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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 38028

FusionGeneSummary for THRA_CDK12

check button Fusion gene summary
Fusion gene informationFusion gene name: THRA_CDK12
Fusion gene ID: 38028
HgeneTgene
Gene symbol

THRA

CDK12

Gene ID

7067

51755

Gene namethyroid hormone receptor alphacyclin dependent kinase 12
SynonymsAR7|CHNG6|EAR7|ERB-T-1|ERBA|ERBA1|NR1A1|THRA1|THRA2|c-ERBA-1CRK7|CRKR|CRKRS
Cytomap

17q21.1

17q12

Type of geneprotein-codingprotein-coding
Descriptionthyroid hormone receptor alphaEAR-7ERBA-related 7V-erbA-related protein 7c-erbA-alphanuclear receptor subfamily 1 group A member 1thyroid hormone receptor alpha 1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homocyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12
Modification date2018052320180523
UniProtAcc

P10827

Q9NYV4

Ensembl transtripts involved in fusion geneENST00000394121, ENST00000264637, 
ENST00000584985, ENST00000450525, 
ENST00000546243, 
ENST00000430627, 
ENST00000447079, ENST00000559545, 
Fusion gene scores* DoF score11 X 8 X 9=79227 X 15 X 12=4860
# samples 1531
** MAII scorelog2(15/792*10)=-2.40053792958373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(31/4860*10)=-3.97061619321891
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: THRA [Title/Abstract] AND CDK12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTHRA

GO:0006357

regulation of transcription by RNA polymerase II

18052923

HgeneTHRA

GO:0006366

transcription by RNA polymerase II

8710870|9653119

HgeneTHRA

GO:0009755

hormone-mediated signaling pathway

18052923

HgeneTHRA

GO:0017055

negative regulation of RNA polymerase II transcriptional preinitiation complex assembly

8524305

HgeneTHRA

GO:0045892

negative regulation of transcription, DNA-templated

8710870

HgeneTHRA

GO:2000143

negative regulation of DNA-templated transcription, initiation

8524305

TgeneCDK12

GO:0046777

protein autophosphorylation

11683387


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-8289-01ATHRAchr17

38245586

+CDK12chr17

37686884

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000394121ENST00000430627THRAchr17

38245586

+CDK12chr17

37686884

+
Frame-shiftENST00000394121ENST00000447079THRAchr17

38245586

+CDK12chr17

37686884

+
5CDS-intronENST00000394121ENST00000559545THRAchr17

38245586

+CDK12chr17

37686884

+
In-frameENST00000264637ENST00000430627THRAchr17

38245586

+CDK12chr17

37686884

+
Frame-shiftENST00000264637ENST00000447079THRAchr17

38245586

+CDK12chr17

37686884

+
5CDS-intronENST00000264637ENST00000559545THRAchr17

38245586

+CDK12chr17

37686884

+
In-frameENST00000584985ENST00000430627THRAchr17

38245586

+CDK12chr17

37686884

+
Frame-shiftENST00000584985ENST00000447079THRAchr17

38245586

+CDK12chr17

37686884

+
5CDS-intronENST00000584985ENST00000559545THRAchr17

38245586

+CDK12chr17

37686884

+
In-frameENST00000450525ENST00000430627THRAchr17

38245586

+CDK12chr17

37686884

+
Frame-shiftENST00000450525ENST00000447079THRAchr17

38245586

+CDK12chr17

37686884

+
5CDS-intronENST00000450525ENST00000559545THRAchr17

38245586

+CDK12chr17

37686884

+
Frame-shiftENST00000546243ENST00000430627THRAchr17

38245586

+CDK12chr17

37686884

+
In-frameENST00000546243ENST00000447079THRAchr17

38245586

+CDK12chr17

37686884

+
5CDS-intronENST00000546243ENST00000559545THRAchr17

38245586

+CDK12chr17

37686884

+

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FusionProtFeatures for THRA_CDK12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
THRA

P10827

CDK12

Q9NYV4

Isoform Alpha-1: Nuclear hormone receptor that can actas a repressor or activator of transcription. High affinityreceptor for thyroid hormones, including triiodothyronine andthyroxine. {ECO:0000269|PubMed:12699376,ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:18237438,ECO:0000269|PubMed:19926848}. Isoform Alpha-2: Does not bind thyroid hormone andfunctions as a weak dominant negative inhibitor of thyroid hormoneaction. {ECO:0000269|PubMed:8910441}. Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II(POLR2A), thereby acting as a key regulator of transcriptionelongation. Regulates the expression of genes involved in DNArepair and is required for the maintenance of genomic stability.Preferentially phosphorylates 'Ser-5' in CTD repeats that arealready phosphorylated at 'Ser-7', but can also phosphorylate'Ser-2'. Required for RNA splicing, possibly by phosphorylatingSRSF1/SF2. Involved in regulation of MAP kinase activity, possiblyleading to affect the response to estrogen inhibitors.{ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820,ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619,ECO:0000269|PubMed:24662513}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHRAchr17:38245586chr17:37686884ENST00000264637+91053_127370491DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686884ENST00000394121+91053_127370491DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686884ENST00000584985+91053_127370452DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686884ENST00000264637+9101_52370491RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686884ENST00000394121+9101_52370491RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686884ENST00000584985+9101_52370452RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686884ENST00000264637+91053_73370491Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000264637+91091_115370491Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000394121+91053_73370491Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000394121+91091_115370491Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000584985+91053_73370452Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000584985+91091_115370452Zinc fingerNR C4-type
TgeneCDK12chr17:38245586chr17:37686884ENST00000430627+12141266_128012531482Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38245586chr17:37686884ENST00000447079+0141266_1280-111491Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38245586chr17:37686884ENST00000447079+014407_413-111491Compositional biasNote=Poly-Ala
TgeneCDK12chr17:38245586chr17:37686884ENST00000447079+014535_540-111491Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38245586chr17:37686884ENST00000447079+014727_1020-111491DomainProtein kinase
TgeneCDK12chr17:38245586chr17:37686884ENST00000447079+014733_741-111491Nucleotide bindingNote=ATP
TgeneCDK12chr17:38245586chr17:37686884ENST00000447079+014814_819-111491Nucleotide bindingNote=ATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHRAchr17:38245586chr17:37686884ENST00000450525+1953_127-164411DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686884ENST00000546243+1953_127-134411DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686884ENST00000264637+910163_407370491DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686884ENST00000394121+910163_407370491DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686884ENST00000450525+19163_407-164411DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686884ENST00000546243+19163_407-134411DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686884ENST00000584985+910163_407370452DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686884ENST00000450525+191_52-164411RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686884ENST00000546243+191_52-134411RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686884ENST00000450525+1953_73-164411Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000450525+1991_115-164411Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000546243+1953_73-134411Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000546243+1991_115-134411Zinc fingerNR C4-type
TgeneCDK12chr17:38245586chr17:37686884ENST00000430627+1214407_41312531482Compositional biasNote=Poly-Ala
TgeneCDK12chr17:38245586chr17:37686884ENST00000430627+1214535_54012531482Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38245586chr17:37686884ENST00000430627+1214727_102012531482DomainProtein kinase
TgeneCDK12chr17:38245586chr17:37686884ENST00000430627+1214733_74112531482Nucleotide bindingNote=ATP
TgeneCDK12chr17:38245586chr17:37686884ENST00000430627+1214814_81912531482Nucleotide bindingNote=ATP


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FusionGeneSequence for THRA_CDK12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_THRA_ENST00000394121_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_598aa
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE
SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKRRGPLSPPDLHRRHLHPLWLKAIFPAPPRSXTQPXQPPCCNFYPSLKQSLLATCHMSTRPXDQWSTPPDPVQTGLMETLM
GLKQGSVPLTLMNETLVQPXQNPWSRPWXRTGPSQALXATLGSPAVTRAQGQCSFQGTRTSVLPGSPXRYTRWSGNHSXRLREAAILWYM

>In-frame_THRA_ENST00000264637_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_598aa
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE
SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKRRGPLSPPDLHRRHLHPLWLKAIFPAPPRSXTQPXQPPCCNFYPSLKQSLLATCHMSTRPXDQWSTPPDPVQTGLMETLM
GLKQGSVPLTLMNETLVQPXQNPWSRPWXRTGPSQALXATLGSPAVTRAQGQCSFQGTRTSVLPGSPXRYTRWSGNHSXRLREAAILWYM

>In-frame_THRA_ENST00000584985_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_598aa
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE
SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKRRGPLSPPDLHRRHLHPLWLKAIFPAPPRSXTQPXQPPCCNFYPSLKQSLLATCHMSTRPXDQWSTPPDPVQTGLMETLM
GLKQGSVPLTLMNETLVQPXQNPWSRPWXRTGPSQALXATLGSPAVTRAQGQCSFQGTRTSVLPGSPXRYTRWSGNHSXRLREAAILWYM

>In-frame_THRA_ENST00000450525_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_1696aa
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE
SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEVXSLRRPEGVRSWWGGAWREGAELGAEGDPPTPLLSFLSSL
DRFSSHTHTRTAQVPPQTSSPGTGQTTELAMERTVWEAGGAVSCSSQDPILSEGRGRAGGLRRDKPPXPXGKEECGLGEDALNSPPTHTX
ERAPTQFLGLGLPSRLRASLLPQMPGCKERLGLAPPLEVKIYSHSNCTLETKQGEKTNEEKLDREKNTKKRERAIERDDIKLLTEADQRG
GPPLYHPMHFASCPFFPHIREKCPHTRAPRVGLPIRAVSXHNRVLATPLAIPRPLCPFGTPQPXYVLCFLPLVPAEFHLPLMLDASWPLT
SLPCCPHSSPLSAQPXGPLPIHLLLPHLGTHPGKNCGSNSYPPYILQYXLETGCCCIGWVGGRRAVRERLPEPSTPLALCFPVSHLSSGL
SLTSALLPSSYSLHXLWAGRYQNGGVXISDTXLGPQGRGGRCSFFFKALLASCPSAPGPLPLFFSLIQGLWLEPLSPSWXGCSVGLHLGE
LSSSPSLWLPPTPQGREGERRWSSHGSRRWGGTEQTRGCWAQGCMSAGMDGWTQMPPEAMGIGAGGGGRGARASCALHYWGKNVLSSGEP
ATPPXPSACHSPLHTHTHTHTHTHTHGHAHTDMGRQCYAARQGTVLPQSFRCSNRGGGPGGAPAVTCACACPTLLGPRAARAVFVSILSL
SPGVLNPVLLQSHGXALLYLPTTPGGPVEFLTCLLSSPSLHPHPNPSIPILSHGHGREKALKSLSLLXALGTPPPSPIIXAVIPSSPDPS
LPPRXCGVYVCVPLRECVSEYTWXGRSQGDSGVPRTCSRAAAVPVPAVEVGDRALSWGPLVLMRGMALMWVLSMPPPVLARGTRAGRVEQ
QVQYRWEDGLLGIGRGGQARTRGCQSHDHYPAPTTRLSISVLPLPSLITHIPHPASSLLRLGEGGGGAPTPSPGGGSAGLGEGRALXERD
RPXGGQXLLPWELLGGGEGDTAQRRYXMYEKLVLGWGEGGCGQKQGRRXVSSPGRGGTGRGDLRGSYSCPTLTISMSVMCDFSPRCVLGQ
DFKERYFYGNCCSSILLYIYVINIXXKXRRGPLSPPDLHRRHLHPLWLKAIFPAPPRSXTQPXQPPCCNFYPSLKQSLLATCHMSTRPXD
QWSTPPDPVQTGLMETLMGLKQGSVPLTLMNETLVQPXQNPWSRPWXRTGPSQALXATLGSPAVTRAQGQCSFQGTRTSVLPGSPXRYTR

>In-frame_THRA_ENST00000546243_chr17_38245586_+_CDK12_ENST00000447079_chr17_37686884_+_1779aa
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE
SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEVXSLRRPEGVRSWWGGAWREGAELGAEGDPPTPLLSFLSSL
DRFSSHTHTRTAQVPPQTSSPGTGQTTELAMERTVWEAGGAVSCSSQDPILSAQRLQCPERFLSYPSFHPVLXIFNEIICQSEVIICIWL
LQSCPLYSLLTCYXQATYEIMMLAPVPPGWAIARTFTSTLPXXIQVENMERIITLKSKCFISSLPALTDRKRERTVSVLRWLRRGSLIFK
VLGWGIVCGFFLLNFNLGVLGFFPLKRIVFTKFELLFGFCYKGNRVAWLIXINVSFLSTISHFAFKXTLFPHXASXTYFFSKXITHPXSL
LHFDKRYALLPAHKAGCRTWHSWASRXTLPSLFPFLLMCALSLSFSLSLSLSLSLSLSVSLARSRCFSLFEAFVWKKSLRCPRTWDNSLL
FLKXRKGNSDSYIVLCNSSILKCFVFXTMFXWGSXFVSVDSLDIAAELWLEMMPPFLEGXXQHLAYCLHIYFYVKKKTKTFQTEHCDIVK
EKNKSXRYMEMXPSLGWVFFXRYINTXPFLKKXFXNSILXGRTVLTYPHPSMCTLPVLLGIFPPKRFGFGFGKRGXIVLPGKNFALSXTG
NEKGKGCQDGIIWEASHSGFYFYVSTSIXSVLKTDTCHIIYLHRLRPSGNIGXAPFYKEKVNILQHLGGXFSKLKFHVSMPSSYFKKXNL
LIRERCITXKKKTLKKXKKNPLQILTXRLFSPVNEIXLDIGVCISLLFSGFXSGLASRAKHXFRKRAFXLFWHXWLFIPVCPVRFTRLTD
MLLVNRIKVHLNLLSVDFLVLRHGPLCFRIFEFELLGPTPCFLLKNVSLGYFQKYLFNEKKLVSHQIXIKFSIYFIVFWLSAVINNVFPS
PLPPLIFNYAKYPKXYTXASIPSSLLGKGVSVCVSVCVCMIPSHPHPHFGSLLKXKQSLVVLTISKSRGEKKTYLNILESVWRKKRYLLI
FQLRYLXTXWKXRFGRISPXLFENYRPNXFHSKVVFVLFXLLYNERYCLLNTLFXTDEKSDSVHEWEAKLVXPXSFLWFXKQIYLTQFPX
FFLQLSIGTISIXKQHQIYTFKAGQLAQICKXNFYXLMPXTSPNHLYVCVYIXYAYIVTVLKWLPAGFERECCIRKVSVATSFSLIXVPD
TDSFLSRFXPPLGVSCLCTDILXYIKFFSFSLXKWKVEIGKLNISCYYTTFAPLHLLLNLYPLSISNHVXRTFFLHFILGVLCLRIIIDS
LTPPPSKRLSGFEEVLENARLGTREXMSWEKPXNVIFLKXKSYTNNGTKPSKELSFMYPDSSXQERXVGLSSTVIKGSWXEAVXTQRIVL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_THRA_ENST00000394121_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_1796nt
ATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAAC
GGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCA
ACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCC
TGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATG
GCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATG
ATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCC
CAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTG
GACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCC
GAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAG
AGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTT
GAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCG
GGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATT
CCGCACTTCTGGCCCAAGCTGCTGATGAAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTG
AAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTC
CTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATG
GGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGA
ACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACC
TCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATG
CAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAA

>In-frame_THRA_ENST00000264637_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_1796nt
ATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAAC
GGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCA
ACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCC
TGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATG
GCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATG
ATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCC
CAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTG
GACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCC
GAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAG
AGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTT
GAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCG
GGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATT
CCGCACTTCTGGCCCAAGCTGCTGATGAAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTG
AAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTC
CTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATG
GGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGA
ACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACC
TCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATG
CAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAA

>In-frame_THRA_ENST00000584985_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_1796nt
ATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAAC
GGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCA
ACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCC
TGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATG
GCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATG
ATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCC
CAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTG
GACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCC
GAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAG
AGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTT
GAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCG
GGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATT
CCGCACTTCTGGCCCAAGCTGCTGATGAAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTG
AAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTC
CTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATG
GGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGA
ACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACC
TCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATG
CAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAA

>In-frame_THRA_ENST00000450525_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_5090nt
ATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAAC
GGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCA
ACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCC
TGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATG
GCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATG
ATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCC
CAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTG
GACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCC
GAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAG
AGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTT
GAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCG
GGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATT
CCGCACTTCTGGCCCAAGCTGCTGATGAAGGTGACTGACCTCCGCATGATCGGGGCCTGCCACGCCAGCCGCTTCCTCCACATGAAAGTC
GAGTGCCCCACCGAACTCTTCCCCCCACTCTTCCTCGAGGTCTTTGAGGATCAGGAAGTCTAAAGCCTCAGGCGGCCAGAGGGTGTGCGG
AGCTGGTGGGGAGGAGCCTGGAGAGAAGGGGCAGAGCTGGGGGCTGAGGGAGACCCCCCCACACCCCTTCTCTCCTTCCTCTCGTCCTTG
GATAGATTCAGCTCCCACACACACACCCGCACTGCCCAGGTCCCTCCTCAGACCTCCAGCCCTGGGACAGGGCAAACAACTGAACTTGCT
ATGGAAAGGACAGTGTGGGAGGCTGGGGGAGCTGTGTCCTGCAGTTCCCAGGACCCCATCCTCTCAGAAGGTAGGGGAAGGGCGGGAGGA
TTGAGAAGGGACAAGCCACCTTGACCGTAGGGGAAGGAGGAATGTGGGCTGGGGGAAGATGCCCTCAACTCACCCCCTACACACACATGA
GAGAGAGCCCCCACCCAGTTCCTTGGCCTAGGTCTCCCCTCCAGGCTGAGGGCCTCTCTACTTCCCCAGATGCCTGGGTGCAAAGAACGG
CTTGGCTTGGCTCCTCCTCTGGAGGTTAAAATTTATAGTCATTCTAACTGCACTTTGGAAACCAAGCAAGGGGAGAAGACAAATGAAGAA
AAACTAGACAGAGAGAAAAATACAAAAAAGAGAGAGCGAGCGATAGAGAGAGATGATATTAAGTTATTAACTGAGGCTGACCAGAGGGGA
GGACCCCCCCTTTACCACCCCATGCACTTTGCGAGCTGCCCCTTCTTCCCCCACATCAGAGAGAAATGCCCCCACACCAGAGCCCCAAGG
GTAGGGCTGCCGATCAGAGCTGTGAGTTAACACAACAGGGTCCTGGCCACCCCCCTTGCCATACCCCGCCCTCTGTGCCCCTTTGGCACC
CCCCAACCCTAGTATGTCCTCTGCTTTCTGCCACTCGTGCCCGCTGAGTTCCATCTACCTCTCATGCTGGATGCCAGCTGGCCCCTCACC
AGCCTGCCCTGCTGCCCACACAGCTCCCCTTTAAGTGCCCAGCCCTAGGGGCCTCTCCCCATCCACCTCCTCCTTCCACACCTTGGCACC
CACCCAGGAAAAAACTGTGGCTCCAACTCCTACCCTCCTTATATCCTGCAGTATTAGCTAGAAACCGGATGCTGCTGCATTGGTTGGGTC
GGGGGTAGGAGGGCTGTGCGTGAGCGTCTCCCAGAACCCTCCACCCCTTTAGCACTCTGTTTCCCTGTTTCCCATCTGTCTTCTGGGCTC
TCTCTAACCTCTGCCCTCCTCCCCAGCTCCTACTCACTGCACTAACTCTGGGCGGGCAGGTACCAGAATGGGGGTGTTTAGATAAGTGAC
ACTTAGTTGGGGCCCCAGGGGAGGGGTGGTCGGTGCTCCTTTTTCTTTAAAGCTCTTTTGGCCAGCTGCCCCTCTGCCCCGGGACCCCTT
CCCCTCTTCTTTTCTCTAATTCAGGGACTTTGGCTTGAGCCCCTCTCGCCCTCCTGGTGAGGGTGCTCTGTTGGTCTGCACTTGGGTGAG
CTGTCCTCCTCCCCCTCCCTGTGGCTGCCGCCCACTCCTCAGGGGAGAGAGGGAGAGAGGAGGTGGTCCTCCCATGGGAGCAGGAGGTGG
GGTGGGACAGAGCAGACCAGAGGGTGCTGGGCTCAGGGCTGCATGTCGGCAGGGATGGATGGGTGGACACAGATGCCCCCGGAAGCCATG
GGGATTGGGGCAGGGGGTGGGGGGAGGGGTGCCAGGGCTTCCTGCGCTTTGCACTATTGGGGCAAAAATGTCTTAAGCAGTGGGGAACCT
GCCACCCCACCCTGACCCTCAGCCTGCCACAGCCCCCTACACACACACACACACACACACACACACACACACACACACGGACATGCACAC
ACGGACATGGGAAGGCAATGCTATGCTGCCCGTCAGGGCACTGTCCTTCCCCAATCGTTCAGGTGTTCCAACAGGGGTGGAGGGCCTGGA
GGAGCACCCGCTGTCACCTGTGCATGTGCCTGTCCCACCCTGCTGGGGCCTCGGGCTGCCCGCGCTGTCTTTGTCTCTATCCTCTCTCTC
TCTCCTGGAGTACTGAATCCTGTATTACTCCAGTCCCATGGGTAGGCCCTCTTGTACCTTCCTACCACGCCTGGGGGCCCAGTGGAATTC
CTGACCTGTCTGCTGTCTTCCCCATCCCTCCATCCCCACCCCAACCCCTCCATCCCCATTCTCAGCCATGGACACGGCAGAGAAAAGGCC
TTGAAGAGCCTTAGCCTCTTATAGGCACTTGGGACTCCCCCACCCTCCCCAATCATATGAGCTGTGATCCCATCCTCCCCGGACCCCTCC
CTTCCCCCTCGGTGATGTGGGGTGTATGTGTGCGTTCCTCTGCGTGAATGTGTGAGTGAGTACACATGGTAGGGGAGGAGCCAGGGCGAC
TCAGGAGTGCCACGCACCTGCTCTAGAGCGGCAGCTGTCCCAGTCCCTGCTGTGGAAGTGGGGGACAGGGCCCTCTCCTGGGGGCCATTG
GTGCTAATGAGGGGGATGGCCTTGATGTGGGTGCTCAGCATGCCTCCCCCAGTATTGGCCCGGGGCACTAGGGCAGGCAGGGTGGAGCAG
CAGGTGCAGTATCGGTGGGAGGACGGGTTGCTGGGAATAGGACGAGGGGGCCAGGCCAGGACAAGGGGTTGCCAGAGCCATGACCACTAC
CCCGCCCCCACCACCCGCCTCTCCATCTCAGTATTGCCCCTCCCATCACTCATAACACACATACCTCATCCAGCCTCCTCCCTGCTCAGA
CTTGGGGAGGGTGGGGGAGGAGCCCCTACCCCTTCTCCTGGTGGCGGGTCTGCAGGGCTGGGAGAGGGCAGGGCGTTGTGAGAGAGAGAC
CGTCCATAAGGAGGACAGTAACTCCTGCCCTGGGAACTCCTGGGCGGGGGGGAGGGGGACACTGCCCAGAGGCGCTACTGAATGTATGAG
AAGCTGGTGCTGGGCTGGGGGGAGGGGGGTTGTGGCCAGAAACAGGGAAGGAGGTAGGTCTCTTCCCCAGGGAGGGGTGGGACCGGCAGG
GGTGACTTGAGGGGCTCCTACTCCTGCCCCACGTTGACAATCAGTATGTCTGTTATGTGCGATTTTTCACCCCGTTGTGTTTTGGGTCAG
GATTTTAAAGAAAGATATTTTTATGGTAATTGTTGCTCGTCTATTTTACTATATATTTATGTAATAAATATATGATGAAAATAAAGAAGA
GGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACC
CAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGAC
CAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATG
AACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGG
AGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGG
TGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGC
CAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGC

>In-frame_THRA_ENST00000546243_chr17_38245586_+_CDK12_ENST00000447079_chr17_37686884_+_5337nt
ATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAAC
GGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCA
ACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCC
TGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATG
GCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATG
ATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCC
CAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTG
GACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCC
GAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAG
AGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTT
GAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCG
GGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATT
CCGCACTTCTGGCCCAAGCTGCTGATGAAGGTGACTGACCTCCGCATGATCGGGGCCTGCCACGCCAGCCGCTTCCTCCACATGAAAGTC
GAGTGCCCCACCGAACTCTTCCCCCCACTCTTCCTCGAGGTCTTTGAGGATCAGGAAGTCTAAAGCCTCAGGCGGCCAGAGGGTGTGCGG
AGCTGGTGGGGAGGAGCCTGGAGAGAAGGGGCAGAGCTGGGGGCTGAGGGAGACCCCCCCACACCCCTTCTCTCCTTCCTCTCGTCCTTG
GATAGATTCAGCTCCCACACACACACCCGCACTGCCCAGGTCCCTCCTCAGACCTCCAGCCCTGGGACAGGGCAAACAACTGAACTTGCT
ATGGAAAGGACAGTGTGGGAGGCTGGGGGAGCTGTGTCCTGCAGTTCCCAGGACCCCATCCTCTCAGCCCAGAGACTTCAGTGTCCTGAA
AGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTA
CTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCTGGATGG
GCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAATGTTTT
ATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAA
GTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTC
ACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCCACCATC
TCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAAAGTTTA
CTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCC
AGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCG
CTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCTTTACTT
TTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACCATGTTC
TGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAA
TAACAGCATTTAGCATATTGTTTACACATATATTTTTATGTCAAAAAAAAAACAAAAACCTTTCAAACAGAGCATTGTGATATTGTCAAA
GAGAAAAACAAATCCTGAAGATACATGGAAATGTAACCTAGTTTAGGGTGGGTATTTTTCTGAAGATACATCAATACCTGACCTTTTTTA
AAAAAATAATTTTAAAACAGCATACTGTGAGGAAGAACAGTATTGACATACCCACATCCCAGCATGTGTACCCTGCCAGTTCTTTTAGGG
ATTTTTCCTCCAAAGAGATTTGGATTTGGTTTTGGTAAAAGGGGTTAAATTGTGCTTCCAGGCAAGAACTTTGCCTTATCATAAACAGGA
AATGAAAAAGGGAAGGGCTGTCAGGATGGGATAATTTGGGAGGCTTCTCATTCTGGCTTCTATTTCTATGTGAGTACCAGCATATAGAGT
GTTTTAAAAACAGATACATGTCATATAATTTATCTGCACAGACTTAGACCTTCAGGAAACATAGGTTAAGCCCCCTTTTACAAAGAAAAA
GTAAACATACTTCAGCATCTTGGAGGGTAGTTTTCAAAACTCAAGTTTCATGTTTCAATGCCAAGTTCTTATTTTAAAAAATAAAATCTA
CTTATAAGAGAAAGGTGCATTACTTAAAAAAAAAAAACTTTAAAGAAATGAAAGAAGAACCCTCTTCAGATACTTACTTGAAGACTGTTT
TCCCCTGTTAATGAGATATAGCTAGATATCGGTGTGTGTATTTCTTTATTATTCTCTGGTTTTTGATCTGGCCTTGCCTCCAGGGCCAAA
CACTGATTTAGAAAGAGAGCCTTCTAGCTATTTTGGCATTGATGGCTTTTTATACCAGTGTGTCCAGTTAGATTTACTAGGCTTACTGAC
ATGCTATTGGTAAATCGCATTAAAGTTCATCTGAACCTTCTGTCTGTTGACTTCTTAGTCCTCAGACATGGGCCTTTGTGTTTTAGAATA
TTTGAATTTGAGTTATTGGGCCCCACTCCCTGTTTTTTATTAAAGAACGTGAGCCTGGGATACTTTCAGAAGTATCTGTTCAATGAAAAA
AAGTTGGTTTCCCATCAAATATGAATAAAATTCTCTATATATTTCATTGTATTTTGGTTATCAGCAGTCATCAATAATGTTTTTCCCTCC
CCTCTCCCACCTCTTATTTTTAATTATGCCAAATATCCTAAATAATATACTTAAGCCTCCATTCCCTCATCCCTACTAGGGAAGGGGGTG
AGTGTATGTGTGAGTGTATGTGTATGTATGATCCCATCTCACCCCCACCCCCATTTTGGGAGTCTTTTAAAATGAAAACAAAGTTTGGTA
GTTTTGACTATTTCTAAAAGCAGAGGAGAAAAAAAAACTTATTTAAATATCCTGGAATCTGTATGGAGGAAGAAAAGGTATTTGTTAATT
TTTCAGTTACGTTATCTATAAACATGATGGAAGTAAAGGTTTGGCAGAATTTCACCTTGACTATTTGAAAATTACAGACCCAATTAATTC
CATTCAAAAGTGGTTTTCGTTTTGTTTTAATTATTGTACAATGAGAGATATTGTCTATTAAATACATTATTTTGAACAGATGAGAAATCT
GATTCTGTTCATGAGTGGGAGGCAAAACTGGTTTGACCGTGATCATTTTTGTGGTTTTGAAAACAAATATACTTGACCCAGTTTCCTTAG
TTTTTTCTTCAACTGTCCATAGGAACGATAAGTATTTGAAAGCAACATCAAATCTATACGTTTAAAGCAGGGCAGTTAGCACAAATTTGC
AAGTAGAACTTCTATTAGCTTATGCCATAGACATCACCCAACCACTTGTATGTGTGTGTGTATATATAATATGCATATATAGTTACCGTG
CTAAAATGGTTACCAGCAGGTTTTGAGAGAGAATGCTGCATCAGAAAAGTGTCAGTTGCCACCTCATTCTCCCTGATTTAGGTTCCTGAC
ACTGATTCCTTTCTCTCTCGTTTTTGACCCCCATTGGGTGTATCTTGTCTATGTACAGATATTTTGTAATATATTAAATTTTTTTCTTTC
AGTTTATAAAAATGGAAAGTGGAGATTGGAAAATTAAATATTTCCTGTTACTATACCACTTTTGCTCCATTGCATTTACTTCTTAATCTG
TACCCCCTGAGCATATCTAATCATGTATAAAGGACGTTTTTCCTCCACTTTATCTTAGGGGTTCTCTGTCTCAGAATCATTATAGACTCA
TTAACTCCCCCTCCCAGCAAAAGGTTATCAGGATTTGAAGAGGTGCTTGAAAACGCTAGACTAGGAACTAGAGAATAAATGAGTTGGGAA
AAACCATGAAATGTGATTTTTTTAAAGTAGAAAAGTTATACAAATAATGGTACCAAACCATCAAAAGAGTTGAGCTTCATGTACCCTGAC
TCCTCCTGACAGGAGAGGTAAGTGGGTTTGAGCTCAACTGTCATCAAGGGAAGTTGGTAAGAGGCTGTTTAGACCCAAAGGATAGTCTTA
AACCAGACTTCACCACCCACCCTACCTCAGTTCCCATGTTATTACATGCAGAGTCAGCATGGGGATTAGTGTACCTACCTTTGCTGAGAT
TTCCCGATGCGTTGCCAATCCAGAAAGTGAATCAAAAAGTTGTTTAAAAGTTAAAATCTCTATTGTTTCCAAAATCTTTCCCATCTCCAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_THRA_ENST00000394121_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_3513nt
AGCAGATTGTTGGGGGAAATGGCTGGTGACAGAGAATAGAAAGAGCCTATATGGAGAAGGGTGACGTTGGAAAAGGGAGGCAGTGGATCG
GTATTGATGTTAGAAATGAGAGGGGAGGGAGGTAACAGGGAATGAACCCCCACAAGGATGAAAAACGTAAGATGATTGAAGTTAAAAGGA
CATCAGGGGTCACCTGCCCAGCCCTCGCAGCTGAAGCTTGAGGAAGCTCTGCCCCCGACAGCAGTGGCGATTTGTCAAGGGATCTCTGGA
CAGGACAAGACTCCGAAGCTACTCCCCCAGCACACAGCCCGGGACCCACAAACCCAGCTTGCCCCCAGCCCTCCCACCTGCCACTCCCTG
GCCCCTCCCACCGCCCGCCCCCCTTGGGGCGCAGGGCATGGTGTGAAAGGCCAAGTGCTGAGGCGGGTATCATGGGTGCTGTGCCCTAGG
GCCTGGGTGGCAGGGGGTGGGTGGCCTGTGGGTGTGCCGGGGGGGCCAGTGTGCCCACCCCAGTCTCTTGGCGTGCTGGAGGGCATCCTG
GATGGAATTGAAGTGAATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGGTCACCAGATGGAAA
GCGAAAAAGAAAGAACGGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGT
GTGTGGGGACAAGGCAACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACAATCCAGAAGAACCT
CCATCCCACCTATTCCTGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTG
CATCGCCGTGGGCATGGCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAGAACCGGGAGCGGCG
GCGGAAGGAGGAGATGATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCA
TCGCAGCACCAATGCCCAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCCATTGTCTCCATGCC
GGACGGAGACAAGGTGGACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAA
ACTGCCCATGTTCTCCGAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCCCTGCGGGCGGCTGT
CCGCTACGACCCTGAGAGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGT
CTCCGACGCCATCTTTGAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAGGCTGTGCTGCTAAT
GTCAACAGACCGCTCGGGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCA
CCGCAAACACAACATTCCGCACTTCTGGCCCAAGCTGCTGATGAAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCT
CCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAG
CCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACT
TATGGAAACACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTC
CAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTT
CCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGC
AATTCTGTGGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTT
CACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGA
GTTCCTTACTAACCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCA
TTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACG
AAATAATGATGTTGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATA
TGGAGAGGATCATTACATTGAAAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTAT
TGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTG
TTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGC
TGATTTGAATAAATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACT
TTTTTTCCAAATAAATTACTCATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAA
CGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTC
TCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGT
TGAGATGCCCAAGAACCTGGGATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTT
CAATTCTAAAATGTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGT
GGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAATAACAGCATTTAGCATATTGTTTACACATATATTTTTATGTCAAAAAAAAAACAA

