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Fusion gene ID: 37882 |
FusionGeneSummary for TF_TTL |
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Fusion gene information | Fusion gene name: TF_TTL | Fusion gene ID: 37882 | Hgene | Tgene | Gene symbol | TF | TTL | Gene ID | 7018 | 150465 |
Gene name | transferrin | tubulin tyrosine ligase | |
Synonyms | HEL-S-71p|PRO1557|PRO2086|TFQTL1 | - | |
Cytomap | 3q22.1 | 2q14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | serotransferrinbeta-1 metal-binding globulinepididymis secretory sperm binding protein Li 71psiderophilin | tubulin--tyrosine ligase2410003M22Rik | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P02787 | Q8NG68 | |
Ensembl transtripts involved in fusion gene | ENST00000402696, ENST00000264998, ENST00000475382, | ENST00000233336, ENST00000460450, | |
Fusion gene scores | * DoF score | 13 X 9 X 2=234 | 1 X 1 X 1=1 |
# samples | 17 | 2 | |
** MAII score | log2(17/234*10)=-0.460973783445703 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/1*10)=4.32192809488736 | |
Context | PubMed: TF [Title/Abstract] AND TTL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TF | GO:0048260 | positive regulation of receptor-mediated endocytosis | 12704209 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE766500 | TF | chr3 | 133478137 | - | TTL | chr2 | 113280709 | + | ||
ChiTaRS3.1 | BE766507 | TF | chr3 | 133478137 | - | TTL | chr2 | 113280709 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000402696 | ENST00000233336 | TF | chr3 | 133478137 | - | TTL | chr2 | 113280709 | + |
5CDS-intron | ENST00000402696 | ENST00000460450 | TF | chr3 | 133478137 | - | TTL | chr2 | 113280709 | + |
5CDS-intron | ENST00000264998 | ENST00000233336 | TF | chr3 | 133478137 | - | TTL | chr2 | 113280709 | + |
5CDS-intron | ENST00000264998 | ENST00000460450 | TF | chr3 | 133478137 | - | TTL | chr2 | 113280709 | + |
intron-intron | ENST00000475382 | ENST00000233336 | TF | chr3 | 133478137 | - | TTL | chr2 | 113280709 | + |
intron-intron | ENST00000475382 | ENST00000460450 | TF | chr3 | 133478137 | - | TTL | chr2 | 113280709 | + |
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FusionProtFeatures for TF_TTL |
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Hgene | Tgene |
TF | TTL |
Transferrins are iron binding transport proteins whichcan bind two Fe(3+) ions in association with the binding of ananion, usually bicarbonate. It is responsible for the transport ofiron from sites of absorption and heme degradation to those ofstorage and utilization. Serum transferrin may also have a furtherrole in stimulating cell proliferation. | Catalyzes the post-translational addition of a tyrosineto the C-terminal end of detyrosinated alpha-tubulin.{ECO:0000269|PubMed:25908662}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TF_TTL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TF_TTL |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TF_TTL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | TF | P02787 | DB00515 | Cisplatin | Serotransferrin | small molecule | approved |
Hgene | TF | P02787 | DB01592 | Iron | Serotransferrin | small molecule | approved |
Hgene | TF | P02787 | DB01370 | Aluminium | Serotransferrin | small molecule | approved|investigational |
Hgene | TF | P02787 | DB01593 | Zinc | Serotransferrin | small molecule | approved|investigational |
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RelatedDiseases for TF_TTL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TF | C0036341 | Schizophrenia | 3 | PSYGENET |
Hgene | TF | C0521802 | Congenital atransferrinemia | 3 | CTD_human;HPO;ORPHANET;UNIPROT |
Hgene | TF | C0001973 | Alcoholic Intoxication, Chronic | 2 | CTD_human |
Hgene | TF | C0002395 | Alzheimer's Disease | 2 | CTD_human |
Hgene | TF | C0015695 | Fatty Liver | 2 | CTD_human |
Hgene | TF | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
Hgene | TF | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
Hgene | TF | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | TF | C0013502 | Echinococcosis | 1 | CTD_human |
Hgene | TF | C0019158 | Hepatitis | 1 | CTD_human |
Hgene | TF | C0021368 | Inflammation | 1 | CTD_human |
Hgene | TF | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | TF | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
Hgene | TF | C0028754 | Obesity | 1 | CTD_human |
Hgene | TF | C0030524 | Paratuberculosis | 1 | CTD_human |
Hgene | TF | C0035258 | Restless Legs Syndrome | 1 | CTD_human |
Hgene | TF | C0036337 | Schizoaffective Disorder | 1 | PSYGENET |
Hgene | TF | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Hgene | TF | C0271901 | Microcytic hypochromic anemia (disorder) | 1 | CTD_human |
Hgene | TF | C0282193 | Iron Overload | 1 | CTD_human |
Hgene | TF | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Hgene | TF | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |