FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 37981

FusionGeneSummary for THBS4_SCFD2

check button Fusion gene summary
Fusion gene informationFusion gene name: THBS4_SCFD2
Fusion gene ID: 37981
HgeneTgene
Gene symbol

THBS4

SCFD2

Gene ID

7060

152579

Gene namethrombospondin 4sec1 family domain containing 2
SynonymsTSP-4|TSP4STXBP1L1
Cytomap

5q14.1

4q12

Type of geneprotein-codingprotein-coding
Descriptionthrombospondin-4sec1 family domain-containing protein 2syntaxin binding protein 1-like 1
Modification date2018051920180519
UniProtAcc

P35443

Q8WU76

Ensembl transtripts involved in fusion geneENST00000350881, ENST00000511733, 
ENST00000504720, 
ENST00000401642, 
ENST00000388940, 
Fusion gene scores* DoF score3 X 2 X 3=1810 X 8 X 10=800
# samples 311
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/800*10)=-2.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: THBS4 [Title/Abstract] AND SCFD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTHBS4

GO:0001938

positive regulation of endothelial cell proliferation

12952849

HgeneTHBS4

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

16099885

HgeneTHBS4

GO:0051451

myoblast migration

7519904

HgeneTHBS4

GO:0071603

endothelial cell-cell adhesion

12952849

HgeneTHBS4

GO:0090023

positive regulation of neutrophil chemotaxis

16099885


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-92-7341-01ATHBS4chr5

79287235

+SCFD2chr4

54011749

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000350881ENST00000401642THBS4chr5

79287235

+SCFD2chr4

54011749

-
intron-3CDSENST00000350881ENST00000388940THBS4chr5

79287235

+SCFD2chr4

54011749

-
intron-3CDSENST00000511733ENST00000401642THBS4chr5

79287235

+SCFD2chr4

54011749

-
intron-3CDSENST00000511733ENST00000388940THBS4chr5

79287235

+SCFD2chr4

54011749

-
intron-3CDSENST00000504720ENST00000401642THBS4chr5

79287235

+SCFD2chr4

54011749

-
intron-3CDSENST00000504720ENST00000388940THBS4chr5

79287235

+SCFD2chr4

54011749

-

Top

FusionProtFeatures for THBS4_SCFD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
THBS4

P35443

SCFD2

Q8WU76

Adhesive glycoprotein that mediates cell-to-cell andcell-to-matrix interactions and is involved in various processesincluding cellular proliferation, migration, adhesion andattachment, inflammatory response to CNS injury, regulation ofvascular inflammation and adaptive responses of the heart topressure overload and in myocardial function and remodeling. Bindsto structural extracellular matrix (ECM) proteins and modulatesthe ECM in response to tissue damage, contributing tocardioprotective and adaptive ECM remodeling. Plays a role in ERstress response, via its interaction with the activatingtranscription factor 6 alpha (ATF6) which produces adaptive ERstress response factors and protects myocardium from pressureoverload. May contribute to spinal presynaptic hypersensitivityand neuropathic pain states after peripheral nerve injury. Mayplay a role in regulating protective astrogenesis from thesubventricular zone (SVZ) niche after injury in a NOTCH1-dependentmanner (By similarity). {ECO:0000250,ECO:0000269|PubMed:19441079}. May be involved in protein transport.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for THBS4_SCFD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for THBS4_SCFD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
THBS4THBS3, APPSCFD2USE1, STX12, NAPG, SIRT2, RINT1, NBAS, SEC22B, BNIP1, ZW10, C19orf25, VAMP4, STX18


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for THBS4_SCFD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for THBS4_SCFD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource