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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37978

FusionGeneSummary for THBS3_HDGF

check button Fusion gene summary
Fusion gene informationFusion gene name: THBS3_HDGF
Fusion gene ID: 37978
HgeneTgene
Gene symbol

THBS3

HDGF

Gene ID

7059

3068

Gene namethrombospondin 3heparin binding growth factor
SynonymsTSP3HMG1L2
Cytomap

1q22

1q23.1

Type of geneprotein-codingprotein-coding
Descriptionthrombospondin-3hepatoma-derived growth factorhepatoma derived growth factorhigh mobility group protein 1-like 2
Modification date2018051920180522
UniProtAcc

P49746

P51858

Ensembl transtripts involved in fusion geneENST00000368378, ENST00000541576, 
ENST00000457183, ENST00000541990, 
ENST00000486260, 
ENST00000357325, 
ENST00000537739, ENST00000368209, 
ENST00000465180, ENST00000416666, 
ENST00000368206, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 6 X 3=90
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: THBS3 [Title/Abstract] AND HDGF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHDGF

GO:0000122

negative regulation of transcription by RNA polymerase II

19162039


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-78-7539-01ATHBS3chr1

155175991

-HDGFchr1

156715165

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000368378ENST00000357325THBS3chr1

155175991

-HDGFchr1

156715165

-
Frame-shitENST00000368378ENST00000537739THBS3chr1

155175991

-HDGFchr1

156715165

-
Frame-shitENST00000368378ENST00000368209THBS3chr1

155175991

-HDGFchr1

156715165

-
5CDS-5UTRENST00000368378ENST00000465180THBS3chr1

155175991

-HDGFchr1

156715165

-
5CDS-5UTRENST00000368378ENST00000416666THBS3chr1

155175991

-HDGFchr1

156715165

-
5CDS-5UTRENST00000368378ENST00000368206THBS3chr1

155175991

-HDGFchr1

156715165

-
intron-3CDSENST00000541576ENST00000357325THBS3chr1

155175991

-HDGFchr1

156715165

-
intron-3CDSENST00000541576ENST00000537739THBS3chr1

155175991

-HDGFchr1

156715165

-
intron-3CDSENST00000541576ENST00000368209THBS3chr1

155175991

-HDGFchr1

156715165

-
intron-5UTRENST00000541576ENST00000465180THBS3chr1

155175991

-HDGFchr1

156715165

-
intron-5UTRENST00000541576ENST00000416666THBS3chr1

155175991

-HDGFchr1

156715165

-
intron-5UTRENST00000541576ENST00000368206THBS3chr1

155175991

-HDGFchr1

156715165

-
Frame-shitENST00000457183ENST00000357325THBS3chr1

155175991

-HDGFchr1

156715165

-
Frame-shitENST00000457183ENST00000537739THBS3chr1

155175991

-HDGFchr1

156715165

-
Frame-shitENST00000457183ENST00000368209THBS3chr1

155175991

-HDGFchr1

156715165

-
5CDS-5UTRENST00000457183ENST00000465180THBS3chr1

155175991

-HDGFchr1

156715165

-
5CDS-5UTRENST00000457183ENST00000416666THBS3chr1

155175991

-HDGFchr1

156715165

-
5CDS-5UTRENST00000457183ENST00000368206THBS3chr1

155175991

-HDGFchr1

156715165

-
intron-3CDSENST00000541990ENST00000357325THBS3chr1

155175991

-HDGFchr1

156715165

-
intron-3CDSENST00000541990ENST00000537739THBS3chr1

155175991

-HDGFchr1

156715165

-
intron-3CDSENST00000541990ENST00000368209THBS3chr1

155175991

-HDGFchr1

156715165

-
intron-5UTRENST00000541990ENST00000465180THBS3chr1

155175991

-HDGFchr1

156715165

-
intron-5UTRENST00000541990ENST00000416666THBS3chr1

155175991

-HDGFchr1

156715165

-
intron-5UTRENST00000541990ENST00000368206THBS3chr1

155175991

-HDGFchr1

156715165

-
5UTR-3CDSENST00000486260ENST00000357325THBS3chr1

155175991

-HDGFchr1

156715165

-
5UTR-3CDSENST00000486260ENST00000537739THBS3chr1

155175991

-HDGFchr1

156715165

-
5UTR-3CDSENST00000486260ENST00000368209THBS3chr1

155175991

-HDGFchr1

156715165

-
5UTR-5UTRENST00000486260ENST00000465180THBS3chr1

155175991

-HDGFchr1

156715165

-
5UTR-5UTRENST00000486260ENST00000416666THBS3chr1

155175991

-HDGFchr1

156715165

-
5UTR-5UTRENST00000486260ENST00000368206THBS3chr1

155175991

-HDGFchr1

156715165

-

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FusionProtFeatures for THBS3_HDGF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
THBS3

