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Fusion gene ID: 37908 |
FusionGeneSummary for TGFBR2_XPC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TGFBR2_XPC | Fusion gene ID: 37908 | Hgene | Tgene | Gene symbol | TGFBR2 | XPC | Gene ID | 7048 | 7508 |
| Gene name | transforming growth factor beta receptor 2 | XPC complex subunit, DNA damage recognition and repair factor | |
| Synonyms | AAT3|FAA3|LDS1B|LDS2|LDS2B|MFS2|RIIC|TAAD2|TBR-ii|TBRII|TGFR-2|TGFbeta-RII | RAD4|XP3|XPCC|p125 | |
| Cytomap | 3p24.1 | 3p25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TGF-beta receptor type-2TGF-beta receptor type IIBTGF-beta type II receptortbetaR-IItransforming growth factor beta receptor IItransforming growth factor beta receptor type IICtransforming growth factor, beta receptor II (70/80kDa)transforming grow | DNA repair protein complementing XP-C cellsmutant xeroderma pigmentosum group Cxeroderma pigmentosum, complementation group C | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P37173 | Q01831 | |
| Ensembl transtripts involved in fusion gene | ENST00000295754, ENST00000359013, | ENST00000285021, ENST00000449060, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 4 X 4 X 3=48 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TGFBR2 [Title/Abstract] AND XPC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TGFBR2 | GO:0006468 | protein phosphorylation | 12015308 |
| Hgene | TGFBR2 | GO:0006915 | apoptotic process | 17471240 |
| Hgene | TGFBR2 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 18453574 |
| Hgene | TGFBR2 | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 26459119 |
| Hgene | TGFBR2 | GO:0018105 | peptidyl-serine phosphorylation | 12015308 |
| Hgene | TGFBR2 | GO:0018107 | peptidyl-threonine phosphorylation | 12015308 |
| Hgene | TGFBR2 | GO:0042493 | response to drug | 17878231 |
| Hgene | TGFBR2 | GO:0060389 | pathway-restricted SMAD protein phosphorylation | 18453574 |
| Hgene | TGFBR2 | GO:0070723 | response to cholesterol | 17878231 |
| Hgene | TGFBR2 | GO:2000563 | positive regulation of CD4-positive, alpha-beta T cell proliferation | 17164348 |
| Tgene | XPC | GO:0000715 | nucleotide-excision repair, DNA damage recognition | 10873465|19941824 |
| Tgene | XPC | GO:0006289 | nucleotide-excision repair | 8168482|9734359 |
| Tgene | XPC | GO:0070914 | UV-damage excision repair | 8077226 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A1L2-01A | TGFBR2 | chr3 | 30648469 | + | XPC | chr3 | 14214562 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000295754 | ENST00000285021 | TGFBR2 | chr3 | 30648469 | + | XPC | chr3 | 14214562 | - |
| In-frame | ENST00000295754 | ENST00000449060 | TGFBR2 | chr3 | 30648469 | + | XPC | chr3 | 14214562 | - |
| In-frame | ENST00000359013 | ENST00000285021 | TGFBR2 | chr3 | 30648469 | + | XPC | chr3 | 14214562 | - |
| In-frame | ENST00000359013 | ENST00000449060 | TGFBR2 | chr3 | 30648469 | + | XPC | chr3 | 14214562 | - |
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FusionProtFeatures for TGFBR2_XPC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TGFBR2 | XPC |
| Transmembrane serine/threonine kinase forming with theTGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 andTGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cellsurface to the cytoplasm and is thus regulating a plethora ofphysiological and pathological processes including cell cyclearrest in epithelial and hematopoietic cells, control ofmesenchymal cell proliferation and differentiation, wound healing,extracellular matrix production, immunosuppression andcarcinogenesis. The formation of the receptor complex composed of2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to thecytokine dimer results in the phosphorylation and the activationof TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1phosphorylates SMAD2 which dissociates from the receptor andinteracts with SMAD4. The SMAD2-SMAD4 complex is subsequentlytranslocated to the nucleus where it modulates the transcriptionof the TGF-beta-regulated genes. This constitutes the canonicalSMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.{ECO:0000269|PubMed:7774578}. | Involved in global genome nucleotide excision repair(GG-NER) by acting as damage sensing and DNA-binding factorcomponent of the XPC complex. Has only a low DNA repair activityby itself which is stimulated by RAD23B and RAD23A. Has apreference to bind DNA containing a short single-stranded segmentbut not to damaged oligonucleotides. This feature is proposed tobe related to a dynamic sensor function: XPC can rapidly screenduplex DNA for non-hydrogen-bonded bases by forming a transientnucleoprotein intermediate complex which matures into a stablerecognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the firstfactor bound at the sites of DNA damage and together with othercore recognition factors, XPA, RPA and the TFIIH complex, is partof the pre-incision (or initial recognition) complex. The XPCcomplex recognizes a wide spectrum of damaged DNA characterized bydistortions of the DNA helix such as single-stranded loops,mismatched bubbles or single-stranded overhangs. The orientationof XPC complex binding appears to be crucial for inducing aproductive NER. XPC complex is proposed to recognize and tointeract with unpaired bases on the undamaged DNA strand which isfollowed by recruitment of the TFIIH complex and subsequentscanning for lesions in the opposite strand in a 5'-to-3'direction by the NER machinery. Cyclobutane pyrimidine dimers(CPDs) which are formed upon UV-induced DNA damage esacpedetection by the XPC complex due to a low degree of structuralperurbation. Instead they are detected by the UV-DDB complex whichin turn recruits and cooperates with the XPC complex in therespective DNA repair. In vitro, the XPC:RAD23B dimer issufficient to initiate NER; it preferentially binds to cisplatinand UV-damaged double-stranded DNA and also binds to a variety ofchemically and structurally diverse DNA adducts. XPC:RAD23Bcontacts DNA both 5' and 3' of a cisplatin lesion with apreference for the 5' side. XPC:RAD23B induces a bend in DNA uponbinding. XPC:RAD23B stimulates the activity of DNA glycosylasesTDG and SMUG1. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 124_130 | 34 | 941 | Compositional bias | Note=Poly-Glu |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 359_395 | 34 | 941 | Compositional bias | Note=Lys-rich (basic) |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 408_431 | 34 | 941 | Compositional bias | Note=Arg/Lys-rich (basic) |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 432_461 | 34 | 941 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 466_493 | 34 | 941 | Compositional bias | Note=Arg/Lys-rich (basic) |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 501_507 | 34 | 941 | Compositional bias | Note=Poly-Ser |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 124_130 | 34 | 904 | Compositional bias | Note=Poly-Glu |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 359_395 | 34 | 904 | Compositional bias | Note=Lys-rich (basic) |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 408_431 | 34 | 904 | Compositional bias | Note=Arg/Lys-rich (basic) |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 432_461 | 34 | 904 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 466_493 | 34 | 904 | Compositional bias | Note=Arg/Lys-rich (basic) |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 501_507 | 34 | 904 | Compositional bias | Note=Poly-Ser |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 390_395 | 34 | 941 | Motif | Nuclear localization signal |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 390_395 | 34 | 904 | Motif | Nuclear localization signal |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 607_741 | 34 | 941 | Region | Note=DNA-binding%3B preference for heteroduplex DNA |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 607_766 | 34 | 941 | Region | Note=Minimal sensor domain involved in damage recognition |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 767_831 | 34 | 941 | Region | Note=DNA-binding%3B preference for single stranded DNA%3B required for formation of stable nucleoprotein complex |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 607_741 | 34 | 904 | Region | Note=DNA-binding%3B preference for heteroduplex DNA |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 607_766 | 34 | 904 | Region | Note=Minimal sensor domain involved in damage recognition |
| Tgene | >XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 767_831 | 34 | 904 | Region | Note=DNA-binding%3B preference for single stranded DNA%3B required for formation of stable nucleoprotein complex |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TGFBR2 | chr3:30648469 | chr3:14214562 | ENST00000295754 | + | 1 | 7 | 244_544 | 31 | 568 | Domain | Protein kinase |
| Hgene | >TGFBR2 | chr3:30648469 | chr3:14214562 | ENST00000359013 | + | 1 | 8 | 244_544 | 31 | 593 | Domain | Protein kinase |
| Hgene | >TGFBR2 | chr3:30648469 | chr3:14214562 | ENST00000295754 | + | 1 | 7 | 250_258 | 31 | 568 | Nucleotide binding | ATP |
| Hgene | >TGFBR2 | chr3:30648469 | chr3:14214562 | ENST00000359013 | + | 1 | 8 | 250_258 | 31 | 593 | Nucleotide binding | ATP |
| Hgene | >TGFBR2 | chr3:30648469 | chr3:14214562 | ENST00000295754 | + | 1 | 7 | 188_567 | 31 | 568 | Topological domain | Cytoplasmic |
| Hgene | >TGFBR2 | chr3:30648469 | chr3:14214562 | ENST00000295754 | + | 1 | 7 | 23_166 | 31 | 568 | Topological domain | Extracellular |
| Hgene | >TGFBR2 | chr3:30648469 | chr3:14214562 | ENST00000359013 | + | 1 | 8 | 188_567 | 31 | 593 | Topological domain | Cytoplasmic |
| Hgene | >TGFBR2 | chr3:30648469 | chr3:14214562 | ENST00000359013 | + | 1 | 8 | 23_166 | 31 | 593 | Topological domain | Extracellular |
| Hgene | >TGFBR2 | chr3:30648469 | chr3:14214562 | ENST00000295754 | + | 1 | 7 | 167_187 | 31 | 568 | Transmembrane | Helical |
| Hgene | >TGFBR2 | chr3:30648469 | chr3:14214562 | ENST00000359013 | + | 1 | 8 | 167_187 | 31 | 593 | Transmembrane | Helical |
| Tgene | XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 30_177 | 34 | 941 | Compositional bias | Note=Glu-rich (acidic) |
| Tgene | XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 30_34 | 34 | 941 | Compositional bias | Note=Poly-Glu |
| Tgene | XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 30_177 | 34 | 904 | Compositional bias | Note=Glu-rich (acidic) |
| Tgene | XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 30_34 | 34 | 904 | Compositional bias | Note=Poly-Glu |