>In-frame_THRA_ENST00000264637_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_3537nt
GAGGCGGCCTGCAGGGAGCAGCCGCGAGCCGGCCGGGCGCGCCGAGCCCGAGCCCCAGCCGGAGCGGGGCGGGGGAGGGAGGAGCCAGAG
CGGCCGCCGCCTCTGCCGGAGGAGCCGCGGGGCCGCCACACTCGCCCCCCGCCCCCCCCGCGCTCACTCGCACTCACACCCGGGCGCAGG
AGGCGGGCGGCCCGGGCCCCACCGGCCCCCCATGGACGCCCCCAGCACGGGGCGCTGAGACCCCCGCGTCGCTGCCCAGCCCGGTCCGGC
GCGCCACGCCGAGGGATCTCTGGACAGGACAAGACTCCGAAGCTACTCCCCCAGCACACAGCCCGGGACCCACAAACCCAGCTTGCCCCC
AGCCCTCCCACCTGCCACTCCCTGGCCCCTCCCACCGCCCGCCCCCCTTGGGGCGCAGGGCATGGTGTGAAAGGCCAAGTGCTGAGGCGG
GTATCATGGGTGCTGTGCCCTAGGGCCTGGGTGGCAGGGGGTGGGTGGCCTGTGGGTGTGCCGGGGGGGCCAGTGTGCCCACCCCAGTCT
CTTGGCGTGCTGGAGGGCATCCTGGATGGAATTGAAGTGAATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAA
CAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAACGGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCT
GGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCAACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTT
TCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCCTGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTG
CCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATGGCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCT
GATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATGATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCT
GATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCCCAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGG
CCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTGGACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCAC
CCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCCGAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGA
GATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAGAGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCT
CAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTTGAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGC
TCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCGGGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCT
GGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATTCCGCACTTCTGGCCCAAGCTGCTGATGAAGAGAAGAGGCCCCCTGAGCCC
CCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCC
GCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCC
ACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGT
CCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTAC
CAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCA
TTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGG
GCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCA
CCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAG
TTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCA
CTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTAC
CTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGA
AGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCT
TTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCT
ATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTC
CCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCC
CTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTC
TCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTG
AGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACT
CTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACA
GCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAATAACAGCATTTAGCATATTGTTTACACATAT

