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Fusion gene ID: 3789 |
FusionGeneSummary for BAG1_USP34 |
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Fusion gene information | Fusion gene name: BAG1_USP34 | Fusion gene ID: 3789 | Hgene | Tgene | Gene symbol | BAG1 | USP34 | Gene ID | 573 | 9736 |
Gene name | BCL2 associated athanogene 1 | ubiquitin specific peptidase 34 | |
Synonyms | BAG-1|HAP|RAP46 | - | |
Cytomap | 9p13.3 | 2p15 | |
Type of gene | protein-coding | protein-coding | |
Description | BAG family molecular chaperone regulator 1BCL2-associated athanogeneBcl-2 associating athanogene-1 proteinBcl-2-binding proteinglucocortoid receptor-associated protein RAP46receptor-associated protein, 46-KD | ubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | Q99933 | Q70CQ2 | |
Ensembl transtripts involved in fusion gene | ENST00000472232, ENST00000467389, ENST00000379704, | ENST00000398571, ENST00000472689, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 7 X 2=84 |
# samples | 1 | 7 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BAG1 [Title/Abstract] AND USP34 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BAG1 | GO:0051085 | chaperone cofactor-dependent protein refolding | 12853476 |
Tgene | USP34 | GO:0016579 | protein deubiquitination | 14715245 |
Tgene | USP34 | GO:0071108 | protein K48-linked deubiquitination | 21383061 |
Tgene | USP34 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 21383061 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI471677 | BAG1 | chr9 | 33255092 | + | USP34 | chr2 | 61694016 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000472232 | ENST00000398571 | BAG1 | chr9 | 33255092 | + | USP34 | chr2 | 61694016 | + |
intron-intron | ENST00000472232 | ENST00000472689 | BAG1 | chr9 | 33255092 | + | USP34 | chr2 | 61694016 | + |
intron-intron | ENST00000467389 | ENST00000398571 | BAG1 | chr9 | 33255092 | + | USP34 | chr2 | 61694016 | + |
intron-intron | ENST00000467389 | ENST00000472689 | BAG1 | chr9 | 33255092 | + | USP34 | chr2 | 61694016 | + |
intron-intron | ENST00000379704 | ENST00000398571 | BAG1 | chr9 | 33255092 | + | USP34 | chr2 | 61694016 | + |
intron-intron | ENST00000379704 | ENST00000472689 | BAG1 | chr9 | 33255092 | + | USP34 | chr2 | 61694016 | + |
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FusionProtFeatures for BAG1_USP34 |
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Hgene | Tgene |
BAG1 | USP34 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BAG1_USP34 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BAG1_USP34 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BAG1_USP34 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BAG1_USP34 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BAG1 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
Hgene | BAG1 | C0011570 | Mental Depression | 1 | PSYGENET |
Hgene | BAG1 | C0011581 | Depressive disorder | 1 | PSYGENET |
Hgene | BAG1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | BAG1 | C1134719 | Invasive Ductal Breast Carcinoma | 1 | CTD_human |
Hgene | BAG1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |