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Fusion gene ID: 37981 |
FusionGeneSummary for THBS4_SCFD2 |
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Fusion gene information | Fusion gene name: THBS4_SCFD2 | Fusion gene ID: 37981 | Hgene | Tgene | Gene symbol | THBS4 | SCFD2 | Gene ID | 7060 | 152579 |
Gene name | thrombospondin 4 | sec1 family domain containing 2 | |
Synonyms | TSP-4|TSP4 | STXBP1L1 | |
Cytomap | 5q14.1 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | thrombospondin-4 | sec1 family domain-containing protein 2syntaxin binding protein 1-like 1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P35443 | Q8WU76 | |
Ensembl transtripts involved in fusion gene | ENST00000350881, ENST00000511733, ENST00000504720, | ENST00000401642, ENST00000388940, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 10 X 8 X 10=800 |
# samples | 3 | 11 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/800*10)=-2.86249647625006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: THBS4 [Title/Abstract] AND SCFD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | THBS4 | GO:0001938 | positive regulation of endothelial cell proliferation | 12952849 |
Hgene | THBS4 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 16099885 |
Hgene | THBS4 | GO:0051451 | myoblast migration | 7519904 |
Hgene | THBS4 | GO:0071603 | endothelial cell-cell adhesion | 12952849 |
Hgene | THBS4 | GO:0090023 | positive regulation of neutrophil chemotaxis | 16099885 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-92-7341-01A | THBS4 | chr5 | 79287235 | + | SCFD2 | chr4 | 54011749 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000350881 | ENST00000401642 | THBS4 | chr5 | 79287235 | + | SCFD2 | chr4 | 54011749 | - |
intron-3CDS | ENST00000350881 | ENST00000388940 | THBS4 | chr5 | 79287235 | + | SCFD2 | chr4 | 54011749 | - |
intron-3CDS | ENST00000511733 | ENST00000401642 | THBS4 | chr5 | 79287235 | + | SCFD2 | chr4 | 54011749 | - |
intron-3CDS | ENST00000511733 | ENST00000388940 | THBS4 | chr5 | 79287235 | + | SCFD2 | chr4 | 54011749 | - |
intron-3CDS | ENST00000504720 | ENST00000401642 | THBS4 | chr5 | 79287235 | + | SCFD2 | chr4 | 54011749 | - |
intron-3CDS | ENST00000504720 | ENST00000388940 | THBS4 | chr5 | 79287235 | + | SCFD2 | chr4 | 54011749 | - |
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FusionProtFeatures for THBS4_SCFD2 |
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Hgene | Tgene |
THBS4 | SCFD2 |
Adhesive glycoprotein that mediates cell-to-cell andcell-to-matrix interactions and is involved in various processesincluding cellular proliferation, migration, adhesion andattachment, inflammatory response to CNS injury, regulation ofvascular inflammation and adaptive responses of the heart topressure overload and in myocardial function and remodeling. Bindsto structural extracellular matrix (ECM) proteins and modulatesthe ECM in response to tissue damage, contributing tocardioprotective and adaptive ECM remodeling. Plays a role in ERstress response, via its interaction with the activatingtranscription factor 6 alpha (ATF6) which produces adaptive ERstress response factors and protects myocardium from pressureoverload. May contribute to spinal presynaptic hypersensitivityand neuropathic pain states after peripheral nerve injury. Mayplay a role in regulating protective astrogenesis from thesubventricular zone (SVZ) niche after injury in a NOTCH1-dependentmanner (By similarity). {ECO:0000250,ECO:0000269|PubMed:19441079}. | May be involved in protein transport. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for THBS4_SCFD2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for THBS4_SCFD2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
THBS4 | THBS3, APP | SCFD2 | USE1, STX12, NAPG, SIRT2, RINT1, NBAS, SEC22B, BNIP1, ZW10, C19orf25, VAMP4, STX18 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for THBS4_SCFD2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for THBS4_SCFD2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |