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Fusion gene ID: 38032 |
FusionGeneSummary for THRA_PSMD3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: THRA_PSMD3 | Fusion gene ID: 38032 | Hgene | Tgene | Gene symbol | THRA | PSMD3 | Gene ID | 7067 | 5709 |
| Gene name | thyroid hormone receptor alpha | proteasome 26S subunit, non-ATPase 3 | |
| Synonyms | AR7|CHNG6|EAR7|ERB-T-1|ERBA|ERBA1|NR1A1|THRA1|THRA2|c-ERBA-1 | P58|RPN3|S3|TSTA2 | |
| Cytomap | 17q21.1 | 17q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | thyroid hormone receptor alphaEAR-7ERBA-related 7V-erbA-related protein 7c-erbA-alphanuclear receptor subfamily 1 group A member 1thyroid hormone receptor alpha 1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homo | 26S proteasome non-ATPase regulatory subunit 326S proteasome regulatory subunit RPN326S proteasome regulatory subunit S3proteasome (prosome, macropain) 26S subunit, non-ATPase, 3proteasome subunit p58tissue specific transplantation antigen 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P10827 | O43242 | |
| Ensembl transtripts involved in fusion gene | ENST00000394121, ENST00000264637, ENST00000584985, ENST00000450525, ENST00000546243, | ENST00000264639, ENST00000541736, | |
| Fusion gene scores | * DoF score | 11 X 8 X 9=792 | 10 X 9 X 6=540 |
| # samples | 15 | 11 | |
| ** MAII score | log2(15/792*10)=-2.40053792958373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/540*10)=-2.29545588352617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: THRA [Title/Abstract] AND PSMD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | THRA | GO:0006357 | regulation of transcription by RNA polymerase II | 18052923 |
| Hgene | THRA | GO:0006366 | transcription by RNA polymerase II | 8710870|9653119 |
| Hgene | THRA | GO:0009755 | hormone-mediated signaling pathway | 18052923 |
| Hgene | THRA | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly | 8524305 |
| Hgene | THRA | GO:0045892 | negative regulation of transcription, DNA-templated | 8710870 |
| Hgene | THRA | GO:2000143 | negative regulation of DNA-templated transcription, initiation | 8524305 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-95-7043-01A | THRA | chr17 | 38245586 | + | PSMD3 | chr17 | 38140547 | + |
| TCGA | RV | LUSC | TCGA-85-8479-01A | THRA | chr17 | 38241068 | + | PSMD3 | chr17 | 38142828 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000394121 | ENST00000264639 | THRA | chr17 | 38245586 | + | PSMD3 | chr17 | 38140547 | + |
| 5CDS-intron | ENST00000394121 | ENST00000541736 | THRA | chr17 | 38245586 | + | PSMD3 | chr17 | 38140547 | + |
| Frame-shift | ENST00000264637 | ENST00000264639 | THRA | chr17 | 38245586 | + | PSMD3 | chr17 | 38140547 | + |
| 5CDS-intron | ENST00000264637 | ENST00000541736 | THRA | chr17 | 38245586 | + | PSMD3 | chr17 | 38140547 | + |
| Frame-shift | ENST00000584985 | ENST00000264639 | THRA | chr17 | 38245586 | + | PSMD3 | chr17 | 38140547 | + |
| 5CDS-intron | ENST00000584985 | ENST00000541736 | THRA | chr17 | 38245586 | + | PSMD3 | chr17 | 38140547 | + |
| Frame-shift | ENST00000450525 | ENST00000264639 | THRA | chr17 | 38245586 | + | PSMD3 | chr17 | 38140547 | + |
| 5CDS-intron | ENST00000450525 | ENST00000541736 | THRA | chr17 | 38245586 | + | PSMD3 | chr17 | 38140547 | + |
| In-frame | ENST00000546243 | ENST00000264639 | THRA | chr17 | 38245586 | + | PSMD3 | chr17 | 38140547 | + |
| 5CDS-intron | ENST00000546243 | ENST00000541736 | THRA | chr17 | 38245586 | + | PSMD3 | chr17 | 38140547 | + |
| In-frame | ENST00000394121 | ENST00000264639 | THRA | chr17 | 38241068 | + | PSMD3 | chr17 | 38142828 | + |
| 5CDS-5UTR | ENST00000394121 | ENST00000541736 | THRA | chr17 | 38241068 | + | PSMD3 | chr17 | 38142828 | + |
| In-frame | ENST00000264637 | ENST00000264639 | THRA | chr17 | 38241068 | + | PSMD3 | chr17 | 38142828 | + |
| 5CDS-5UTR | ENST00000264637 | ENST00000541736 | THRA | chr17 | 38241068 | + | PSMD3 | chr17 | 38142828 | + |
| In-frame | ENST00000584985 | ENST00000264639 | THRA | chr17 | 38241068 | + | PSMD3 | chr17 | 38142828 | + |
| 5CDS-5UTR | ENST00000584985 | ENST00000541736 | THRA | chr17 | 38241068 | + | PSMD3 | chr17 | 38142828 | + |
| In-frame | ENST00000450525 | ENST00000264639 | THRA | chr17 | 38241068 | + | PSMD3 | chr17 | 38142828 | + |
| 5CDS-5UTR | ENST00000450525 | ENST00000541736 | THRA | chr17 | 38241068 | + | PSMD3 | chr17 | 38142828 | + |
| In-frame | ENST00000546243 | ENST00000264639 | THRA | chr17 | 38241068 | + | PSMD3 | chr17 | 38142828 | + |
| 5CDS-5UTR | ENST00000546243 | ENST00000541736 | THRA | chr17 | 38241068 | + | PSMD3 | chr17 | 38142828 | + |
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FusionProtFeatures for THRA_PSMD3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| THRA | PSMD3 |
| Isoform Alpha-1: Nuclear hormone receptor that can actas a repressor or activator of transcription. High affinityreceptor for thyroid hormones, including triiodothyronine andthyroxine. {ECO:0000269|PubMed:12699376,ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:18237438,ECO:0000269|PubMed:19926848}. Isoform Alpha-2: Does not bind thyroid hormone andfunctions as a weak dominant negative inhibitor of thyroid hormoneaction. {ECO:0000269|PubMed:8910441}. | Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinatedproteins. This complex plays a key role in the maintenance ofprotein homeostasis by removing misfolded or damaged proteins,which could impair cellular functions, and by removing proteinswhose functions are no longer required. Therefore, the proteasomeparticipates in numerous cellular processes, including cell cycleprogression, apoptosis, or DNA damage repair.{ECO:0000269|PubMed:1317798}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000264637 | + | 6 | 10 | 53_127 | 192 | 491 | DNA binding | Nuclear receptor |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000394121 | + | 6 | 10 | 53_127 | 192 | 491 | DNA binding | Nuclear receptor |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000450525 | + | 6 | 9 | 53_127 | 192 | 411 | DNA binding | Nuclear receptor |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000546243 | + | 6 | 9 | 53_127 | 192 | 411 | DNA binding | Nuclear receptor |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000584985 | + | 6 | 10 | 53_127 | 192 | 452 | DNA binding | Nuclear receptor |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000264637 | + | 6 | 10 | 1_52 | 192 | 491 | Region | Note=Modulating |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000394121 | + | 6 | 10 | 1_52 | 192 | 491 | Region | Note=Modulating |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000450525 | + | 6 | 9 | 1_52 | 192 | 411 | Region | Note=Modulating |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000546243 | + | 6 | 9 | 1_52 | 192 | 411 | Region | Note=Modulating |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000584985 | + | 6 | 10 | 1_52 | 192 | 452 | Region | Note=Modulating |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000264637 | + | 6 | 10 | 53_73 | 192 | 491 | Zinc finger | NR C4-type |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000264637 | + | 6 | 10 | 91_115 | 192 | 491 | Zinc finger | NR C4-type |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000394121 | + | 6 | 10 | 53_73 | 192 | 491 | Zinc finger | NR C4-type |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000394121 | + | 6 | 10 | 91_115 | 192 | 491 | Zinc finger | NR C4-type |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000450525 | + | 6 | 9 | 53_73 | 192 | 411 | Zinc finger | NR C4-type |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000450525 | + | 6 | 9 | 91_115 | 192 | 411 | Zinc finger | NR C4-type |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000546243 | + | 6 | 9 | 53_73 | 192 | 411 | Zinc finger | NR C4-type |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000546243 | + | 6 | 9 | 91_115 | 192 | 411 | Zinc finger | NR C4-type |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000584985 | + | 6 | 10 | 53_73 | 192 | 452 | Zinc finger | NR C4-type |
| Hgene | THRA | chr17:38241068 | chr17:38142828 | ENST00000584985 | + | 6 | 10 | 91_115 | 192 | 452 | Zinc finger | NR C4-type |
| Tgene | >PSMD3 | chr17:38241068 | chr17:38142828 | ENST00000264639 | + | 1 | 12 | 286_465 | 137 | 535 | Domain | PCI |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >THRA | chr17:38241068 | chr17:38142828 | ENST00000264637 | + | 6 | 10 | 163_407 | 192 | 491 | Domain | NR LBD |
| Hgene | >THRA | chr17:38241068 | chr17:38142828 | ENST00000394121 | + | 6 | 10 | 163_407 | 192 | 491 | Domain | NR LBD |
| Hgene | >THRA | chr17:38241068 | chr17:38142828 | ENST00000450525 | + | 6 | 9 | 163_407 | 192 | 411 | Domain | NR LBD |
| Hgene | >THRA | chr17:38241068 | chr17:38142828 | ENST00000546243 | + | 6 | 9 | 163_407 | 192 | 411 | Domain | NR LBD |
| Hgene | >THRA | chr17:38241068 | chr17:38142828 | ENST00000584985 | + | 6 | 10 | 163_407 | 192 | 452 | Domain | NR LBD |
| Tgene | PSMD3 | chr17:38241068 | chr17:38142828 | ENST00000264639 | + | 1 | 12 | 26_32 | 137 | 535 | Compositional bias | Note=Poly-Pro |
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FusionGeneSequence for THRA_PSMD3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_THRA_ENST00000546243_chr17_38245586_+_PSMD3_ENST00000264639_chr17_38140547_+_964aa MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI PHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEVXSLRRPEGVRSWWGGAWREGAELGAEGDPPTPLLSFLSSL DRFSSHTHTRTAQVPPQTSSPGTGQTTELAMERTVWEAGGAVSCSSQDPILSDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHY VLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKRYKEAQKISDDLMQKISTQNRR ALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYY TGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQ FGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTRE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_THRA_ENST00000546243_chr17_38245586_+_PSMD3_ENST00000264639_chr17_38140547_+_2892nt ATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAAC GGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCA ACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCC TGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATG GCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATG ATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCC CAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTG GACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCC GAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAG AGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTT GAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCG GGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATT CCGCACTTCTGGCCCAAGCTGCTGATGAAGGTGACTGACCTCCGCATGATCGGGGCCTGCCACGCCAGCCGCTTCCTCCACATGAAAGTC GAGTGCCCCACCGAACTCTTCCCCCCACTCTTCCTCGAGGTCTTTGAGGATCAGGAAGTCTAAAGCCTCAGGCGGCCAGAGGGTGTGCGG AGCTGGTGGGGAGGAGCCTGGAGAGAAGGGGCAGAGCTGGGGGCTGAGGGAGACCCCCCCACACCCCTTCTCTCCTTCCTCTCGTCCTTG GATAGATTCAGCTCCCACACACACACCCGCACTGCCCAGGTCCCTCCTCAGACCTCCAGCCCTGGGACAGGGCAAACAACTGAACTTGCT ATGGAAAGGACAGTGTGGGAGGCTGGGGGAGCTGTGTCCTGCAGTTCCCAGGACCCCATCCTCTCAGACATCAAGGAGCACGTGAAACAG CTAGAGAAAGCGGTTTCAGGCAAGGAGCCGAGATTCGTGCTGCGGGCCCTGCGGATGCTGCCTTCCACATCACGCCGCCTCAACCACTAT GTTCTGTATAAGGCTGTGCAGGGCTTCTTCACTTCAAATAATGCCACTCGAGACTTTTTGCTCCCCTTCCTGGAAGAGCCCATGGACACA GAGGCTGATTTACAGTTCCGTCCCCGCACGGGAAAAGCTGCGTCGACACCCCTCCTGCCTGAAGTGGAAGCCTATCTCCAACTCCTCGTG GTCATCTTCATGATGAACAGCAAGCGCTACAAAGAGGCACAGAAGATCTCTGATGATCTGATGCAGAAGATCAGTACTCAGAACCGCCGG GCCCTAGACCTTGTAGCCGCAAAGTGTTACTATTATCACGCCCGGGTCTATGAGTTCCTGGACAAGCTGGATGTGGTGCGCAGCTTCTTG CATGCTCGGCTCCGGACAGCTACGCTTCGGCATGACGCAGACGGGCAGGCCACCCTGTTGAACCTCCTGCTGCGGAATTACCTACACTAC AGCTTGTACGACCAGGCTGAGAAGCTGGTGTCCAAGTCTGTGTTCCCAGAGCAGGCCAACAACAATGAGTGGGCCAGGTACCTCTACTAC ACAGGGCGAATCAAAGCCATCCAGCTGGAGTACTCAGAGGCCCGGAGAACGATGACCAACGCCCTTCGCAAGGCCCCTCAGCACACAGCT GTCGGCTTCAAACAGACGGTGCACAAGCTTCTCATCGTGGTGGAGCTGTTGCTGGGGGAGATCCCTGACCGGCTGCAGTTCCGCCAGCCC TCCCTCAAGCGCTCACTCATGCCCTATTTCCTTCTGACTCAAGCTGTCAGGACAGGAAACCTAGCCAAGTTCAACCAGGTCCTGGATCAG TTTGGGGAGAAGTTTCAAGCAGATGGGACCTACACCCTAATTATCCGGCTGCGGCACAACGTGATTAAGACAGGTGTACGCATGATCAGC CTCTCCTATTCCCGAATCTCCTTGGCTGACATCGCCCAGAAGCTGCAGTTGGATAGCCCCGAAGATGCAGAGTTCATTGTTGCCAAGGCC ATCCGGGATGGTGTCATTGAGGCCAGCATCAACCACGAGAAGGGCTATGTCCAATCCAAGGAGATGATTGACATCTATTCCACCCGAGAG CCCCAGCTAGCCTTCCACCAGCGCATCTCCTTCTGCCTAGATATCCACAACATGTCTGTCAAGGCCATGAGGTTTCCTCCCAAATCGTAC AACAAGGACTTGGAGTCTGCAGAGGAACGGCGTGAGCGAGAACAGCAGGACTTGGAGTTTGCCAAGGAGATGGCAGAAGATGATGATGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_THRA_ENST00000546243_chr17_38245586_+_PSMD3_ENST00000264639_chr17_38140547_+_4121nt GACTGACGGCGCAGCCTCCGGGCCTAGCCACAGCAGCAACGGCAGAGGCCAGCGGGCGAGGTCAAGATGGTGGCTCCGCGGGCGGGGGAG GCAGTGGAGGGAGGAGGAGTCAGACCTTAGCCAGCCGGAAACACCGAAACCCAGAGACCTCCTGGGGAGCCGCCGCCGCCGCCCTCTCGG CCATCGCTGCCTCCGCCGCCTGCTCCACCTCGAGGGACGCGAGCGGGCGGCGGGGCTGGCCGTGAGAGAGACAGGAGAGGAAGGAGGGCA GGGGCGGAGTTGCCCGCCTTAGCCCCCGCCCCCGGCCGCGGCCCCGGGCCCTGCCCCGCGCGGCCCTGCCCGGCCCACCGAGCCCTGGTG TGGCAGCGGCTCATGGCGGCCGTGGGGCCCCCGCAGCAGCAGGTGCGGATGGCCCATCAGCAGGTCTGGGCGGCGCTCGAAGTGGCGCTC CGGGTGCCCTGCCTTTACATCATCGACGCCATCTTCAACTCCTACCCGGATTCCAGCCAAAGCCGGTTCTGCATCGTGCTCCAGATCTTC CTCCGGCTCTTTGGGATCTCTGGACAGGACAAGACTCCGAAGCTACTCCCCCAGCACACAGCCCGGGACCCACAAACCCAGCTTGCCCCC AGCCCTCCCACCTGCCACTCCCTGGCCCCTCCCACCGCCCGCCCCCCTTGGGGCGCAGGGCATGGTGTGAAAGGCCAAGTGCTGAGGCGG GTATCATGGGTGCTGTGCCCTAGGGCCTGGGTGGCAGGGGGTGGGTGGCCTGTGGGTGTGCCGGGGGGGCCAGTGTGCCCACCCCAGTCT CTTGGCGTGCTGGAGGGCATCCTGGATGGAATTGAAGTGAATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAA CAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAACGGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCT GGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCAACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTT TCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCCTGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTG CCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATGGCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCT GATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATGATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCT GATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCCCAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGG CCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTGGACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCAC CCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCCGAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGA GATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAGAGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCT CAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTTGAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGC TCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCGGGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCT GGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATTCCGCACTTCTGGCCCAAGCTGCTGATGAAGGTGACTGACCTCCGCATGAT CGGGGCCTGCCACGCCAGCCGCTTCCTCCACATGAAAGTCGAGTGCCCCACCGAACTCTTCCCCCCACTCTTCCTCGAGGTCTTTGAGGA TCAGGAAGTCTAAAGCCTCAGGCGGCCAGAGGGTGTGCGGAGCTGGTGGGGAGGAGCCTGGAGAGAAGGGGCAGAGCTGGGGGCTGAGGG AGACCCCCCCACACCCCTTCTCTCCTTCCTCTCGTCCTTGGATAGATTCAGCTCCCACACACACACCCGCACTGCCCAGGTCCCTCCTCA GACCTCCAGCCCTGGGACAGGGCAAACAACTGAACTTGCTATGGAAAGGACAGTGTGGGAGGCTGGGGGAGCTGTGTCCTGCAGTTCCCA GGACCCCATCCTCTCAGACATCAAGGAGCACGTGAAACAGCTAGAGAAAGCGGTTTCAGGCAAGGAGCCGAGATTCGTGCTGCGGGCCCT GCGGATGCTGCCTTCCACATCACGCCGCCTCAACCACTATGTTCTGTATAAGGCTGTGCAGGGCTTCTTCACTTCAAATAATGCCACTCG AGACTTTTTGCTCCCCTTCCTGGAAGAGCCCATGGACACAGAGGCTGATTTACAGTTCCGTCCCCGCACGGGAAAAGCTGCGTCGACACC CCTCCTGCCTGAAGTGGAAGCCTATCTCCAACTCCTCGTGGTCATCTTCATGATGAACAGCAAGCGCTACAAAGAGGCACAGAAGATCTC TGATGATCTGATGCAGAAGATCAGTACTCAGAACCGCCGGGCCCTAGACCTTGTAGCCGCAAAGTGTTACTATTATCACGCCCGGGTCTA TGAGTTCCTGGACAAGCTGGATGTGGTGCGCAGCTTCTTGCATGCTCGGCTCCGGACAGCTACGCTTCGGCATGACGCAGACGGGCAGGC CACCCTGTTGAACCTCCTGCTGCGGAATTACCTACACTACAGCTTGTACGACCAGGCTGAGAAGCTGGTGTCCAAGTCTGTGTTCCCAGA GCAGGCCAACAACAATGAGTGGGCCAGGTACCTCTACTACACAGGGCGAATCAAAGCCATCCAGCTGGAGTACTCAGAGGCCCGGAGAAC GATGACCAACGCCCTTCGCAAGGCCCCTCAGCACACAGCTGTCGGCTTCAAACAGACGGTGCACAAGCTTCTCATCGTGGTGGAGCTGTT GCTGGGGGAGATCCCTGACCGGCTGCAGTTCCGCCAGCCCTCCCTCAAGCGCTCACTCATGCCCTATTTCCTTCTGACTCAAGCTGTCAG GACAGGAAACCTAGCCAAGTTCAACCAGGTCCTGGATCAGTTTGGGGAGAAGTTTCAAGCAGATGGGACCTACACCCTAATTATCCGGCT GCGGCACAACGTGATTAAGACAGGTGTACGCATGATCAGCCTCTCCTATTCCCGAATCTCCTTGGCTGACATCGCCCAGAAGCTGCAGTT