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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37882

FusionGeneSummary for TF_TTL

check button Fusion gene summary
Fusion gene informationFusion gene name: TF_TTL
Fusion gene ID: 37882
HgeneTgene
Gene symbol

TF

TTL

Gene ID

7018

150465

Gene nametransferrintubulin tyrosine ligase
SynonymsHEL-S-71p|PRO1557|PRO2086|TFQTL1-
Cytomap

3q22.1

2q14.1

Type of geneprotein-codingprotein-coding
Descriptionserotransferrinbeta-1 metal-binding globulinepididymis secretory sperm binding protein Li 71psiderophilintubulin--tyrosine ligase2410003M22Rik
Modification date2018052320180519
UniProtAcc

P02787

Q8NG68

Ensembl transtripts involved in fusion geneENST00000402696, ENST00000264998, 
ENST00000475382, 
ENST00000233336, 
ENST00000460450, 
Fusion gene scores* DoF score13 X 9 X 2=2341 X 1 X 1=1
# samples 172
** MAII scorelog2(17/234*10)=-0.460973783445703
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/1*10)=4.32192809488736
Context

PubMed: TF [Title/Abstract] AND TTL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTF

GO:0048260

positive regulation of receptor-mediated endocytosis

12704209


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE766500TFchr3

133478137

-TTLchr2

113280709

+
ChiTaRS3.1BE766507TFchr3

133478137

-TTLchr2

113280709

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000402696ENST00000233336TFchr3

133478137

-TTLchr2

113280709

+
5CDS-intronENST00000402696ENST00000460450TFchr3

133478137

-TTLchr2

113280709

+
5CDS-intronENST00000264998ENST00000233336TFchr3

133478137

-TTLchr2

113280709

+
5CDS-intronENST00000264998ENST00000460450TFchr3

133478137

-TTLchr2

113280709

+
intron-intronENST00000475382ENST00000233336TFchr3

133478137

-TTLchr2

113280709

+
intron-intronENST00000475382ENST00000460450TFchr3

133478137

-TTLchr2

113280709

+

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FusionProtFeatures for TF_TTL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TF

P02787

TTL

Q8NG68

Transferrins are iron binding transport proteins whichcan bind two Fe(3+) ions in association with the binding of ananion, usually bicarbonate. It is responsible for the transport ofiron from sites of absorption and heme degradation to those ofstorage and utilization. Serum transferrin may also have a furtherrole in stimulating cell proliferation. Catalyzes the post-translational addition of a tyrosineto the C-terminal end of detyrosinated alpha-tubulin.{ECO:0000269|PubMed:25908662}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TF_TTL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TF_TTL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TF_TTL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTFP02787DB00515CisplatinSerotransferrinsmall moleculeapproved
HgeneTFP02787DB01592IronSerotransferrinsmall moleculeapproved
HgeneTFP02787DB01370AluminiumSerotransferrinsmall moleculeapproved|investigational
HgeneTFP02787DB01593ZincSerotransferrinsmall moleculeapproved|investigational

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RelatedDiseases for TF_TTL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTFC0036341Schizophrenia3PSYGENET
HgeneTFC0521802Congenital atransferrinemia3CTD_human;HPO;ORPHANET;UNIPROT
HgeneTFC0001973Alcoholic Intoxication, Chronic2CTD_human
HgeneTFC0002395Alzheimer's Disease2CTD_human
HgeneTFC0015695Fatty Liver2CTD_human
HgeneTFC0024667Animal Mammary Neoplasms2CTD_human
HgeneTFC0024668Mammary Neoplasms, Experimental2CTD_human
HgeneTFC0004352Autistic Disorder1CTD_human
HgeneTFC0013502Echinococcosis1CTD_human
HgeneTFC0019158Hepatitis1CTD_human
HgeneTFC0021368Inflammation1CTD_human
HgeneTFC0027626Neoplasm Invasiveness1CTD_human
HgeneTFC0027726Nephrotic Syndrome1CTD_human
HgeneTFC0028754Obesity1CTD_human
HgeneTFC0030524Paratuberculosis1CTD_human
HgeneTFC0035258Restless Legs Syndrome1CTD_human
HgeneTFC0036337Schizoaffective Disorder1PSYGENET
HgeneTFC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneTFC0271901Microcytic hypochromic anemia (disorder)1CTD_human
HgeneTFC0282193Iron Overload1CTD_human
HgeneTFC0345967Malignant mesothelioma1CTD_human
HgeneTFC4277682Chemical and Drug Induced Liver Injury1CTD_human