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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37977

FusionGeneSummary for THBS3_FBXW11

check button Fusion gene summary
Fusion gene informationFusion gene name: THBS3_FBXW11
Fusion gene ID: 37977
HgeneTgene
Gene symbol

THBS3

FBXW11

Gene ID

7059

23291

Gene namethrombospondin 3F-box and WD repeat domain containing 11
SynonymsTSP3BTRC2|BTRCP2|FBW1B|FBXW1B|Fbw11|Hos
Cytomap

1q22

5q35.1

Type of geneprotein-codingprotein-coding
Descriptionthrombospondin-3F-box/WD repeat-containing protein 11F-box and WD repeats protein beta-TrCP2F-box and WD-40 domain protein 11F-box and WD-40 domain protein 1BF-box protein Fbw1bF-box/WD repeat-containing protein 1Bbeta-transducin repeat-containing protein 2homolog
Modification date2018051920180523
UniProtAcc

P49746

Q9UKB1

Ensembl transtripts involved in fusion geneENST00000368378, ENST00000541576, 
ENST00000457183, ENST00000541990, 
ENST00000486260, 		ENST00000296933, 
ENST00000265094, ENST00000393802, 
ENST00000425623, ENST00000522891, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: THBS3 [Title/Abstract] AND FBXW11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFBXW11

GO:0000209

protein polyubiquitination

20347421

TgeneFBXW11

GO:0016567

protein ubiquitination

16885022

TgeneFBXW11

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

20347421

TgeneFBXW11

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

20347421


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE159509THBS3chr1

155175047

-FBXW11chr5

171391015

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000368378ENST00000296933THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000368378ENST00000265094THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000368378ENST00000393802THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000368378ENST00000425623THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000368378ENST00000522891THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000541576ENST00000296933THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000541576ENST00000265094THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000541576ENST00000393802THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000541576ENST00000425623THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000541576ENST00000522891THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000457183ENST00000296933THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000457183ENST00000265094THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000457183ENST00000393802THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000457183ENST00000425623THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000457183ENST00000522891THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000541990ENST00000296933THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000541990ENST00000265094THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000541990ENST00000393802THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000541990ENST00000425623THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000541990ENST00000522891THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000486260ENST00000296933THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000486260ENST00000265094THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000486260ENST00000393802THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000486260ENST00000425623THBS3chr1

155175047

-FBXW11chr5

171391015

+
intron-intronENST00000486260ENST00000522891THBS3chr1

155175047

-FBXW11chr5

171391015

+

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FusionProtFeatures for THBS3_FBXW11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
THBS3

P49746

FBXW11

Q9UKB1

Adhesive glycoprotein that mediates cell-to-cell andcell-to-matrix interactions. Can bind to fibrinogen, fibronectin,laminin and type V collagen. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediatesthe ubiquitination and subsequent proteasomal degradation oftarget proteins. Probably recognizes and binds to phosphorylatedtarget proteins. SCF(FBXW11) mediates the ubiquitination ofphosphorylated CTNNB1 and participates in Wnt signaling.SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA,which degradation frees the associated NFKB1 to translocate intothe nucleus and to activate transcription. SCF(FBXW11) mediatesthe ubiquitination of IFNAR1. SCF(FBXW11) mediates theubiquitination of CEP68; this is required for centriole separationduring mitosis (PubMed:25503564). Involved in the oxidativestress-induced a ubiquitin-mediated decrease in RCAN1. Mediatesthe degradation of CDC25A induced by ionizing radiation in cellsprogressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of theclock-dependent transcription via degradation of phosphorylatedPER1 and phosphorylated PER2. SCF(FBXW11) mediates theubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262).{ECO:0000269|PubMed:10321728, ECO:0000269|PubMed:10437795,ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10648623,ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:14603323,ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18575781,ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:20347421,ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:29420262}. (Microbial infection) Target of human immunodeficiencyvirus type 1 (HIV-1) protein VPU to polyubiquitinate and depleteBST2 from cells and antagonize its antiviral action.{ECO:0000269|PubMed:19730691}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for THBS3_FBXW11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for THBS3_FBXW11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for THBS3_FBXW11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for THBS3_FBXW11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource