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Fusion gene ID: 37978 |
FusionGeneSummary for THBS3_HDGF |
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Fusion gene information | Fusion gene name: THBS3_HDGF | Fusion gene ID: 37978 | Hgene | Tgene | Gene symbol | THBS3 | HDGF | Gene ID | 7059 | 3068 |
Gene name | thrombospondin 3 | heparin binding growth factor | |
Synonyms | TSP3 | HMG1L2 | |
Cytomap | 1q22 | 1q23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | thrombospondin-3 | hepatoma-derived growth factorhepatoma derived growth factorhigh mobility group protein 1-like 2 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | P49746 | P51858 | |
Ensembl transtripts involved in fusion gene | ENST00000368378, ENST00000541576, ENST00000457183, ENST00000541990, ENST00000486260, | ENST00000357325, ENST00000537739, ENST00000368209, ENST00000465180, ENST00000416666, ENST00000368206, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 6 X 3=90 |
# samples | 2 | 6 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: THBS3 [Title/Abstract] AND HDGF [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | HDGF | GO:0000122 | negative regulation of transcription by RNA polymerase II | 19162039 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-78-7539-01A | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000368378 | ENST00000357325 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
Frame-shift | ENST00000368378 | ENST00000537739 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
Frame-shift | ENST00000368378 | ENST00000368209 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
5CDS-5UTR | ENST00000368378 | ENST00000465180 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
5CDS-5UTR | ENST00000368378 | ENST00000416666 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
5CDS-5UTR | ENST00000368378 | ENST00000368206 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
intron-3CDS | ENST00000541576 | ENST00000357325 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
intron-3CDS | ENST00000541576 | ENST00000537739 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
intron-3CDS | ENST00000541576 | ENST00000368209 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
intron-5UTR | ENST00000541576 | ENST00000465180 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
intron-5UTR | ENST00000541576 | ENST00000416666 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
intron-5UTR | ENST00000541576 | ENST00000368206 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
Frame-shift | ENST00000457183 | ENST00000357325 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
Frame-shift | ENST00000457183 | ENST00000537739 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
Frame-shift | ENST00000457183 | ENST00000368209 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
5CDS-5UTR | ENST00000457183 | ENST00000465180 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
5CDS-5UTR | ENST00000457183 | ENST00000416666 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
5CDS-5UTR | ENST00000457183 | ENST00000368206 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
intron-3CDS | ENST00000541990 | ENST00000357325 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
intron-3CDS | ENST00000541990 | ENST00000537739 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
intron-3CDS | ENST00000541990 | ENST00000368209 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
intron-5UTR | ENST00000541990 | ENST00000465180 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
intron-5UTR | ENST00000541990 | ENST00000416666 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
intron-5UTR | ENST00000541990 | ENST00000368206 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
5UTR-3CDS | ENST00000486260 | ENST00000357325 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
5UTR-3CDS | ENST00000486260 | ENST00000537739 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
5UTR-3CDS | ENST00000486260 | ENST00000368209 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
5UTR-5UTR | ENST00000486260 | ENST00000465180 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
5UTR-5UTR | ENST00000486260 | ENST00000416666 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
5UTR-5UTR | ENST00000486260 | ENST00000368206 | THBS3 | chr1 | 155175991 | - | HDGF | chr1 | 156715165 | - |
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FusionProtFeatures for THBS3_HDGF |
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Hgene | Tgene |
THBS3 | HDGF |
Adhesive glycoprotein that mediates cell-to-cell andcell-to-matrix interactions. Can bind to fibrinogen, fibronectin,laminin and type V collagen. | Heparin-binding protein, with mitogenic activity forfibroblasts. Acts as a transcriptional repressor.{ECO:0000269|PubMed:17974029}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for THBS3_HDGF |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for THBS3_HDGF |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
THBS3 | THBS3, HSPD1, BBS2, CPS1, RFC1, SMG8, ASCC3, PC, CCT7, RIC8B, TRO, GTPBP6, METTL13, CCZ1, NDUFA3, PKN2, THBS1, THBS4, TUBA4A, TUBA1A, LRWD1, NSUN2, RPL23, PIK3C2A, TUBB3, TUBB8, PEX1, MTPAP, PEX6, CPSF3L, HPS3, BLVRA, PLD2, PCCA, MTO1, IQSEC2, TOP2A, DDX11, DIP2A, CIRH1A, BBS7, DNM3, RAD21, TIGD5, FANCB, C5orf34, APBB1, TTLL5, BDH1, PDE7A, FDXR, NOL11, ARHGEF1, SH3BP4, MKS1, TBC1D2B, TRMT44, CWF19L1, PPOX, RAD51C, RIPK4, MCM9, RTEL1, CORO7, MAP3K7, CCT2, SLC25A6, DNAJA3, GSG2 | HDGF | XBP1, EMD, KAT5, KAT2A, ABCF1, ATAD3A, BMS1, BRIX1, ASUN, VWA9, C7orf26, C7orf50, C8orf33, CDK1, CDC5L, DDX1, DDX17, DDX21, DDX47, DDX5, DDX50, DHX15, DHX30, DHX9, DIMT1, EBNA1BP2, EFTUD2, EIF2S1, EIF2S3, EIF5B, EXOSC10, EXOSC2, EXOSC3, EXOSC6, FARSB, FBL, GNL3, GRWD1, GTPBP1, H1FX, HDAC1, HDAC2, HIST1H1E, HIST1H2BK, HIST1H3A, HIST1H3D, HIST1H3C, HIST1H3E, HIST1H3I, HIST1H3G, HIST1H3J, HIST1H3H, HIST1H3B, HIST1H3F, HIST1H4I, HIST1H4A, HIST1H4D, HIST1H4F, HIST1H4K, HIST1H4J, HIST1H4C, HIST1H4H, HIST1H4B, HIST1H4E, HIST1H4L, HIST2H4A, HIST4H4, HIST2H4B, HNRNPA2B1, HNRNPA3, HNRNPU, INTS10, KIF2A, KPNA2, LRRC59, MRTO4, MYBBP1A, NACA, NCL, NOP2, PARP1, PGAM5, POLDIP3, POLRMT, PRKDC, PSIP1, PWP2, RBBP4, RBM39, RCC2, RFC1, RFC4, RFC5, RPA1, RPL17, RPL19, RPL22, RPL32, RPL34, RPL35, RPL35A, RPS11, RPS15A, RPS23, RRP1B, RSL1D1, SRSF1, SRSF2, SRSF3, SRSF5, SRSF7, SLC25A3, SLC25A5, SMC3, SNRPD1, SRPK1, SSR1, SSRP1, STAU1, SUB1, SUPT16H, ALYREF, TMPO, TOP1, TSR1, U2AF1, WDR36, WDR5, XRCC5, XRCC6, ZC3HAV1, RNA28S5, RNA18S5, ACTL6A, BAZ1B, BUB3, CBX3, CKAP4, DEK, DNAJA1, DRG1, EEF2, EIF2AK2, EIF2S2, H1F0, H2AFY, H2AFY2, HIST1H1D, HIST1H1C, HIST1H2BD, HIST1H2BG, HIST1H2BF, HIST1H2BE, HIST1H2BI, HIST1H2BC, HMGA2, HMGN1, HP1BP3, HSD17B10, HSPA9, LYAR, MAGEB2, MAP4, MAPK14, MPG, MRPS22, MRPS27, NUDC, PHF6, PLS3, RAN, RBMX, RCC1, RCL1, RFC3, TRMT10C, RPL10, RPP38, RUVBL1, SMARCA5, SRP68, SRP72, SSB, THOC3, U2AF2, UBA52, ZRANB2, KRT1, KRT10, KRT2, PRMT5, PRSS3, HIST2H2BE, JUN, PARK2, ASB6, AHCY, CROCC, MCTS1, OLA1, SH2D4A, UBR7, SNRPF, ENO1, MOV10, NXF1, NTRK1, MSH6, PSME3, APP, EWSR1, EGFR, EGFL6, CPNE2, FOXA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for THBS3_HDGF |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for THBS3_HDGF |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | HDGF | C0019693 | HIV Infections | 1 | CTD_human |