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Fusion gene ID: 3788 |
FusionGeneSummary for BAD_TRMT112 |
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Fusion gene information | Fusion gene name: BAD_TRMT112 | Fusion gene ID: 3788 | Hgene | Tgene | Gene symbol | BAD | TRMT112 | Gene ID | 572 | 51504 |
Gene name | BCL2 associated agonist of cell death | tRNA methyltransferase subunit 11-2 | |
Synonyms | BBC2|BCL2L8 | HSPC152|HSPC170|TRM112|TRMT11-2|hTrm112 | |
Cytomap | 11q13.1 | 11q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | bcl2-associated agonist of cell deathBCL-X/BCL-2 binding proteinBCL2-antagonist of cell death proteinBCL2-binding component 6BCL2-binding proteinbcl-2-binding component 6bcl-2-like protein 8bcl-XL/Bcl-2-associated death promoterbcl2 antagonist of | multifunctional methyltransferase subunit TRM112-like proteinTRM112-like proteintRNA methyltransferase 11-2 homologtRNA methyltransferase 112 homolog | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q92934 | Q9UI30 | |
Ensembl transtripts involved in fusion gene | ENST00000394532, ENST00000309032, ENST00000544785, ENST00000394531, | ENST00000535750, ENST00000535126, ENST00000544844, ENST00000308774, ENST00000539854, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: BAD [Title/Abstract] AND TRMT112 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BAD | GO:0006915 | apoptotic process | 19667065 |
Hgene | BAD | GO:0043065 | positive regulation of apoptotic process | 9388232 |
Hgene | BAD | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 18402937 |
Hgene | BAD | GO:0045862 | positive regulation of proteolysis | 18387192 |
Hgene | BAD | GO:0046931 | pore complex assembly | 19667065|21081150 |
Hgene | BAD | GO:0071316 | cellular response to nicotine | 18676776 |
Hgene | BAD | GO:0097202 | activation of cysteine-type endopeptidase activity | 18387192 |
Tgene | TRMT112 | GO:0018364 | peptidyl-glutamine methylation | 18539146 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-VQ-AA6D-01A | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000394532 | ENST00000535750 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000394532 | ENST00000535126 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000394532 | ENST00000544844 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000394532 | ENST00000308774 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000394532 | ENST00000539854 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000309032 | ENST00000535750 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000309032 | ENST00000535126 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000309032 | ENST00000544844 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000309032 | ENST00000308774 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000309032 | ENST00000539854 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000544785 | ENST00000535750 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000544785 | ENST00000535126 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000544785 | ENST00000544844 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000544785 | ENST00000308774 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000544785 | ENST00000539854 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000394531 | ENST00000535750 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000394531 | ENST00000535126 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000394531 | ENST00000544844 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000394531 | ENST00000308774 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
5CDS-5UTR | ENST00000394531 | ENST00000539854 | BAD | chr11 | 64051654 | - | TRMT112 | chr11 | 64084837 | - |
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FusionProtFeatures for BAD_TRMT112 |
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Hgene | Tgene |
BAD | TRMT112 |
Promotes cell death. Successfully competes for thebinding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the levelof heterodimerization of these proteins with BAX. Can reverse thedeath repressor activity of Bcl-X(L), but not that of Bcl-2 (Bysimilarity). Appears to act as a link between growth factorreceptor signaling and the apoptotic pathways. {ECO:0000250}. | Acts as an activator of both rRNA/tRNA and proteinmethyltransferases (PubMed:25851604). Together withmethyltransferase BUD23, methylates the N(7) position of a guaninein 18S rRNA (PubMed:25851604). The heterodimer with HEMK2/N6AMT1catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:18539146). The heterodimer withALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of theanticodon loop in target tRNA species (PubMed:20308323). Involvedin the pre-rRNA processing steps leading to small-subunit rRNAproduction (PubMed:25851604). {ECO:0000269|PubMed:18539146,ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:25851604}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BAD_TRMT112 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BAD_TRMT112 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BAD | BCL2A1, MCL1, SFN, EWSR1, BCL2L2, BCL2L1, BCL2, YWHAQ, PRKCI, PIM2, YWHAE, YWHAB, YWHAH, S100A10, AKT1, PRKACA, RPS6KA1, RPS6KA5, YWHAZ, YWHAG, SUMO2, PPP1CA, BAX, SNCA, VCP, RAF1, PAK1, BRAF, ARAF, CREB3L3, CDKN1A, PRDX2, KEAP1, STEAP3, GIMAP5, PRKD1, PRKCE, NDUFA12, LIMK1, SORT1, SYNCRIP, APTX, CBY1 | TRMT112 | RGS20, CUL2, RBM39, SRSF11, SRSF3, SF3B1, SAFB, NOP56, ACIN1, SRSF5, NCSTN, RBM14, LUC7L3, SRSF10, THOC1, SART1, SRSF1, PRPF40A, THOC7, SF3A1, THUMPD3, CAND1, IPO7, IPO4, WBSCR22, SCOC, DHX15, NAPRT, NPM1, RPL10, SYNCRIP, TRMT11 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BAD_TRMT112 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BAD_TRMT112 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BAD | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Hgene | BAD | C0007787 | Transient Ischemic Attack | 1 | CTD_human |
Hgene | BAD | C0023418 | leukemia | 1 | CTD_human |