>In-frame_THRA_ENST00000584985_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_3537nt
GAGGCGGCCTGCAGGGAGCAGCCGCGAGCCGGCCGGGCGCGCCGAGCCCGAGCCCCAGCCGGAGCGGGGCGGGGGAGGGAGGAGCCAGAG
CGGCCGCCGCCTCTGCCGGAGGAGCCGCGGGGCCGCCACACTCGCCCCCCGCCCCCCCCGCGCTCACTCGCACTCACACCCGGGCGCAGG
AGGCGGGCGGCCCGGGCCCCACCGGCCCCCCATGGACGCCCCCAGCACGGGGCGCTGAGACCCCCGCGTCGCTGCCCAGCCCGGTCCGGC
GCGCCACGCCGAGGGATCTCTGGACAGGACAAGACTCCGAAGCTACTCCCCCAGCACACAGCCCGGGACCCACAAACCCAGCTTGCCCCC
AGCCCTCCCACCTGCCACTCCCTGGCCCCTCCCACCGCCCGCCCCCCTTGGGGCGCAGGGCATGGTGTGAAAGGCCAAGTGCTGAGGCGG
GTATCATGGGTGCTGTGCCCTAGGGCCTGGGTGGCAGGGGGTGGGTGGCCTGTGGGTGTGCCGGGGGGGCCAGTGTGCCCACCCCAGTCT
CTTGGCGTGCTGGAGGGCATCCTGGATGGAATTGAAGTGAATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAA
CAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAACGGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCT
GGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCAACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTT
TCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCCTGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTG
CCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATGGCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCT
GATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATGATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCT
GATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCCCAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGG
CCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTGGACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCAC
CCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCCGAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGA
GATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAGAGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCT
CAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTTGAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGC
TCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCGGGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCT
GGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATTCCGCACTTCTGGCCCAAGCTGCTGATGAAGAGAAGAGGCCCCCTGAGCCC
CCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCC
GCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCC
ACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGT
CCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTAC
CAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCA
TTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGG
GCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCA
CCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAG
TTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCA
CTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTAC
CTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGA
AGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCT
TTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCT
ATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTC
CCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCC
CTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTC
TCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTG
AGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACT
CTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACA
GCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAATAACAGCATTTAGCATATTGTTTACACATAT

>In-frame_THRA_ENST00000450525_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_6831nt
GAGGCGGCCTGCAGGGAGCAGCCGCGAGCCGGCCGGGCGCGCCGAGCCCGAGCCCCAGCCGGAGCGGGGCGGGGGAGGGAGGAGCCAGAG
CGGCCGCCGCCTCTGCCGGAGGAGCCGCGGGGCCGCCACACTCGCCCCCCGCCCCCCCCGCGCTCACTCGCACTCACACCCGGGCGCAGG
AGGCGGGCGGCCCGGGCCCCACCGGCCCCCCATGGACGCCCCCAGCACGGGGCGCTGAGACCCCCGCGTCGCTGCCCAGCCCGGTCCGGC
GCGCCACGCCGAGGGATCTCTGGACAGGACAAGACTCCGAAGCTACTCCCCCAGCACACAGCCCGGGACCCACAAACCCAGCTTGCCCCC
AGCCCTCCCACCTGCCACTCCCTGGCCCCTCCCACCGCCCGCCCCCCTTGGGGCGCAGGGCATGGTGTGAAAGGCCAAGTGCTGAGGCGG
GTATCATGGGTGCTGTGCCCTAGGGCCTGGGTGGCAGGGGGTGGGTGGCCTGTGGGTGTGCCGGGGGGGCCAGTGTGCCCACCCCAGTCT
CTTGGCGTGCTGGAGGGCATCCTGGATGGAATTGAAGTGAATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAA
CAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAACGGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCT
GGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCAACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTT
TCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCCTGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTG
CCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATGGCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCT
GATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATGATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCT
GATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCCCAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGG
CCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTGGACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCAC
CCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCCGAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGA
GATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAGAGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCT
CAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTTGAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGC
TCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCGGGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCT
GGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATTCCGCACTTCTGGCCCAAGCTGCTGATGAAGGTGACTGACCTCCGCATGAT
CGGGGCCTGCCACGCCAGCCGCTTCCTCCACATGAAAGTCGAGTGCCCCACCGAACTCTTCCCCCCACTCTTCCTCGAGGTCTTTGAGGA
TCAGGAAGTCTAAAGCCTCAGGCGGCCAGAGGGTGTGCGGAGCTGGTGGGGAGGAGCCTGGAGAGAAGGGGCAGAGCTGGGGGCTGAGGG
AGACCCCCCCACACCCCTTCTCTCCTTCCTCTCGTCCTTGGATAGATTCAGCTCCCACACACACACCCGCACTGCCCAGGTCCCTCCTCA
GACCTCCAGCCCTGGGACAGGGCAAACAACTGAACTTGCTATGGAAAGGACAGTGTGGGAGGCTGGGGGAGCTGTGTCCTGCAGTTCCCA
GGACCCCATCCTCTCAGAAGGTAGGGGAAGGGCGGGAGGATTGAGAAGGGACAAGCCACCTTGACCGTAGGGGAAGGAGGAATGTGGGCT
GGGGGAAGATGCCCTCAACTCACCCCCTACACACACATGAGAGAGAGCCCCCACCCAGTTCCTTGGCCTAGGTCTCCCCTCCAGGCTGAG
GGCCTCTCTACTTCCCCAGATGCCTGGGTGCAAAGAACGGCTTGGCTTGGCTCCTCCTCTGGAGGTTAAAATTTATAGTCATTCTAACTG
CACTTTGGAAACCAAGCAAGGGGAGAAGACAAATGAAGAAAAACTAGACAGAGAGAAAAATACAAAAAAGAGAGAGCGAGCGATAGAGAG
AGATGATATTAAGTTATTAACTGAGGCTGACCAGAGGGGAGGACCCCCCCTTTACCACCCCATGCACTTTGCGAGCTGCCCCTTCTTCCC
CCACATCAGAGAGAAATGCCCCCACACCAGAGCCCCAAGGGTAGGGCTGCCGATCAGAGCTGTGAGTTAACACAACAGGGTCCTGGCCAC
CCCCCTTGCCATACCCCGCCCTCTGTGCCCCTTTGGCACCCCCCAACCCTAGTATGTCCTCTGCTTTCTGCCACTCGTGCCCGCTGAGTT
CCATCTACCTCTCATGCTGGATGCCAGCTGGCCCCTCACCAGCCTGCCCTGCTGCCCACACAGCTCCCCTTTAAGTGCCCAGCCCTAGGG
GCCTCTCCCCATCCACCTCCTCCTTCCACACCTTGGCACCCACCCAGGAAAAAACTGTGGCTCCAACTCCTACCCTCCTTATATCCTGCA
GTATTAGCTAGAAACCGGATGCTGCTGCATTGGTTGGGTCGGGGGTAGGAGGGCTGTGCGTGAGCGTCTCCCAGAACCCTCCACCCCTTT
AGCACTCTGTTTCCCTGTTTCCCATCTGTCTTCTGGGCTCTCTCTAACCTCTGCCCTCCTCCCCAGCTCCTACTCACTGCACTAACTCTG
GGCGGGCAGGTACCAGAATGGGGGTGTTTAGATAAGTGACACTTAGTTGGGGCCCCAGGGGAGGGGTGGTCGGTGCTCCTTTTTCTTTAA
AGCTCTTTTGGCCAGCTGCCCCTCTGCCCCGGGACCCCTTCCCCTCTTCTTTTCTCTAATTCAGGGACTTTGGCTTGAGCCCCTCTCGCC
CTCCTGGTGAGGGTGCTCTGTTGGTCTGCACTTGGGTGAGCTGTCCTCCTCCCCCTCCCTGTGGCTGCCGCCCACTCCTCAGGGGAGAGA
GGGAGAGAGGAGGTGGTCCTCCCATGGGAGCAGGAGGTGGGGTGGGACAGAGCAGACCAGAGGGTGCTGGGCTCAGGGCTGCATGTCGGC
AGGGATGGATGGGTGGACACAGATGCCCCCGGAAGCCATGGGGATTGGGGCAGGGGGTGGGGGGAGGGGTGCCAGGGCTTCCTGCGCTTT
GCACTATTGGGGCAAAAATGTCTTAAGCAGTGGGGAACCTGCCACCCCACCCTGACCCTCAGCCTGCCACAGCCCCCTACACACACACAC
ACACACACACACACACACACACACACACGGACATGCACACACGGACATGGGAAGGCAATGCTATGCTGCCCGTCAGGGCACTGTCCTTCC
CCAATCGTTCAGGTGTTCCAACAGGGGTGGAGGGCCTGGAGGAGCACCCGCTGTCACCTGTGCATGTGCCTGTCCCACCCTGCTGGGGCC
TCGGGCTGCCCGCGCTGTCTTTGTCTCTATCCTCTCTCTCTCTCCTGGAGTACTGAATCCTGTATTACTCCAGTCCCATGGGTAGGCCCT
CTTGTACCTTCCTACCACGCCTGGGGGCCCAGTGGAATTCCTGACCTGTCTGCTGTCTTCCCCATCCCTCCATCCCCACCCCAACCCCTC
CATCCCCATTCTCAGCCATGGACACGGCAGAGAAAAGGCCTTGAAGAGCCTTAGCCTCTTATAGGCACTTGGGACTCCCCCACCCTCCCC
AATCATATGAGCTGTGATCCCATCCTCCCCGGACCCCTCCCTTCCCCCTCGGTGATGTGGGGTGTATGTGTGCGTTCCTCTGCGTGAATG
TGTGAGTGAGTACACATGGTAGGGGAGGAGCCAGGGCGACTCAGGAGTGCCACGCACCTGCTCTAGAGCGGCAGCTGTCCCAGTCCCTGC
TGTGGAAGTGGGGGACAGGGCCCTCTCCTGGGGGCCATTGGTGCTAATGAGGGGGATGGCCTTGATGTGGGTGCTCAGCATGCCTCCCCC
AGTATTGGCCCGGGGCACTAGGGCAGGCAGGGTGGAGCAGCAGGTGCAGTATCGGTGGGAGGACGGGTTGCTGGGAATAGGACGAGGGGG
CCAGGCCAGGACAAGGGGTTGCCAGAGCCATGACCACTACCCCGCCCCCACCACCCGCCTCTCCATCTCAGTATTGCCCCTCCCATCACT
CATAACACACATACCTCATCCAGCCTCCTCCCTGCTCAGACTTGGGGAGGGTGGGGGAGGAGCCCCTACCCCTTCTCCTGGTGGCGGGTC
TGCAGGGCTGGGAGAGGGCAGGGCGTTGTGAGAGAGAGACCGTCCATAAGGAGGACAGTAACTCCTGCCCTGGGAACTCCTGGGCGGGGG
GGAGGGGGACACTGCCCAGAGGCGCTACTGAATGTATGAGAAGCTGGTGCTGGGCTGGGGGGAGGGGGGTTGTGGCCAGAAACAGGGAAG
GAGGTAGGTCTCTTCCCCAGGGAGGGGTGGGACCGGCAGGGGTGACTTGAGGGGCTCCTACTCCTGCCCCACGTTGACAATCAGTATGTC
TGTTATGTGCGATTTTTCACCCCGTTGTGTTTTGGGTCAGGATTTTAAAGAAAGATATTTTTATGGTAATTGTTGCTCGTCTATTTTACT
ATATATTTATGTAATAAATATATGATGAAAATAAAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTG
GTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAG
CCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACT
GATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTG
AAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAG
GACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTA
CATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGC
CCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAA
CCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCG
AGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGT
TGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCA
TTACATTGAAAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCA
GGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTT
TTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAA
ATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAAT
AAATTACTCATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTT
GGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTC
TCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAA
GAACCTGGGATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAAT
GTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGA

>In-frame_THRA_ENST00000546243_chr17_38245586_+_CDK12_ENST00000447079_chr17_37686884_+_6602nt
GAGGCGGCCTGCAGGGAGCAGCCGCGAGCCGGCCGGGCGCGCCGAGCCCGAGCCCCAGCCGGAGCGGGGCGGGGGAGGGAGGAGCCAGAG
CGGCCGCCGCCTCTGCCGGAGGAGCCGCGGGGCCGCCACACTCGCCCCCCGCCCCCCCCGCGCTCACTCGCACTCACACCCGGGCGCAGG
AGGCGGGCGGCCCGGGCCCCACCGGCCCCCCATGGACGCCCCCAGCACGGGGCGCTGAGACCCCCGCGTCGCTGCCCAGCCCGGTCCGGC
GCGCCACGCCGAGGGATCTCTGGACAGGACAAGACTCCGAAGCTACTCCCCCAGCACACAGCCCGGGACCCACAAACCCAGCTTGCCCCC
AGCCCTCCCACCTGCCACTCCCTGGCCCCTCCCACCGCCCGCCCCCCTTGGGGCGCAGGGCATGGTGTGAAAGGCCAAGTGCTGAGGCGG
GTATCATGGGTGCTGTGCCCTAGGGCCTGGGTGGCAGGGGGTGGGTGGCCTGTGGGTGTGCCGGGGGGGCCAGTGTGCCCACCCCAGTCT
CTTGGCGTGCTGGAGGGCATCCTGGATGGAATTGAAGTGAATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAA
CAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAACGGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCT
GGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCAACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTT
TCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCCTGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTG
CCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATGGCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCT
GATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATGATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCT
GATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCCCAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGG
CCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTGGACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCAC
CCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCCGAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGA
GATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAGAGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCT
CAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTTGAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGC
TCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCGGGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCT
GGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATTCCGCACTTCTGGCCCAAGCTGCTGATGAAGGTGACTGACCTCCGCATGAT
CGGGGCCTGCCACGCCAGCCGCTTCCTCCACATGAAAGTCGAGTGCCCCACCGAACTCTTCCCCCCACTCTTCCTCGAGGTCTTTGAGGA
TCAGGAAGTCTAAAGCCTCAGGCGGCCAGAGGGTGTGCGGAGCTGGTGGGGAGGAGCCTGGAGAGAAGGGGCAGAGCTGGGGGCTGAGGG
AGACCCCCCCACACCCCTTCTCTCCTTCCTCTCGTCCTTGGATAGATTCAGCTCCCACACACACACCCGCACTGCCCAGGTCCCTCCTCA
GACCTCCAGCCCTGGGACAGGGCAAACAACTGAACTTGCTATGGAAAGGACAGTGTGGGAGGCTGGGGGAGCTGTGTCCTGCAGTTCCCA
GGACCCCATCCTCTCAGGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTCC
AGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCCA
CATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGGG
TTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTCA
GGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAGG
GTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATTG
CAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGCT
TATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACTTCAGTGTC
CTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATTT
GGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCTG
GATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAAT
GTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATTT
TTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATAG
TGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCCA
CCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAAA
GTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACTT
TACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTG
TCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCTT
TACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACCA
TGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAGG
GCTAATAACAGCATTTAGCATATTGTTTACACATATATTTTTATGTCAAAAAAAAAACAAAAACCTTTCAAACAGAGCATTGTGATATTG
TCAAAGAGAAAAACAAATCCTGAAGATACATGGAAATGTAACCTAGTTTAGGGTGGGTATTTTTCTGAAGATACATCAATACCTGACCTT
TTTTAAAAAAATAATTTTAAAACAGCATACTGTGAGGAAGAACAGTATTGACATACCCACATCCCAGCATGTGTACCCTGCCAGTTCTTT
TAGGGATTTTTCCTCCAAAGAGATTTGGATTTGGTTTTGGTAAAAGGGGTTAAATTGTGCTTCCAGGCAAGAACTTTGCCTTATCATAAA
CAGGAAATGAAAAAGGGAAGGGCTGTCAGGATGGGATAATTTGGGAGGCTTCTCATTCTGGCTTCTATTTCTATGTGAGTACCAGCATAT
AGAGTGTTTTAAAAACAGATACATGTCATATAATTTATCTGCACAGACTTAGACCTTCAGGAAACATAGGTTAAGCCCCCTTTTACAAAG
AAAAAGTAAACATACTTCAGCATCTTGGAGGGTAGTTTTCAAAACTCAAGTTTCATGTTTCAATGCCAAGTTCTTATTTTAAAAAATAAA
ATCTACTTATAAGAGAAAGGTGCATTACTTAAAAAAAAAAAACTTTAAAGAAATGAAAGAAGAACCCTCTTCAGATACTTACTTGAAGAC
TGTTTTCCCCTGTTAATGAGATATAGCTAGATATCGGTGTGTGTATTTCTTTATTATTCTCTGGTTTTTGATCTGGCCTTGCCTCCAGGG
CCAAACACTGATTTAGAAAGAGAGCCTTCTAGCTATTTTGGCATTGATGGCTTTTTATACCAGTGTGTCCAGTTAGATTTACTAGGCTTA
CTGACATGCTATTGGTAAATCGCATTAAAGTTCATCTGAACCTTCTGTCTGTTGACTTCTTAGTCCTCAGACATGGGCCTTTGTGTTTTA
GAATATTTGAATTTGAGTTATTGGGCCCCACTCCCTGTTTTTTATTAAAGAACGTGAGCCTGGGATACTTTCAGAAGTATCTGTTCAATG
AAAAAAAGTTGGTTTCCCATCAAATATGAATAAAATTCTCTATATATTTCATTGTATTTTGGTTATCAGCAGTCATCAATAATGTTTTTC
CCTCCCCTCTCCCACCTCTTATTTTTAATTATGCCAAATATCCTAAATAATATACTTAAGCCTCCATTCCCTCATCCCTACTAGGGAAGG
GGGTGAGTGTATGTGTGAGTGTATGTGTATGTATGATCCCATCTCACCCCCACCCCCATTTTGGGAGTCTTTTAAAATGAAAACAAAGTT
TGGTAGTTTTGACTATTTCTAAAAGCAGAGGAGAAAAAAAAACTTATTTAAATATCCTGGAATCTGTATGGAGGAAGAAAAGGTATTTGT
TAATTTTTCAGTTACGTTATCTATAAACATGATGGAAGTAAAGGTTTGGCAGAATTTCACCTTGACTATTTGAAAATTACAGACCCAATT
AATTCCATTCAAAAGTGGTTTTCGTTTTGTTTTAATTATTGTACAATGAGAGATATTGTCTATTAAATACATTATTTTGAACAGATGAGA
AATCTGATTCTGTTCATGAGTGGGAGGCAAAACTGGTTTGACCGTGATCATTTTTGTGGTTTTGAAAACAAATATACTTGACCCAGTTTC
CTTAGTTTTTTCTTCAACTGTCCATAGGAACGATAAGTATTTGAAAGCAACATCAAATCTATACGTTTAAAGCAGGGCAGTTAGCACAAA
TTTGCAAGTAGAACTTCTATTAGCTTATGCCATAGACATCACCCAACCACTTGTATGTGTGTGTGTATATATAATATGCATATATAGTTA
CCGTGCTAAAATGGTTACCAGCAGGTTTTGAGAGAGAATGCTGCATCAGAAAAGTGTCAGTTGCCACCTCATTCTCCCTGATTTAGGTTC
CTGACACTGATTCCTTTCTCTCTCGTTTTTGACCCCCATTGGGTGTATCTTGTCTATGTACAGATATTTTGTAATATATTAAATTTTTTT
CTTTCAGTTTATAAAAATGGAAAGTGGAGATTGGAAAATTAAATATTTCCTGTTACTATACCACTTTTGCTCCATTGCATTTACTTCTTA
ATCTGTACCCCCTGAGCATATCTAATCATGTATAAAGGACGTTTTTCCTCCACTTTATCTTAGGGGTTCTCTGTCTCAGAATCATTATAG
ACTCATTAACTCCCCCTCCCAGCAAAAGGTTATCAGGATTTGAAGAGGTGCTTGAAAACGCTAGACTAGGAACTAGAGAATAAATGAGTT
GGGAAAAACCATGAAATGTGATTTTTTTAAAGTAGAAAAGTTATACAAATAATGGTACCAAACCATCAAAAGAGTTGAGCTTCATGTACC
CTGACTCCTCCTGACAGGAGAGGTAAGTGGGTTTGAGCTCAACTGTCATCAAGGGAAGTTGGTAAGAGGCTGTTTAGACCCAAAGGATAG
TCTTAAACCAGACTTCACCACCCACCCTACCTCAGTTCCCATGTTATTACATGCAGAGTCAGCATGGGGATTAGTGTACCTACCTTTGCT
GAGATTTCCCGATGCGTTGCCAATCCAGAAAGTGAATCAAAAAGTTGTTTAAAAGTTAAAATCTCTATTGTTTCCAAAATCTTTCCCATC