GGATAGCCCCGAAGATGCAGAGTTCATTGTTGCCAAGGCCATCCGGGATGGTGTCATTGAGGCCAGCATCAACCACGAGAAGGGCTATGT CCAATCCAAGGAGATGATTGACATCTATTCCACCCGAGAGCCCCAGCTAGCCTTCCACCAGCGCATCTCCTTCTGCCTAGATATCCACAA CATGTCTGTCAAGGCCATGAGGTTTCCTCCCAAATCGTACAACAAGGACTTGGAGTCTGCAGAGGAACGGCGTGAGCGAGAACAGCAGGA CTTGGAGTTTGCCAAGGAGATGGCAGAAGATGATGATGACAGCTTCCCTTGAGCTGGGGGGCTGGGGAGGGGTAGGGGGAATGGGGACAG GCTCTTTCCCCCTTGGGGGTCCCCTGCCCAGGGCACTGTCCCCATTTTCCCACACACAGCTCATATGCTGCATTCGTGCAGGGGGTGGGG GTGCTGGGAGCCAGCCACCCTGACCTCCCCCAGGGCTCCTCCCCAGCCGGTGACTTACTGTACAGCAGGCAGGAGGGTGGGCAGGCAACC TCCCCGGGCAGGGTCCTGGCCAGCAGTGTGGGAGCAGGAGGGGAAGGATAGTTCTGTGTACTCCTTTAGGGAGTGGGGGACTAGAACTGG |
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FusionGenePPI for THRA_PSMD3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| THRA | NCOA6, TDG, CCND1, MEF2A, EP300, YWHAQ, ITGB3BP, POU2F1, DAP3, NR0B2, NRIP1, HR, AKAP13, MED12, MED16, MED6, MED24, CDK8, MED21, TRIM24, COPS2, TRIP11, RXRA, MED1, FUS, HDAC3, NCOR1, ZBTB3, SUV39H1, PARP1, NCOA1, NCOA2, NCOA3, TAF11, TAF7, GRIP1, NCOR2, EMD, PRKDC, SMC1A, LIG3, XRCC5, XRCC6, HSPA4, TBL1XR1, GPS2, TBL1X, CUL1, RGN, SEPP1, CDK7, MED25, ARID5A, GTF2B, C1D, THRA, CLIC1, FOXJ1, BUB3, PTGES3, RANBP9, AMOTL2, L3MBTL3, ENO1, MOV10, NXF1, UBE2I, CEP76, TRIM63, A2ML1, HAL, CST6, MTNR1B | PSMD3 | PAAF1, PSMD13, PSMD6, PSMD10, PTP4A3, C20orf24, WRAP73, TRAF6, PSMD14, PSMD7, UCHL5, USP14, BLM, MYC, HDAC5, UBE3A, SHFM1, RAD23A, TSPYL2, PSMD8, PSMD12, BRCA2, FKBP8, FBXO25, PSMA2, CDK2, PSMC5, PSMC3, PSMC2, PSMD11, PSMD1, PSMD2, PSMD4, PSMC6, PSMC1, PSMC4, PSMA6, PSMA7, PSMB1, PSMB5, PSMA3, PSMB7, PSMA5, PSMB4, PSMB6, PSMA1, PSMB2, PSMB3, PSMA4, PSMA8, SUGT1, PPP2CA, VCAM1, NOS2, ITGA4, PARK2, RNF11, BAG3, FBXO6, ADRM1, KIAA0368, FLNB, FLNC, KCMF1, RPS13, RPS15A, RPS21, RPS28, RPS8, SQSTM1, TXNL1, UBQLN1, STAU1, SPRTN, SNAI2, HUWE1, ZBTB43, CEP44, MOV10, NXF1, CCDC8, AMFR, CCDC74B, CCDC92, PSMB9, RPS6KB2, AMBRA1, CCAR2, GAPDH, GFPT1, HEATR1, MCFD2, MTCH1, NAA15, NAA16, PPIL4, PSMB8, ATP6V0D1, BCAS2, GNAI1, GNAI3, PSME4, SF3A2, PSMD5, PSMD9, SNF8, SPR, STOML2, TMOD3, NTRK1, PLCG2, TMEM14B, AHSA1, CRY1, CRY2, MCM2, MID1, MID2, SNW1, CDC5L, POU5F1, DERL1, ZNF746, UBLCP1, UBC, CYLD, DLD, HSD17B10, CCND2, UBE2A, LBR, BRCA1, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for THRA_PSMD3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | THRA | P10827 | DB00451 | Levothyroxine | Thyroid hormone receptor alpha | small molecule | approved |
| Hgene | THRA | P10827 | DB00509 | Dextrothyroxine | Thyroid hormone receptor alpha | small molecule | approved|investigational |
| Hgene | THRA | P10827 | DB01118 | Amiodarone | Thyroid hormone receptor alpha | small molecule | approved|investigational |
| Hgene | THRA | P10827 | DB00279 | Liothyronine | Thyroid hormone receptor alpha | small molecule | approved|vet_approved |
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RelatedDiseases for THRA_PSMD3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | THRA | C3280817 | HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 6 | 2 | UNIPROT |
| Hgene | THRA | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | THRA | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
| Tgene | PSMD3 | C0019693 | HIV Infections | 1 | CTD_human |
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