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FusionGeneSequence for TGFBR2_XPC |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TGFBR2_ENST00000295754_chr3_30648469_+_XPC_ENST00000285021_chr3_14214562_-_938aa MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDAFEDEKPPKKSLLSKVSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKDEAL SDGDDLRDFPSDLKKAHHLKRGATMNEDSNEEEEESENDWEEVEELSEPVLGDVRESTAFSRSLLPVKPVEIEIETPEQAKTRERSEKIK LEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSA SEQDNLQTTLERRFAIYSARDDEELVHIFLLILRALQLLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKPKTS KGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSEEDEGPGDKQEKATQRRPHGRERRVASRVSYKEESGSDEAGSGSDFELSSGEAS DPSDEDSEPGPPKQRKAPAPQRTKAGSKSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKWV CVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEFQAKHMDQP LPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQ LREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIV CEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGTSSQAEAARILAAS >In-frame_TGFBR2_ENST00000295754_chr3_30648469_+_XPC_ENST00000449060_chr3_14214562_-_901aa MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDAFEDEKPPKKSLLSKVSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKDEAL SDGDDLRDFPSDLKKAHHLKRGATMNEDSNEEEEESENDWEEAKTRERSEKIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYR NNICSQPDLHAIGLSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSASEQDNLQTTLERRFAIYSARDDEELVHIFLLILRALQ LLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKPKTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSE EDEGPGDKQEKATQRRPHGRERRVASRVSYKEESGSDEAGSGSDFELSSGEASDPSDEDSEPGPPKQRKAPAPQRTKAGSKSASRTHRGS HRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKWVCVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRD VTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYC RGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVY LFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKL LAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGTSSQAEAARILAASWPQNREDEEKQKLKGGPKKTKREKKAAASHLFPFEQL >In-frame_TGFBR2_ENST00000359013_chr3_30648469_+_XPC_ENST00000285021_chr3_14214562_-_938aa MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDAFEDEKPPKKSLLSKVSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKDEAL SDGDDLRDFPSDLKKAHHLKRGATMNEDSNEEEEESENDWEEVEELSEPVLGDVRESTAFSRSLLPVKPVEIEIETPEQAKTRERSEKIK LEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSA SEQDNLQTTLERRFAIYSARDDEELVHIFLLILRALQLLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKPKTS KGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSEEDEGPGDKQEKATQRRPHGRERRVASRVSYKEESGSDEAGSGSDFELSSGEAS DPSDEDSEPGPPKQRKAPAPQRTKAGSKSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKWV CVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEFQAKHMDQP LPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQ LREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIV CEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGTSSQAEAARILAAS >In-frame_TGFBR2_ENST00000359013_chr3_30648469_+_XPC_ENST00000449060_chr3_14214562_-_901aa MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDAFEDEKPPKKSLLSKVSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKDEAL SDGDDLRDFPSDLKKAHHLKRGATMNEDSNEEEEESENDWEEAKTRERSEKIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYR NNICSQPDLHAIGLSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSASEQDNLQTTLERRFAIYSARDDEELVHIFLLILRALQ LLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKPKTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSE EDEGPGDKQEKATQRRPHGRERRVASRVSYKEESGSDEAGSGSDFELSSGEASDPSDEDSEPGPPKQRKAPAPQRTKAGSKSASRTHRGS HRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKWVCVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRD VTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYC RGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVY LFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKL LAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGTSSQAEAARILAASWPQNREDEEKQKLKGGPKKTKREKKAAASHLFPFEQL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TGFBR2_ENST00000295754_chr3_30648469_+_XPC_ENST00000285021_chr3_14214562_-_2814nt ATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCACGATCCCACCGCACGTTCAGAAG TCGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAGGAAAAGAGGCTGCAGTCATCCT GGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAAGGTTATAAAGGATGAAGCCCTC AGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGCTACCATGAATGAAGACAGCAAT GAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGTTGAAGAACTTAGTGAGCCTGTGCTGGGTGACGTGAGAGAAAGTACAGCCTTC TCTCGATCTCTTCTGCCTGTGAAGCCAGTGGAGATAGAGATTGAAACGCCAGAGCAGGCGAAGACAAGAGAAAGAAGTGAAAAGATAAAA CTGGAGTTTGAGACATATCTTCGGAGGGCGATGAAACGTTTCAATAAAGGGGTCCATGAGGACACACACAAGGTTCACCTTCTCTGCCTG CTAGCAAATGGCTTCTATCGAAATAACATCTGCAGCCAGCCAGATCTGCATGCTATTGGCCTGTCCATCATCCCAGCCCGCTTTACCAGA GTGCTGCCTCGAGATGTGGACACCTACTACCTCTCAAACCTGGTGAAGTGGTTCATTGGAACATTTACAGTTAATGCAGAACTTTCAGCC AGTGAACAAGATAACCTGCAGACTACATTGGAAAGGAGATTTGCTATTTACTCTGCTCGAGATGATGAGGAATTGGTCCATATATTCTTA CTGATTCTCCGGGCTCTGCAGCTCTTGACCCGGCTGGTATTGTCTCTACAGCCAATTCCTCTGAAGTCAGCAACAGCAAAGGGAAAGAAA CCTTCCAAGGAAAGATTGACTGCGGATCCAGGAGGCTCCTCAGAAACTTCCAGCCAAGTTCTAGAAAACCACACCAAACCAAAGACCAGC AAAGGAACCAAACAAGAGGAAACCTTTGCTAAGGGCACCTGCAGGCCAAGTGCCAAAGGGAAGAGGAACAAGGGAGGCAGAAAGAAACGG AGCAAGCCCTCCTCCAGCGAGGAAGATGAGGGCCCAGGAGACAAGCAGGAGAAGGCAACCCAGCGACGTCCGCATGGCCGGGAGCGGCGG GTGGCCTCCAGGGTGTCTTATAAAGAGGAGAGTGGGAGTGATGAGGCTGGCAGCGGCTCTGATTTTGAGCTCTCCAGTGGAGAAGCCTCT GATCCCTCTGATGAGGATTCCGAACCTGGCCCTCCAAAGCAGAGGAAAGCCCCCGCTCCTCAGAGGACAAAGGCTGGGTCCAAGAGTGCC TCCAGGACCCATCGTGGGAGCCATCGTAAGGACCCAAGCTTGCCAGCGGCATCCTCAAGCTCTTCAAGCAGTAAAAGAGGCAAGAAAATG TGCAGCGATGGTGAGAAGGCAGAAAAAAGAAGCATAGCTGGTATAGACCAGTGGCTAGAGGTGTTCTGTGAGCAGGAGGAAAAGTGGGTA TGTGTAGACTGTGTGCACGGTGTGGTGGGCCAGCCTCTGACCTGTTACAAGTACGCCACCAAGCCCATGACCTATGTGGTGGGCATTGAC AGTGACGGCTGGGTCCGAGATGTCACACAGAGGTACGACCCAGTCTGGATGACAGTGACCCGCAAGTGCCGGGTTGATGCTGAGTGGTGG GCCGAGACCTTGAGACCATACCAGAGCCCATTTATGGACAGGGAGAAGAAAGAAGACTTGGAGTTTCAGGCTAAACACATGGACCAGCCT TTGCCCACTGCCATTGGCTTATATAAGAACCACCCTCTGTATGCCCTGAAGCGGCATCTCCTGAAATATGAGGCCATCTATCCCGAGACA GCTGCCATCCTTGGGTATTGTCGTGGAGAAGCGGTCTACTCCAGGGATTGTGTGCACACTCTGCATTCCAGGGACACGTGGCTGAAGAAA GCAAGAGTGGTGAGGCTTGGAGAAGTACCCTACAAGATGGTGAAAGGCTTTTCTAACCGTGCTCGGAAAGCCCGACTTGCTGAGCCCCAG CTGCGGGAAGAAAATGACCTGGGCCTGTTTGGCTACTGGCAGACAGAGGAGTATCAGCCCCCAGTGGCCGTGGACGGGAAGGTGCCCCGG AACGAGTTTGGGAATGTGTACCTCTTCCTGCCCAGCATGATGCCTATTGGCTGTGTCCAGCTGAACCTGCCCAATCTACACCGCGTGGCC CGCAAGCTGGACATCGACTGTGTCCAGGCCATCACTGGCTTTGATTTCCATGGCGGCTACTCCCATCCCGTGACTGATGGATACATCGTC TGCGAGGAATTCAAAGACGTGCTCCTGACTGCCTGGGAAAATGAGCAGGCAGTCATTGAAAGGAAGGAGAAGGAGAAAAAGGAGAAGCGG GCTCTAGGGAACTGGAAGTTGCTGGCCAAAGGTCTGCTCATCAGGGAGAGGCTGAAGCGTCGCTACGGGCCCAAGAGTGAGGCAGCAGCT CCCCACACAGATGCAGGAGGTGGACTCTCTTCTGATGAAGAGGAGGGGACCAGCTCTCAAGCAGAAGCGGCCAGGATACTGGCTGCCTCC TGGCCTCAAAACCGAGAAGATGAAGAAAAGCAGAAGCTGAAGGGTGGGCCCAAGAAGACCAAAAGGGAAAAGAAAGCAGCAGCTTCCCAC >In-frame_TGFBR2_ENST00000295754_chr3_30648469_+_XPC_ENST00000449060_chr3_14214562_-_2703nt ATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCACGATCCCACCGCACGTTCAGAAG TCGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAGGAAAAGAGGCTGCAGTCATCCT GGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAAGGTTATAAAGGATGAAGCCCTC AGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGCTACCATGAATGAAGACAGCAAT GAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGCGAAGACAAGAGAAAGAAGTGAAAAGATAAAACTGGAGTTTGAGACATATCTT CGGAGGGCGATGAAACGTTTCAATAAAGGGGTCCATGAGGACACACACAAGGTTCACCTTCTCTGCCTGCTAGCAAATGGCTTCTATCGA AATAACATCTGCAGCCAGCCAGATCTGCATGCTATTGGCCTGTCCATCATCCCAGCCCGCTTTACCAGAGTGCTGCCTCGAGATGTGGAC ACCTACTACCTCTCAAACCTGGTGAAGTGGTTCATTGGAACATTTACAGTTAATGCAGAACTTTCAGCCAGTGAACAAGATAACCTGCAG ACTACATTGGAAAGGAGATTTGCTATTTACTCTGCTCGAGATGATGAGGAATTGGTCCATATATTCTTACTGATTCTCCGGGCTCTGCAG CTCTTGACCCGGCTGGTATTGTCTCTACAGCCAATTCCTCTGAAGTCAGCAACAGCAAAGGGAAAGAAACCTTCCAAGGAAAGATTGACT GCGGATCCAGGAGGCTCCTCAGAAACTTCCAGCCAAGTTCTAGAAAACCACACCAAACCAAAGACCAGCAAAGGAACCAAACAAGAGGAA ACCTTTGCTAAGGGCACCTGCAGGCCAAGTGCCAAAGGGAAGAGGAACAAGGGAGGCAGAAAGAAACGGAGCAAGCCCTCCTCCAGCGAG GAAGATGAGGGCCCAGGAGACAAGCAGGAGAAGGCAACCCAGCGACGTCCGCATGGCCGGGAGCGGCGGGTGGCCTCCAGGGTGTCTTAT AAAGAGGAGAGTGGGAGTGATGAGGCTGGCAGCGGCTCTGATTTTGAGCTCTCCAGTGGAGAAGCCTCTGATCCCTCTGATGAGGATTCC GAACCTGGCCCTCCAAAGCAGAGGAAAGCCCCCGCTCCTCAGAGGACAAAGGCTGGGTCCAAGAGTGCCTCCAGGACCCATCGTGGGAGC CATCGTAAGGACCCAAGCTTGCCAGCGGCATCCTCAAGCTCTTCAAGCAGTAAAAGAGGCAAGAAAATGTGCAGCGATGGTGAGAAGGCA GAAAAAAGAAGCATAGCTGGTATAGACCAGTGGCTAGAGGTGTTCTGTGAGCAGGAGGAAAAGTGGGTATGTGTAGACTGTGTGCACGGT GTGGTGGGCCAGCCTCTGACCTGTTACAAGTACGCCACCAAGCCCATGACCTATGTGGTGGGCATTGACAGTGACGGCTGGGTCCGAGAT GTCACACAGAGGTACGACCCAGTCTGGATGACAGTGACCCGCAAGTGCCGGGTTGATGCTGAGTGGTGGGCCGAGACCTTGAGACCATAC CAGAGCCCATTTATGGACAGGGAGAAGAAAGAAGACTTGGAGTTTCAGGCTAAACACATGGACCAGCCTTTGCCCACTGCCATTGGCTTA TATAAGAACCACCCTCTGTATGCCCTGAAGCGGCATCTCCTGAAATATGAGGCCATCTATCCCGAGACAGCTGCCATCCTTGGGTATTGT CGTGGAGAAGCGGTCTACTCCAGGGATTGTGTGCACACTCTGCATTCCAGGGACACGTGGCTGAAGAAAGCAAGAGTGGTGAGGCTTGGA GAAGTACCCTACAAGATGGTGAAAGGCTTTTCTAACCGTGCTCGGAAAGCCCGACTTGCTGAGCCCCAGCTGCGGGAAGAAAATGACCTG GGCCTGTTTGGCTACTGGCAGACAGAGGAGTATCAGCCCCCAGTGGCCGTGGACGGGAAGGTGCCCCGGAACGAGTTTGGGAATGTGTAC CTCTTCCTGCCCAGCATGATGCCTATTGGCTGTGTCCAGCTGAACCTGCCCAATCTACACCGCGTGGCCCGCAAGCTGGACATCGACTGT GTCCAGGCCATCACTGGCTTTGATTTCCATGGCGGCTACTCCCATCCCGTGACTGATGGATACATCGTCTGCGAGGAATTCAAAGACGTG CTCCTGACTGCCTGGGAAAATGAGCAGGCAGTCATTGAAAGGAAGGAGAAGGAGAAAAAGGAGAAGCGGGCTCTAGGGAACTGGAAGTTG CTGGCCAAAGGTCTGCTCATCAGGGAGAGGCTGAAGCGTCGCTACGGGCCCAAGAGTGAGGCAGCAGCTCCCCACACAGATGCAGGAGGT GGACTCTCTTCTGATGAAGAGGAGGGGACCAGCTCTCAAGCAGAAGCGGCCAGGATACTGGCTGCCTCCTGGCCTCAAAACCGAGAAGAT GAAGAAAAGCAGAAGCTGAAGGGTGGGCCCAAGAAGACCAAAAGGGAAAAGAAAGCAGCAGCTTCCCACCTGTTCCCATTTGAGCAGCTG >In-frame_TGFBR2_ENST00000359013_chr3_30648469_+_XPC_ENST00000285021_chr3_14214562_-_2814nt ATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCACGATCCCACCGCACGTTCAGAAG TCGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAGGAAAAGAGGCTGCAGTCATCCT GGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAAGGTTATAAAGGATGAAGCCCTC AGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGCTACCATGAATGAAGACAGCAAT GAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGTTGAAGAACTTAGTGAGCCTGTGCTGGGTGACGTGAGAGAAAGTACAGCCTTC TCTCGATCTCTTCTGCCTGTGAAGCCAGTGGAGATAGAGATTGAAACGCCAGAGCAGGCGAAGACAAGAGAAAGAAGTGAAAAGATAAAA CTGGAGTTTGAGACATATCTTCGGAGGGCGATGAAACGTTTCAATAAAGGGGTCCATGAGGACACACACAAGGTTCACCTTCTCTGCCTG CTAGCAAATGGCTTCTATCGAAATAACATCTGCAGCCAGCCAGATCTGCATGCTATTGGCCTGTCCATCATCCCAGCCCGCTTTACCAGA GTGCTGCCTCGAGATGTGGACACCTACTACCTCTCAAACCTGGTGAAGTGGTTCATTGGAACATTTACAGTTAATGCAGAACTTTCAGCC AGTGAACAAGATAACCTGCAGACTACATTGGAAAGGAGATTTGCTATTTACTCTGCTCGAGATGATGAGGAATTGGTCCATATATTCTTA CTGATTCTCCGGGCTCTGCAGCTCTTGACCCGGCTGGTATTGTCTCTACAGCCAATTCCTCTGAAGTCAGCAACAGCAAAGGGAAAGAAA CCTTCCAAGGAAAGATTGACTGCGGATCCAGGAGGCTCCTCAGAAACTTCCAGCCAAGTTCTAGAAAACCACACCAAACCAAAGACCAGC AAAGGAACCAAACAAGAGGAAACCTTTGCTAAGGGCACCTGCAGGCCAAGTGCCAAAGGGAAGAGGAACAAGGGAGGCAGAAAGAAACGG AGCAAGCCCTCCTCCAGCGAGGAAGATGAGGGCCCAGGAGACAAGCAGGAGAAGGCAACCCAGCGACGTCCGCATGGCCGGGAGCGGCGG GTGGCCTCCAGGGTGTCTTATAAAGAGGAGAGTGGGAGTGATGAGGCTGGCAGCGGCTCTGATTTTGAGCTCTCCAGTGGAGAAGCCTCT GATCCCTCTGATGAGGATTCCGAACCTGGCCCTCCAAAGCAGAGGAAAGCCCCCGCTCCTCAGAGGACAAAGGCTGGGTCCAAGAGTGCC TCCAGGACCCATCGTGGGAGCCATCGTAAGGACCCAAGCTTGCCAGCGGCATCCTCAAGCTCTTCAAGCAGTAAAAGAGGCAAGAAAATG TGCAGCGATGGTGAGAAGGCAGAAAAAAGAAGCATAGCTGGTATAGACCAGTGGCTAGAGGTGTTCTGTGAGCAGGAGGAAAAGTGGGTA TGTGTAGACTGTGTGCACGGTGTGGTGGGCCAGCCTCTGACCTGTTACAAGTACGCCACCAAGCCCATGACCTATGTGGTGGGCATTGAC AGTGACGGCTGGGTCCGAGATGTCACACAGAGGTACGACCCAGTCTGGATGACAGTGACCCGCAAGTGCCGGGTTGATGCTGAGTGGTGG GCCGAGACCTTGAGACCATACCAGAGCCCATTTATGGACAGGGAGAAGAAAGAAGACTTGGAGTTTCAGGCTAAACACATGGACCAGCCT TTGCCCACTGCCATTGGCTTATATAAGAACCACCCTCTGTATGCCCTGAAGCGGCATCTCCTGAAATATGAGGCCATCTATCCCGAGACA GCTGCCATCCTTGGGTATTGTCGTGGAGAAGCGGTCTACTCCAGGGATTGTGTGCACACTCTGCATTCCAGGGACACGTGGCTGAAGAAA