P49746

HDGF

P51858

Adhesive glycoprotein that mediates cell-to-cell andcell-to-matrix interactions. Can bind to fibrinogen, fibronectin,laminin and type V collagen. Heparin-binding protein, with mitogenic activity forfibroblasts. Acts as a transcriptional repressor.{ECO:0000269|PubMed:17974029}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for THBS3_HDGF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for THBS3_HDGF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
THBS3THBS3, HSPD1, BBS2, CPS1, RFC1, SMG8, ASCC3, PC, CCT7, RIC8B, TRO, GTPBP6, METTL13, CCZ1, NDUFA3, PKN2, THBS1, THBS4, TUBA4A, TUBA1A, LRWD1, NSUN2, RPL23, PIK3C2A, TUBB3, TUBB8, PEX1, MTPAP, PEX6, CPSF3L, HPS3, BLVRA, PLD2, PCCA, MTO1, IQSEC2, TOP2A, DDX11, DIP2A, CIRH1A, BBS7, DNM3, RAD21, TIGD5, FANCB, C5orf34, APBB1, TTLL5, BDH1, PDE7A, FDXR, NOL11, ARHGEF1, SH3BP4, MKS1, TBC1D2B, TRMT44, CWF19L1, PPOX, RAD51C, RIPK4, MCM9, RTEL1, CORO7, MAP3K7, CCT2, SLC25A6, DNAJA3, GSG2HDGFXBP1, EMD, KAT5, KAT2A, ABCF1, ATAD3A, BMS1, BRIX1, ASUN, VWA9, C7orf26, C7orf50, C8orf33, CDK1, CDC5L, DDX1, DDX17, DDX21, DDX47, DDX5, DDX50, DHX15, DHX30, DHX9, DIMT1, EBNA1BP2, EFTUD2, EIF2S1, EIF2S3, EIF5B, EXOSC10, EXOSC2, EXOSC3, EXOSC6, FARSB, FBL, GNL3, GRWD1, GTPBP1, H1FX, HDAC1, HDAC2, HIST1H1E, HIST1H2BK, HIST1H3A, HIST1H3D, HIST1H3C, HIST1H3E, HIST1H3I, HIST1H3G, HIST1H3J, HIST1H3H, HIST1H3B, HIST1H3F, HIST1H4I, HIST1H4A, HIST1H4D, HIST1H4F, HIST1H4K, HIST1H4J, HIST1H4C, HIST1H4H, HIST1H4B, HIST1H4E, HIST1H4L, HIST2H4A, HIST4H4, HIST2H4B, HNRNPA2B1, HNRNPA3, HNRNPU, INTS10, KIF2A, KPNA2, LRRC59, MRTO4, MYBBP1A, NACA, NCL, NOP2, PARP1, PGAM5, POLDIP3, POLRMT, PRKDC, PSIP1, PWP2, RBBP4, RBM39, RCC2, RFC1, RFC4, RFC5, RPA1, RPL17, RPL19, RPL22, RPL32, RPL34, RPL35, RPL35A, RPS11, RPS15A, RPS23, RRP1B, RSL1D1, SRSF1, SRSF2, SRSF3, SRSF5, SRSF7, SLC25A3, SLC25A5, SMC3, SNRPD1, SRPK1, SSR1, SSRP1, STAU1, SUB1, SUPT16H, ALYREF, TMPO, TOP1, TSR1, U2AF1, WDR36, WDR5, XRCC5, XRCC6, ZC3HAV1, RNA28S5, RNA18S5, ACTL6A, BAZ1B, BUB3, CBX3, CKAP4, DEK, DNAJA1, DRG1, EEF2, EIF2AK2, EIF2S2, H1F0, H2AFY, H2AFY2, HIST1H1D, HIST1H1C, HIST1H2BD, HIST1H2BG, HIST1H2BF, HIST1H2BE, HIST1H2BI, HIST1H2BC, HMGA2, HMGN1, HP1BP3, HSD17B10, HSPA9, LYAR, MAGEB2, MAP4, MAPK14, MPG, MRPS22, MRPS27, NUDC, PHF6, PLS3, RAN, RBMX, RCC1, RCL1, RFC3, TRMT10C, RPL10, RPP38, RUVBL1, SMARCA5, SRP68, SRP72, SSB, THOC3, U2AF2, UBA52, ZRANB2, KRT1, KRT10, KRT2, PRMT5, PRSS3, HIST2H2BE, JUN, PARK2, ASB6, AHCY, CROCC, MCTS1, OLA1, SH2D4A, UBR7, SNRPF, ENO1, MOV10, NXF1, NTRK1, MSH6, PSME3, APP, EWSR1, EGFR, EGFL6, CPNE2, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for THBS3_HDGF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for THBS3_HDGF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHDGFC0019693HIV Infections1CTD_human