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FusionGenePPI for THRA_CDK12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
THRANCOA6, TDG, CCND1, MEF2A, EP300, YWHAQ, ITGB3BP, POU2F1, DAP3, NR0B2, NRIP1, HR, AKAP13, MED12, MED16, MED6, MED24, CDK8, MED21, TRIM24, COPS2, TRIP11, RXRA, MED1, FUS, HDAC3, NCOR1, ZBTB3, SUV39H1, PARP1, NCOA1, NCOA2, NCOA3, TAF11, TAF7, GRIP1, NCOR2, EMD, PRKDC, SMC1A, LIG3, XRCC5, XRCC6, HSPA4, TBL1XR1, GPS2, TBL1X, CUL1, RGN, SEPP1, CDK7, MED25, ARID5A, GTF2B, C1D, THRA, CLIC1, FOXJ1, BUB3, PTGES3, RANBP9, AMOTL2, L3MBTL3, ENO1, MOV10, NXF1, UBE2I, CEP76, TRIM63, A2ML1, HAL, CST6, MTNR1BCDK12MGMT, SRRM2, RBM39, ELAVL1, MYC, PRPF4, CDK13, CCNK, TRIM24, IPPK, VPS51, ZNF606, TCEB3, BARD1, PAXIP1, PRPF40A, EWSR1, CDK20, CDK9, PIN1, RPL14, ACAA1, MAP4K4, SCAF4, SUPT16H, SRPK2, CLK1, BCLAF1, RNPS1, SNW1, PCGF1, CDX1, RPL37A, RRS1, ZNF2, FGF8, RPS14, WEE1, LASP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for THRA_CDK12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTHRAP10827DB00451LevothyroxineThyroid hormone receptor alphasmall moleculeapproved
HgeneTHRAP10827DB00509DextrothyroxineThyroid hormone receptor alphasmall moleculeapproved|investigational
HgeneTHRAP10827DB01118AmiodaroneThyroid hormone receptor alphasmall moleculeapproved|investigational
HgeneTHRAP10827DB00279LiothyronineThyroid hormone receptor alphasmall moleculeapproved|vet_approved

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RelatedDiseases for THRA_CDK12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTHRAC3280817HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 62UNIPROT
HgeneTHRAC0014175Endometriosis1CTD_human
HgeneTHRAC0019284Diaphragmatic Hernia1CTD_human