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Fusion gene ID: 38028 |
FusionGeneSummary for THRA_CDK12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: THRA_CDK12 | Fusion gene ID: 38028 | Hgene | Tgene | Gene symbol | THRA | CDK12 | Gene ID | 7067 | 51755 |
| Gene name | thyroid hormone receptor alpha | cyclin dependent kinase 12 | |
| Synonyms | AR7|CHNG6|EAR7|ERB-T-1|ERBA|ERBA1|NR1A1|THRA1|THRA2|c-ERBA-1 | CRK7|CRKR|CRKRS | |
| Cytomap | 17q21.1 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | thyroid hormone receptor alphaEAR-7ERBA-related 7V-erbA-related protein 7c-erbA-alphanuclear receptor subfamily 1 group A member 1thyroid hormone receptor alpha 1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homo | cyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P10827 | Q9NYV4 | |
| Ensembl transtripts involved in fusion gene | ENST00000394121, ENST00000264637, ENST00000584985, ENST00000450525, ENST00000546243, | ENST00000430627, ENST00000447079, ENST00000559545, | |
| Fusion gene scores | * DoF score | 11 X 8 X 9=792 | 27 X 15 X 12=4860 |
| # samples | 15 | 31 | |
| ** MAII score | log2(15/792*10)=-2.40053792958373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(31/4860*10)=-3.97061619321891 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: THRA [Title/Abstract] AND CDK12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | THRA | GO:0006357 | regulation of transcription by RNA polymerase II | 18052923 |
| Hgene | THRA | GO:0006366 | transcription by RNA polymerase II | 8710870|9653119 |
| Hgene | THRA | GO:0009755 | hormone-mediated signaling pathway | 18052923 |
| Hgene | THRA | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly | 8524305 |
| Hgene | THRA | GO:0045892 | negative regulation of transcription, DNA-templated | 8710870 |
| Hgene | THRA | GO:2000143 | negative regulation of DNA-templated transcription, initiation | 8524305 |
| Tgene | CDK12 | GO:0046777 | protein autophosphorylation | 11683387 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-BR-8289-01A | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394121 | ENST00000430627 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| Frame-shift | ENST00000394121 | ENST00000447079 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| 5CDS-intron | ENST00000394121 | ENST00000559545 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| In-frame | ENST00000264637 | ENST00000430627 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| Frame-shift | ENST00000264637 | ENST00000447079 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| 5CDS-intron | ENST00000264637 | ENST00000559545 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| In-frame | ENST00000584985 | ENST00000430627 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| Frame-shift | ENST00000584985 | ENST00000447079 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| 5CDS-intron | ENST00000584985 | ENST00000559545 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| In-frame | ENST00000450525 | ENST00000430627 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| Frame-shift | ENST00000450525 | ENST00000447079 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| 5CDS-intron | ENST00000450525 | ENST00000559545 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| Frame-shift | ENST00000546243 | ENST00000430627 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| In-frame | ENST00000546243 | ENST00000447079 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
| 5CDS-intron | ENST00000546243 | ENST00000559545 | THRA | chr17 | 38245586 | + | CDK12 | chr17 | 37686884 | + |
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FusionProtFeatures for THRA_CDK12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| THRA | CDK12 |
| Isoform Alpha-1: Nuclear hormone receptor that can actas a repressor or activator of transcription. High affinityreceptor for thyroid hormones, including triiodothyronine andthyroxine. {ECO:0000269|PubMed:12699376,ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:18237438,ECO:0000269|PubMed:19926848}. Isoform Alpha-2: Does not bind thyroid hormone andfunctions as a weak dominant negative inhibitor of thyroid hormoneaction. {ECO:0000269|PubMed:8910441}. | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II(POLR2A), thereby acting as a key regulator of transcriptionelongation. Regulates the expression of genes involved in DNArepair and is required for the maintenance of genomic stability.Preferentially phosphorylates 'Ser-5' in CTD repeats that arealready phosphorylated at 'Ser-7', but can also phosphorylate'Ser-2'. Required for RNA splicing, possibly by phosphorylatingSRSF1/SF2. Involved in regulation of MAP kinase activity, possiblyleading to affect the response to estrogen inhibitors.{ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820,ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619,ECO:0000269|PubMed:24662513}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | THRA | chr17:38245586 | chr17:37686884 | ENST00000264637 | + | 9 | 10 | 53_127 | 370 | 491 | DNA binding | Nuclear receptor |
| Hgene | THRA | chr17:38245586 | chr17:37686884 | ENST00000394121 | + | 9 | 10 | 53_127 | 370 | 491 | DNA binding | Nuclear receptor |
| Hgene | THRA | chr17:38245586 | chr17:37686884 | ENST00000584985 | + | 9 | 10 | 53_127 | 370 | 452 | DNA binding | Nuclear receptor |
| Hgene | THRA | chr17:38245586 | chr17:37686884 | ENST00000264637 | + | 9 | 10 | 1_52 | 370 | 491 | Region | Note=Modulating |
| Hgene | THRA | chr17:38245586 | chr17:37686884 | ENST00000394121 | + | 9 | 10 | 1_52 | 370 | 491 | Region | Note=Modulating |
| Hgene | THRA | chr17:38245586 | chr17:37686884 | ENST00000584985 | + | 9 | 10 | 1_52 | 370 | 452 | Region | Note=Modulating |
| Hgene | THRA | chr17:38245586 | chr17:37686884 | ENST00000264637 | + | 9 | 10 | 53_73 | 370 | 491 | Zinc finger | NR C4-type |
| Hgene | THRA | chr17:38245586 | chr17:37686884 | ENST00000264637 | + | 9 | 10 | 91_115 | 370 | 491 | Zinc finger | NR C4-type |
| Hgene | THRA | chr17:38245586 | chr17:37686884 | ENST00000394121 | + | 9 | 10 | 53_73 | 370 | 491 | Zinc finger | NR C4-type |
| Hgene | THRA | chr17:38245586 | chr17:37686884 | ENST00000394121 | + | 9 | 10 | 91_115 | 370 | 491 | Zinc finger | NR C4-type |
| Hgene | THRA | chr17:38245586 | chr17:37686884 | ENST00000584985 | + | 9 | 10 | 53_73 | 370 | 452 | Zinc finger | NR C4-type |
