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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37934

FusionGeneSummary for TGOLN2_KYNU

check button Fusion gene summary
Fusion gene informationFusion gene name: TGOLN2_KYNU
Fusion gene ID: 37934
HgeneTgene
Gene symbol

TGOLN2

KYNU

Gene ID

10618

8942

Gene nametrans-golgi network protein 2kynureninase
SynonymsTGN38|TGN46|TGN48|TGN51|TTGN2KYNUU|VCRL2
Cytomap

2p11.2

2q22.2

Type of geneprotein-codingprotein-coding
Descriptiontrans-Golgi network integral membrane protein 2TGN38 homologtrans-Golgi network protein (46, 48, 51kD isoforms)trans-Golgi network protein TGN51kynureninaseL-kynurenine hydrolase
Modification date2018052320180523
UniProtAcc

O43493

Q16719

Ensembl transtripts involved in fusion geneENST00000282120, ENST00000377386, 
ENST00000398263, ENST00000409232, 
ENST00000409015, ENST00000444342, 
ENST00000264170, ENST00000375773, 
ENST00000409512, ENST00000410015, 
Fusion gene scores* DoF score7 X 7 X 3=1478 X 7 X 6=336
# samples 710
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TGOLN2 [Title/Abstract] AND KYNU [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKYNU

GO:0019805

quinolinate biosynthetic process

9291104

TgeneKYNU

GO:0034341

response to interferon-gamma

9291104

TgeneKYNU

GO:0043420

anthranilate metabolic process

11985583


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF997792TGOLN2chr2

85547966

-KYNUchr2

143725968

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000282120ENST00000264170TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000282120ENST00000375773TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000282120ENST00000409512TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000282120ENST00000410015TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000377386ENST00000264170TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000377386ENST00000375773TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000377386ENST00000409512TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000377386ENST00000410015TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000398263ENST00000264170TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000398263ENST00000375773TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000398263ENST00000409512TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000398263ENST00000410015TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000409232ENST00000264170TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000409232ENST00000375773TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000409232ENST00000409512TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000409232ENST00000410015TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000409015ENST00000264170TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000409015ENST00000375773TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000409015ENST00000409512TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000409015ENST00000410015TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000444342ENST00000264170TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000444342ENST00000375773TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000444342ENST00000409512TGOLN2chr2

85547966

-KYNUchr2

143725968

-
intron-intronENST00000444342ENST00000410015TGOLN2chr2

85547966

-KYNUchr2

143725968

-

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FusionProtFeatures for TGOLN2_KYNU


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TGOLN2

O43493

KYNU

Q16719

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preferencefor the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyaseactivity. {ECO:0000269|PubMed:11985583,ECO:0000269|PubMed:17300176, ECO:0000269|PubMed:28792876,ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TGOLN2_KYNU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TGOLN2_KYNU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TGOLN2_KYNU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneKYNUQ16719DB00114Pyridoxal PhosphateKynureninase {ECO:0000255|HAMAP-Rule:MF_03017}small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for TGOLN2_KYNU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTGOLN2C0040128Thyroid Diseases1CTD_human
HgeneTGOLN2C0525045Mood Disorders1PSYGENET
TgeneKYNUC0021368Inflammation1CTD_human
TgeneKYNUC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneKYNUC0041696Unipolar Depression1PSYGENET
TgeneKYNUC0268474Hydroxykynureninuria1CTD_human;ORPHANET;UNIPROT
TgeneKYNUC0344315Depressed mood1PSYGENET
TgeneKYNUC0524851Neurodegenerative Disorders1CTD_human
TgeneKYNUC1269683Major Depressive Disorder1PSYGENET