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Fusion gene ID: 37981 |
FusionGeneSummary for THBS4_SCFD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: THBS4_SCFD2 | Fusion gene ID: 37981 | Hgene | Tgene | Gene symbol | THBS4 | SCFD2 | Gene ID | 7060 | 152579 |
| Gene name | thrombospondin 4 | sec1 family domain containing 2 | |
| Synonyms | TSP-4|TSP4 | STXBP1L1 | |
| Cytomap | 5q14.1 | 4q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | thrombospondin-4 | sec1 family domain-containing protein 2syntaxin binding protein 1-like 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P35443 | Q8WU76 | |
| Ensembl transtripts involved in fusion gene | ENST00000350881, ENST00000511733, ENST00000504720, | ENST00000401642, ENST00000388940, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 10 X 8 X 10=800 |
| # samples | 3 | 11 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/800*10)=-2.86249647625006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: THBS4 [Title/Abstract] AND SCFD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | THBS4 | GO:0001938 | positive regulation of endothelial cell proliferation | 12952849 |
| Hgene | THBS4 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 16099885 |
| Hgene | THBS4 | GO:0051451 | myoblast migration | 7519904 |
| Hgene | THBS4 | GO:0071603 | endothelial cell-cell adhesion | 12952849 |
| Hgene | THBS4 | GO:0090023 | positive regulation of neutrophil chemotaxis | 16099885 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-92-7341-01A | THBS4 | chr5 | 79287235 | + | SCFD2 | chr4 | 54011749 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000350881 | ENST00000401642 | THBS4 | chr5 | 79287235 | + | SCFD2 | chr4 | 54011749 | - |
| intron-3CDS | ENST00000350881 | ENST00000388940 | THBS4 | chr5 | 79287235 | + | SCFD2 | chr4 | 54011749 | - |
| intron-3CDS | ENST00000511733 | ENST00000401642 | THBS4 | chr5 | 79287235 | + | SCFD2 | chr4 | 54011749 | - |
| intron-3CDS | ENST00000511733 | ENST00000388940 | THBS4 | chr5 | 79287235 | + | SCFD2 | chr4 | 54011749 | - |
| intron-3CDS | ENST00000504720 | ENST00000401642 | THBS4 | chr5 | 79287235 | + | SCFD2 | chr4 | 54011749 | - |
| intron-3CDS | ENST00000504720 | ENST00000388940 | THBS4 | chr5 | 79287235 | + | SCFD2 | chr4 | 54011749 | - |
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FusionProtFeatures for THBS4_SCFD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| THBS4 | SCFD2 |
| Adhesive glycoprotein that mediates cell-to-cell andcell-to-matrix interactions and is involved in various processesincluding cellular proliferation, migration, adhesion andattachment, inflammatory response to CNS injury, regulation ofvascular inflammation and adaptive responses of the heart topressure overload and in myocardial function and remodeling. Bindsto structural extracellular matrix (ECM) proteins and modulatesthe ECM in response to tissue damage, contributing tocardioprotective and adaptive ECM remodeling. Plays a role in ERstress response, via its interaction with the activatingtranscription factor 6 alpha (ATF6) which produces adaptive ERstress response factors and protects myocardium from pressureoverload. May contribute to spinal presynaptic hypersensitivityand neuropathic pain states after peripheral nerve injury. Mayplay a role in regulating protective astrogenesis from thesubventricular zone (SVZ) niche after injury in a NOTCH1-dependentmanner (By similarity). {ECO:0000250,ECO:0000269|PubMed:19441079}. | May be involved in protein transport. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for THBS4_SCFD2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for THBS4_SCFD2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| THBS4 | THBS3, APP | SCFD2 | USE1, STX12, NAPG, SIRT2, RINT1, NBAS, SEC22B, BNIP1, ZW10, C19orf25, VAMP4, STX18 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for THBS4_SCFD2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for THBS4_SCFD2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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