|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 38036 |
FusionGeneSummary for THRB_LMCD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: THRB_LMCD1 | Fusion gene ID: 38036 | Hgene | Tgene | Gene symbol | THRB | LMCD1 | Gene ID | 7068 | 29995 |
| Gene name | thyroid hormone receptor beta | LIM and cysteine rich domains 1 | |
| Synonyms | C-ERBA-2|C-ERBA-BETA|ERBA2|GRTH|NR1A2|PRTH|THR1|THRB1|THRB2 | - | |
| Cytomap | 3p24.2 | 3p25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | thyroid hormone receptor betanuclear receptor subfamily 1 group A member 2oncogene ERBA2thyroid hormone nuclear receptor beta variant 1thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) | LIM and cysteine-rich domains protein 1dyxin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P10828 | Q9NZU5 | |
| Ensembl transtripts involved in fusion gene | ENST00000396671, ENST00000356447, ENST00000416420, ENST00000280696, | ENST00000157600, ENST00000535732, ENST00000454244, ENST00000397386, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 2 X 3=24 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: THRB [Title/Abstract] AND LMCD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A0CW-01A | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000396671 | ENST00000157600 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| In-frame | ENST00000396671 | ENST00000535732 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| 5CDS-intron | ENST00000396671 | ENST00000454244 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| 5CDS-5UTR | ENST00000396671 | ENST00000397386 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| In-frame | ENST00000356447 | ENST00000157600 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| In-frame | ENST00000356447 | ENST00000535732 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| 5CDS-intron | ENST00000356447 | ENST00000454244 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| 5CDS-5UTR | ENST00000356447 | ENST00000397386 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| Frame-shift | ENST00000416420 | ENST00000157600 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| Frame-shift | ENST00000416420 | ENST00000535732 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| 5CDS-intron | ENST00000416420 | ENST00000454244 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| 5CDS-5UTR | ENST00000416420 | ENST00000397386 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| In-frame | ENST00000280696 | ENST00000157600 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| In-frame | ENST00000280696 | ENST00000535732 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| 5CDS-intron | ENST00000280696 | ENST00000454244 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
| 5CDS-5UTR | ENST00000280696 | ENST00000397386 | THRB | chr3 | 24184992 | - | LMCD1 | chr3 | 8574423 | + |
Top |
FusionProtFeatures for THRB_LMCD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| THRB | LMCD1 |
| Nuclear hormone receptor that can act as a repressor oractivator of transcription. High affinity receptor for thyroidhormones, including triiodothyronine and thyroxine.{ECO:0000269|PubMed:12699376, ECO:0000269|PubMed:14673100,ECO:0000269|PubMed:16781732, ECO:0000269|PubMed:17418816,ECO:0000269|PubMed:18237438, ECO:0000269|PubMed:18798561,ECO:0000269|PubMed:19926848}. | Transcriptional cofactor that restricts GATA6 functionby inhibiting DNA-binding, resulting in repression of GATA6transcriptional activation of downstream target genes. RepressesGATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to thecTNC promoter (By similarity). Plays a critical role in thedevelopment of cardiac hypertrophy via activation ofcalcineurin/nuclear factor of activated T-cells signaling pathway.{ECO:0000250, ECO:0000269|PubMed:20026769}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000280696 | - | 4 | 7 | 107_181 | 261 | 477 | DNA binding | Nuclear receptor |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000356447 | - | 7 | 10 | 107_181 | 246 | 462 | DNA binding | Nuclear receptor |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000396671 | - | 8 | 11 | 107_181 | 246 | 462 | DNA binding | Nuclear receptor |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000416420 | - | 9 | 12 | 107_181 | 246 | 462 | DNA binding | Nuclear receptor |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000280696 | - | 4 | 7 | 1_106 | 261 | 477 | Region | Note=Modulating |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000356447 | - | 7 | 10 | 1_106 | 246 | 462 | Region | Note=Modulating |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000396671 | - | 8 | 11 | 1_106 | 246 | 462 | Region | Note=Modulating |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000416420 | - | 9 | 12 | 1_106 | 246 | 462 | Region | Note=Modulating |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000280696 | - | 4 | 7 | 107_127 | 261 | 477 | Zinc finger | NR C4-type |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000280696 | - | 4 | 7 | 145_169 | 261 | 477 | Zinc finger | NR C4-type |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000356447 | - | 7 | 10 | 107_127 | 246 | 462 | Zinc finger | NR C4-type |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000356447 | - | 7 | 10 | 145_169 | 246 | 462 | Zinc finger | NR C4-type |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000396671 | - | 8 | 11 | 107_127 | 246 | 462 | Zinc finger | NR C4-type |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000396671 | - | 8 | 11 | 145_169 | 246 | 462 | Zinc finger | NR C4-type |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000416420 | - | 9 | 12 | 107_127 | 246 | 462 | Zinc finger | NR C4-type |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000416420 | - | 9 | 12 | 145_169 | 246 | 462 | Zinc finger | NR C4-type |
| Tgene | >LMCD1 | chr3:24184992 | chr3:8574423 | ENST00000157600 | + | 0 | 6 | 28_58 | 14 | 366 | Compositional bias | Note=Cys-rich |
| Tgene | >LMCD1 | chr3:24184992 | chr3:8574423 | ENST00000157600 | + | 0 | 6 | 241_306 | 14 | 366 | Domain | LIM zinc-binding 1 |
| Tgene | >LMCD1 | chr3:24184992 | chr3:8574423 | ENST00000157600 | + | 0 | 6 | 307_365 | 14 | 366 | Domain | LIM zinc-binding 2 |
| Tgene | >LMCD1 | chr3:24184992 | chr3:8574423 | ENST00000157600 | + | 0 | 6 | 99_206 | 14 | 366 | Domain | PET |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >THRB | chr3:24184992 | chr3:8574423 | ENST00000280696 | - | 4 | 7 | 217_461 | 261 | 477 | Domain | NR LBD |
| Hgene | >THRB | chr3:24184992 | chr3:8574423 | ENST00000356447 | - | 7 | 10 | 217_461 | 246 | 462 | Domain | NR LBD |
| Hgene | >THRB | chr3:24184992 | chr3:8574423 | ENST00000396671 | - | 8 | 11 | 217_461 | 246 | 462 | Domain | NR LBD |
| Hgene | >THRB | chr3:24184992 | chr3:8574423 | ENST00000416420 | - | 9 | 12 | 217_461 | 246 | 462 | Domain | NR LBD |
Top |
FusionGeneSequence for THRB_LMCD1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_THRB_ENST00000396671_chr3_24184992_-_LMCD1_ENST00000157600_chr3_8574423_+_352aa MSLGQLQSARGVACLGCKGTCSGFEPHSWRKICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNP IATGKDPTFDTITYEWAPPGVTQKLGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEAL GVGEVALPGQGGLPKEEGKQQEKPEGAETTAATTNGSLSDPSKEVEYVCELCKGAAPPDSPVVYSDRAGYNKQWHPTCFVCAKCSEPLVD >In-frame_THRB_ENST00000396671_chr3_24184992_-_LMCD1_ENST00000535732_chr3_8574423_+_234aa MSLGQLQSARGVACLGCKGTCSGFEPHSWRKICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNP IATGKDPTFDTITYEWAPPGVTQKLGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEAL >In-frame_THRB_ENST00000356447_chr3_24184992_-_LMCD1_ENST00000157600_chr3_8574423_+_598aa MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEE KKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLMSLGQLQSARGVACLGCKGTCSGF EPHSWRKICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEWAPPGVTQK LGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEALGVGEVALPGQGGLPKEEGKQQEKP EGAETTAATTNGSLSDPSKEVEYVCELCKGAAPPDSPVVYSDRAGYNKQWHPTCFVCAKCSEPLVDLIYFWKDGAPWCGRHYCESLRPRC >In-frame_THRB_ENST00000356447_chr3_24184992_-_LMCD1_ENST00000535732_chr3_8574423_+_480aa MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEE KKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLMSLGQLQSARGVACLGCKGTCSGF EPHSWRKICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEWAPPGVTQK LGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEALGVGEVALPGQGGLPKEEGKQQEKP >In-frame_THRB_ENST00000280696_chr3_24184992_-_LMCD1_ENST00000157600_chr3_8574423_+_613aa MNYCMQEIYEVHPAAGSNCYMQSTDYYAYFEDSPGYSGCDAQAVPSNNIYMEQAWAVNQPYTCSYPGNMFKSKDSDLDMALNQYSQPEYF TEEKPTFSQVQSPSYSQKKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLMSLGQLQSA RGVACLGCKGTCSGFEPHSWRKICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTF DTITYEWAPPGVTQKLGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEALGVGEVALPG QGGLPKEEGKQQEKPEGAETTAATTNGSLSDPSKEVEYVCELCKGAAPPDSPVVYSDRAGYNKQWHPTCFVCAKCSEPLVDLIYFWKDGA >In-frame_THRB_ENST00000280696_chr3_24184992_-_LMCD1_ENST00000535732_chr3_8574423_+_495aa MNYCMQEIYEVHPAAGSNCYMQSTDYYAYFEDSPGYSGCDAQAVPSNNIYMEQAWAVNQPYTCSYPGNMFKSKDSDLDMALNQYSQPEYF TEEKPTFSQVQSPSYSQKKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLMSLGQLQSA RGVACLGCKGTCSGFEPHSWRKICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTF DTITYEWAPPGVTQKLGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEALGVGEVALPG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_THRB_ENST00000396671_chr3_24184992_-_LMCD1_ENST00000157600_chr3_8574423_+_1056nt ATGTCCCTGGGCCAGCTGCAGTCAGCAAGAGGTGTGGCATGTTTGGGATGCAAGGGGACGTGTTCGGGCTTCGAGCCACATTCATGGAGG AAAATATGCAAGTCTTGCAAATGCAGCCAAGAGGACCACTGCCTAACATCTGACCTAGAAGACGATCGGAAAATTGGCCGCTTGCTGATG GACTCCAAGTATTCCACCCTCACTGCTCGGGTGAAAGGCGGGGACGGCATCCGGATTTACAAGAGGAACCGGATGATCATGACCAACCCT ATTGCTACTGGGAAAGATCCCACTTTTGACACCATCACCTACGAGTGGGCTCCCCCTGGAGTCACCCAGAAACTGGGACTGCAGTACATG GAGCTCATCCCCAAGGAGAAGCAGCCAGTGACAGGCACAGAGGGTGCCTTTTACCGCCGCCGCCAGCTCATGCACCAGCTCCCCATCTAT GACCAGGATCCCTCGCGCTGCCGTGGACTTTTGGAGAATGAGTTGAAACTGATGGAAGAATTTGTCAAGCAATATAAGAGCGAGGCCCTC GGCGTGGGAGAAGTGGCCCTCCCGGGGCAGGGTGGCTTGCCCAAGGAGGAGGGGAAGCAGCAGGAAAAGCCAGAGGGGGCAGAGACCACT GCTGCTACCACCAACGGCAGTCTCAGTGACCCGTCCAAAGAAGTGGAATACGTCTGCGAGCTCTGCAAGGGAGCGGCCCCTCCTGACAGC CCCGTGGTCTACTCGGACAGGGCAGGCTACAACAAGCAGTGGCACCCCACCTGCTTTGTGTGTGCCAAGTGCTCCGAGCCGCTGGTGGAC CTCATCTACTTCTGGAAGGATGGTGCACCCTGGTGCGGCCGCCATTACTGCGAGAGTCTGCGGCCCCGGTGCTCCGGCTGCGATGAGATA ATATTCGCTGAGGACTACCAGCGTGTGGAAGATCTGGCCTGGCACCGAAAGCACTTTGTCTGTGAGGGTTGTGAGCAGCTGCTGAGCGGC >In-frame_THRB_ENST00000396671_chr3_24184992_-_LMCD1_ENST00000535732_chr3_8574423_+_702nt ATGTCCCTGGGCCAGCTGCAGTCAGCAAGAGGTGTGGCATGTTTGGGATGCAAGGGGACGTGTTCGGGCTTCGAGCCACATTCATGGAGG AAAATATGCAAGTCTTGCAAATGCAGCCAAGAGGACCACTGCCTAACATCTGACCTAGAAGACGATCGGAAAATTGGCCGCTTGCTGATG GACTCCAAGTATTCCACCCTCACTGCTCGGGTGAAAGGCGGGGACGGCATCCGGATTTACAAGAGGAACCGGATGATCATGACCAACCCT ATTGCTACTGGGAAAGATCCCACTTTTGACACCATCACCTACGAGTGGGCTCCCCCTGGAGTCACCCAGAAACTGGGACTGCAGTACATG GAGCTCATCCCCAAGGAGAAGCAGCCAGTGACAGGCACAGAGGGTGCCTTTTACCGCCGCCGCCAGCTCATGCACCAGCTCCCCATCTAT GACCAGGATCCCTCGCGCTGCCGTGGACTTTTGGAGAATGAGTTGAAACTGATGGAAGAATTTGTCAAGCAATATAAGAGCGAGGCCCTC GGCGTGGGAGAAGTGGCCCTCCCGGGGCAGGGTGGCTTGCCCAAGGAGGAGGGGAAGCAGCAGGAAAAGCCAGAGGGGGCAGAGACCACT >In-frame_THRB_ENST00000356447_chr3_24184992_-_LMCD1_ENST00000157600_chr3_8574423_+_1794nt ATGACTCCCAACAGTATGACAGAAAATGGCCTTACAGCCTGGGACAAACCGAAGCACTGTCCAGACCGAGAACACGACTGGAAGCTAGTA GGAATGTCTGAAGCCTGCCTACATAGGAAGAGCCATTCAGAGAGGCGCAGCACGTTGAAAAATGAACAGTCGTCGCCACATCTCATCCAG ACCACTTGGACTAGCTCAATATTCCATCTGGACCATGATGATGTGAACGACCAGAGTGTCTCAAGTGCCCAGACCTTCCAAACGGAGGAG AAGAAATGTAAAGGGTACATCCCCAGTTACTTAGACAAGGACGAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGC TGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACCATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAA TGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGTCGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTG GATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAGAACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCAC AAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACTGTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAG CAAAAACGGAAATTCCTGATGTCCCTGGGCCAGCTGCAGTCAGCAAGAGGTGTGGCATGTTTGGGATGCAAGGGGACGTGTTCGGGCTTC GAGCCACATTCATGGAGGAAAATATGCAAGTCTTGCAAATGCAGCCAAGAGGACCACTGCCTAACATCTGACCTAGAAGACGATCGGAAA ATTGGCCGCTTGCTGATGGACTCCAAGTATTCCACCCTCACTGCTCGGGTGAAAGGCGGGGACGGCATCCGGATTTACAAGAGGAACCGG ATGATCATGACCAACCCTATTGCTACTGGGAAAGATCCCACTTTTGACACCATCACCTACGAGTGGGCTCCCCCTGGAGTCACCCAGAAA CTGGGACTGCAGTACATGGAGCTCATCCCCAAGGAGAAGCAGCCAGTGACAGGCACAGAGGGTGCCTTTTACCGCCGCCGCCAGCTCATG CACCAGCTCCCCATCTATGACCAGGATCCCTCGCGCTGCCGTGGACTTTTGGAGAATGAGTTGAAACTGATGGAAGAATTTGTCAAGCAA TATAAGAGCGAGGCCCTCGGCGTGGGAGAAGTGGCCCTCCCGGGGCAGGGTGGCTTGCCCAAGGAGGAGGGGAAGCAGCAGGAAAAGCCA GAGGGGGCAGAGACCACTGCTGCTACCACCAACGGCAGTCTCAGTGACCCGTCCAAAGAAGTGGAATACGTCTGCGAGCTCTGCAAGGGA GCGGCCCCTCCTGACAGCCCCGTGGTCTACTCGGACAGGGCAGGCTACAACAAGCAGTGGCACCCCACCTGCTTTGTGTGTGCCAAGTGC TCCGAGCCGCTGGTGGACCTCATCTACTTCTGGAAGGATGGTGCACCCTGGTGCGGCCGCCATTACTGCGAGAGTCTGCGGCCCCGGTGC TCCGGCTGCGATGAGATAATATTCGCTGAGGACTACCAGCGTGTGGAAGATCTGGCCTGGCACCGAAAGCACTTTGTCTGTGAGGGTTGT >In-frame_THRB_ENST00000356447_chr3_24184992_-_LMCD1_ENST00000535732_chr3_8574423_+_1440nt ATGACTCCCAACAGTATGACAGAAAATGGCCTTACAGCCTGGGACAAACCGAAGCACTGTCCAGACCGAGAACACGACTGGAAGCTAGTA GGAATGTCTGAAGCCTGCCTACATAGGAAGAGCCATTCAGAGAGGCGCAGCACGTTGAAAAATGAACAGTCGTCGCCACATCTCATCCAG ACCACTTGGACTAGCTCAATATTCCATCTGGACCATGATGATGTGAACGACCAGAGTGTCTCAAGTGCCCAGACCTTCCAAACGGAGGAG AAGAAATGTAAAGGGTACATCCCCAGTTACTTAGACAAGGACGAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGC TGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACCATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAA TGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGTCGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTG GATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAGAACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCAC AAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACTGTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAG CAAAAACGGAAATTCCTGATGTCCCTGGGCCAGCTGCAGTCAGCAAGAGGTGTGGCATGTTTGGGATGCAAGGGGACGTGTTCGGGCTTC GAGCCACATTCATGGAGGAAAATATGCAAGTCTTGCAAATGCAGCCAAGAGGACCACTGCCTAACATCTGACCTAGAAGACGATCGGAAA ATTGGCCGCTTGCTGATGGACTCCAAGTATTCCACCCTCACTGCTCGGGTGAAAGGCGGGGACGGCATCCGGATTTACAAGAGGAACCGG ATGATCATGACCAACCCTATTGCTACTGGGAAAGATCCCACTTTTGACACCATCACCTACGAGTGGGCTCCCCCTGGAGTCACCCAGAAA CTGGGACTGCAGTACATGGAGCTCATCCCCAAGGAGAAGCAGCCAGTGACAGGCACAGAGGGTGCCTTTTACCGCCGCCGCCAGCTCATG CACCAGCTCCCCATCTATGACCAGGATCCCTCGCGCTGCCGTGGACTTTTGGAGAATGAGTTGAAACTGATGGAAGAATTTGTCAAGCAA TATAAGAGCGAGGCCCTCGGCGTGGGAGAAGTGGCCCTCCCGGGGCAGGGTGGCTTGCCCAAGGAGGAGGGGAAGCAGCAGGAAAAGCCA GAGGGGGCAGAGACCACTGCTGCTACCACCAACGGCAGTCTCAGTGACCCGTCCAAAGAAGTGGAATACAAGCCAGTCCCACTCGTGTGA >In-frame_THRB_ENST00000280696_chr3_24184992_-_LMCD1_ENST00000157600_chr3_8574423_+_1839nt ATGAACTACTGTATGCAAGAAATATATGAAGTGCACCCAGCTGCCGGCAGCAATTGCTACATGCAGTCCACTGATTATTACGCGTATTTT GAAGATAGTCCGGGTTACAGCGGTTGCGATGCTCAGGCTGTGCCCAGTAACAACATATATATGGAACAGGCCTGGGCAGTGAATCAGCCT TATACCTGTAGTTACCCTGGAAACATGTTTAAAAGCAAGGACTCTGACTTGGACATGGCCCTGAATCAATACAGCCAACCTGAATATTTC ACTGAAGAAAAGCCTACTTTTTCTCAAGTGCAGTCGCCATCGTATTCTCAAAAAAAAGGGTACATCCCCAGTTACTTAGACAAGGACGAG CTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACCATT CAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGTCGC TTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAGAAC CGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACTGTC ACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGATGTCCCTGGGCCAGCTGCAGTCAGCA AGAGGTGTGGCATGTTTGGGATGCAAGGGGACGTGTTCGGGCTTCGAGCCACATTCATGGAGGAAAATATGCAAGTCTTGCAAATGCAGC CAAGAGGACCACTGCCTAACATCTGACCTAGAAGACGATCGGAAAATTGGCCGCTTGCTGATGGACTCCAAGTATTCCACCCTCACTGCT CGGGTGAAAGGCGGGGACGGCATCCGGATTTACAAGAGGAACCGGATGATCATGACCAACCCTATTGCTACTGGGAAAGATCCCACTTTT GACACCATCACCTACGAGTGGGCTCCCCCTGGAGTCACCCAGAAACTGGGACTGCAGTACATGGAGCTCATCCCCAAGGAGAAGCAGCCA GTGACAGGCACAGAGGGTGCCTTTTACCGCCGCCGCCAGCTCATGCACCAGCTCCCCATCTATGACCAGGATCCCTCGCGCTGCCGTGGA CTTTTGGAGAATGAGTTGAAACTGATGGAAGAATTTGTCAAGCAATATAAGAGCGAGGCCCTCGGCGTGGGAGAAGTGGCCCTCCCGGGG CAGGGTGGCTTGCCCAAGGAGGAGGGGAAGCAGCAGGAAAAGCCAGAGGGGGCAGAGACCACTGCTGCTACCACCAACGGCAGTCTCAGT GACCCGTCCAAAGAAGTGGAATACGTCTGCGAGCTCTGCAAGGGAGCGGCCCCTCCTGACAGCCCCGTGGTCTACTCGGACAGGGCAGGC TACAACAAGCAGTGGCACCCCACCTGCTTTGTGTGTGCCAAGTGCTCCGAGCCGCTGGTGGACCTCATCTACTTCTGGAAGGATGGTGCA CCCTGGTGCGGCCGCCATTACTGCGAGAGTCTGCGGCCCCGGTGCTCCGGCTGCGATGAGATAATATTCGCTGAGGACTACCAGCGTGTG GAAGATCTGGCCTGGCACCGAAAGCACTTTGTCTGTGAGGGTTGTGAGCAGCTGCTGAGCGGCCGGGCGTACATCGTCACCAAGGGTCAG >In-frame_THRB_ENST00000280696_chr3_24184992_-_LMCD1_ENST00000535732_chr3_8574423_+_1485nt ATGAACTACTGTATGCAAGAAATATATGAAGTGCACCCAGCTGCCGGCAGCAATTGCTACATGCAGTCCACTGATTATTACGCGTATTTT GAAGATAGTCCGGGTTACAGCGGTTGCGATGCTCAGGCTGTGCCCAGTAACAACATATATATGGAACAGGCCTGGGCAGTGAATCAGCCT TATACCTGTAGTTACCCTGGAAACATGTTTAAAAGCAAGGACTCTGACTTGGACATGGCCCTGAATCAATACAGCCAACCTGAATATTTC