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Fusion gene ID: 3788 |
FusionGeneSummary for BAD_TRMT112 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BAD_TRMT112 | Fusion gene ID: 3788 | Hgene | Tgene | Gene symbol | BAD | TRMT112 | Gene ID | 572 | 51504 |
| Gene name | BCL2 associated agonist of cell death | tRNA methyltransferase subunit 11-2 | |
| Synonyms | BBC2|BCL2L8 | HSPC152|HSPC170|TRM112|TRMT11-2|hTrm112 | |
| Cytomap | 11q13.1 | 11q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bcl2-associated agonist of cell deathBCL-X/BCL-2 binding proteinBCL2-antagonist of cell death proteinBCL2-binding component 6BCL2-binding proteinbcl-2-binding component 6bcl-2-like protein 8bcl-XL/Bcl-2-associated death promoterbcl2 antagonist of | multifunctional methyltransferase subunit TRM112-like proteinTRM112-like proteintRNA methyltransferase 11-2 homologtRNA methyltransferase 112 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q92934 | Q9UI30 | |
| Ensembl transtripts involved in fusion gene | ENST00000394532, ENST00000309032, ENST00000544785, ENST00000394531, | ENST00000535750, ENST00000535126, ENST00000544844, ENST00000308774, ENST00000539854, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: BAD [Title/Abstract] AND TRMT112 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BAD | GO:0006915 | apoptotic process | 19667065 |
| Hgene | BAD | GO:0043065 | positive regulation of apoptotic process | 9388232 |
| Hgene | BAD | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 18402937 |
| Hgene | BAD | GO:0045862 | positive regulation of proteolysis | 18387192 |
| Hgene | BAD | GO:0046931 | pore complex assembly | 19667065|21081150 |
| Hgene | BAD | GO:0071316 | cellular response to nicotine | 18676776 |
| Hgene | BAD | GO:0097202 | activation of cysteine-type endopeptidase activity | 18387192 |
| Tgene | TRMT112 | GO:0018364 | peptidyl-glutamine methylation | 18539146 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-VQ-AA6D-01A | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000394532 | ENST00000535750 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000394532 | ENST00000535126 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000394532 | ENST00000544844 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000394532 | ENST00000308774 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000394532 | ENST00000539854 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000309032 | ENST00000535750 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000309032 | ENST00000535126 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000309032 | ENST00000544844 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000309032 | ENST00000308774 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000309032 | ENST00000539854 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000544785 | ENST00000535750 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000544785 | ENST00000535126 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000544785 | ENST00000544844 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000544785 | ENST00000308774 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000544785 | ENST00000539854 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000394531 | ENST00000535750 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000394531 | ENST00000535126 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000394531 | ENST00000544844 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000394531 | ENST00000308774 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
| 5CDS-5UTR | ENST00000394531 | ENST00000539854 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
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FusionProtFeatures for BAD_TRMT112 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BAD | TRMT112 |
| Promotes cell death. Successfully competes for thebinding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the levelof heterodimerization of these proteins with BAX. Can reverse thedeath repressor activity of Bcl-X(L), but not that of Bcl-2 (Bysimilarity). Appears to act as a link between growth factorreceptor signaling and the apoptotic pathways. {ECO:0000250}. | Acts as an activator of both rRNA/tRNA and proteinmethyltransferases (PubMed:25851604). Together withmethyltransferase BUD23, methylates the N(7) position of a guaninein 18S rRNA (PubMed:25851604). The heterodimer with HEMK2/N6AMT1catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:18539146). The heterodimer withALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of theanticodon loop in target tRNA species (PubMed:20308323). Involvedin the pre-rRNA processing steps leading to small-subunit rRNAproduction (PubMed:25851604). {ECO:0000269|PubMed:18539146,ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:25851604}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BAD_TRMT112 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BAD_TRMT112 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BAD | BCL2A1, MCL1, SFN, EWSR1, BCL2L2, BCL2L1, BCL2, YWHAQ, PRKCI, PIM2, YWHAE, YWHAB, YWHAH, S100A10, AKT1, PRKACA, RPS6KA1, RPS6KA5, YWHAZ, YWHAG, SUMO2, PPP1CA, BAX, SNCA, VCP, RAF1, PAK1, BRAF, ARAF, CREB3L3, CDKN1A, PRDX2, KEAP1, STEAP3, GIMAP5, PRKD1, PRKCE, NDUFA12, LIMK1, SORT1, SYNCRIP, APTX, CBY1 | TRMT112 | RGS20, CUL2, RBM39, SRSF11, SRSF3, SF3B1, SAFB, NOP56, ACIN1, SRSF5, NCSTN, RBM14, LUC7L3, SRSF10, THOC1, SART1, SRSF1, PRPF40A, THOC7, SF3A1, THUMPD3, CAND1, IPO7, IPO4, WBSCR22, SCOC, DHX15, NAPRT, NPM1, RPL10, SYNCRIP, TRMT11 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BAD_TRMT112 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BAD_TRMT112 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BAD | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Hgene | BAD | C0007787 | Transient Ischemic Attack | 1 | CTD_human |
| Hgene | BAD | C0023418 | leukemia | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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