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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37916

FusionGeneSummary for TGFBRAP1_ARHGAP15

check button Fusion gene summary
Fusion gene informationFusion gene name: TGFBRAP1_ARHGAP15
Fusion gene ID: 37916
HgeneTgene
Gene symbol

TGFBRAP1

ARHGAP15

Gene ID

9392

55843

Gene nametransforming growth factor beta receptor associated protein 1Rho GTPase activating protein 15
SynonymsTRAP-1|TRAP1|VPS3BM046
Cytomap

2q12.1-q12.2

2q22.2-q22.3

Type of geneprotein-codingprotein-coding
Descriptiontransforming growth factor-beta receptor-associated protein 1TGF-beta receptor-associated protein 1VPS3 CORVET complex subunitrho GTPase-activating protein 15rho-type GTPase-activating protein 15
Modification date2018052320180523
UniProtAcc

Q8WUH2

Q53QZ3

Ensembl transtripts involved in fusion geneENST00000393359, ENST00000258449, 
ENST00000409869, ENST00000295095, 
ENST00000473426, 
Fusion gene scores* DoF score4 X 3 X 3=369 X 8 X 5=360
# samples 49
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TGFBRAP1 [Title/Abstract] AND ARHGAP15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTGFBRAP1

GO:0006355

regulation of transcription, DNA-templated

11278302

HgeneTGFBRAP1

GO:0007165

signal transduction

11278302

TgeneARHGAP15

GO:0008360

regulation of cell shape

12650940


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-AB2O-01ATGFBRAP1chr2

105885729

-ARHGAP15chr2

144193170

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000393359ENST00000409869TGFBRAP1chr2

105885729

-ARHGAP15chr2

144193170

+
5CDS-intronENST00000393359ENST00000295095TGFBRAP1chr2

105885729

-ARHGAP15chr2

144193170

+
5CDS-intronENST00000393359ENST00000473426TGFBRAP1chr2

105885729

-ARHGAP15chr2

144193170

+
5CDS-intronENST00000258449ENST00000409869TGFBRAP1chr2

105885729

-ARHGAP15chr2

144193170

+
5CDS-intronENST00000258449ENST00000295095TGFBRAP1chr2

105885729

-ARHGAP15chr2

144193170

+
5CDS-intronENST00000258449ENST00000473426TGFBRAP1chr2

105885729

-ARHGAP15chr2

144193170

+

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FusionProtFeatures for TGFBRAP1_ARHGAP15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TGFBRAP1

Q8WUH2

ARHGAP15

Q53QZ3

Plays a role in the TGF-beta/activin signaling pathway.It associates with inactive heteromeric TGF-beta and activinreceptor complexes, mainly through the type II receptor, and isreleased upon activation of signaling. May recruit SMAD4 to thevicinity of the receptor complex and facilitate its interactionwith receptor-regulated Smads, such as SMAD2.{ECO:0000269|PubMed:11278302, ECO:0000269|PubMed:9545258}. Plays a role in vesicle-mediated protein trafficking ofthe endocytic membrane transport pathway. Believed to act as acomponent of the putative CORVET endosomal tethering complexeswhich is proposed to be involved in the Rab5-to-Rab7 endosomeconversion probably implicating MON1A/B, and via binding SNAREsand SNARE complexes to mediate tethering and docking events duringSNARE-mediated membrane fusion. The CORVET complex is proposed tofunction as a Rab5 effector to mediate early endosome fusionprobably in specific endosome subpopulations (PubMed:25266290).Functions predominantly in APPL1-containing endosomes and indegradative but not recycling trafficking of endocytosed cargo(PubMed:25266290). {ECO:0000269|PubMed:25266290,ECO:0000305|PubMed:25266290}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TGFBRAP1_ARHGAP15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TGFBRAP1_ARHGAP15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TGFBRAP1ALOX5, SMAD4, UVRAG, VPS41, NRBF2, VPS11, ACVR1, TGFBR1, TGFBR2, VPS18, VPS16, VPS8, VPS33A, ISOC2, C15orf27, ARFGAP1, C7orf60, CROCC, TRIM25ARHGAP15RAC1, SNCA, PRNP, CD93, KDM1A, APP, DHPS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TGFBRAP1_ARHGAP15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TGFBRAP1_ARHGAP15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource