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Fusion gene ID: 37919 |
FusionGeneSummary for TGFBRAP1_RPLP2 |
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Fusion gene information | Fusion gene name: TGFBRAP1_RPLP2 | Fusion gene ID: 37919 | Hgene | Tgene | Gene symbol | TGFBRAP1 | RPLP2 | Gene ID | 9392 | 6181 |
Gene name | transforming growth factor beta receptor associated protein 1 | ribosomal protein lateral stalk subunit P2 | |
Synonyms | TRAP-1|TRAP1|VPS3 | D11S2243E|LP2|P2|RPP2 | |
Cytomap | 2q12.1-q12.2 | 11p15.5 | |
Type of gene | protein-coding | protein-coding | |
Description | transforming growth factor-beta receptor-associated protein 1TGF-beta receptor-associated protein 1VPS3 CORVET complex subunit | 60S acidic ribosomal protein P2acidic ribosomal phosphoprotein P2large ribosomal subunit protein P2renal carcinoma antigen NY-REN-44ribosomal protein, large, P2 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q8WUH2 | P05387 | |
Ensembl transtripts involved in fusion gene | ENST00000393359, ENST00000258449, | ENST00000321153, ENST00000532004, ENST00000530797, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 6 X 6 X 2=72 |
# samples | 4 | 7 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TGFBRAP1 [Title/Abstract] AND RPLP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TGFBRAP1 | GO:0006355 | regulation of transcription, DNA-templated | 11278302 |
Hgene | TGFBRAP1 | GO:0007165 | signal transduction | 11278302 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BC010093 | TGFBRAP1 | chr2 | 105889455 | - | RPLP2 | chr11 | 810003 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000393359 | ENST00000321153 | TGFBRAP1 | chr2 | 105889455 | - | RPLP2 | chr11 | 810003 | + |
intron-3UTR | ENST00000393359 | ENST00000532004 | TGFBRAP1 | chr2 | 105889455 | - | RPLP2 | chr11 | 810003 | + |
intron-5UTR | ENST00000393359 | ENST00000530797 | TGFBRAP1 | chr2 | 105889455 | - | RPLP2 | chr11 | 810003 | + |
intron-5UTR | ENST00000258449 | ENST00000321153 | TGFBRAP1 | chr2 | 105889455 | - | RPLP2 | chr11 | 810003 | + |
intron-3UTR | ENST00000258449 | ENST00000532004 | TGFBRAP1 | chr2 | 105889455 | - | RPLP2 | chr11 | 810003 | + |
intron-5UTR | ENST00000258449 | ENST00000530797 | TGFBRAP1 | chr2 | 105889455 | - | RPLP2 | chr11 | 810003 | + |
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FusionProtFeatures for TGFBRAP1_RPLP2 |
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Hgene | Tgene |
TGFBRAP1 | RPLP2 |
Plays a role in the TGF-beta/activin signaling pathway.It associates with inactive heteromeric TGF-beta and activinreceptor complexes, mainly through the type II receptor, and isreleased upon activation of signaling. May recruit SMAD4 to thevicinity of the receptor complex and facilitate its interactionwith receptor-regulated Smads, such as SMAD2.{ECO:0000269|PubMed:11278302, ECO:0000269|PubMed:9545258}. Plays a role in vesicle-mediated protein trafficking ofthe endocytic membrane transport pathway. Believed to act as acomponent of the putative CORVET endosomal tethering complexeswhich is proposed to be involved in the Rab5-to-Rab7 endosomeconversion probably implicating MON1A/B, and via binding SNAREsand SNARE complexes to mediate tethering and docking events duringSNARE-mediated membrane fusion. The CORVET complex is proposed tofunction as a Rab5 effector to mediate early endosome fusionprobably in specific endosome subpopulations (PubMed:25266290).Functions predominantly in APPL1-containing endosomes and indegradative but not recycling trafficking of endocytosed cargo(PubMed:25266290). {ECO:0000269|PubMed:25266290,ECO:0000305|PubMed:25266290}. | Plays an important role in the elongation step ofprotein synthesis. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TGFBRAP1_RPLP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TGFBRAP1_RPLP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TGFBRAP1_RPLP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TGFBRAP1_RPLP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |