0221054Welander Distal Myopathy1UNIPROT