| Hgene | THRA | chr17:38245586 | chr17:37686884 | ENST00000584985 | + | 9 | 10 | 91_115 | 370 | 452 | Zinc finger | NR C4-type |
| Tgene | >CDK12 | chr17:38245586 | chr17:37686884 | ENST00000430627 | + | 12 | 14 | 1266_1280 | 1253 | 1482 | Compositional bias | Note=Poly-Pro |
| Tgene | >CDK12 | chr17:38245586 | chr17:37686884 | ENST00000447079 | + | 0 | 14 | 1266_1280 | -11 | 1491 | Compositional bias | Note=Poly-Pro |
| Tgene | >CDK12 | chr17:38245586 | chr17:37686884 | ENST00000447079 | + | 0 | 14 | 407_413 | -11 | 1491 | Compositional bias | Note=Poly-Ala |
| Tgene | >CDK12 | chr17:38245586 | chr17:37686884 | ENST00000447079 | + | 0 | 14 | 535_540 | -11 | 1491 | Compositional bias | Note=Poly-Pro |
| Tgene | >CDK12 | chr17:38245586 | chr17:37686884 | ENST00000447079 | + | 0 | 14 | 727_1020 | -11 | 1491 | Domain | Protein kinase |
| Tgene | >CDK12 | chr17:38245586 | chr17:37686884 | ENST00000447079 | + | 0 | 14 | 733_741 | -11 | 1491 | Nucleotide binding | Note=ATP |
| Tgene | >CDK12 | chr17:38245586 | chr17:37686884 | ENST00000447079 | + | 0 | 14 | 814_819 | -11 | 1491 | Nucleotide binding | Note=ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >THRA | chr17:38245586 | chr17:37686884 | ENST00000450525 | + | 1 | 9 | 53_127 | -164 | 411 | DNA binding | Nuclear receptor |
| Hgene | >THRA | chr17:38245586 | chr17:37686884 | ENST00000546243 | + | 1 | 9 | 53_127 | -134 | 411 | DNA binding | Nuclear receptor |
| Hgene | >THRA | chr17:38245586 | chr17:37686884 | ENST00000264637 | + | 9 | 10 | 163_407 | 370 | 491 | Domain | NR LBD |
| Hgene | >THRA | chr17:38245586 | chr17:37686884 | ENST00000394121 | + | 9 | 10 | 163_407 | 370 | 491 | Domain | NR LBD |
| Hgene | >THRA | chr17:38245586 | chr17:37686884 | ENST00000450525 | + | 1 | 9 | 163_407 | -164 | 411 | Domain | NR LBD |
| Hgene | >THRA | chr17:38245586 | chr17:37686884 | ENST00000546243 | + | 1 | 9 | 163_407 | -134 | 411 | Domain | NR LBD |
| Hgene | >THRA | chr17:38245586 | chr17:37686884 | ENST00000584985 | + | 9 | 10 | 163_407 | 370 | 452 | Domain | NR LBD |
| Hgene | >THRA | chr17:38245586 | chr17:37686884 | ENST00000450525 | + | 1 | 9 | 1_52 | -164 | 411 | Region | Note=Modulating |
| Hgene | >THRA | chr17:38245586 | chr17:37686884 | ENST00000546243 | + | 1 | 9 | 1_52 | -134 | 411 | Region | Note=Modulating |
| Hgene | >THRA | chr17:38245586 | chr17:37686884 | ENST00000450525 | + | 1 | 9 | 53_73 | -164 | 411 | Zinc finger | NR C4-type |
| Hgene | >THRA | chr17:38245586 | chr17:37686884 | ENST00000450525 | + | 1 | 9 | 91_115 | -164 | 411 | Zinc finger | NR C4-type |
| Hgene | >THRA | chr17:38245586 | chr17:37686884 | ENST00000546243 | + | 1 | 9 | 53_73 | -134 | 411 | Zinc finger | NR C4-type |
| Hgene | >THRA | chr17:38245586 | chr17:37686884 | ENST00000546243 | + | 1 | 9 | 91_115 | -134 | 411 | Zinc finger | NR C4-type |
| Tgene | CDK12 | chr17:38245586 | chr17:37686884 | ENST00000430627 | + | 12 | 14 | 407_413 | 1253 | 1482 | Compositional bias | Note=Poly-Ala |
| Tgene | CDK12 | chr17:38245586 | chr17:37686884 | ENST00000430627 | + | 12 | 14 | 535_540 | 1253 | 1482 | Compositional bias | Note=Poly-Pro |
| Tgene | CDK12 | chr17:38245586 | chr17:37686884 | ENST00000430627 | + | 12 | 14 | 727_1020 | 1253 | 1482 | Domain | Protein kinase |
| Tgene | CDK12 | chr17:38245586 | chr17:37686884 | ENST00000430627 | + | 12 | 14 | 733_741 | 1253 | 1482 | Nucleotide binding | Note=ATP |
| Tgene | CDK12 | chr17:38245586 | chr17:37686884 | ENST00000430627 | + | 12 | 14 | 814_819 | 1253 | 1482 | Nucleotide binding | Note=ATP |
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FusionGeneSequence for THRA_CDK12 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_THRA_ENST00000394121_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_598aa MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI PHFWPKLLMKRRGPLSPPDLHRRHLHPLWLKAIFPAPPRSXTQPXQPPCCNFYPSLKQSLLATCHMSTRPXDQWSTPPDPVQTGLMETLM GLKQGSVPLTLMNETLVQPXQNPWSRPWXRTGPSQALXATLGSPAVTRAQGQCSFQGTRTSVLPGSPXRYTRWSGNHSXRLREAAILWYM >In-frame_THRA_ENST00000264637_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_598aa MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI PHFWPKLLMKRRGPLSPPDLHRRHLHPLWLKAIFPAPPRSXTQPXQPPCCNFYPSLKQSLLATCHMSTRPXDQWSTPPDPVQTGLMETLM GLKQGSVPLTLMNETLVQPXQNPWSRPWXRTGPSQALXATLGSPAVTRAQGQCSFQGTRTSVLPGSPXRYTRWSGNHSXRLREAAILWYM >In-frame_THRA_ENST00000584985_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_598aa MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI PHFWPKLLMKRRGPLSPPDLHRRHLHPLWLKAIFPAPPRSXTQPXQPPCCNFYPSLKQSLLATCHMSTRPXDQWSTPPDPVQTGLMETLM GLKQGSVPLTLMNETLVQPXQNPWSRPWXRTGPSQALXATLGSPAVTRAQGQCSFQGTRTSVLPGSPXRYTRWSGNHSXRLREAAILWYM >In-frame_THRA_ENST00000450525_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_1696aa MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI PHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEVXSLRRPEGVRSWWGGAWREGAELGAEGDPPTPLLSFLSSL DRFSSHTHTRTAQVPPQTSSPGTGQTTELAMERTVWEAGGAVSCSSQDPILSEGRGRAGGLRRDKPPXPXGKEECGLGEDALNSPPTHTX ERAPTQFLGLGLPSRLRASLLPQMPGCKERLGLAPPLEVKIYSHSNCTLETKQGEKTNEEKLDREKNTKKRERAIERDDIKLLTEADQRG GPPLYHPMHFASCPFFPHIREKCPHTRAPRVGLPIRAVSXHNRVLATPLAIPRPLCPFGTPQPXYVLCFLPLVPAEFHLPLMLDASWPLT SLPCCPHSSPLSAQPXGPLPIHLLLPHLGTHPGKNCGSNSYPPYILQYXLETGCCCIGWVGGRRAVRERLPEPSTPLALCFPVSHLSSGL SLTSALLPSSYSLHXLWAGRYQNGGVXISDTXLGPQGRGGRCSFFFKALLASCPSAPGPLPLFFSLIQGLWLEPLSPSWXGCSVGLHLGE LSSSPSLWLPPTPQGREGERRWSSHGSRRWGGTEQTRGCWAQGCMSAGMDGWTQMPPEAMGIGAGGGGRGARASCALHYWGKNVLSSGEP ATPPXPSACHSPLHTHTHTHTHTHTHGHAHTDMGRQCYAARQGTVLPQSFRCSNRGGGPGGAPAVTCACACPTLLGPRAARAVFVSILSL SPGVLNPVLLQSHGXALLYLPTTPGGPVEFLTCLLSSPSLHPHPNPSIPILSHGHGREKALKSLSLLXALGTPPPSPIIXAVIPSSPDPS LPPRXCGVYVCVPLRECVSEYTWXGRSQGDSGVPRTCSRAAAVPVPAVEVGDRALSWGPLVLMRGMALMWVLSMPPPVLARGTRAGRVEQ QVQYRWEDGLLGIGRGGQARTRGCQSHDHYPAPTTRLSISVLPLPSLITHIPHPASSLLRLGEGGGGAPTPSPGGGSAGLGEGRALXERD RPXGGQXLLPWELLGGGEGDTAQRRYXMYEKLVLGWGEGGCGQKQGRRXVSSPGRGGTGRGDLRGSYSCPTLTISMSVMCDFSPRCVLGQ DFKERYFYGNCCSSILLYIYVINIXXKXRRGPLSPPDLHRRHLHPLWLKAIFPAPPRSXTQPXQPPCCNFYPSLKQSLLATCHMSTRPXD QWSTPPDPVQTGLMETLMGLKQGSVPLTLMNETLVQPXQNPWSRPWXRTGPSQALXATLGSPAVTRAQGQCSFQGTRTSVLPGSPXRYTR >In-frame_THRA_ENST00000546243_chr17_38245586_+_CDK12_ENST00000447079_chr17_37686884_+_1779aa MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI PHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEVXSLRRPEGVRSWWGGAWREGAELGAEGDPPTPLLSFLSSL DRFSSHTHTRTAQVPPQTSSPGTGQTTELAMERTVWEAGGAVSCSSQDPILSAQRLQCPERFLSYPSFHPVLXIFNEIICQSEVIICIWL LQSCPLYSLLTCYXQATYEIMMLAPVPPGWAIARTFTSTLPXXIQVENMERIITLKSKCFISSLPALTDRKRERTVSVLRWLRRGSLIFK VLGWGIVCGFFLLNFNLGVLGFFPLKRIVFTKFELLFGFCYKGNRVAWLIXINVSFLSTISHFAFKXTLFPHXASXTYFFSKXITHPXSL LHFDKRYALLPAHKAGCRTWHSWASRXTLPSLFPFLLMCALSLSFSLSLSLSLSLSLSVSLARSRCFSLFEAFVWKKSLRCPRTWDNSLL FLKXRKGNSDSYIVLCNSSILKCFVFXTMFXWGSXFVSVDSLDIAAELWLEMMPPFLEGXXQHLAYCLHIYFYVKKKTKTFQTEHCDIVK EKNKSXRYMEMXPSLGWVFFXRYINTXPFLKKXFXNSILXGRTVLTYPHPSMCTLPVLLGIFPPKRFGFGFGKRGXIVLPGKNFALSXTG NEKGKGCQDGIIWEASHSGFYFYVSTSIXSVLKTDTCHIIYLHRLRPSGNIGXAPFYKEKVNILQHLGGXFSKLKFHVSMPSSYFKKXNL LIRERCITXKKKTLKKXKKNPLQILTXRLFSPVNEIXLDIGVCISLLFSGFXSGLASRAKHXFRKRAFXLFWHXWLFIPVCPVRFTRLTD MLLVNRIKVHLNLLSVDFLVLRHGPLCFRIFEFELLGPTPCFLLKNVSLGYFQKYLFNEKKLVSHQIXIKFSIYFIVFWLSAVINNVFPS PLPPLIFNYAKYPKXYTXASIPSSLLGKGVSVCVSVCVCMIPSHPHPHFGSLLKXKQSLVVLTISKSRGEKKTYLNILESVWRKKRYLLI FQLRYLXTXWKXRFGRISPXLFENYRPNXFHSKVVFVLFXLLYNERYCLLNTLFXTDEKSDSVHEWEAKLVXPXSFLWFXKQIYLTQFPX FFLQLSIGTISIXKQHQIYTFKAGQLAQICKXNFYXLMPXTSPNHLYVCVYIXYAYIVTVLKWLPAGFERECCIRKVSVATSFSLIXVPD TDSFLSRFXPPLGVSCLCTDILXYIKFFSFSLXKWKVEIGKLNISCYYTTFAPLHLLLNLYPLSISNHVXRTFFLHFILGVLCLRIIIDS LTPPPSKRLSGFEEVLENARLGTREXMSWEKPXNVIFLKXKSYTNNGTKPSKELSFMYPDSSXQERXVGLSSTVIKGSWXEAVXTQRIVL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_THRA_ENST00000394121_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_1796nt ATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAAC GGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCA ACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCC TGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATG GCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATG ATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCC CAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTG GACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCC GAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAG AGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTT GAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCG GGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATT CCGCACTTCTGGCCCAAGCTGCTGATGAAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTG AAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTC CTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATG GGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGA ACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACC TCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATG CAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAA >In-frame_THRA_ENST00000264637_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_1796nt ATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAAC GGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCA ACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCC TGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATG GCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATG ATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCC CAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTG GACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCC GAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAG AGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTT GAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCG GGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATT CCGCACTTCTGGCCCAAGCTGCTGATGAAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTG AAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTC CTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATG GGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGA ACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACC TCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATG CAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAA >In-frame_THRA_ENST00000584985_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_1796nt ATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAAC GGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCA ACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCC TGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATG GCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATG ATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCC CAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTG GACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCC GAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAG AGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTT GAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCG GGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATT CCGCACTTCTGGCCCAAGCTGCTGATGAAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTG AAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTC CTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATG GGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGA ACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACC TCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATG CAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAA >In-frame_THRA_ENST00000450525_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_5090nt ATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAAC GGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCA ACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCC TGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATG GCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATG ATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCC CAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTG GACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCC GAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAG AGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTT GAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCG GGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATT CCGCACTTCTGGCCCAAGCTGCTGATGAAGGTGACTGACCTCCGCATGATCGGGGCCTGCCACGCCAGCCGCTTCCTCCACATGAAAGTC GAGTGCCCCACCGAACTCTTCCCCCCACTCTTCCTCGAGGTCTTTGAGGATCAGGAAGTCTAAAGCCTCAGGCGGCCAGAGGGTGTGCGG AGCTGGTGGGGAGGAGCCTGGAGAGAAGGGGCAGAGCTGGGGGCTGAGGGAGACCCCCCCACACCCCTTCTCTCCTTCCTCTCGTCCTTG GATAGATTCAGCTCCCACACACACACCCGCACTGCCCAGGTCCCTCCTCAGACCTCCAGCCCTGGGACAGGGCAAACAACTGAACTTGCT ATGGAAAGGACAGTGTGGGAGGCTGGGGGAGCTGTGTCCTGCAGTTCCCAGGACCCCATCCTCTCAGAAGGTAGGGGAAGGGCGGGAGGA TTGAGAAGGGACAAGCCACCTTGACCGTAGGGGAAGGAGGAATGTGGGCTGGGGGAAGATGCCCTCAACTCACCCCCTACACACACATGA GAGAGAGCCCCCACCCAGTTCCTTGGCCTAGGTCTCCCCTCCAGGCTGAGGGCCTCTCTACTTCCCCAGATGCCTGGGTGCAAAGAACGG CTTGGCTTGGCTCCTCCTCTGGAGGTTAAAATTTATAGTCATTCTAACTGCACTTTGGAAACCAAGCAAGGGGAGAAGACAAATGAAGAA AAACTAGACAGAGAGAAAAATACAAAAAAGAGAGAGCGAGCGATAGAGAGAGATGATATTAAGTTATTAACTGAGGCTGACCAGAGGGGA GGACCCCCCCTTTACCACCCCATGCACTTTGCGAGCTGCCCCTTCTTCCCCCACATCAGAGAGAAATGCCCCCACACCAGAGCCCCAAGG GTAGGGCTGCCGATCAGAGCTGTGAGTTAACACAACAGGGTCCTGGCCACCCCCCTTGCCATACCCCGCCCTCTGTGCCCCTTTGGCACC CCCCAACCCTAGTATGTCCTCTGCTTTCTGCCACTCGTGCCCGCTGAGTTCCATCTACCTCTCATGCTGGATGCCAGCTGGCCCCTCACC AGCCTGCCCTGCTGCCCACACAGCTCCCCTTTAAGTGCCCAGCCCTAGGGGCCTCTCCCCATCCACCTCCTCCTTCCACACCTTGGCACC CACCCAGGAAAAAACTGTGGCTCCAACTCCTACCCTCCTTATATCCTGCAGTATTAGCTAGAAACCGGATGCTGCTGCATTGGTTGGGTC GGGGGTAGGAGGGCTGTGCGTGAGCGTCTCCCAGAACCCTCCACCCCTTTAGCACTCTGTTTCCCTGTTTCCCATCTGTCTTCTGGGCTC TCTCTAACCTCTGCCCTCCTCCCCAGCTCCTACTCACTGCACTAACTCTGGGCGGGCAGGTACCAGAATGGGGGTGTTTAGATAAGTGAC ACTTAGTTGGGGCCCCAGGGGAGGGGTGGTCGGTGCTCCTTTTTCTTTAAAGCTCTTTTGGCCAGCTGCCCCTCTGCCCCGGGACCCCTT CCCCTCTTCTTTTCTCTAATTCAGGGACTTTGGCTTGAGCCCCTCTCGCCCTCCTGGTGAGGGTGCTCTGTTGGTCTGCACTTGGGTGAG CTGTCCTCCTCCCCCTCCCTGTGGCTGCCGCCCACTCCTCAGGGGAGAGAGGGAGAGAGGAGGTGGTCCTCCCATGGGAGCAGGAGGTGG GGTGGGACAGAGCAGACCAGAGGGTGCTGGGCTCAGGGCTGCATGTCGGCAGGGATGGATGGGTGGACACAGATGCCCCCGGAAGCCATG GGGATTGGGGCAGGGGGTGGGGGGAGGGGTGCCAGGGCTTCCTGCGCTTTGCACTATTGGGGCAAAAATGTCTTAAGCAGTGGGGAACCT GCCACCCCACCCTGACCCTCAGCCTGCCACAGCCCCCTACACACACACACACACACACACACACACACACACACACACGGACATGCACAC ACGGACATGGGAAGGCAATGCTATGCTGCCCGTCAGGGCACTGTCCTTCCCCAATCGTTCAGGTGTTCCAACAGGGGTGGAGGGCCTGGA GGAGCACCCGCTGTCACCTGTGCATGTGCCTGTCCCACCCTGCTGGGGCCTCGGGCTGCCCGCGCTGTCTTTGTCTCTATCCTCTCTCTC TCTCCTGGAGTACTGAATCCTGTATTACTCCAGTCCCATGGGTAGGCCCTCTTGTACCTTCCTACCACGCCTGGGGGCCCAGTGGAATTC CTGACCTGTCTGCTGTCTTCCCCATCCCTCCATCCCCACCCCAACCCCTCCATCCCCATTCTCAGCCATGGACACGGCAGAGAAAAGGCC TTGAAGAGCCTTAGCCTCTTATAGGCACTTGGGACTCCCCCACCCTCCCCAATCATATGAGCTGTGATCCCATCCTCCCCGGACCCCTCC CTTCCCCCTCGGTGATGTGGGGTGTATGTGTGCGTTCCTCTGCGTGAATGTGTGAGTGAGTACACATGGTAGGGGAGGAGCCAGGGCGAC TCAGGAGTGCCACGCACCTGCTCTAGAGCGGCAGCTGTCCCAGTCCCTGCTGTGGAAGTGGGGGACAGGGCCCTCTCCTGGGGGCCATTG GTGCTAATGAGGGGGATGGCCTTGATGTGGGTGCTCAGCATGCCTCCCCCAGTATTGGCCCGGGGCACTAGGGCAGGCAGGGTGGAGCAG CAGGTGCAGTATCGGTGGGAGGACGGGTTGCTGGGAATAGGACGAGGGGGCCAGGCCAGGACAAGGGGTTGCCAGAGCCATGACCACTAC CCCGCCCCCACCACCCGCCTCTCCATCTCAGTATTGCCCCTCCCATCACTCATAACACACATACCTCATCCAGCCTCCTCCCTGCTCAGA CTTGGGGAGGGTGGGGGAGGAGCCCCTACCCCTTCTCCTGGTGGCGGGTCTGCAGGGCTGGGAGAGGGCAGGGCGTTGTGAGAGAGAGAC CGTCCATAAGGAGGACAGTAACTCCTGCCCTGGGAACTCCTGGGCGGGGGGGAGGGGGACACTGCCCAGAGGCGCTACTGAATGTATGAG AAGCTGGTGCTGGGCTGGGGGGAGGGGGGTTGTGGCCAGAAACAGGGAAGGAGGTAGGTCTCTTCCCCAGGGAGGGGTGGGACCGGCAGG GGTGACTTGAGGGGCTCCTACTCCTGCCCCACGTTGACAATCAGTATGTCTGTTATGTGCGATTTTTCACCCCGTTGTGTTTTGGGTCAG GATTTTAAAGAAAGATATTTTTATGGTAATTGTTGCTCGTCTATTTTACTATATATTTATGTAATAAATATATGATGAAAATAAAGAAGA GGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACC CAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGAC CAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATG AACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGG AGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGG TGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGC CAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGC >In-frame_THRA_ENST00000546243_chr17_38245586_+_CDK12_ENST00000447079_chr17_37686884_+_5337nt ATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAAC GGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCA ACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCC TGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATG GCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATG ATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCC CAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTG GACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCC GAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAG AGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTT GAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCG GGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATT CCGCACTTCTGGCCCAAGCTGCTGATGAAGGTGACTGACCTCCGCATGATCGGGGCCTGCCACGCCAGCCGCTTCCTCCACATGAAAGTC GAGTGCCCCACCGAACTCTTCCCCCCACTCTTCCTCGAGGTCTTTGAGGATCAGGAAGTCTAAAGCCTCAGGCGGCCAGAGGGTGTGCGG AGCTGGTGGGGAGGAGCCTGGAGAGAAGGGGCAGAGCTGGGGGCTGAGGGAGACCCCCCCACACCCCTTCTCTCCTTCCTCTCGTCCTTG GATAGATTCAGCTCCCACACACACACCCGCACTGCCCAGGTCCCTCCTCAGACCTCCAGCCCTGGGACAGGGCAAACAACTGAACTTGCT ATGGAAAGGACAGTGTGGGAGGCTGGGGGAGCTGTGTCCTGCAGTTCCCAGGACCCCATCCTCTCAGCCCAGAGACTTCAGTGTCCTGAA AGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTA CTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCTGGATGG GCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAATGTTTT ATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAA GTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTC ACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCCACCATC TCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAAAGTTTA CTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCC AGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCG CTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCTTTACTT TTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACCATGTTC TGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAA TAACAGCATTTAGCATATTGTTTACACATATATTTTTATGTCAAAAAAAAAACAAAAACCTTTCAAACAGAGCATTGTGATATTGTCAAA GAGAAAAACAAATCCTGAAGATACATGGAAATGTAACCTAGTTTAGGGTGGGTATTTTTCTGAAGATACATCAATACCTGACCTTTTTTA AAAAAATAATTTTAAAACAGCATACTGTGAGGAAGAACAGTATTGACATACCCACATCCCAGCATGTGTACCCTGCCAGTTCTTTTAGGG ATTTTTCCTCCAAAGAGATTTGGATTTGGTTTTGGTAAAAGGGGTTAAATTGTGCTTCCAGGCAAGAACTTTGCCTTATCATAAACAGGA AATGAAAAAGGGAAGGGCTGTCAGGATGGGATAATTTGGGAGGCTTCTCATTCTGGCTTCTATTTCTATGTGAGTACCAGCATATAGAGT GTTTTAAAAACAGATACATGTCATATAATTTATCTGCACAGACTTAGACCTTCAGGAAACATAGGTTAAGCCCCCTTTTACAAAGAAAAA GTAAACATACTTCAGCATCTTGGAGGGTAGTTTTCAAAACTCAAGTTTCATGTTTCAATGCCAAGTTCTTATTTTAAAAAATAAAATCTA CTTATAAGAGAAAGGTGCATTACTTAAAAAAAAAAAACTTTAAAGAAATGAAAGAAGAACCCTCTTCAGATACTTACTTGAAGACTGTTT TCCCCTGTTAATGAGATATAGCTAGATATCGGTGTGTGTATTTCTTTATTATTCTCTGGTTTTTGATCTGGCCTTGCCTCCAGGGCCAAA CACTGATTTAGAAAGAGAGCCTTCTAGCTATTTTGGCATTGATGGCTTTTTATACCAGTGTGTCCAGTTAGATTTACTAGGCTTACTGAC ATGCTATTGGTAAATCGCATTAAAGTTCATCTGAACCTTCTGTCTGTTGACTTCTTAGTCCTCAGACATGGGCCTTTGTGTTTTAGAATA TTTGAATTTGAGTTATTGGGCCCCACTCCCTGTTTTTTATTAAAGAACGTGAGCCTGGGATACTTTCAGAAGTATCTGTTCAATGAAAAA AAGTTGGTTTCCCATCAAATATGAATAAAATTCTCTATATATTTCATTGTATTTTGGTTATCAGCAGTCATCAATAATGTTTTTCCCTCC CCTCTCCCACCTCTTATTTTTAATTATGCCAAATATCCTAAATAATATACTTAAGCCTCCATTCCCTCATCCCTACTAGGGAAGGGGGTG AGTGTATGTGTGAGTGTATGTGTATGTATGATCCCATCTCACCCCCACCCCCATTTTGGGAGTCTTTTAAAATGAAAACAAAGTTTGGTA GTTTTGACTATTTCTAAAAGCAGAGGAGAAAAAAAAACTTATTTAAATATCCTGGAATCTGTATGGAGGAAGAAAAGGTATTTGTTAATT TTTCAGTTACGTTATCTATAAACATGATGGAAGTAAAGGTTTGGCAGAATTTCACCTTGACTATTTGAAAATTACAGACCCAATTAATTC CATTCAAAAGTGGTTTTCGTTTTGTTTTAATTATTGTACAATGAGAGATATTGTCTATTAAATACATTATTTTGAACAGATGAGAAATCT GATTCTGTTCATGAGTGGGAGGCAAAACTGGTTTGACCGTGATCATTTTTGTGGTTTTGAAAACAAATATACTTGACCCAGTTTCCTTAG TTTTTTCTTCAACTGTCCATAGGAACGATAAGTATTTGAAAGCAACATCAAATCTATACGTTTAAAGCAGGGCAGTTAGCACAAATTTGC AAGTAGAACTTCTATTAGCTTATGCCATAGACATCACCCAACCACTTGTATGTGTGTGTGTATATATAATATGCATATATAGTTACCGTG CTAAAATGGTTACCAGCAGGTTTTGAGAGAGAATGCTGCATCAGAAAAGTGTCAGTTGCCACCTCATTCTCCCTGATTTAGGTTCCTGAC ACTGATTCCTTTCTCTCTCGTTTTTGACCCCCATTGGGTGTATCTTGTCTATGTACAGATATTTTGTAATATATTAAATTTTTTTCTTTC AGTTTATAAAAATGGAAAGTGGAGATTGGAAAATTAAATATTTCCTGTTACTATACCACTTTTGCTCCATTGCATTTACTTCTTAATCTG TACCCCCTGAGCATATCTAATCATGTATAAAGGACGTTTTTCCTCCACTTTATCTTAGGGGTTCTCTGTCTCAGAATCATTATAGACTCA TTAACTCCCCCTCCCAGCAAAAGGTTATCAGGATTTGAAGAGGTGCTTGAAAACGCTAGACTAGGAACTAGAGAATAAATGAGTTGGGAA AAACCATGAAATGTGATTTTTTTAAAGTAGAAAAGTTATACAAATAATGGTACCAAACCATCAAAAGAGTTGAGCTTCATGTACCCTGAC TCCTCCTGACAGGAGAGGTAAGTGGGTTTGAGCTCAACTGTCATCAAGGGAAGTTGGTAAGAGGCTGTTTAGACCCAAAGGATAGTCTTA AACCAGACTTCACCACCCACCCTACCTCAGTTCCCATGTTATTACATGCAGAGTCAGCATGGGGATTAGTGTACCTACCTTTGCTGAGAT TTCCCGATGCGTTGCCAATCCAGAAAGTGAATCAAAAAGTTGTTTAAAAGTTAAAATCTCTATTGTTTCCAAAATCTTTCCCATCTCCAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_THRA_ENST00000394121_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_3513nt AGCAGATTGTTGGGGGAAATGGCTGGTGACAGAGAATAGAAAGAGCCTATATGGAGAAGGGTGACGTTGGAAAAGGGAGGCAGTGGATCG GTATTGATGTTAGAAATGAGAGGGGAGGGAGGTAACAGGGAATGAACCCCCACAAGGATGAAAAACGTAAGATGATTGAAGTTAAAAGGA CATCAGGGGTCACCTGCCCAGCCCTCGCAGCTGAAGCTTGAGGAAGCTCTGCCCCCGACAGCAGTGGCGATTTGTCAAGGGATCTCTGGA CAGGACAAGACTCCGAAGCTACTCCCCCAGCACACAGCCCGGGACCCACAAACCCAGCTTGCCCCCAGCCCTCCCACCTGCCACTCCCTG GCCCCTCCCACCGCCCGCCCCCCTTGGGGCGCAGGGCATGGTGTGAAAGGCCAAGTGCTGAGGCGGGTATCATGGGTGCTGTGCCCTAGG GCCTGGGTGGCAGGGGGTGGGTGGCCTGTGGGTGTGCCGGGGGGGCCAGTGTGCCCACCCCAGTCTCTTGGCGTGCTGGAGGGCATCCTG GATGGAATTGAAGTGAATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGGTCACCAGATGGAAA GCGAAAAAGAAAGAACGGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGT GTGTGGGGACAAGGCAACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACAATCCAGAAGAACCT CCATCCCACCTATTCCTGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTG CATCGCCGTGGGCATGGCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAGAACCGGGAGCGGCG GCGGAAGGAGGAGATGATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCA TCGCAGCACCAATGCCCAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCCATTGTCTCCATGCC GGACGGAGACAAGGTGGACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAA ACTGCCCATGTTCTCCGAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCCCTGCGGGCGGCTGT CCGCTACGACCCTGAGAGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGT CTCCGACGCCATCTTTGAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAGGCTGTGCTGCTAAT GTCAACAGACCGCTCGGGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCA CCGCAAACACAACATTCCGCACTTCTGGCCCAAGCTGCTGATGAAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCT CCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAG CCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACT TATGGAAACACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTC CAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTT CCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGC AATTCTGTGGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTT CACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGA GTTCCTTACTAACCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCA TTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACG AAATAATGATGTTGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATA TGGAGAGGATCATTACATTGAAAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTAT TGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTG TTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGC TGATTTGAATAAATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACT TTTTTTCCAAATAAATTACTCATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAA CGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTC TCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGT TGAGATGCCCAAGAACCTGGGATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTT CAATTCTAAAATGTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGT GGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAATAACAGCATTTAGCATATTGTTTACACATATATTTTTATGTCAAAAAAAAAACAA >In-frame_THRA_ENST00000264637_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_3537nt GAGGCGGCCTGCAGGGAGCAGCCGCGAGCCGGCCGGGCGCGCCGAGCCCGAGCCCCAGCCGGAGCGGGGCGGGGGAGGGAGGAGCCAGAG CGGCCGCCGCCTCTGCCGGAGGAGCCGCGGGGCCGCCACACTCGCCCCCCGCCCCCCCCGCGCTCACTCGCACTCACACCCGGGCGCAGG AGGCGGGCGGCCCGGGCCCCACCGGCCCCCCATGGACGCCCCCAGCACGGGGCGCTGAGACCCCCGCGTCGCTGCCCAGCCCGGTCCGGC GCGCCACGCCGAGGGATCTCTGGACAGGACAAGACTCCGAAGCTACTCCCCCAGCACACAGCCCGGGACCCACAAACCCAGCTTGCCCCC AGCCCTCCCACCTGCCACTCCCTGGCCCCTCCCACCGCCCGCCCCCCTTGGGGCGCAGGGCATGGTGTGAAAGGCCAAGTGCTGAGGCGG GTATCATGGGTGCTGTGCCCTAGGGCCTGGGTGGCAGGGGGTGGGTGGCCTGTGGGTGTGCCGGGGGGGCCAGTGTGCCCACCCCAGTCT CTTGGCGTGCTGGAGGGCATCCTGGATGGAATTGAAGTGAATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAA CAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAACGGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCT GGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCAACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTT TCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCCTGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTG CCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATGGCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCT GATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATGATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCT GATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCCCAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGG CCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTGGACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCAC CCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCCGAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGA GATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAGAGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCT CAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTTGAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGC TCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCGGGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCT GGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATTCCGCACTTCTGGCCCAAGCTGCTGATGAAGAGAAGAGGCCCCCTGAGCCC CCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCC GCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCC ACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGT CCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTAC CAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCA TTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGG GCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCA CCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAG TTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCA CTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTAC CTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGA AGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCT TTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCT ATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTC CCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCC CTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTC TCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTG AGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACT CTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACA GCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAATAACAGCATTTAGCATATTGTTTACACATAT >In-frame_THRA_ENST00000584985_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_3537nt GAGGCGGCCTGCAGGGAGCAGCCGCGAGCCGGCCGGGCGCGCCGAGCCCGAGCCCCAGCCGGAGCGGGGCGGGGGAGGGAGGAGCCAGAG CGGCCGCCGCCTCTGCCGGAGGAGCCGCGGGGCCGCCACACTCGCCCCCCGCCCCCCCCGCGCTCACTCGCACTCACACCCGGGCGCAGG AGGCGGGCGGCCCGGGCCCCACCGGCCCCCCATGGACGCCCCCAGCACGGGGCGCTGAGACCCCCGCGTCGCTGCCCAGCCCGGTCCGGC GCGCCACGCCGAGGGATCTCTGGACAGGACAAGACTCCGAAGCTACTCCCCCAGCACACAGCCCGGGACCCACAAACCCAGCTTGCCCCC AGCCCTCCCACCTGCCACTCCCTGGCCCCTCCCACCGCCCGCCCCCCTTGGGGCGCAGGGCATGGTGTGAAAGGCCAAGTGCTGAGGCGG GTATCATGGGTGCTGTGCCCTAGGGCCTGGGTGGCAGGGGGTGGGTGGCCTGTGGGTGTGCCGGGGGGGCCAGTGTGCCCACCCCAGTCT CTTGGCGTGCTGGAGGGCATCCTGGATGGAATTGAAGTGAATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAA CAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAACGGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCT GGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCAACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTT TCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCCTGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTG CCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATGGCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCT GATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATGATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCT GATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCCCAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGG CCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTGGACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCAC CCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCCGAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGA GATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAGAGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCT CAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTTGAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGC TCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCGGGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCT GGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATTCCGCACTTCTGGCCCAAGCTGCTGATGAAGAGAAGAGGCCCCCTGAGCCC CCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCC GCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCC ACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGT CCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTAC CAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCA TTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGG GCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCA CCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAG TTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCA CTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTAC CTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGA AGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCT TTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCT ATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTC CCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCC CTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTC TCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTG AGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACT CTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACA GCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAATAACAGCATTTAGCATATTGTTTACACATAT >In-frame_THRA_ENST00000450525_chr17_38245586_+_CDK12_ENST00000430627_chr17_37686884_+_6831nt GAGGCGGCCTGCAGGGAGCAGCCGCGAGCCGGCCGGGCGCGCCGAGCCCGAGCCCCAGCCGGAGCGGGGCGGGGGAGGGAGGAGCCAGAG CGGCCGCCGCCTCTGCCGGAGGAGCCGCGGGGCCGCCACACTCGCCCCCCGCCCCCCCCGCGCTCACTCGCACTCACACCCGGGCGCAGG AGGCGGGCGGCCCGGGCCCCACCGGCCCCCCATGGACGCCCCCAGCACGGGGCGCTGAGACCCCCGCGTCGCTGCCCAGCCCGGTCCGGC GCGCCACGCCGAGGGATCTCTGGACAGGACAAGACTCCGAAGCTACTCCCCCAGCACACAGCCCGGGACCCACAAACCCAGCTTGCCCCC AGCCCTCCCACCTGCCACTCCCTGGCCCCTCCCACCGCCCGCCCCCCTTGGGGCGCAGGGCATGGTGTGAAAGGCCAAGTGCTGAGGCGG GTATCATGGGTGCTGTGCCCTAGGGCCTGGGTGGCAGGGGGTGGGTGGCCTGTGGGTGTGCCGGGGGGGCCAGTGTGCCCACCCCAGTCT CTTGGCGTGCTGGAGGGCATCCTGGATGGAATTGAAGTGAATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAA CAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAACGGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCT GGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCAACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTT TCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCCTGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTG CCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATGGCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCT GATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATGATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCT GATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCCCAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGG CCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTGGACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCAC CCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCCGAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGA GATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAGAGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCT CAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTTGAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGC TCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCGGGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCT GGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATTCCGCACTTCTGGCCCAAGCTGCTGATGAAGGTGACTGACCTCCGCATGAT CGGGGCCTGCCACGCCAGCCGCTTCCTCCACATGAAAGTCGAGTGCCCCACCGAACTCTTCCCCCCACTCTTCCTCGAGGTCTTTGAGGA TCAGGAAGTCTAAAGCCTCAGGCGGCCAGAGGGTGTGCGGAGCTGGTGGGGAGGAGCCTGGAGAGAAGGGGCAGAGCTGGGGGCTGAGGG AGACCCCCCCACACCCCTTCTCTCCTTCCTCTCGTCCTTGGATAGATTCAGCTCCCACACACACACCCGCACTGCCCAGGTCCCTCCTCA GACCTCCAGCCCTGGGACAGGGCAAACAACTGAACTTGCTATGGAAAGGACAGTGTGGGAGGCTGGGGGAGCTGTGTCCTGCAGTTCCCA GGACCCCATCCTCTCAGAAGGTAGGGGAAGGGCGGGAGGATTGAGAAGGGACAAGCCACCTTGACCGTAGGGGAAGGAGGAATGTGGGCT GGGGGAAGATGCCCTCAACTCACCCCCTACACACACATGAGAGAGAGCCCCCACCCAGTTCCTTGGCCTAGGTCTCCCCTCCAGGCTGAG GGCCTCTCTACTTCCCCAGATGCCTGGGTGCAAAGAACGGCTTGGCTTGGCTCCTCCTCTGGAGGTTAAAATTTATAGTCATTCTAACTG CACTTTGGAAACCAAGCAAGGGGAGAAGACAAATGAAGAAAAACTAGACAGAGAGAAAAATACAAAAAAGAGAGAGCGAGCGATAGAGAG AGATGATATTAAGTTATTAACTGAGGCTGACCAGAGGGGAGGACCCCCCCTTTACCACCCCATGCACTTTGCGAGCTGCCCCTTCTTCCC CCACATCAGAGAGAAATGCCCCCACACCAGAGCCCCAAGGGTAGGGCTGCCGATCAGAGCTGTGAGTTAACACAACAGGGTCCTGGCCAC CCCCCTTGCCATACCCCGCCCTCTGTGCCCCTTTGGCACCCCCCAACCCTAGTATGTCCTCTGCTTTCTGCCACTCGTGCCCGCTGAGTT CCATCTACCTCTCATGCTGGATGCCAGCTGGCCCCTCACCAGCCTGCCCTGCTGCCCACACAGCTCCCCTTTAAGTGCCCAGCCCTAGGG GCCTCTCCCCATCCACCTCCTCCTTCCACACCTTGGCACCCACCCAGGAAAAAACTGTGGCTCCAACTCCTACCCTCCTTATATCCTGCA GTATTAGCTAGAAACCGGATGCTGCTGCATTGGTTGGGTCGGGGGTAGGAGGGCTGTGCGTGAGCGTCTCCCAGAACCCTCCACCCCTTT AGCACTCTGTTTCCCTGTTTCCCATCTGTCTTCTGGGCTCTCTCTAACCTCTGCCCTCCTCCCCAGCTCCTACTCACTGCACTAACTCTG GGCGGGCAGGTACCAGAATGGGGGTGTTTAGATAAGTGACACTTAGTTGGGGCCCCAGGGGAGGGGTGGTCGGTGCTCCTTTTTCTTTAA AGCTCTTTTGGCCAGCTGCCCCTCTGCCCCGGGACCCCTTCCCCTCTTCTTTTCTCTAATTCAGGGACTTTGGCTTGAGCCCCTCTCGCC CTCCTGGTGAGGGTGCTCTGTTGGTCTGCACTTGGGTGAGCTGTCCTCCTCCCCCTCCCTGTGGCTGCCGCCCACTCCTCAGGGGAGAGA GGGAGAGAGGAGGTGGTCCTCCCATGGGAGCAGGAGGTGGGGTGGGACAGAGCAGACCAGAGGGTGCTGGGCTCAGGGCTGCATGTCGGC AGGGATGGATGGGTGGACACAGATGCCCCCGGAAGCCATGGGGATTGGGGCAGGGGGTGGGGGGAGGGGTGCCAGGGCTTCCTGCGCTTT GCACTATTGGGGCAAAAATGTCTTAAGCAGTGGGGAACCTGCCACCCCACCCTGACCCTCAGCCTGCCACAGCCCCCTACACACACACAC ACACACACACACACACACACACACACACGGACATGCACACACGGACATGGGAAGGCAATGCTATGCTGCCCGTCAGGGCACTGTCCTTCC CCAATCGTTCAGGTGTTCCAACAGGGGTGGAGGGCCTGGAGGAGCACCCGCTGTCACCTGTGCATGTGCCTGTCCCACCCTGCTGGGGCC TCGGGCTGCCCGCGCTGTCTTTGTCTCTATCCTCTCTCTCTCTCCTGGAGTACTGAATCCTGTATTACTCCAGTCCCATGGGTAGGCCCT CTTGTACCTTCCTACCACGCCTGGGGGCCCAGTGGAATTCCTGACCTGTCTGCTGTCTTCCCCATCCCTCCATCCCCACCCCAACCCCTC CATCCCCATTCTCAGCCATGGACACGGCAGAGAAAAGGCCTTGAAGAGCCTTAGCCTCTTATAGGCACTTGGGACTCCCCCACCCTCCCC AATCATATGAGCTGTGATCCCATCCTCCCCGGACCCCTCCCTTCCCCCTCGGTGATGTGGGGTGTATGTGTGCGTTCCTCTGCGTGAATG TGTGAGTGAGTACACATGGTAGGGGAGGAGCCAGGGCGACTCAGGAGTGCCACGCACCTGCTCTAGAGCGGCAGCTGTCCCAGTCCCTGC TGTGGAAGTGGGGGACAGGGCCCTCTCCTGGGGGCCATTGGTGCTAATGAGGGGGATGGCCTTGATGTGGGTGCTCAGCATGCCTCCCCC AGTATTGGCCCGGGGCACTAGGGCAGGCAGGGTGGAGCAGCAGGTGCAGTATCGGTGGGAGGACGGGTTGCTGGGAATAGGACGAGGGGG CCAGGCCAGGACAAGGGGTTGCCAGAGCCATGACCACTACCCCGCCCCCACCACCCGCCTCTCCATCTCAGTATTGCCCCTCCCATCACT CATAACACACATACCTCATCCAGCCTCCTCCCTGCTCAGACTTGGGGAGGGTGGGGGAGGAGCCCCTACCCCTTCTCCTGGTGGCGGGTC TGCAGGGCTGGGAGAGGGCAGGGCGTTGTGAGAGAGAGACCGTCCATAAGGAGGACAGTAACTCCTGCCCTGGGAACTCCTGGGCGGGGG GGAGGGGGACACTGCCCAGAGGCGCTACTGAATGTATGAGAAGCTGGTGCTGGGCTGGGGGGAGGGGGGTTGTGGCCAGAAACAGGGAAG GAGGTAGGTCTCTTCCCCAGGGAGGGGTGGGACCGGCAGGGGTGACTTGAGGGGCTCCTACTCCTGCCCCACGTTGACAATCAGTATGTC TGTTATGTGCGATTTTTCACCCCGTTGTGTTTTGGGTCAGGATTTTAAAGAAAGATATTTTTATGGTAATTGTTGCTCGTCTATTTTACT ATATATTTATGTAATAAATATATGATGAAAATAAAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTG GTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAG CCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACT GATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTG AAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAG GACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTA CATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGC CCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAA CCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCG AGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGT TGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCA TTACATTGAAAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCA GGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTT TTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAA ATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAAT AAATTACTCATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTT GGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTC TCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAA GAACCTGGGATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAAT GTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGA >In-frame_THRA_ENST00000546243_chr17_38245586_+_CDK12_ENST00000447079_chr17_37686884_+_6602nt GAGGCGGCCTGCAGGGAGCAGCCGCGAGCCGGCCGGGCGCGCCGAGCCCGAGCCCCAGCCGGAGCGGGGCGGGGGAGGGAGGAGCCAGAG CGGCCGCCGCCTCTGCCGGAGGAGCCGCGGGGCCGCCACACTCGCCCCCCGCCCCCCCCGCGCTCACTCGCACTCACACCCGGGCGCAGG AGGCGGGCGGCCCGGGCCCCACCGGCCCCCCATGGACGCCCCCAGCACGGGGCGCTGAGACCCCCGCGTCGCTGCCCAGCCCGGTCCGGC GCGCCACGCCGAGGGATCTCTGGACAGGACAAGACTCCGAAGCTACTCCCCCAGCACACAGCCCGGGACCCACAAACCCAGCTTGCCCCC AGCCCTCCCACCTGCCACTCCCTGGCCCCTCCCACCGCCCGCCCCCCTTGGGGCGCAGGGCATGGTGTGAAAGGCCAAGTGCTGAGGCGG GTATCATGGGTGCTGTGCCCTAGGGCCTGGGTGGCAGGGGGTGGGTGGCCTGTGGGTGTGCCGGGGGGGCCAGTGTGCCCACCCCAGTCT CTTGGCGTGCTGGAGGGCATCCTGGATGGAATTGAAGTGAATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAA CAGTGCCAGGTCACCAGATGGAAAGCGAAAAAGAAAGAACGGCCAATGTTCCCTGAAAACCAGCATGTCAGGGTATATCCCTAGTTACCT GGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCAACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTT TCGCCGCACAATCCAGAAGAACCTCCATCCCACCTATTCCTGCAAATATGACAGCTGCTGTGTCATTGACAAGATCACCCGCAATCAGTG CCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATGGCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCT GATTGAGCAGAACCGGGAGCGGCGGCGGAAGGAGGAGATGATCCGATCACTGCAGCAGCGACCAGAGCCCACTCCTGAAGAGTGGGATCT GATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCCCAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGG CCAGTCACCCATTGTCTCCATGCCGGACGGAGACAAGGTGGACCTGGAAGCCTTCAGCGAGTTTACCAAGATCATCACCCCGGCCATCAC CCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCCGAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGA GATCATGTCCCTGCGGGCGGCTGTCCGCTACGACCCTGAGAGCGACACCCTGACGCTGAGTGGGGAGATGGCTGTCAAGCGGGAGCAGCT CAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTTGAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGC TCTGCTGCAGGCTGTGCTGCTAATGTCAACAGACCGCTCGGGCCTGCTGTGTGTGGACAAGATCGAGAAGAGTCAGGAGGCGTACCTGCT GGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATTCCGCACTTCTGGCCCAAGCTGCTGATGAAGGTGACTGACCTCCGCATGAT CGGGGCCTGCCACGCCAGCCGCTTCCTCCACATGAAAGTCGAGTGCCCCACCGAACTCTTCCCCCCACTCTTCCTCGAGGTCTTTGAGGA TCAGGAAGTCTAAAGCCTCAGGCGGCCAGAGGGTGTGCGGAGCTGGTGGGGAGGAGCCTGGAGAGAAGGGGCAGAGCTGGGGGCTGAGGG AGACCCCCCCACACCCCTTCTCTCCTTCCTCTCGTCCTTGGATAGATTCAGCTCCCACACACACACCCGCACTGCCCAGGTCCCTCCTCA GACCTCCAGCCCTGGGACAGGGCAAACAACTGAACTTGCTATGGAAAGGACAGTGTGGGAGGCTGGGGGAGCTGTGTCCTGCAGTTCCCA GGACCCCATCCTCTCAGGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTCC AGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCCA CATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGGG TTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTCA GGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAGG GTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATTG CAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGCT TATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACTTCAGTGTC CTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATTT GGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCTG GATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAAT GTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATTT TTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATAG TGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCCA CCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAAA GTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACTT TACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTG TCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCTT TACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACCA TGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAGG GCTAATAACAGCATTTAGCATATTGTTTACACATATATTTTTATGTCAAAAAAAAAACAAAAACCTTTCAAACAGAGCATTGTGATATTG TCAAAGAGAAAAACAAATCCTGAAGATACATGGAAATGTAACCTAGTTTAGGGTGGGTATTTTTCTGAAGATACATCAATACCTGACCTT TTTTAAAAAAATAATTTTAAAACAGCATACTGTGAGGAAGAACAGTATTGACATACCCACATCCCAGCATGTGTACCCTGCCAGTTCTTT TAGGGATTTTTCCTCCAAAGAGATTTGGATTTGGTTTTGGTAAAAGGGGTTAAATTGTGCTTCCAGGCAAGAACTTTGCCTTATCATAAA CAGGAAATGAAAAAGGGAAGGGCTGTCAGGATGGGATAATTTGGGAGGCTTCTCATTCTGGCTTCTATTTCTATGTGAGTACCAGCATAT AGAGTGTTTTAAAAACAGATACATGTCATATAATTTATCTGCACAGACTTAGACCTTCAGGAAACATAGGTTAAGCCCCCTTTTACAAAG AAAAAGTAAACATACTTCAGCATCTTGGAGGGTAGTTTTCAAAACTCAAGTTTCATGTTTCAATGCCAAGTTCTTATTTTAAAAAATAAA ATCTACTTATAAGAGAAAGGTGCATTACTTAAAAAAAAAAAACTTTAAAGAAATGAAAGAAGAACCCTCTTCAGATACTTACTTGAAGAC TGTTTTCCCCTGTTAATGAGATATAGCTAGATATCGGTGTGTGTATTTCTTTATTATTCTCTGGTTTTTGATCTGGCCTTGCCTCCAGGG CCAAACACTGATTTAGAAAGAGAGCCTTCTAGCTATTTTGGCATTGATGGCTTTTTATACCAGTGTGTCCAGTTAGATTTACTAGGCTTA CTGACATGCTATTGGTAAATCGCATTAAAGTTCATCTGAACCTTCTGTCTGTTGACTTCTTAGTCCTCAGACATGGGCCTTTGTGTTTTA GAATATTTGAATTTGAGTTATTGGGCCCCACTCCCTGTTTTTTATTAAAGAACGTGAGCCTGGGATACTTTCAGAAGTATCTGTTCAATG AAAAAAAGTTGGTTTCCCATCAAATATGAATAAAATTCTCTATATATTTCATTGTATTTTGGTTATCAGCAGTCATCAATAATGTTTTTC CCTCCCCTCTCCCACCTCTTATTTTTAATTATGCCAAATATCCTAAATAATATACTTAAGCCTCCATTCCCTCATCCCTACTAGGGAAGG GGGTGAGTGTATGTGTGAGTGTATGTGTATGTATGATCCCATCTCACCCCCACCCCCATTTTGGGAGTCTTTTAAAATGAAAACAAAGTT TGGTAGTTTTGACTATTTCTAAAAGCAGAGGAGAAAAAAAAACTTATTTAAATATCCTGGAATCTGTATGGAGGAAGAAAAGGTATTTGT TAATTTTTCAGTTACGTTATCTATAAACATGATGGAAGTAAAGGTTTGGCAGAATTTCACCTTGACTATTTGAAAATTACAGACCCAATT AATTCCATTCAAAAGTGGTTTTCGTTTTGTTTTAATTATTGTACAATGAGAGATATTGTCTATTAAATACATTATTTTGAACAGATGAGA AATCTGATTCTGTTCATGAGTGGGAGGCAAAACTGGTTTGACCGTGATCATTTTTGTGGTTTTGAAAACAAATATACTTGACCCAGTTTC CTTAGTTTTTTCTTCAACTGTCCATAGGAACGATAAGTATTTGAAAGCAACATCAAATCTATACGTTTAAAGCAGGGCAGTTAGCACAAA TTTGCAAGTAGAACTTCTATTAGCTTATGCCATAGACATCACCCAACCACTTGTATGTGTGTGTGTATATATAATATGCATATATAGTTA CCGTGCTAAAATGGTTACCAGCAGGTTTTGAGAGAGAATGCTGCATCAGAAAAGTGTCAGTTGCCACCTCATTCTCCCTGATTTAGGTTC CTGACACTGATTCCTTTCTCTCTCGTTTTTGACCCCCATTGGGTGTATCTTGTCTATGTACAGATATTTTGTAATATATTAAATTTTTTT CTTTCAGTTTATAAAAATGGAAAGTGGAGATTGGAAAATTAAATATTTCCTGTTACTATACCACTTTTGCTCCATTGCATTTACTTCTTA ATCTGTACCCCCTGAGCATATCTAATCATGTATAAAGGACGTTTTTCCTCCACTTTATCTTAGGGGTTCTCTGTCTCAGAATCATTATAG ACTCATTAACTCCCCCTCCCAGCAAAAGGTTATCAGGATTTGAAGAGGTGCTTGAAAACGCTAGACTAGGAACTAGAGAATAAATGAGTT GGGAAAAACCATGAAATGTGATTTTTTTAAAGTAGAAAAGTTATACAAATAATGGTACCAAACCATCAAAAGAGTTGAGCTTCATGTACC CTGACTCCTCCTGACAGGAGAGGTAAGTGGGTTTGAGCTCAACTGTCATCAAGGGAAGTTGGTAAGAGGCTGTTTAGACCCAAAGGATAG TCTTAAACCAGACTTCACCACCCACCCTACCTCAGTTCCCATGTTATTACATGCAGAGTCAGCATGGGGATTAGTGTACCTACCTTTGCT GAGATTTCCCGATGCGTTGCCAATCCAGAAAGTGAATCAAAAAGTTGTTTAAAAGTTAAAATCTCTATTGTTTCCAAAATCTTTCCCATC 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FusionGenePPI for THRA_CDK12 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| THRA | NCOA6, TDG, CCND1, MEF2A, EP300, YWHAQ, ITGB3BP, POU2F1, DAP3, NR0B2, NRIP1, HR, AKAP13, MED12, MED16, MED6, MED24, CDK8, MED21, TRIM24, COPS2, TRIP11, RXRA, MED1, FUS, HDAC3, NCOR1, ZBTB3, SUV39H1, PARP1, NCOA1, NCOA2, NCOA3, TAF11, TAF7, GRIP1, NCOR2, EMD, PRKDC, SMC1A, LIG3, XRCC5, XRCC6, HSPA4, TBL1XR1, GPS2, TBL1X, CUL1, RGN, SEPP1, CDK7, MED25, ARID5A, GTF2B, C1D, THRA, CLIC1, FOXJ1, BUB3, PTGES3, RANBP9, AMOTL2, L3MBTL3, ENO1, MOV10, NXF1, UBE2I, CEP76, TRIM63, A2ML1, HAL, CST6, MTNR1B | CDK12 | MGMT, SRRM2, RBM39, ELAVL1, MYC, PRPF4, CDK13, CCNK, TRIM24, IPPK, VPS51, ZNF606, TCEB3, BARD1, PAXIP1, PRPF40A, EWSR1, CDK20, CDK9, PIN1, RPL14, ACAA1, MAP4K4, SCAF4, SUPT16H, SRPK2, CLK1, BCLAF1, RNPS1, SNW1, PCGF1, CDX1, RPL37A, RRS1, ZNF2, FGF8, RPS14, WEE1, LASP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for THRA_CDK12 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | THRA | P10827 | DB00451 | Levothyroxine | Thyroid hormone receptor alpha | small molecule | approved |
| Hgene | THRA | P10827 | DB00509 | Dextrothyroxine | Thyroid hormone receptor alpha | small molecule | approved|investigational |
| Hgene | THRA | P10827 | DB01118 | Amiodarone | Thyroid hormone receptor alpha | small molecule | approved|investigational |
| Hgene | THRA | P10827 | DB00279 | Liothyronine | Thyroid hormone receptor alpha | small molecule | approved|vet_approved |
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RelatedDiseases for THRA_CDK12 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | THRA | C3280817 | HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 6 | 2 | UNIPROT |
| Hgene | THRA | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | THRA | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
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