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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37984

FusionGeneSummary for THEMIS2_THEMIS2

check button Fusion gene summary
Fusion gene informationFusion gene name: THEMIS2_THEMIS2
Fusion gene ID: 37984
HgeneTgene
Gene symbol

THEMIS2

THEMIS2

Gene ID

9473

9473

Gene namethymocyte selection associated family member 2thymocyte selection associated family member 2
SynonymsC1orf38|ICB-1|ICB1C1orf38|ICB-1|ICB1
Cytomap

1p35.3

1p35.3

Type of geneprotein-codingprotein-coding
Descriptionprotein THEMIS2basement membrane-inducedinduced by contact to basement membrane 1 proteinprotein ICB-1thymocyte-expressed molecule involved in selection protein 2protein THEMIS2basement membrane-inducedinduced by contact to basement membrane 1 proteinprotein ICB-1thymocyte-expressed molecule involved in selection protein 2
Modification date2018051920180519
UniProtAcc

Q5TEJ8

Q5TEJ8

Ensembl transtripts involved in fusion geneENST00000373925, ENST00000328928, 
ENST00000373927, ENST00000373921, 
ENST00000492877, 		ENST00000373925, 
ENST00000328928, ENST00000373927, 
ENST00000373921, ENST00000492877, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: THEMIS2 [Title/Abstract] AND THEMIS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF873826THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000373925ENST00000373925THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000373925ENST00000328928THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000373925ENST00000373927THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000373925ENST00000373921THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000373925ENST00000492877THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000328928ENST00000373925THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000328928ENST00000328928THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000328928ENST00000373927THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000328928ENST00000373921THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000328928ENST00000492877THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000373927ENST00000373925THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000373927ENST00000328928THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000373927ENST00000373927THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000373927ENST00000373921THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000373927ENST00000492877THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
5CDS-intronENST00000373921ENST00000373925THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
5CDS-intronENST00000373921ENST00000328928THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
5CDS-intronENST00000373921ENST00000373927THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
5CDS-intronENST00000373921ENST00000373921THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
5CDS-intronENST00000373921ENST00000492877THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000492877ENST00000373925THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000492877ENST00000328928THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000492877ENST00000373927THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000492877ENST00000373921THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+
intron-intronENST00000492877ENST00000492877THEMIS2chr1

28208842

-THEMIS2chr1

28208957

+

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FusionProtFeatures for THEMIS2_THEMIS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
THEMIS2

Q5TEJ8

THEMIS2

Q5TEJ8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for THEMIS2_THEMIS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for THEMIS2_THEMIS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for THEMIS2_THEMIS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for THEMIS2_THEMIS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTHEMIS2C1458155Mammary Neoplasms1CTD_human
TgeneTHEMIS2C1458155Mammary Neoplasms1CTD_human