ACTGAAGAAAAGCCTACTTTTTCTCAAGTGCAGTCGCCATCGTATTCTCAAAAAAAAGGGTACATCCCCAGTTACTTAGACAAGGACGAG CTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACCATT CAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGTCGC TTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAGAAC CGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACTGTC ACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGATGTCCCTGGGCCAGCTGCAGTCAGCA AGAGGTGTGGCATGTTTGGGATGCAAGGGGACGTGTTCGGGCTTCGAGCCACATTCATGGAGGAAAATATGCAAGTCTTGCAAATGCAGC CAAGAGGACCACTGCCTAACATCTGACCTAGAAGACGATCGGAAAATTGGCCGCTTGCTGATGGACTCCAAGTATTCCACCCTCACTGCT CGGGTGAAAGGCGGGGACGGCATCCGGATTTACAAGAGGAACCGGATGATCATGACCAACCCTATTGCTACTGGGAAAGATCCCACTTTT GACACCATCACCTACGAGTGGGCTCCCCCTGGAGTCACCCAGAAACTGGGACTGCAGTACATGGAGCTCATCCCCAAGGAGAAGCAGCCA GTGACAGGCACAGAGGGTGCCTTTTACCGCCGCCGCCAGCTCATGCACCAGCTCCCCATCTATGACCAGGATCCCTCGCGCTGCCGTGGA CTTTTGGAGAATGAGTTGAAACTGATGGAAGAATTTGTCAAGCAATATAAGAGCGAGGCCCTCGGCGTGGGAGAAGTGGCCCTCCCGGGG CAGGGTGGCTTGCCCAAGGAGGAGGGGAAGCAGCAGGAAAAGCCAGAGGGGGCAGAGACCACTGCTGCTACCACCAACGGCAGTCTCAGT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_THRB_ENST00000396671_chr3_24184992_-_LMCD1_ENST00000157600_chr3_8574423_+_2664nt AGACCTCCTGCTCCGCGGGCTCGGGGCAAGAGCCCGCAGGCTACCTTCCCCGGGCAGGGGCGCTCAACCCAACCGGCTCCAGGGCACTGA TCTGCGATTTCCTTCTGGTTGGCTGTCCTGCGTGGGTGCCAAGTTCCACACATGATTTAATGAATAAGAAGCTCGCCAGAGAGGCAAACT CCAGCATTTTATATTTCATCTGCCCCCAGTGACTTCACTGTAGGAAGAGGAAATGCAGAAAAACAAACGTCTTGAAGACTGAAAGCCTGT TATTCAAAGAGGTTAGCAGTAGACTGTTGGAAGTAAGGAGATGTCAGTGAAAAAAGGGATCCAGAATGATTACTAACCTATGACTCCCAA CAGTATGACAGAAAATGGCCTTACAGCCTGGGACAAACCGAAGCACTGTCCAGACCGAGAACACGACTGGAAGCTAGTAGGAATGTCTGA AGCCTGCCTACATAGGAAGAGCCATTCAGAGAGGCGCAGCACGTTGAAAAATGAACAGTCGTCGCCACATCTCATCCAGACCACTTGGAC TAGCTCAATATTCCATCTGGACCATGATGATGTGAACGACCAGAGTGTCTCAAGTGCCCAGACCTTCCAAACGGAGGAGAAGAAATGTAA AGGGTACATCCCCAGTTACTTAGACAAGGACGAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTG TGAAGGCTGCAAGGGTTTCTTTAGAAGAACCATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGA CAAAGTCACGCGAAATCAGTGCCAGGAATGTCGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAA GAGGCTGGCCAAGAGGAAGCTGATAGAGGAGAACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCC CACAGACGAGGAATGGGAGCTCATCAAAACTGTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAA ATTCCTGATGTCCCTGGGCCAGCTGCAGTCAGCAAGAGGTGTGGCATGTTTGGGATGCAAGGGGACGTGTTCGGGCTTCGAGCCACATTC ATGGAGGAAAATATGCAAGTCTTGCAAATGCAGCCAAGAGGACCACTGCCTAACATCTGACCTAGAAGACGATCGGAAAATTGGCCGCTT GCTGATGGACTCCAAGTATTCCACCCTCACTGCTCGGGTGAAAGGCGGGGACGGCATCCGGATTTACAAGAGGAACCGGATGATCATGAC CAACCCTATTGCTACTGGGAAAGATCCCACTTTTGACACCATCACCTACGAGTGGGCTCCCCCTGGAGTCACCCAGAAACTGGGACTGCA GTACATGGAGCTCATCCCCAAGGAGAAGCAGCCAGTGACAGGCACAGAGGGTGCCTTTTACCGCCGCCGCCAGCTCATGCACCAGCTCCC CATCTATGACCAGGATCCCTCGCGCTGCCGTGGACTTTTGGAGAATGAGTTGAAACTGATGGAAGAATTTGTCAAGCAATATAAGAGCGA GGCCCTCGGCGTGGGAGAAGTGGCCCTCCCGGGGCAGGGTGGCTTGCCCAAGGAGGAGGGGAAGCAGCAGGAAAAGCCAGAGGGGGCAGA GACCACTGCTGCTACCACCAACGGCAGTCTCAGTGACCCGTCCAAAGAAGTGGAATACGTCTGCGAGCTCTGCAAGGGAGCGGCCCCTCC TGACAGCCCCGTGGTCTACTCGGACAGGGCAGGCTACAACAAGCAGTGGCACCCCACCTGCTTTGTGTGTGCCAAGTGCTCCGAGCCGCT GGTGGACCTCATCTACTTCTGGAAGGATGGTGCACCCTGGTGCGGCCGCCATTACTGCGAGAGTCTGCGGCCCCGGTGCTCCGGCTGCGA TGAGATAATATTCGCTGAGGACTACCAGCGTGTGGAAGATCTGGCCTGGCACCGAAAGCACTTTGTCTGTGAGGGTTGTGAGCAGCTGCT GAGCGGCCGGGCGTACATCGTCACCAAGGGTCAGCTTCTGTGCCCAACTTGCAGCAAGTCCAAACGCTCCTGAAGGGCTGCCCACCCACA GCCAGAATCCACAGGATCCCACCGAGAAGGAGAGCCAGGTGTGCCGAGACCATCCTAAGGGTCCGATGTGACAGCAAGCAAGTGAAATAA ACAATGATTTGCTTTTCAGTGAGAATATATATATGAGATATATATAGATATATATTCTAGGTTGGGTGGTGGTAGATCCTTGAGGGTCAG TAGTTTCAAAACCAAAAATATTCTAAGAAGTCTTAGGATGGAGTTCCTTTTCTTTCTGTTGTTGTTTCCCAGCTACAACCAACTAAAGAC ACAAATGGCGTTCTGCAAGGGGACTCTGGGAGGAGTTTTCCAGAATGCAATTCCGAGTGAGCAAATCGCATAGCTGTAGAATGTGCGTGC TTTTTTGTGGACACAGGAGCTCCTCCAGGAGCAGGCTGGGATCCCAACTATCGCTTGTTGCCTCTTTTTCAAGTGGAATTTGAATTTTAA >In-frame_THRB_ENST00000396671_chr3_24184992_-_LMCD1_ENST00000535732_chr3_8574423_+_1789nt AGACCTCCTGCTCCGCGGGCTCGGGGCAAGAGCCCGCAGGCTACCTTCCCCGGGCAGGGGCGCTCAACCCAACCGGCTCCAGGGCACTGA TCTGCGATTTCCTTCTGGTTGGCTGTCCTGCGTGGGTGCCAAGTTCCACACATGATTTAATGAATAAGAAGCTCGCCAGAGAGGCAAACT CCAGCATTTTATATTTCATCTGCCCCCAGTGACTTCACTGTAGGAAGAGGAAATGCAGAAAAACAAACGTCTTGAAGACTGAAAGCCTGT TATTCAAAGAGGTTAGCAGTAGACTGTTGGAAGTAAGGAGATGTCAGTGAAAAAAGGGATCCAGAATGATTACTAACCTATGACTCCCAA CAGTATGACAGAAAATGGCCTTACAGCCTGGGACAAACCGAAGCACTGTCCAGACCGAGAACACGACTGGAAGCTAGTAGGAATGTCTGA AGCCTGCCTACATAGGAAGAGCCATTCAGAGAGGCGCAGCACGTTGAAAAATGAACAGTCGTCGCCACATCTCATCCAGACCACTTGGAC TAGCTCAATATTCCATCTGGACCATGATGATGTGAACGACCAGAGTGTCTCAAGTGCCCAGACCTTCCAAACGGAGGAGAAGAAATGTAA AGGGTACATCCCCAGTTACTTAGACAAGGACGAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTG TGAAGGCTGCAAGGGTTTCTTTAGAAGAACCATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGA CAAAGTCACGCGAAATCAGTGCCAGGAATGTCGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAA GAGGCTGGCCAAGAGGAAGCTGATAGAGGAGAACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCC CACAGACGAGGAATGGGAGCTCATCAAAACTGTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAA ATTCCTGATGTCCCTGGGCCAGCTGCAGTCAGCAAGAGGTGTGGCATGTTTGGGATGCAAGGGGACGTGTTCGGGCTTCGAGCCACATTC ATGGAGGAAAATATGCAAGTCTTGCAAATGCAGCCAAGAGGACCACTGCCTAACATCTGACCTAGAAGACGATCGGAAAATTGGCCGCTT GCTGATGGACTCCAAGTATTCCACCCTCACTGCTCGGGTGAAAGGCGGGGACGGCATCCGGATTTACAAGAGGAACCGGATGATCATGAC CAACCCTATTGCTACTGGGAAAGATCCCACTTTTGACACCATCACCTACGAGTGGGCTCCCCCTGGAGTCACCCAGAAACTGGGACTGCA GTACATGGAGCTCATCCCCAAGGAGAAGCAGCCAGTGACAGGCACAGAGGGTGCCTTTTACCGCCGCCGCCAGCTCATGCACCAGCTCCC CATCTATGACCAGGATCCCTCGCGCTGCCGTGGACTTTTGGAGAATGAGTTGAAACTGATGGAAGAATTTGTCAAGCAATATAAGAGCGA GGCCCTCGGCGTGGGAGAAGTGGCCCTCCCGGGGCAGGGTGGCTTGCCCAAGGAGGAGGGGAAGCAGCAGGAAAAGCCAGAGGGGGCAGA >In-frame_THRB_ENST00000356447_chr3_24184992_-_LMCD1_ENST00000157600_chr3_8574423_+_2600nt CGGCGGGGATTAACTTTGCATGAATAATGTGAGTGCGCTTGGAAAAGAGACCTCCTGCTCCGCGGGCTCGGGGCAAGAGCCCGCAGGCTA CCTTCCCCGGGCAGGGGCGCTCAACCCAACCGGCTCCAGGGCACTGGTAATTTGGCTAGAGGACCGCGCGGAGGCAGCGGGATCTGCGAT TTCCTTCTGGTTGGCTGTCCTGCGTGGGTGCCAAGTTCCACACATGATTTAATGAATAAGAAGGAGATGTCAGTGAAAAAAGGGATCCAG AATGATTACTAACCTATGACTCCCAACAGTATGACAGAAAATGGCCTTACAGCCTGGGACAAACCGAAGCACTGTCCAGACCGAGAACAC GACTGGAAGCTAGTAGGAATGTCTGAAGCCTGCCTACATAGGAAGAGCCATTCAGAGAGGCGCAGCACGTTGAAAAATGAACAGTCGTCG CCACATCTCATCCAGACCACTTGGACTAGCTCAATATTCCATCTGGACCATGATGATGTGAACGACCAGAGTGTCTCAAGTGCCCAGACC TTCCAAACGGAGGAGAAGAAATGTAAAGGGTACATCCCCAGTTACTTAGACAAGGACGAGCTCTGTGTAGTGTGTGGTGACAAAGCCACC GGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACCATTCAGAAAAATCTCCATCCATCCTATTCCTGT AAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGTCGCTTTAAGAAATGCATCTATGTTGGCATGGCA ACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAGAACCGGGAGAAAAGACGGCGGGAAGAGCTGCAG AAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACTGTCACCGAAGCCCATGTGGCGACCAACGCCCAA GGCAGCCACTGGAAGCAAAAACGGAAATTCCTGATGTCCCTGGGCCAGCTGCAGTCAGCAAGAGGTGTGGCATGTTTGGGATGCAAGGGG ACGTGTTCGGGCTTCGAGCCACATTCATGGAGGAAAATATGCAAGTCTTGCAAATGCAGCCAAGAGGACCACTGCCTAACATCTGACCTA GAAGACGATCGGAAAATTGGCCGCTTGCTGATGGACTCCAAGTATTCCACCCTCACTGCTCGGGTGAAAGGCGGGGACGGCATCCGGATT TACAAGAGGAACCGGATGATCATGACCAACCCTATTGCTACTGGGAAAGATCCCACTTTTGACACCATCACCTACGAGTGGGCTCCCCCT GGAGTCACCCAGAAACTGGGACTGCAGTACATGGAGCTCATCCCCAAGGAGAAGCAGCCAGTGACAGGCACAGAGGGTGCCTTTTACCGC CGCCGCCAGCTCATGCACCAGCTCCCCATCTATGACCAGGATCCCTCGCGCTGCCGTGGACTTTTGGAGAATGAGTTGAAACTGATGGAA GAATTTGTCAAGCAATATAAGAGCGAGGCCCTCGGCGTGGGAGAAGTGGCCCTCCCGGGGCAGGGTGGCTTGCCCAAGGAGGAGGGGAAG CAGCAGGAAAAGCCAGAGGGGGCAGAGACCACTGCTGCTACCACCAACGGCAGTCTCAGTGACCCGTCCAAAGAAGTGGAATACGTCTGC GAGCTCTGCAAGGGAGCGGCCCCTCCTGACAGCCCCGTGGTCTACTCGGACAGGGCAGGCTACAACAAGCAGTGGCACCCCACCTGCTTT GTGTGTGCCAAGTGCTCCGAGCCGCTGGTGGACCTCATCTACTTCTGGAAGGATGGTGCACCCTGGTGCGGCCGCCATTACTGCGAGAGT CTGCGGCCCCGGTGCTCCGGCTGCGATGAGATAATATTCGCTGAGGACTACCAGCGTGTGGAAGATCTGGCCTGGCACCGAAAGCACTTT GTCTGTGAGGGTTGTGAGCAGCTGCTGAGCGGCCGGGCGTACATCGTCACCAAGGGTCAGCTTCTGTGCCCAACTTGCAGCAAGTCCAAA CGCTCCTGAAGGGCTGCCCACCCACAGCCAGAATCCACAGGATCCCACCGAGAAGGAGAGCCAGGTGTGCCGAGACCATCCTAAGGGTCC GATGTGACAGCAAGCAAGTGAAATAAACAATGATTTGCTTTTCAGTGAGAATATATATATGAGATATATATAGATATATATTCTAGGTTG GGTGGTGGTAGATCCTTGAGGGTCAGTAGTTTCAAAACCAAAAATATTCTAAGAAGTCTTAGGATGGAGTTCCTTTTCTTTCTGTTGTTG TTTCCCAGCTACAACCAACTAAAGACACAAATGGCGTTCTGCAAGGGGACTCTGGGAGGAGTTTTCCAGAATGCAATTCCGAGTGAGCAA ATCGCATAGCTGTAGAATGTGCGTGCTTTTTTGTGGACACAGGAGCTCCTCCAGGAGCAGGCTGGGATCCCAACTATCGCTTGTTGCCTC >In-frame_THRB_ENST00000356447_chr3_24184992_-_LMCD1_ENST00000535732_chr3_8574423_+_1725nt CGGCGGGGATTAACTTTGCATGAATAATGTGAGTGCGCTTGGAAAAGAGACCTCCTGCTCCGCGGGCTCGGGGCAAGAGCCCGCAGGCTA CCTTCCCCGGGCAGGGGCGCTCAACCCAACCGGCTCCAGGGCACTGGTAATTTGGCTAGAGGACCGCGCGGAGGCAGCGGGATCTGCGAT TTCCTTCTGGTTGGCTGTCCTGCGTGGGTGCCAAGTTCCACACATGATTTAATGAATAAGAAGGAGATGTCAGTGAAAAAAGGGATCCAG AATGATTACTAACCTATGACTCCCAACAGTATGACAGAAAATGGCCTTACAGCCTGGGACAAACCGAAGCACTGTCCAGACCGAGAACAC GACTGGAAGCTAGTAGGAATGTCTGAAGCCTGCCTACATAGGAAGAGCCATTCAGAGAGGCGCAGCACGTTGAAAAATGAACAGTCGTCG CCACATCTCATCCAGACCACTTGGACTAGCTCAATATTCCATCTGGACCATGATGATGTGAACGACCAGAGTGTCTCAAGTGCCCAGACC TTCCAAACGGAGGAGAAGAAATGTAAAGGGTACATCCCCAGTTACTTAGACAAGGACGAGCTCTGTGTAGTGTGTGGTGACAAAGCCACC GGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACCATTCAGAAAAATCTCCATCCATCCTATTCCTGT AAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGTCGCTTTAAGAAATGCATCTATGTTGGCATGGCA ACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAGAACCGGGAGAAAAGACGGCGGGAAGAGCTGCAG AAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACTGTCACCGAAGCCCATGTGGCGACCAACGCCCAA GGCAGCCACTGGAAGCAAAAACGGAAATTCCTGATGTCCCTGGGCCAGCTGCAGTCAGCAAGAGGTGTGGCATGTTTGGGATGCAAGGGG ACGTGTTCGGGCTTCGAGCCACATTCATGGAGGAAAATATGCAAGTCTTGCAAATGCAGCCAAGAGGACCACTGCCTAACATCTGACCTA GAAGACGATCGGAAAATTGGCCGCTTGCTGATGGACTCCAAGTATTCCACCCTCACTGCTCGGGTGAAAGGCGGGGACGGCATCCGGATT TACAAGAGGAACCGGATGATCATGACCAACCCTATTGCTACTGGGAAAGATCCCACTTTTGACACCATCACCTACGAGTGGGCTCCCCCT GGAGTCACCCAGAAACTGGGACTGCAGTACATGGAGCTCATCCCCAAGGAGAAGCAGCCAGTGACAGGCACAGAGGGTGCCTTTTACCGC CGCCGCCAGCTCATGCACCAGCTCCCCATCTATGACCAGGATCCCTCGCGCTGCCGTGGACTTTTGGAGAATGAGTTGAAACTGATGGAA GAATTTGTCAAGCAATATAAGAGCGAGGCCCTCGGCGTGGGAGAAGTGGCCCTCCCGGGGCAGGGTGGCTTGCCCAAGGAGGAGGGGAAG CAGCAGGAAAAGCCAGAGGGGGCAGAGACCACTGCTGCTACCACCAACGGCAGTCTCAGTGACCCGTCCAAAGAAGTGGAATACAAGCCA >In-frame_THRB_ENST00000280696_chr3_24184992_-_LMCD1_ENST00000157600_chr3_8574423_+_2601nt CAGAAGAGCTCAAAAGACACCTCGGTCTAAATAGGATTTTAGCACATCAGGTGCTATTACAAAGTAAAGCAGGCTGGGTTGCTGTGTTGG TGGTGGTGTTTATTCATCTTCCCTTCGCGTTTCATGTGTATGTATGTATGCTTCTCTGCGTATATGCCCAGCTCTCAGGGTGTATGGGGC TGGAGAATGCATGCGTAGACTGTGTGTATATGTAAACTAGAAACTGAACCAGGGAAACAAAATGAACTACTGTATGCAAGAAATATATGA AGTGCACCCAGCTGCCGGCAGCAATTGCTACATGCAGTCCACTGATTATTACGCGTATTTTGAAGATAGTCCGGGTTACAGCGGTTGCGA TGCTCAGGCTGTGCCCAGTAACAACATATATATGGAACAGGCCTGGGCAGTGAATCAGCCTTATACCTGTAGTTACCCTGGAAACATGTT TAAAAGCAAGGACTCTGACTTGGACATGGCCCTGAATCAATACAGCCAACCTGAATATTTCACTGAAGAAAAGCCTACTTTTTCTCAAGT GCAGTCGCCATCGTATTCTCAAAAAAAAGGGTACATCCCCAGTTACTTAGACAAGGACGAGCTCTGTGTAGTGTGTGGTGACAAAGCCAC CGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACCATTCAGAAAAATCTCCATCCATCCTATTCCTG TAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGTCGCTTTAAGAAATGCATCTATGTTGGCATGGC AACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAGAACCGGGAGAAAAGACGGCGGGAAGAGCTGCA GAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACTGTCACCGAAGCCCATGTGGCGACCAACGCCCA AGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGATGTCCCTGGGCCAGCTGCAGTCAGCAAGAGGTGTGGCATGTTTGGGATGCAAGGG GACGTGTTCGGGCTTCGAGCCACATTCATGGAGGAAAATATGCAAGTCTTGCAAATGCAGCCAAGAGGACCACTGCCTAACATCTGACCT AGAAGACGATCGGAAAATTGGCCGCTTGCTGATGGACTCCAAGTATTCCACCCTCACTGCTCGGGTGAAAGGCGGGGACGGCATCCGGAT TTACAAGAGGAACCGGATGATCATGACCAACCCTATTGCTACTGGGAAAGATCCCACTTTTGACACCATCACCTACGAGTGGGCTCCCCC TGGAGTCACCCAGAAACTGGGACTGCAGTACATGGAGCTCATCCCCAAGGAGAAGCAGCCAGTGACAGGCACAGAGGGTGCCTTTTACCG CCGCCGCCAGCTCATGCACCAGCTCCCCATCTATGACCAGGATCCCTCGCGCTGCCGTGGACTTTTGGAGAATGAGTTGAAACTGATGGA AGAATTTGTCAAGCAATATAAGAGCGAGGCCCTCGGCGTGGGAGAAGTGGCCCTCCCGGGGCAGGGTGGCTTGCCCAAGGAGGAGGGGAA GCAGCAGGAAAAGCCAGAGGGGGCAGAGACCACTGCTGCTACCACCAACGGCAGTCTCAGTGACCCGTCCAAAGAAGTGGAATACGTCTG CGAGCTCTGCAAGGGAGCGGCCCCTCCTGACAGCCCCGTGGTCTACTCGGACAGGGCAGGCTACAACAAGCAGTGGCACCCCACCTGCTT TGTGTGTGCCAAGTGCTCCGAGCCGCTGGTGGACCTCATCTACTTCTGGAAGGATGGTGCACCCTGGTGCGGCCGCCATTACTGCGAGAG TCTGCGGCCCCGGTGCTCCGGCTGCGATGAGATAATATTCGCTGAGGACTACCAGCGTGTGGAAGATCTGGCCTGGCACCGAAAGCACTT TGTCTGTGAGGGTTGTGAGCAGCTGCTGAGCGGCCGGGCGTACATCGTCACCAAGGGTCAGCTTCTGTGCCCAACTTGCAGCAAGTCCAA ACGCTCCTGAAGGGCTGCCCACCCACAGCCAGAATCCACAGGATCCCACCGAGAAGGAGAGCCAGGTGTGCCGAGACCATCCTAAGGGTC CGATGTGACAGCAAGCAAGTGAAATAAACAATGATTTGCTTTTCAGTGAGAATATATATATGAGATATATATAGATATATATTCTAGGTT GGGTGGTGGTAGATCCTTGAGGGTCAGTAGTTTCAAAACCAAAAATATTCTAAGAAGTCTTAGGATGGAGTTCCTTTTCTTTCTGTTGTT GTTTCCCAGCTACAACCAACTAAAGACACAAATGGCGTTCTGCAAGGGGACTCTGGGAGGAGTTTTCCAGAATGCAATTCCGAGTGAGCA AATCGCATAGCTGTAGAATGTGCGTGCTTTTTTGTGGACACAGGAGCTCCTCCAGGAGCAGGCTGGGATCCCAACTATCGCTTGTTGCCT >In-frame_THRB_ENST00000280696_chr3_24184992_-_LMCD1_ENST00000535732_chr3_8574423_+_1726nt CAGAAGAGCTCAAAAGACACCTCGGTCTAAATAGGATTTTAGCACATCAGGTGCTATTACAAAGTAAAGCAGGCTGGGTTGCTGTGTTGG TGGTGGTGTTTATTCATCTTCCCTTCGCGTTTCATGTGTATGTATGTATGCTTCTCTGCGTATATGCCCAGCTCTCAGGGTGTATGGGGC TGGAGAATGCATGCGTAGACTGTGTGTATATGTAAACTAGAAACTGAACCAGGGAAACAAAATGAACTACTGTATGCAAGAAATATATGA AGTGCACCCAGCTGCCGGCAGCAATTGCTACATGCAGTCCACTGATTATTACGCGTATTTTGAAGATAGTCCGGGTTACAGCGGTTGCGA TGCTCAGGCTGTGCCCAGTAACAACATATATATGGAACAGGCCTGGGCAGTGAATCAGCCTTATACCTGTAGTTACCCTGGAAACATGTT TAAAAGCAAGGACTCTGACTTGGACATGGCCCTGAATCAATACAGCCAACCTGAATATTTCACTGAAGAAAAGCCTACTTTTTCTCAAGT GCAGTCGCCATCGTATTCTCAAAAAAAAGGGTACATCCCCAGTTACTTAGACAAGGACGAGCTCTGTGTAGTGTGTGGTGACAAAGCCAC CGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACCATTCAGAAAAATCTCCATCCATCCTATTCCTG TAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGTCGCTTTAAGAAATGCATCTATGTTGGCATGGC AACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAGAACCGGGAGAAAAGACGGCGGGAAGAGCTGCA GAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACTGTCACCGAAGCCCATGTGGCGACCAACGCCCA AGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGATGTCCCTGGGCCAGCTGCAGTCAGCAAGAGGTGTGGCATGTTTGGGATGCAAGGG GACGTGTTCGGGCTTCGAGCCACATTCATGGAGGAAAATATGCAAGTCTTGCAAATGCAGCCAAGAGGACCACTGCCTAACATCTGACCT AGAAGACGATCGGAAAATTGGCCGCTTGCTGATGGACTCCAAGTATTCCACCCTCACTGCTCGGGTGAAAGGCGGGGACGGCATCCGGAT TTACAAGAGGAACCGGATGATCATGACCAACCCTATTGCTACTGGGAAAGATCCCACTTTTGACACCATCACCTACGAGTGGGCTCCCCC TGGAGTCACCCAGAAACTGGGACTGCAGTACATGGAGCTCATCCCCAAGGAGAAGCAGCCAGTGACAGGCACAGAGGGTGCCTTTTACCG CCGCCGCCAGCTCATGCACCAGCTCCCCATCTATGACCAGGATCCCTCGCGCTGCCGTGGACTTTTGGAGAATGAGTTGAAACTGATGGA AGAATTTGTCAAGCAATATAAGAGCGAGGCCCTCGGCGTGGGAGAAGTGGCCCTCCCGGGGCAGGGTGGCTTGCCCAAGGAGGAGGGGAA GCAGCAGGAAAAGCCAGAGGGGGCAGAGACCACTGCTGCTACCACCAACGGCAGTCTCAGTGACCCGTCCAAAGAAGTGGAATACAAGCC |
Top |
FusionGenePPI for THRB_LMCD1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| THRB | PSMC5, BRD8, NCOA2, NRBF2, NCOA6, RXRA, CCND1, TBL1X, TRIP4, PRMT1, TSG101, TP53, PPARGC1B, PPARGC1A, COPS2, THRB, NCOR2, NCOA1, NR2F6, NCOR1, SRC, LRIF1, PRKDC, SMC1A, PARP1, LIG3, XRCC5, XRCC6, HSPA4, TBL1XR1, HDAC3, GPS2, CAMK2B, NRIP1, HMGN3, NCOA3, RXRG, RXRB, MED21, ROBO4, ANP32A, ATF2, C1D, MMS19, ADAT3, RANBP9, NSD1, UBE2I, ACTA2, ACTBL2, ACTB, PDLIM7, DNM3, NRAS | LMCD1 | IKBKG, PRKAG3, APP, NKX3-1, FBXO25, TRIM63, TRIM55, SCLT1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000280696 | - | 4 | 7 | 244_461 | 261 | 477 | NR2F6 |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000356447 | - | 7 | 10 | 244_461 | 246 | 462 | NR2F6 |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000396671 | - | 8 | 11 | 244_461 | 246 | 462 | NR2F6 |
| Hgene | THRB | chr3:24184992 | chr3:8574423 | ENST00000416420 | - | 9 | 12 | 244_461 | 246 | 462 | NR2F6 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for THRB_LMCD1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | THRB | P10828 | DB00451 | Levothyroxine | Thyroid hormone receptor beta | small molecule | approved |
| Hgene | THRB | P10828 | DB00509 | Dextrothyroxine | Thyroid hormone receptor beta | small molecule | approved|investigational |
| Hgene | THRB | P10828 | DB01118 | Amiodarone | Thyroid hormone receptor beta | small molecule | approved|investigational |
| Hgene | THRB | P10828 | DB00279 | Liothyronine | Thyroid hormone receptor beta | small molecule | approved|vet_approved |
Top |
RelatedDiseases for THRB_LMCD1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | THRB | C2937288 | THYROID HORMONE RESISTANCE, GENERALIZED, AUTOSOMAL DOMINANT | 19 | CTD_human;UNIPROT |
| Hgene | THRB | C1840364 | THYROID HORMONE RESISTANCE, SELECTIVE PITUITARY | 3 | CTD_human;ORPHANET;UNIPROT |
| Hgene | THRB | C2940786 | Thyroid Hormone Resistance Syndrome | 2 | CTD_human;HPO;ORPHANET |
| Hgene | THRB | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
| Hgene | THRB | C0206682 | Follicular thyroid carcinoma | 1 | CTD_human |
| Hgene | THRB | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Tgene | LMCD1 | C0026266 | Mitral Valve Insufficiency | 1 | CTD_human |
| Tgene | LMCD1 | C0026267 | Mitral Valve Prolapse Syndrome | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|