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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37935

FusionGeneSummary for TGOLN2_PSME2

check button Fusion gene summary
Fusion gene informationFusion gene name: TGOLN2_PSME2
Fusion gene ID: 37935
HgeneTgene
Gene symbol

TGOLN2

PSME2

Gene ID

10618

5721

Gene nametrans-golgi network protein 2proteasome activator subunit 2
SynonymsTGN38|TGN46|TGN48|TGN51|TTGN2PA28B|PA28beta|REGbeta
Cytomap

2p11.2

14q12

Type of geneprotein-codingprotein-coding
Descriptiontrans-Golgi network integral membrane protein 2TGN38 homologtrans-Golgi network protein (46, 48, 51kD isoforms)trans-Golgi network protein TGN51proteasome activator complex subunit 211S regulator complex beta subunit11S regulator complex subunit betaMCP activator, 31-kD subunitREG-betaactivator of multicatalytic protease subunit 2cell migration-inducing protein 22proteasome (prosome, macro
Modification date2018052320180523
UniProtAcc

O43493

Q9UL46

Ensembl transtripts involved in fusion geneENST00000282120, ENST00000377386, 
ENST00000398263, ENST00000409232, 
ENST00000409015, ENST00000444342, 
ENST00000560410, ENST00000216802, 
ENST00000471700, 
Fusion gene scores* DoF score7 X 7 X 3=1472 X 2 X 2=8
# samples 72
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: TGOLN2 [Title/Abstract] AND PSME2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG999584TGOLN2chr2

85548383

+PSME2chr14

24613539

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000282120ENST00000560410TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000282120ENST00000216802TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000282120ENST00000471700TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000377386ENST00000560410TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000377386ENST00000216802TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000377386ENST00000471700TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000398263ENST00000560410TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000398263ENST00000216802TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000398263ENST00000471700TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000409232ENST00000560410TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000409232ENST00000216802TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000409232ENST00000471700TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000409015ENST00000560410TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000409015ENST00000216802TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000409015ENST00000471700TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000444342ENST00000560410TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000444342ENST00000216802TGOLN2chr2

85548383

+PSME2chr14

24613539

-
intron-intronENST00000444342ENST00000471700TGOLN2chr2

85548383

+PSME2chr14

24613539

-

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FusionProtFeatures for TGOLN2_PSME2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TGOLN2

O43493

PSME2

Q9UL46

Implicated in immunoproteasome assembly and required forefficient antigen processing. The PA28 activator complex enhancesthe generation of class I binding peptides by altering thecleavage pattern of the proteasome.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TGOLN2_PSME2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TGOLN2_PSME2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TGOLN2_PSME2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TGOLN2_PSME2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTGOLN2C0040128Thyroid Diseases1CTD_human
HgeneTGOLN2C0525045Mood Disorders1PSYGENET
TgenePSME2C0019693HIV Infections1CTD_human
TgenePSME2C0023893Liver Cirrhosis, Experimental1CTD_human
TgenePSME2C0279626Squamous cell carcinoma of esophagus1CTD_human