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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37936

FusionGeneSummary for TGOLN2_TGOLN2

check button Fusion gene summary
Fusion gene informationFusion gene name: TGOLN2_TGOLN2
Fusion gene ID: 37936
HgeneTgene
Gene symbol

TGOLN2

TGOLN2

Gene ID

10618

10618

Gene nametrans-golgi network protein 2trans-golgi network protein 2
SynonymsTGN38|TGN46|TGN48|TGN51|TTGN2TGN38|TGN46|TGN48|TGN51|TTGN2
Cytomap

2p11.2

2p11.2

Type of geneprotein-codingprotein-coding
Descriptiontrans-Golgi network integral membrane protein 2TGN38 homologtrans-Golgi network protein (46, 48, 51kD isoforms)trans-Golgi network protein TGN51trans-Golgi network integral membrane protein 2TGN38 homologtrans-Golgi network protein (46, 48, 51kD isoforms)trans-Golgi network protein TGN51
Modification date2018052320180523
UniProtAcc

O43493

O43493

Ensembl transtripts involved in fusion geneENST00000282120, ENST00000377386, 
ENST00000398263, ENST00000409232, 
ENST00000409015, ENST00000444342, 
ENST00000282120, ENST00000377386, 
ENST00000398263, ENST00000409232, 
ENST00000409015, ENST00000444342, 
Fusion gene scores* DoF score7 X 7 X 3=1478 X 8 X 1=64
# samples 78
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/64*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TGOLN2 [Title/Abstract] AND TGOLN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE933259TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000282120ENST00000282120TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000282120ENST00000377386TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000282120ENST00000398263TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000282120ENST00000409232TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000282120ENST00000409015TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-intronENST00000282120ENST00000444342TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000377386ENST00000282120TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000377386ENST00000377386TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000377386ENST00000398263TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000377386ENST00000409232TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000377386ENST00000409015TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-intronENST00000377386ENST00000444342TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000398263ENST00000282120TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000398263ENST00000377386TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000398263ENST00000398263TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000398263ENST00000409232TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000398263ENST00000409015TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-intronENST00000398263ENST00000444342TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000409232ENST00000282120TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000409232ENST00000377386TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000409232ENST00000398263TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000409232ENST00000409232TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000409232ENST00000409015TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-intronENST00000409232ENST00000444342TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000409015ENST00000282120TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000409015ENST00000377386TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000409015ENST00000398263TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000409015ENST00000409232TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000409015ENST00000409015TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-intronENST00000409015ENST00000444342TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000444342ENST00000282120TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000444342ENST00000377386TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000444342ENST00000398263TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000444342ENST00000409232TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-3UTRENST00000444342ENST00000409015TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+
intron-intronENST00000444342ENST00000444342TGOLN2chr2

85549344

-TGOLN2chr2

85549479

+

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FusionProtFeatures for TGOLN2_TGOLN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TGOLN2

O43493

TGOLN2

O43493


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TGOLN2_TGOLN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TGOLN2_TGOLN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TGOLN2_TGOLN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TGOLN2_TGOLN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTGOLN2C0040128Thyroid Diseases1CTD_human
HgeneTGOLN2C0525045Mood Disorders1PSYGENET
TgeneTGOLN2C0040128Thyroid Diseases1CTD_human
TgeneTGOLN2C0525045Mood Disorders1PSYGENET