GCAAGAGTGGTGAGGCTTGGAGAAGTACCCTACAAGATGGTGAAAGGCTTTTCTAACCGTGCTCGGAAAGCCCGACTTGCTGAGCCCCAG CTGCGGGAAGAAAATGACCTGGGCCTGTTTGGCTACTGGCAGACAGAGGAGTATCAGCCCCCAGTGGCCGTGGACGGGAAGGTGCCCCGG AACGAGTTTGGGAATGTGTACCTCTTCCTGCCCAGCATGATGCCTATTGGCTGTGTCCAGCTGAACCTGCCCAATCTACACCGCGTGGCC CGCAAGCTGGACATCGACTGTGTCCAGGCCATCACTGGCTTTGATTTCCATGGCGGCTACTCCCATCCCGTGACTGATGGATACATCGTC TGCGAGGAATTCAAAGACGTGCTCCTGACTGCCTGGGAAAATGAGCAGGCAGTCATTGAAAGGAAGGAGAAGGAGAAAAAGGAGAAGCGG GCTCTAGGGAACTGGAAGTTGCTGGCCAAAGGTCTGCTCATCAGGGAGAGGCTGAAGCGTCGCTACGGGCCCAAGAGTGAGGCAGCAGCT CCCCACACAGATGCAGGAGGTGGACTCTCTTCTGATGAAGAGGAGGGGACCAGCTCTCAAGCAGAAGCGGCCAGGATACTGGCTGCCTCC TGGCCTCAAAACCGAGAAGATGAAGAAAAGCAGAAGCTGAAGGGTGGGCCCAAGAAGACCAAAAGGGAAAAGAAAGCAGCAGCTTCCCAC >In-frame_TGFBR2_ENST00000359013_chr3_30648469_+_XPC_ENST00000449060_chr3_14214562_-_2703nt ATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCACGATCCCACCGCACGTTCAGAAG TCGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAGGAAAAGAGGCTGCAGTCATCCT GGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAAGGTTATAAAGGATGAAGCCCTC AGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGCTACCATGAATGAAGACAGCAAT GAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGCGAAGACAAGAGAAAGAAGTGAAAAGATAAAACTGGAGTTTGAGACATATCTT CGGAGGGCGATGAAACGTTTCAATAAAGGGGTCCATGAGGACACACACAAGGTTCACCTTCTCTGCCTGCTAGCAAATGGCTTCTATCGA AATAACATCTGCAGCCAGCCAGATCTGCATGCTATTGGCCTGTCCATCATCCCAGCCCGCTTTACCAGAGTGCTGCCTCGAGATGTGGAC ACCTACTACCTCTCAAACCTGGTGAAGTGGTTCATTGGAACATTTACAGTTAATGCAGAACTTTCAGCCAGTGAACAAGATAACCTGCAG ACTACATTGGAAAGGAGATTTGCTATTTACTCTGCTCGAGATGATGAGGAATTGGTCCATATATTCTTACTGATTCTCCGGGCTCTGCAG CTCTTGACCCGGCTGGTATTGTCTCTACAGCCAATTCCTCTGAAGTCAGCAACAGCAAAGGGAAAGAAACCTTCCAAGGAAAGATTGACT GCGGATCCAGGAGGCTCCTCAGAAACTTCCAGCCAAGTTCTAGAAAACCACACCAAACCAAAGACCAGCAAAGGAACCAAACAAGAGGAA ACCTTTGCTAAGGGCACCTGCAGGCCAAGTGCCAAAGGGAAGAGGAACAAGGGAGGCAGAAAGAAACGGAGCAAGCCCTCCTCCAGCGAG GAAGATGAGGGCCCAGGAGACAAGCAGGAGAAGGCAACCCAGCGACGTCCGCATGGCCGGGAGCGGCGGGTGGCCTCCAGGGTGTCTTAT AAAGAGGAGAGTGGGAGTGATGAGGCTGGCAGCGGCTCTGATTTTGAGCTCTCCAGTGGAGAAGCCTCTGATCCCTCTGATGAGGATTCC GAACCTGGCCCTCCAAAGCAGAGGAAAGCCCCCGCTCCTCAGAGGACAAAGGCTGGGTCCAAGAGTGCCTCCAGGACCCATCGTGGGAGC CATCGTAAGGACCCAAGCTTGCCAGCGGCATCCTCAAGCTCTTCAAGCAGTAAAAGAGGCAAGAAAATGTGCAGCGATGGTGAGAAGGCA GAAAAAAGAAGCATAGCTGGTATAGACCAGTGGCTAGAGGTGTTCTGTGAGCAGGAGGAAAAGTGGGTATGTGTAGACTGTGTGCACGGT GTGGTGGGCCAGCCTCTGACCTGTTACAAGTACGCCACCAAGCCCATGACCTATGTGGTGGGCATTGACAGTGACGGCTGGGTCCGAGAT GTCACACAGAGGTACGACCCAGTCTGGATGACAGTGACCCGCAAGTGCCGGGTTGATGCTGAGTGGTGGGCCGAGACCTTGAGACCATAC CAGAGCCCATTTATGGACAGGGAGAAGAAAGAAGACTTGGAGTTTCAGGCTAAACACATGGACCAGCCTTTGCCCACTGCCATTGGCTTA TATAAGAACCACCCTCTGTATGCCCTGAAGCGGCATCTCCTGAAATATGAGGCCATCTATCCCGAGACAGCTGCCATCCTTGGGTATTGT CGTGGAGAAGCGGTCTACTCCAGGGATTGTGTGCACACTCTGCATTCCAGGGACACGTGGCTGAAGAAAGCAAGAGTGGTGAGGCTTGGA GAAGTACCCTACAAGATGGTGAAAGGCTTTTCTAACCGTGCTCGGAAAGCCCGACTTGCTGAGCCCCAGCTGCGGGAAGAAAATGACCTG GGCCTGTTTGGCTACTGGCAGACAGAGGAGTATCAGCCCCCAGTGGCCGTGGACGGGAAGGTGCCCCGGAACGAGTTTGGGAATGTGTAC CTCTTCCTGCCCAGCATGATGCCTATTGGCTGTGTCCAGCTGAACCTGCCCAATCTACACCGCGTGGCCCGCAAGCTGGACATCGACTGT GTCCAGGCCATCACTGGCTTTGATTTCCATGGCGGCTACTCCCATCCCGTGACTGATGGATACATCGTCTGCGAGGAATTCAAAGACGTG CTCCTGACTGCCTGGGAAAATGAGCAGGCAGTCATTGAAAGGAAGGAGAAGGAGAAAAAGGAGAAGCGGGCTCTAGGGAACTGGAAGTTG CTGGCCAAAGGTCTGCTCATCAGGGAGAGGCTGAAGCGTCGCTACGGGCCCAAGAGTGAGGCAGCAGCTCCCCACACAGATGCAGGAGGT GGACTCTCTTCTGATGAAGAGGAGGGGACCAGCTCTCAAGCAGAAGCGGCCAGGATACTGGCTGCCTCCTGGCCTCAAAACCGAGAAGAT GAAGAAAAGCAGAAGCTGAAGGGTGGGCCCAAGAAGACCAAAAGGGAAAAGAAAGCAGCAGCTTCCCACCTGTTCCCATTTGAGCAGCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TGFBR2_ENST00000295754_chr3_30648469_+_XPC_ENST00000285021_chr3_14214562_-_3990nt GGAGAGGGAGAAGGCTCTCGGGCGGAGAGAGGTCCTGCCCAGCTGTTGGCGAGGAGTTTCCTGTTTCCCCCGCAGCGCTGAGTTGAAGTT GAGTGAGTCACTCGCGCGCACGGAGCGACGACACCCCCGCGCGTGCACCCGCTCGGGACAGGAGCCGGACTCCTGTGCAGCTTCCCTCGG CCGCCGGGGGCCTCCCCGCGCCTCGCCGGCCTCCAGGCCCCCTCCTGGCTGGCGAGCGGGCGCCACATCTGGCCCGCACATCTGCGCTGC CGGCCCGGCGCGGGGTCCGGAGAGGGCGCGGCGCGGAGGCGCAGCCAGGGGTCCGGGAAGGCGCCGTCCGCTGCGCTGGGGGCTCGGTCT ATGACGAGCAGCGGGGTCTGCCATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCAC GATCCCACCGCACGTTCAGAAGTCGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAG GAAAAGAGGCTGCAGTCATCCTGGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAA GGTTATAAAGGATGAAGCCCTCAGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGC TACCATGAATGAAGACAGCAATGAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGTTGAAGAACTTAGTGAGCCTGTGCTGGGTGA CGTGAGAGAAAGTACAGCCTTCTCTCGATCTCTTCTGCCTGTGAAGCCAGTGGAGATAGAGATTGAAACGCCAGAGCAGGCGAAGACAAG AGAAAGAAGTGAAAAGATAAAACTGGAGTTTGAGACATATCTTCGGAGGGCGATGAAACGTTTCAATAAAGGGGTCCATGAGGACACACA CAAGGTTCACCTTCTCTGCCTGCTAGCAAATGGCTTCTATCGAAATAACATCTGCAGCCAGCCAGATCTGCATGCTATTGGCCTGTCCAT CATCCCAGCCCGCTTTACCAGAGTGCTGCCTCGAGATGTGGACACCTACTACCTCTCAAACCTGGTGAAGTGGTTCATTGGAACATTTAC AGTTAATGCAGAACTTTCAGCCAGTGAACAAGATAACCTGCAGACTACATTGGAAAGGAGATTTGCTATTTACTCTGCTCGAGATGATGA GGAATTGGTCCATATATTCTTACTGATTCTCCGGGCTCTGCAGCTCTTGACCCGGCTGGTATTGTCTCTACAGCCAATTCCTCTGAAGTC AGCAACAGCAAAGGGAAAGAAACCTTCCAAGGAAAGATTGACTGCGGATCCAGGAGGCTCCTCAGAAACTTCCAGCCAAGTTCTAGAAAA CCACACCAAACCAAAGACCAGCAAAGGAACCAAACAAGAGGAAACCTTTGCTAAGGGCACCTGCAGGCCAAGTGCCAAAGGGAAGAGGAA CAAGGGAGGCAGAAAGAAACGGAGCAAGCCCTCCTCCAGCGAGGAAGATGAGGGCCCAGGAGACAAGCAGGAGAAGGCAACCCAGCGACG TCCGCATGGCCGGGAGCGGCGGGTGGCCTCCAGGGTGTCTTATAAAGAGGAGAGTGGGAGTGATGAGGCTGGCAGCGGCTCTGATTTTGA GCTCTCCAGTGGAGAAGCCTCTGATCCCTCTGATGAGGATTCCGAACCTGGCCCTCCAAAGCAGAGGAAAGCCCCCGCTCCTCAGAGGAC AAAGGCTGGGTCCAAGAGTGCCTCCAGGACCCATCGTGGGAGCCATCGTAAGGACCCAAGCTTGCCAGCGGCATCCTCAAGCTCTTCAAG CAGTAAAAGAGGCAAGAAAATGTGCAGCGATGGTGAGAAGGCAGAAAAAAGAAGCATAGCTGGTATAGACCAGTGGCTAGAGGTGTTCTG TGAGCAGGAGGAAAAGTGGGTATGTGTAGACTGTGTGCACGGTGTGGTGGGCCAGCCTCTGACCTGTTACAAGTACGCCACCAAGCCCAT GACCTATGTGGTGGGCATTGACAGTGACGGCTGGGTCCGAGATGTCACACAGAGGTACGACCCAGTCTGGATGACAGTGACCCGCAAGTG CCGGGTTGATGCTGAGTGGTGGGCCGAGACCTTGAGACCATACCAGAGCCCATTTATGGACAGGGAGAAGAAAGAAGACTTGGAGTTTCA GGCTAAACACATGGACCAGCCTTTGCCCACTGCCATTGGCTTATATAAGAACCACCCTCTGTATGCCCTGAAGCGGCATCTCCTGAAATA TGAGGCCATCTATCCCGAGACAGCTGCCATCCTTGGGTATTGTCGTGGAGAAGCGGTCTACTCCAGGGATTGTGTGCACACTCTGCATTC CAGGGACACGTGGCTGAAGAAAGCAAGAGTGGTGAGGCTTGGAGAAGTACCCTACAAGATGGTGAAAGGCTTTTCTAACCGTGCTCGGAA AGCCCGACTTGCTGAGCCCCAGCTGCGGGAAGAAAATGACCTGGGCCTGTTTGGCTACTGGCAGACAGAGGAGTATCAGCCCCCAGTGGC CGTGGACGGGAAGGTGCCCCGGAACGAGTTTGGGAATGTGTACCTCTTCCTGCCCAGCATGATGCCTATTGGCTGTGTCCAGCTGAACCT GCCCAATCTACACCGCGTGGCCCGCAAGCTGGACATCGACTGTGTCCAGGCCATCACTGGCTTTGATTTCCATGGCGGCTACTCCCATCC CGTGACTGATGGATACATCGTCTGCGAGGAATTCAAAGACGTGCTCCTGACTGCCTGGGAAAATGAGCAGGCAGTCATTGAAAGGAAGGA GAAGGAGAAAAAGGAGAAGCGGGCTCTAGGGAACTGGAAGTTGCTGGCCAAAGGTCTGCTCATCAGGGAGAGGCTGAAGCGTCGCTACGG GCCCAAGAGTGAGGCAGCAGCTCCCCACACAGATGCAGGAGGTGGACTCTCTTCTGATGAAGAGGAGGGGACCAGCTCTCAAGCAGAAGC GGCCAGGATACTGGCTGCCTCCTGGCCTCAAAACCGAGAAGATGAAGAAAAGCAGAAGCTGAAGGGTGGGCCCAAGAAGACCAAAAGGGA AAAGAAAGCAGCAGCTTCCCACCTGTTCCCATTTGAGCAGCTGTGAGCTGAGCGCCCACTAGAGGGGCACCCACCAGTTGCTGCTGCCCC ACTACAGGCCCCACACCTGCCCTGGGCATGCCCAGCCCCTGGTGGTGGGGGCTTCTCTGCTGAGAAGGCAAACTGAGGCAGCATGCACGG AGGCGGGGTCAGGGGAGACGAGGCCAAGCTGAGGAGGTGCTGCAGGTCCCGTCTGGCTCCAGCCCTTGTCAGATTCACCCAGGGTGAAGC CTTCAAAGCTTTTTGCTACCAAAGCCCACTCACCCTTTGAGCTACAGAACACTTTGCTAGGAGATACTCTTCTGCCTCCTAGACCTGTTC TTTCCATCTTTAGAAACATCAGTTTTTGTATGGAAGCCACCGGGAGATTTCTGGATGGTGGTGCATCCGTGAATGCGCTGATCGTTTCTT CCAGTTAGAGTCTTCATCTGTCCGACAAGTTCACTCGCCTCGGTTGCGGACCTAGGACCATTTCTCTGCAGGCCACTTACCTTCCCCTGA GTCAGGCTTACTAATGCTGCCCTCACTGCCTCTTTGCAGTAGGGGAGAGAGCAGAGAAGTACAGGTCATCTGCTGGGATCTAGTTTTCCA AGTAACATTTTGTGGTGACAGAAGCCTAAAAAAAGCTAAAATCAGGAAAGAAAAGGAAAAATACGAATTGAAAATTAAGGAAATGTTAGT AAAATAGATGAGTGTTAAACTAGATTGTATTCATTACTAGATAAAATGTATAAAGCTCTCTGTACTAAGGAGAAATGACTTTTATAACAT >In-frame_TGFBR2_ENST00000295754_chr3_30648469_+_XPC_ENST00000449060_chr3_14214562_-_3085nt GGAGAGGGAGAAGGCTCTCGGGCGGAGAGAGGTCCTGCCCAGCTGTTGGCGAGGAGTTTCCTGTTTCCCCCGCAGCGCTGAGTTGAAGTT GAGTGAGTCACTCGCGCGCACGGAGCGACGACACCCCCGCGCGTGCACCCGCTCGGGACAGGAGCCGGACTCCTGTGCAGCTTCCCTCGG CCGCCGGGGGCCTCCCCGCGCCTCGCCGGCCTCCAGGCCCCCTCCTGGCTGGCGAGCGGGCGCCACATCTGGCCCGCACATCTGCGCTGC CGGCCCGGCGCGGGGTCCGGAGAGGGCGCGGCGCGGAGGCGCAGCCAGGGGTCCGGGAAGGCGCCGTCCGCTGCGCTGGGGGCTCGGTCT ATGACGAGCAGCGGGGTCTGCCATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCAC GATCCCACCGCACGTTCAGAAGTCGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAG GAAAAGAGGCTGCAGTCATCCTGGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAA GGTTATAAAGGATGAAGCCCTCAGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGC TACCATGAATGAAGACAGCAATGAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGCGAAGACAAGAGAAAGAAGTGAAAAGATAAA ACTGGAGTTTGAGACATATCTTCGGAGGGCGATGAAACGTTTCAATAAAGGGGTCCATGAGGACACACACAAGGTTCACCTTCTCTGCCT GCTAGCAAATGGCTTCTATCGAAATAACATCTGCAGCCAGCCAGATCTGCATGCTATTGGCCTGTCCATCATCCCAGCCCGCTTTACCAG AGTGCTGCCTCGAGATGTGGACACCTACTACCTCTCAAACCTGGTGAAGTGGTTCATTGGAACATTTACAGTTAATGCAGAACTTTCAGC CAGTGAACAAGATAACCTGCAGACTACATTGGAAAGGAGATTTGCTATTTACTCTGCTCGAGATGATGAGGAATTGGTCCATATATTCTT ACTGATTCTCCGGGCTCTGCAGCTCTTGACCCGGCTGGTATTGTCTCTACAGCCAATTCCTCTGAAGTCAGCAACAGCAAAGGGAAAGAA ACCTTCCAAGGAAAGATTGACTGCGGATCCAGGAGGCTCCTCAGAAACTTCCAGCCAAGTTCTAGAAAACCACACCAAACCAAAGACCAG CAAAGGAACCAAACAAGAGGAAACCTTTGCTAAGGGCACCTGCAGGCCAAGTGCCAAAGGGAAGAGGAACAAGGGAGGCAGAAAGAAACG GAGCAAGCCCTCCTCCAGCGAGGAAGATGAGGGCCCAGGAGACAAGCAGGAGAAGGCAACCCAGCGACGTCCGCATGGCCGGGAGCGGCG GGTGGCCTCCAGGGTGTCTTATAAAGAGGAGAGTGGGAGTGATGAGGCTGGCAGCGGCTCTGATTTTGAGCTCTCCAGTGGAGAAGCCTC TGATCCCTCTGATGAGGATTCCGAACCTGGCCCTCCAAAGCAGAGGAAAGCCCCCGCTCCTCAGAGGACAAAGGCTGGGTCCAAGAGTGC CTCCAGGACCCATCGTGGGAGCCATCGTAAGGACCCAAGCTTGCCAGCGGCATCCTCAAGCTCTTCAAGCAGTAAAAGAGGCAAGAAAAT GTGCAGCGATGGTGAGAAGGCAGAAAAAAGAAGCATAGCTGGTATAGACCAGTGGCTAGAGGTGTTCTGTGAGCAGGAGGAAAAGTGGGT ATGTGTAGACTGTGTGCACGGTGTGGTGGGCCAGCCTCTGACCTGTTACAAGTACGCCACCAAGCCCATGACCTATGTGGTGGGCATTGA CAGTGACGGCTGGGTCCGAGATGTCACACAGAGGTACGACCCAGTCTGGATGACAGTGACCCGCAAGTGCCGGGTTGATGCTGAGTGGTG GGCCGAGACCTTGAGACCATACCAGAGCCCATTTATGGACAGGGAGAAGAAAGAAGACTTGGAGTTTCAGGCTAAACACATGGACCAGCC TTTGCCCACTGCCATTGGCTTATATAAGAACCACCCTCTGTATGCCCTGAAGCGGCATCTCCTGAAATATGAGGCCATCTATCCCGAGAC AGCTGCCATCCTTGGGTATTGTCGTGGAGAAGCGGTCTACTCCAGGGATTGTGTGCACACTCTGCATTCCAGGGACACGTGGCTGAAGAA AGCAAGAGTGGTGAGGCTTGGAGAAGTACCCTACAAGATGGTGAAAGGCTTTTCTAACCGTGCTCGGAAAGCCCGACTTGCTGAGCCCCA GCTGCGGGAAGAAAATGACCTGGGCCTGTTTGGCTACTGGCAGACAGAGGAGTATCAGCCCCCAGTGGCCGTGGACGGGAAGGTGCCCCG GAACGAGTTTGGGAATGTGTACCTCTTCCTGCCCAGCATGATGCCTATTGGCTGTGTCCAGCTGAACCTGCCCAATCTACACCGCGTGGC CCGCAAGCTGGACATCGACTGTGTCCAGGCCATCACTGGCTTTGATTTCCATGGCGGCTACTCCCATCCCGTGACTGATGGATACATCGT CTGCGAGGAATTCAAAGACGTGCTCCTGACTGCCTGGGAAAATGAGCAGGCAGTCATTGAAAGGAAGGAGAAGGAGAAAAAGGAGAAGCG GGCTCTAGGGAACTGGAAGTTGCTGGCCAAAGGTCTGCTCATCAGGGAGAGGCTGAAGCGTCGCTACGGGCCCAAGAGTGAGGCAGCAGC TCCCCACACAGATGCAGGAGGTGGACTCTCTTCTGATGAAGAGGAGGGGACCAGCTCTCAAGCAGAAGCGGCCAGGATACTGGCTGCCTC CTGGCCTCAAAACCGAGAAGATGAAGAAAAGCAGAAGCTGAAGGGTGGGCCCAAGAAGACCAAAAGGGAAAAGAAAGCAGCAGCTTCCCA >In-frame_TGFBR2_ENST00000359013_chr3_30648469_+_XPC_ENST00000285021_chr3_14214562_-_3891nt ACTCGCGCGCACGGAGCGACGACACCCCCGCGCGTGCACCCGCTCGGGACAGGAGCCGGACTCCTGTGCAGCTTCCCTCGGCCGCCGGGG GCCTCCCCGCGCCTCGCCGGCCTCCAGGCCCCCTCCTGGCTGGCGAGCGGGCGCCACATCTGGCCCGCACATCTGCGCTGCCGGCCCGGC GCGGGGTCCGGAGAGGGCGCGGCGCGGAGGCGCAGCCAGGGGTCCGGGAAGGCGCCGTCCGCTGCGCTGGGGGCTCGGTCTATGACGAGC AGCGGGGTCTGCCATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCACGATCCCACC GCACGTTCAGAAGTCGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAGGAAAAGAGG CTGCAGTCATCCTGGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAAGGTTATAAA GGATGAAGCCCTCAGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGCTACCATGAA TGAAGACAGCAATGAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGTTGAAGAACTTAGTGAGCCTGTGCTGGGTGACGTGAGAGA AAGTACAGCCTTCTCTCGATCTCTTCTGCCTGTGAAGCCAGTGGAGATAGAGATTGAAACGCCAGAGCAGGCGAAGACAAGAGAAAGAAG TGAAAAGATAAAACTGGAGTTTGAGACATATCTTCGGAGGGCGATGAAACGTTTCAATAAAGGGGTCCATGAGGACACACACAAGGTTCA CCTTCTCTGCCTGCTAGCAAATGGCTTCTATCGAAATAACATCTGCAGCCAGCCAGATCTGCATGCTATTGGCCTGTCCATCATCCCAGC CCGCTTTACCAGAGTGCTGCCTCGAGATGTGGACACCTACTACCTCTCAAACCTGGTGAAGTGGTTCATTGGAACATTTACAGTTAATGC AGAACTTTCAGCCAGTGAACAAGATAACCTGCAGACTACATTGGAAAGGAGATTTGCTATTTACTCTGCTCGAGATGATGAGGAATTGGT CCATATATTCTTACTGATTCTCCGGGCTCTGCAGCTCTTGACCCGGCTGGTATTGTCTCTACAGCCAATTCCTCTGAAGTCAGCAACAGC AAAGGGAAAGAAACCTTCCAAGGAAAGATTGACTGCGGATCCAGGAGGCTCCTCAGAAACTTCCAGCCAAGTTCTAGAAAACCACACCAA ACCAAAGACCAGCAAAGGAACCAAACAAGAGGAAACCTTTGCTAAGGGCACCTGCAGGCCAAGTGCCAAAGGGAAGAGGAACAAGGGAGG CAGAAAGAAACGGAGCAAGCCCTCCTCCAGCGAGGAAGATGAGGGCCCAGGAGACAAGCAGGAGAAGGCAACCCAGCGACGTCCGCATGG CCGGGAGCGGCGGGTGGCCTCCAGGGTGTCTTATAAAGAGGAGAGTGGGAGTGATGAGGCTGGCAGCGGCTCTGATTTTGAGCTCTCCAG TGGAGAAGCCTCTGATCCCTCTGATGAGGATTCCGAACCTGGCCCTCCAAAGCAGAGGAAAGCCCCCGCTCCTCAGAGGACAAAGGCTGG GTCCAAGAGTGCCTCCAGGACCCATCGTGGGAGCCATCGTAAGGACCCAAGCTTGCCAGCGGCATCCTCAAGCTCTTCAAGCAGTAAAAG AGGCAAGAAAATGTGCAGCGATGGTGAGAAGGCAGAAAAAAGAAGCATAGCTGGTATAGACCAGTGGCTAGAGGTGTTCTGTGAGCAGGA GGAAAAGTGGGTATGTGTAGACTGTGTGCACGGTGTGGTGGGCCAGCCTCTGACCTGTTACAAGTACGCCACCAAGCCCATGACCTATGT GGTGGGCATTGACAGTGACGGCTGGGTCCGAGATGTCACACAGAGGTACGACCCAGTCTGGATGACAGTGACCCGCAAGTGCCGGGTTGA TGCTGAGTGGTGGGCCGAGACCTTGAGACCATACCAGAGCCCATTTATGGACAGGGAGAAGAAAGAAGACTTGGAGTTTCAGGCTAAACA CATGGACCAGCCTTTGCCCACTGCCATTGGCTTATATAAGAACCACCCTCTGTATGCCCTGAAGCGGCATCTCCTGAAATATGAGGCCAT CTATCCCGAGACAGCTGCCATCCTTGGGTATTGTCGTGGAGAAGCGGTCTACTCCAGGGATTGTGTGCACACTCTGCATTCCAGGGACAC GTGGCTGAAGAAAGCAAGAGTGGTGAGGCTTGGAGAAGTACCCTACAAGATGGTGAAAGGCTTTTCTAACCGTGCTCGGAAAGCCCGACT TGCTGAGCCCCAGCTGCGGGAAGAAAATGACCTGGGCCTGTTTGGCTACTGGCAGACAGAGGAGTATCAGCCCCCAGTGGCCGTGGACGG GAAGGTGCCCCGGAACGAGTTTGGGAATGTGTACCTCTTCCTGCCCAGCATGATGCCTATTGGCTGTGTCCAGCTGAACCTGCCCAATCT ACACCGCGTGGCCCGCAAGCTGGACATCGACTGTGTCCAGGCCATCACTGGCTTTGATTTCCATGGCGGCTACTCCCATCCCGTGACTGA TGGATACATCGTCTGCGAGGAATTCAAAGACGTGCTCCTGACTGCCTGGGAAAATGAGCAGGCAGTCATTGAAAGGAAGGAGAAGGAGAA AAAGGAGAAGCGGGCTCTAGGGAACTGGAAGTTGCTGGCCAAAGGTCTGCTCATCAGGGAGAGGCTGAAGCGTCGCTACGGGCCCAAGAG TGAGGCAGCAGCTCCCCACACAGATGCAGGAGGTGGACTCTCTTCTGATGAAGAGGAGGGGACCAGCTCTCAAGCAGAAGCGGCCAGGAT ACTGGCTGCCTCCTGGCCTCAAAACCGAGAAGATGAAGAAAAGCAGAAGCTGAAGGGTGGGCCCAAGAAGACCAAAAGGGAAAAGAAAGC AGCAGCTTCCCACCTGTTCCCATTTGAGCAGCTGTGAGCTGAGCGCCCACTAGAGGGGCACCCACCAGTTGCTGCTGCCCCACTACAGGC CCCACACCTGCCCTGGGCATGCCCAGCCCCTGGTGGTGGGGGCTTCTCTGCTGAGAAGGCAAACTGAGGCAGCATGCACGGAGGCGGGGT CAGGGGAGACGAGGCCAAGCTGAGGAGGTGCTGCAGGTCCCGTCTGGCTCCAGCCCTTGTCAGATTCACCCAGGGTGAAGCCTTCAAAGC TTTTTGCTACCAAAGCCCACTCACCCTTTGAGCTACAGAACACTTTGCTAGGAGATACTCTTCTGCCTCCTAGACCTGTTCTTTCCATCT TTAGAAACATCAGTTTTTGTATGGAAGCCACCGGGAGATTTCTGGATGGTGGTGCATCCGTGAATGCGCTGATCGTTTCTTCCAGTTAGA GTCTTCATCTGTCCGACAAGTTCACTCGCCTCGGTTGCGGACCTAGGACCATTTCTCTGCAGGCCACTTACCTTCCCCTGAGTCAGGCTT ACTAATGCTGCCCTCACTGCCTCTTTGCAGTAGGGGAGAGAGCAGAGAAGTACAGGTCATCTGCTGGGATCTAGTTTTCCAAGTAACATT TTGTGGTGACAGAAGCCTAAAAAAAGCTAAAATCAGGAAAGAAAAGGAAAAATACGAATTGAAAATTAAGGAAATGTTAGTAAAATAGAT GAGTGTTAAACTAGATTGTATTCATTACTAGATAAAATGTATAAAGCTCTCTGTACTAAGGAGAAATGACTTTTATAACATTTTGAGAAA >In-frame_TGFBR2_ENST00000359013_chr3_30648469_+_XPC_ENST00000449060_chr3_14214562_-_2986nt ACTCGCGCGCACGGAGCGACGACACCCCCGCGCGTGCACCCGCTCGGGACAGGAGCCGGACTCCTGTGCAGCTTCCCTCGGCCGCCGGGG GCCTCCCCGCGCCTCGCCGGCCTCCAGGCCCCCTCCTGGCTGGCGAGCGGGCGCCACATCTGGCCCGCACATCTGCGCTGCCGGCCCGGC GCGGGGTCCGGAGAGGGCGCGGCGCGGAGGCGCAGCCAGGGGTCCGGGAAGGCGCCGTCCGCTGCGCTGGGGGCTCGGTCTATGACGAGC AGCGGGGTCTGCCATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCACGATCCCACC GCACGTTCAGAAGTCGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAGGAAAAGAGG CTGCAGTCATCCTGGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAAGGTTATAAA GGATGAAGCCCTCAGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGCTACCATGAA TGAAGACAGCAATGAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGCGAAGACAAGAGAAAGAAGTGAAAAGATAAAACTGGAGTT TGAGACATATCTTCGGAGGGCGATGAAACGTTTCAATAAAGGGGTCCATGAGGACACACACAAGGTTCACCTTCTCTGCCTGCTAGCAAA TGGCTTCTATCGAAATAACATCTGCAGCCAGCCAGATCTGCATGCTATTGGCCTGTCCATCATCCCAGCCCGCTTTACCAGAGTGCTGCC TCGAGATGTGGACACCTACTACCTCTCAAACCTGGTGAAGTGGTTCATTGGAACATTTACAGTTAATGCAGAACTTTCAGCCAGTGAACA AGATAACCTGCAGACTACATTGGAAAGGAGATTTGCTATTTACTCTGCTCGAGATGATGAGGAATTGGTCCATATATTCTTACTGATTCT CCGGGCTCTGCAGCTCTTGACCCGGCTGGTATTGTCTCTACAGCCAATTCCTCTGAAGTCAGCAACAGCAAAGGGAAAGAAACCTTCCAA GGAAAGATTGACTGCGGATCCAGGAGGCTCCTCAGAAACTTCCAGCCAAGTTCTAGAAAACCACACCAAACCAAAGACCAGCAAAGGAAC CAAACAAGAGGAAACCTTTGCTAAGGGCACCTGCAGGCCAAGTGCCAAAGGGAAGAGGAACAAGGGAGGCAGAAAGAAACGGAGCAAGCC CTCCTCCAGCGAGGAAGATGAGGGCCCAGGAGACAAGCAGGAGAAGGCAACCCAGCGACGTCCGCATGGCCGGGAGCGGCGGGTGGCCTC CAGGGTGTCTTATAAAGAGGAGAGTGGGAGTGATGAGGCTGGCAGCGGCTCTGATTTTGAGCTCTCCAGTGGAGAAGCCTCTGATCCCTC TGATGAGGATTCCGAACCTGGCCCTCCAAAGCAGAGGAAAGCCCCCGCTCCTCAGAGGACAAAGGCTGGGTCCAAGAGTGCCTCCAGGAC CCATCGTGGGAGCCATCGTAAGGACCCAAGCTTGCCAGCGGCATCCTCAAGCTCTTCAAGCAGTAAAAGAGGCAAGAAAATGTGCAGCGA TGGTGAGAAGGCAGAAAAAAGAAGCATAGCTGGTATAGACCAGTGGCTAGAGGTGTTCTGTGAGCAGGAGGAAAAGTGGGTATGTGTAGA CTGTGTGCACGGTGTGGTGGGCCAGCCTCTGACCTGTTACAAGTACGCCACCAAGCCCATGACCTATGTGGTGGGCATTGACAGTGACGG CTGGGTCCGAGATGTCACACAGAGGTACGACCCAGTCTGGATGACAGTGACCCGCAAGTGCCGGGTTGATGCTGAGTGGTGGGCCGAGAC CTTGAGACCATACCAGAGCCCATTTATGGACAGGGAGAAGAAAGAAGACTTGGAGTTTCAGGCTAAACACATGGACCAGCCTTTGCCCAC TGCCATTGGCTTATATAAGAACCACCCTCTGTATGCCCTGAAGCGGCATCTCCTGAAATATGAGGCCATCTATCCCGAGACAGCTGCCAT CCTTGGGTATTGTCGTGGAGAAGCGGTCTACTCCAGGGATTGTGTGCACACTCTGCATTCCAGGGACACGTGGCTGAAGAAAGCAAGAGT GGTGAGGCTTGGAGAAGTACCCTACAAGATGGTGAAAGGCTTTTCTAACCGTGCTCGGAAAGCCCGACTTGCTGAGCCCCAGCTGCGGGA AGAAAATGACCTGGGCCTGTTTGGCTACTGGCAGACAGAGGAGTATCAGCCCCCAGTGGCCGTGGACGGGAAGGTGCCCCGGAACGAGTT TGGGAATGTGTACCTCTTCCTGCCCAGCATGATGCCTATTGGCTGTGTCCAGCTGAACCTGCCCAATCTACACCGCGTGGCCCGCAAGCT GGACATCGACTGTGTCCAGGCCATCACTGGCTTTGATTTCCATGGCGGCTACTCCCATCCCGTGACTGATGGATACATCGTCTGCGAGGA ATTCAAAGACGTGCTCCTGACTGCCTGGGAAAATGAGCAGGCAGTCATTGAAAGGAAGGAGAAGGAGAAAAAGGAGAAGCGGGCTCTAGG GAACTGGAAGTTGCTGGCCAAAGGTCTGCTCATCAGGGAGAGGCTGAAGCGTCGCTACGGGCCCAAGAGTGAGGCAGCAGCTCCCCACAC AGATGCAGGAGGTGGACTCTCTTCTGATGAAGAGGAGGGGACCAGCTCTCAAGCAGAAGCGGCCAGGATACTGGCTGCCTCCTGGCCTCA AAACCGAGAAGATGAAGAAAAGCAGAAGCTGAAGGGTGGGCCCAAGAAGACCAAAAGGGAAAAGAAAGCAGCAGCTTCCCACCTGTTCCC |
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FusionGenePPI for TGFBR2_XPC |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TGFBR2 | CLU, TGFBR1, TGFB3, SMURF2, SMAD7, ENG, DAB2, AP2B1, CTNNB1, TGFBR3, TGFB1, TGFB2, CCNB2, CCNB1, STRAP, PIK3R1, PIK3R2, SNX6, ACVR1, HSP90AA1, SMURF1, TSC22D1, TRAF6, MAP3K7, PAK1, CDC42, ARHGEF6, KCNK18, FBXO34, OXSR1, PPP1R16B, OCLN, APP, IQGAP1, PEG10, NRP1, TERT, PDGFRA, RCVRN, GOPC, NRP2, TRAF4, CBL, PIK3CB, CDC6, PKN3, PLEKHH3, ACVR2B, ACVR2A, PKN2, TYK2, JAK1, PIK3R3, LSR, RAB6B, RAB6A, WDR44, MARCH7, CD320, RELT, BMPR1A, ERBB2, DENND6A, FGFR1, DIP2A, PTPRS, PTPRF, EHD4, ACVR1B, NDFIP1, MFAP3, MYADM, SBF1, FMN2, FAM171A2, LRP10, CTDNEP1, SPSB1, EIF3I, DAXX, TGFBRAP1, SH3KBP1, RASSF1, TRIM25 | XPC | RAD23A, CETN2, RAD23B, ERCC3, SMARCB1, ATR, ATM, H2AFX, CHAF1A, BANF1, DDB1, DDB2, UBE4B, GTF2H1, XPA, HMGB1, RPA1, MECP2, WRAP53, CHRAC1, ZCCHC6, USP11, TOP2B, POU5F1, SMAD1, ZNF512B, RNF111, LSM3, TP53, MDM2, UBC, PSMD4, USP7, RPA4, SPIN2B, RPA2, RNF146, SIRT6, POLB, CSNK2A2, APLF, HIST1H2BA, TDG, HIST1H2BG, HIST1H3A, NPM1, EMC2, PHF8, CETN1, HIST1H2BO, HIST1H2BD, PARP2, CETN3, CHD1L, MACROD1, XRCC6, SSRP1, APOBEC3C, H2AFY2, SUPT16H, PARP1, NAA40, HIST2H2AB, WDR76, SDC2, HIST1H2AG, H2AFY, HIST2H4A, TSEN2, ALX3, ZNF428, MTF1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 847_866 | 34 | 941 | CETN2 |
| Tgene | XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 847_866 | 34 | 904 | CETN2 |
| Tgene | XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 816_940 | 34 | 941 | ERCC2 and GTF2H1 |
| Tgene | XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 816_940 | 34 | 904 | ERCC2 and GTF2H1 |
| Tgene | XPC | chr3:30648469 | chr3:14214562 | ENST00000285021 | - | 0 | 16 | 496_734 | 34 | 941 | RAD23B |
| Tgene | XPC | chr3:30648469 | chr3:14214562 | ENST00000449060 | - | 0 | 16 | 496_734 | 34 | 904 | RAD23B |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TGFBR2_XPC |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | TGFBR2 | P37173 | DB09462 | Glycerin | TGF-beta receptor type-2 | small molecule | approved|investigational |
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RelatedDiseases for TGFBR2_XPC |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TGFBR2 | C2674574 | Aortic aneurysm, familial thoracic 3 | 11 | CTD_human;ORPHANET;UNIPROT |
| Hgene | TGFBR2 | C2697932 | Loeys-Dietz Syndrome | 5 | CTD_human |
| Hgene | TGFBR2 | C0002949 | Aneurysm, Dissecting | 2 | CTD_human;HPO |
| Hgene | TGFBR2 | C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_human |
| Hgene | TGFBR2 | C0376634 | Craniofacial Abnormalities | 2 | CTD_human |
| Hgene | TGFBR2 | C0920269 | Microsatellite Instability | 2 | CTD_human |
| Hgene | TGFBR2 | C1860896 | COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 6 | 2 | UNIPROT |
| Hgene | TGFBR2 | C0003486 | Aortic Aneurysm | 1 | CTD_human;HPO |
| Hgene | TGFBR2 | C0005940 | Bone Diseases | 1 | CTD_human |
| Hgene | TGFBR2 | C0005967 | Bone neoplasms | 1 | CTD_human |
| Hgene | TGFBR2 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Hgene | TGFBR2 | C0009405 | Hereditary Nonpolyposis Colorectal Neoplasms | 1 | CTD_human |
| Hgene | TGFBR2 | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
| Hgene | TGFBR2 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Hgene | TGFBR2 | C0015393 | Eye Abnormalities | 1 | CTD_human |
| Hgene | TGFBR2 | C0015672 | Fatigue | 1 | CTD_human;HPO |
| Hgene | TGFBR2 | C0019294 | Hernia, Inguinal | 1 | CTD_human |
| Hgene | TGFBR2 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | TGFBR2 | C0024796 | Marfan Syndrome | 1 | CTD_human |
| Hgene | TGFBR2 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | TGFBR2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | TGFBR2 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | TGFBR2 | C0149931 | Migraine Disorders | 1 | CTD_human;HPO |
| Hgene | TGFBR2 | C0152018 | Esophageal carcinoma | 1 | HPO;UNIPROT |
| Hgene | TGFBR2 | C0162872 | Aortic Aneurysm, Thoracic | 1 | CTD_human |
| Tgene | XPC | C2752147 | XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C | 2 | CTD_human;UNIPROT |
| Tgene | XPC | C0002514 | Amino Acid Metabolism, Inborn Errors | 1 | CTD_human |
| Tgene | XPC | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | XPC | C0008625 | Chromosome Aberrations | 1 | CTD_human |
| Tgene | XPC | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Tgene | XPC | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Tgene | XPC | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human |
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